Robert S Fry

Works (14)

Updated: April 25th, 2025 18:20

2021 article

Two distinct trophectoderm lineage stem cells from human pluripotent stem cells

Mischler, A., Karakis, V., Mahinthakumar, J., Carberry, C. K., Miguel, A. S., Rager, J. E., … Rao, B. M. (2021, January 1). Journal of Biological Chemistry, Vol. 296, p. 100386.

By: A. Mischler n, V. Karakis n, J. Mahinthakumar  n, C. Carberry *, A. Miguel n , J. Rager *, R. Fry *, B. Rao n 

Contributors: A. Mischler n, V. Karakis n, J. Mahinthakumar  n, C. Carberry *, A. Miguel n , J. Rager *, R. Fry*, B. Rao n 

MeSH headings : CDX2 Transcription Factor / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Culture Media; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Female; Humans; Placenta / cytology; Placenta / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Pregnancy; Trophoblasts / cytology; Trophoblasts / metabolism
topics (OpenAlex): Pluripotent Stem Cells Research; Epigenetics and DNA Methylation; Genetic Syndromes and Imprinting
TL;DR: Derivation of hTSCs and hTESCs from pluripotent stem cells significantly enables construction of models for normal and pathological placental development. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 7, 2021

2015 article

Effect of dietary copper amount and source on copper metabolism and oxidative stress of weanling pigs in short-term feeding1

Huang, Y. L., Ashwell, M. S., Fry, R. S., Lloyd, K. E., Flowers, W. L., & Spears, J. W. (2015, May 29). Journal of Animal Science, Vol. 93, pp. 2948–2955.

By: Y. Huang *, M. Ashwell n , R. Fry n, K. Lloyd n, W. Flowers n  & J. Spears n

author keywords: copper; copper metabolism; oxidative stress; pigs
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants / metabolism; Chlorides / pharmacology; Copper / metabolism; Copper Sulfate / pharmacology; Diet / veterinary; Dietary Supplements; Duodenum / metabolism; Gene Expression Regulation; Ileum / metabolism; Intestinal Mucosa / metabolism; Jejunum / metabolism; Liver / metabolism; Male; Malondialdehyde / metabolism; Oxidative Stress / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Swine / physiology
topics (OpenAlex): Trace Elements in Health; Animal Nutrition and Physiology; Heavy Metal Exposure and Toxicity
TL;DR: Feeding weanling pigs increased Cu resulted in modulation of duodenal and liver at the transcription level, and when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO4. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Amount and source of dietary copper affects small intestine morphology, duodenal lipid peroxidation, hepatic oxidative stress,and mRNA expression of hepatic copper regulatory proteins in weanling pigs1,2

Fry, R. S., Ashwell, M. S., Lloyd, K. E., O'Nan, A. T., Flowers, W. L., Stewart, K. R., & Spears, J. W. (2012, May 15). Journal of Animal Science, Vol. 90, pp. 3112–3119.

By: R. Fry n, M. Ashwell n , K. Lloyd n, A. O'Nan n, W. Flowers n , K. Stewart n, J. Spears n

author keywords: copper; copper proteins; mucosal histology; oxidative stress; pigs
MeSH headings : Animals; Copper / metabolism; Copper / pharmacology; Duodenum / drug effects; Duodenum / metabolism; Gene Expression Regulation / drug effects; Intestinal Mucosa / drug effects; Lipid Peroxidation / drug effects; Liver / metabolism; Male; Malondialdehyde / metabolism; Oxidative Stress / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Swine / blood; Swine / metabolism
topics (OpenAlex): Trace Elements in Health; Heavy Metal Exposure and Toxicity; Plant Micronutrient Interactions and Effects
TL;DR: Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO(4), and feeding weanling pigs increased Cu resulted in modulation of certain Cu transporters and chaperones at the transcription level. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Chromium propionate enhances insulin sensitivity in growing cattle

Spears, J. W., Whisnant, C. S., Huntington, G. B., Lloyd, K. E., Fry, R. S., Krafka, K., … Hyda, J. (2012, March 26). Journal of Dairy Science.

By: J. Spears n, C. Whisnant n, G. Huntington n, K. Lloyd n, R. Fry n, K. Krafka, A. Lamptey, J. Hyda

author keywords: chromium; insulin sensitivity; cattle
MeSH headings : Animals; Blood Glucose / analysis; Cattle / growth & development; Diet / veterinary; Dietary Supplements; Fatty Acids, Nonesterified / blood; Female; Glucose / administration & dosage; Glucose Tolerance Test; Insulin / blood; Propionates / administration & dosage; Zea mays
topics (OpenAlex): Chromium effects and bioremediation; Oral and gingival health research
TL;DR: Results indicate that Cr Prop supplementation increased tissue sensitivity to insulin in growing heifers. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Effect of dietary copper and breed on gene products involved in copper acquisition, distribution, and use in Angus and Simmental cows and fetuses1,2

Fry, R. S., Spears, J. W., Lloyd, K. E., O'Nan, A. T., & Ashwell, M. S. (2012, November 13). Journal of Animal Science, Vol. 91, pp. 861–871.

