Ryan Brandt

Works (1)

Updated: July 5th, 2023 15:36

2017 journal article

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains

PLOS PATHOGENS, 13(6).

By: T. Benzine*, R. Brandt n, W. Lovell *, D. Yamane *, P. Neddermann *, R. De Francesco *, S. Lemon *, A. Perelson *, R. Ke n, D. McGivern *

MeSH headings : Half-Life; Hepacivirus / chemistry; Hepacivirus / classification; Hepacivirus / drug effects; Hepacivirus / physiology; Hepatitis C / virology; Humans; Kinetics; Viral Nonstructural Proteins / antagonists & inhibitors; Viral Nonstructural Proteins / chemistry; Viral Nonstructural Proteins / genetics; Viral Nonstructural Proteins / metabolism; Virus Assembly / drug effects; Virus Replication / drug effects
TL;DR: In nascent RNA capture assays, the rate of RNA synthesis decline following NS5A inhibitor addition was significantly faster for H77D compared to H77S.3 indicating different half-lives of functional RCs. (via Semantic Scholar)
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