By: R. Fry n, J. Spears n, K. Lloyd n, A. O'Nan n & M. Ashwell n 

author keywords: breed; cattle; copper; deficiency; fetus; placentome
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Copper / blood; Copper / pharmacokinetics; Copper / pharmacology; Female; Fetus / metabolism; Gene Expression Regulation / drug effects; Liver / metabolism; Minerals; Pregnancy
topics (OpenAlex): Trace Elements in Health; Plant Micronutrient Interactions and Effects
TL;DR: Less expression of duodenal Ctr1 and a tendency for less CTR1 suggest that Simmentals have a lesser ability to absorb and utilize dietary Cu, and may explain why Simmental are more prone to Cu deficiency than Angus. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 article

Tolerance of cattle to increased dietary sulfur and effect of dietary cation-anion balance

Spears, J. W., Lloyd, K. E., & Fry, R. S. (2011, March 8). Journal of Animal Science.

By: J. Spears n, K. Lloyd n & R. Fry n

author keywords: cattle; copper; selenium; sulfur
MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Body Composition; Cattle / growth & development; Copper / blood; Copper / metabolism; Diet / veterinary; Liver; Male; Sulfur / adverse effects; Sulfur / metabolism; Zinc / blood
topics (OpenAlex): Ruminant Nutrition and Digestive Physiology; Reproductive Physiology in Livestock; Animal Nutrition and Physiology
TL;DR: It is indicated that steers fed growing diets can tolerate up to 0.46% S with minimum effects on performance, and increasing DCAB did not prevent these depressions. (via Semantic Scholar)
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13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2010 article

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cells in Vivo That Is Controlled at the Level of Protein Stability

Nose, Y., Wood, L. K., Kim, B.-E., Prohaska, J. R., Fry, R. S., Spears, J. W., & Thiele, D. J. (2010, August 11). Journal of Biological Chemistry.

By: Y. Nose*, L. Wood*, B. Kim *, J. Prohaska*, R. Fry n, J. Spears n, D. Thiele *

MeSH headings : Amino Acid Sequence; Animals; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Cell Polarity; Copper / metabolism; Copper Transporter 1; Diet; Epithelial Cells / cytology; Epithelial Cells / metabolism; Humans; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Protein Stability; Rats; Swine
topics (OpenAlex): Trace Elements in Health; Heavy Metal Exposure and Toxicity; Iron Metabolism and Disorders
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Source: Web Of Science
Added: August 6, 2018

2010 article

Effect of dietary boron on physiological responses in growing steers inoculated with bovine herpesvirus type-1

Fry, R. S., Brown, T. T., Lloyd, K. E., Hansen, S. L., Legleiter, L. R., Robarge, W. P., & Spears, J. W. (2010, May 21). Research in Veterinary Science.

By: R. Fry n, T. Brown n, K. Lloyd n, S. Hansen n, L. Legleiter n, W. Robarge n, J. Spears n

author keywords: Boron; Cattle; BHV-1; Acute phase proteins; Cytokines; Plasma B
MeSH headings : Acute-Phase Reaction; Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Body Temperature; Boron / pharmacology; Cattle; Cytokines / blood; Diet / veterinary; Dietary Supplements; Dose-Response Relationship, Drug; Eating / drug effects; Herpesvirus 1, Bovine; Infectious Bovine Rhinotracheitis / immunology; Male; Time Factors; Weight Gain / drug effects
topics (OpenAlex): Herpesvirus Infections and Treatments; T-cell and Retrovirus Studies; Peanut Plant Research Studies
TL;DR: Dairy B did not affect the duration and severity of clinical signs of BHV-1 and had minimal effects on plasma acute phase proteins and cytokines and Supplementation of B increased plasma B concentrations in a dose-responsive manner. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 article

Effects of supplementing dairy cows with chromium propionate on milk and tissue chromium concentrations

Lloyd, K. E., Fellner, V., McLeod, S. J., Fry, R. S., Krafka, K., Lamptey, A., & Spears, J. W. (2010, September 20). Journal of Dairy Science, Vol. 93, pp. 4774–4780.

By: K. Lloyd n, V. Fellner n , S. McLeod n, R. Fry n, K. Krafka, A. Lamptey, J. Spears n

author keywords: chromium; dairy cattle; milk; tissue
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle / metabolism; Diet / veterinary; Dietary Supplements; Female; Milk / chemistry; Propionates / administration & dosage
topics (OpenAlex): Chromium effects and bioremediation; Heavy metals in environment; Heavy Metal Exposure and Toxicity
TL;DR: Supplementation of Cr Prop at a level of 2 mg of Cr/kg of DM did not affect Cr concentration in milk, muscle, or fat, the major bovine products consumed by humans. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 article

High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves

Hansen, S. L., Ashwell, M. S., Moeser, A. J., Fry, R. S., Knutson, M. D., & Spears, J. W. (2010, February 1). Journal of Dairy Science, Vol. 93, pp. 656–665.

By: S. Hansen n, M. Ashwell n , A. Moeser n, R. Fry n, M. Knutson * & J. Spears n

author keywords: cattle; iron; manganese; metal transporter
MeSH headings : Animals; Body Weight / physiology; Cattle / metabolism; Cattle / physiology; Diet / veterinary; Duodenum / chemistry; Duodenum / drug effects; Gene Expression Regulation / drug effects; Heart / drug effects; Iron / analysis; Iron / blood; Iron / metabolism; Iron, Dietary / metabolism; Iron, Dietary / pharmacology; Liver / drug effects; Liver / metabolism; Male; Manganese / analysis; Manganese / blood; Manganese / metabolism; Membrane Transport Proteins / metabolism; Myocardium / chemistry; Oxidative Stress / drug effects
topics (OpenAlex): Iron Metabolism and Disorders; Plant Micronutrient Interactions and Effects; Trace Elements in Health
TL;DR: Feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 article

Investigation of breed and sex effects on cytochrome P450 gene expression in cattle liver

Ashwell, M. S., Fry, R. S., Spears, J. W., O’Nan, A. T., & Maltecca, C. (2010, June 17). Research in Veterinary Science, Vol. 90, pp. 235–237.

By: M. Ashwell n , R. Fry n, J. Spears n, A. O’Nan n & C. Maltecca n 

Contributors: M. Ashwell n , R. Fry n, J. Spears n, . A.T. O'Nan n & C. Maltecca n 

author keywords: Cytochrome P450; Cattle; Gene expression; Liver
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Female; Gene Expression Regulation, Enzymologic / genetics; Gene Expression Regulation, Enzymologic / physiology; Liver / enzymology; Male; Sex Characteristics
topics (OpenAlex): Molecular Biology Techniques and Applications; Genetic and phenotypic traits in livestock; Pharmacogenetics and Drug Metabolism
TL;DR: Breed and/or sex of an animal may need to be considered before administering a dose of a xenobiotic due to the potential for harmful drug residues in foodstuffs as well as improper treatment of disease conditions. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 article

Effect of dietary boron on immune function in growing beef steers*

Fry, R. S., Lloyd, K. E., Jacobi, S. K., Siciliano, P. D., Robarge, W. P., & Spears, J. W. (2009, March 31). Journal of Animal Physiology and Animal Nutrition, Vol. 94, pp. 273–279.

By: R. Fry n, K. Lloyd n, S. Jacobi n, P. Siciliano n , W. Robarge n & J. Spears n

author keywords: cattle; boron; immunoglobulins; cytokines; lymphocytes
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Boron / administration & dosage; Boron / blood; Boron / pharmacology; Cattle / growth & development; Cattle / immunology; Diet / veterinary; Dietary Supplements; Dose-Response Relationship, Drug; Male; Phytohemagglutinins / immunology; Time Factors; Weight Gain
topics (OpenAlex): Plant Micronutrient Interactions and Effects; Animal Nutrition and Physiology; Trace Elements in Health
TL;DR: Results from this study indicate that supplemental B had minimal effects on immune function and did not affect performance of growing steers. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle

Hansen, S. L., Ashwell, M. S., Legleiter, L. R., Fry, R. S., Lloyd, K. E., & Spears, J. W. (2008, September 8). British Journal Of Nutrition, Vol. 101, pp. 1068–1078.

By: S. Hansen n, M. Ashwell n , L. Legleiter n, R. Fry n, K. Lloyd n & J. Spears n

author keywords: Cattle; Copper; Growth; Manganese
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight / drug effects; Cattle / growth & development; Cattle / metabolism; Copper / deficiency; Cyclooxygenase 1 / genetics; Depression, Chemical; Female; Gene Expression / drug effects; Liver / metabolism; Male; Manganese / administration & dosage; Manganese / analysis; Nutritional Status; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / methods; Superoxide Dismutase / genetics; Superoxide Dismutase-1; Time Factors
topics (OpenAlex): Trace Elements in Health; Plant Micronutrient Interactions and Effects; Heavy Metal Exposure and Toxicity
TL;DR: In conclusion, feeding a Cu − deficient diet in combination with high Mn negatively affected the growth and Cu status of beef cattle. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Exposure to low dietary copper or low copper coupled with high dietary manganese for one year does not alter brain prion protein characteristics in the mature cow1,2

Legleiter, L. R., Liu, H. C., Lloyd, K. E., Hansen, S. L., Fry, R. S., & Spears, J. W. (2007, October 22). Journal of Animal Science.

By: L. Legleiter n, H. Liu n, K. Lloyd n, S. Hansen n, R. Fry n & J. Spears n

author keywords: bovine; copper; manganese; prion
MeSH headings : Animals; Blotting, Western / veterinary; Brain / metabolism; Cattle; Copper / administration & dosage; Copper / deficiency; Dose-Response Relationship, Drug; Encephalopathy, Bovine Spongiform / metabolism; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Manganese / administration & dosage; Molecular Weight; Prions / drug effects; Prions / pathogenicity; Random Allocation
topics (OpenAlex): Prion Diseases and Protein Misfolding; Trace Elements in Health
TL;DR: It is concluded that Cu deficiency, coupled with excessive Mn intake, in the bovine may decrease brain Cu and increase brain Mn. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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