Robert S. Fry

Works (14)

Updated: August 5th, 2023 21:15

2021 journal article

Two distinct trophectoderm lineage stem cells from human pluripotent stem cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 296.

By: A. Mischler n, V. Karakis n, J. Mahinthakumar  n, C. Carberry *, A. San Miguel n , J. Rager *, R. Fry *, B. Rao n

MeSH headings : CDX2 Transcription Factor / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Culture Media; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Female; Humans; Placenta / cytology; Placenta / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Pregnancy; Trophoblasts / cytology; Trophoblasts / metabolism
TL;DR: Derivation of hTSCs and hTESCs from pluripotent stem cells significantly enables construction of models for normal and pathological placental development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 7, 2021

2015 article

Effect of dietary copper amount and source on copper metabolism and oxidative stress of weanling pigs in short-term feeding

Huang, Y. L., Ashwell, M. S., Fry, R. S., Lloyd, K. E., Flowers, W. L., & Spears, J. W. (2015, June). JOURNAL OF ANIMAL SCIENCE, Vol. 93, pp. 2948–2955.

By: Y. Huang *, M. Ashwell  n, R. Fry n, K. Lloyd n, W. Flowers n  & J. Spears n

author keywords: copper; copper metabolism; oxidative stress; pigs
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants / metabolism; Chlorides / pharmacology; Copper / metabolism; Copper Sulfate / pharmacology; Diet / veterinary; Dietary Supplements; Duodenum / metabolism; Gene Expression Regulation; Ileum / metabolism; Intestinal Mucosa / metabolism; Jejunum / metabolism; Liver / metabolism; Male; Malondialdehyde / metabolism; Oxidative Stress / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Swine / physiology
TL;DR: Feeding weanling pigs increased Cu resulted in modulation of duodenal and liver at the transcription level, and when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO4. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Amount and source of dietary copper affects small intestine morphology, duodenal lipid peroxidation, hepatic oxidative stress, and mRNA expression of hepatic copper regulatory proteins in weanling pigs

JOURNAL OF ANIMAL SCIENCE, 90(9), 3112–3119.

By: R. Fry n, M. Ashwell  n, K. Lloyd n, A. O'Nan n, W. Flowers n , K. Stewart n, J. Spears n

author keywords: copper; copper proteins; mucosal histology; oxidative stress; pigs
MeSH headings : Animals; Copper / metabolism; Copper / pharmacology; Duodenum / drug effects; Duodenum / metabolism; Gene Expression Regulation / drug effects; Intestinal Mucosa / drug effects; Lipid Peroxidation / drug effects; Liver / metabolism; Male; Malondialdehyde / metabolism; Oxidative Stress / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Swine / blood; Swine / metabolism
TL;DR: Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO(4), and feeding weanling pigs increased Cu resulted in modulation of certain Cu transporters and chaperones at the transcription level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Chromium propionate enhances insulin sensitivity in growing cattle

JOURNAL OF DAIRY SCIENCE, 95(4), 2037–2045.

By: J. Spears n, C. Whisnant n, G. Huntington n, K. Lloyd n, R. Fry n, K. Krafka, A. Lamptey, J. Hyda

author keywords: chromium; insulin sensitivity; cattle
MeSH headings : Animals; Blood Glucose / analysis; Cattle / growth & development; Diet / veterinary; Dietary Supplements; Fatty Acids, Nonesterified / blood; Female; Glucose / administration & dosage; Glucose Tolerance Test; Insulin / blood; Propionates / administration & dosage; Zea mays
TL;DR: Results indicate that Cr Prop supplementation increased tissue sensitivity to insulin in growing heifers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Effect of dietary copper and breed on gene products involved in copper acquisition, distribution, and use in Angus and Simmental cows and fetuses

JOURNAL OF ANIMAL SCIENCE, 91(2), 861–871.

By: R. Fry n, J. Spears n, K. Lloyd n, A. O'Nan n & M. Ashwell  n

author keywords: breed; cattle; copper; deficiency; fetus; placentome
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Copper / blood; Copper / pharmacokinetics; Copper / pharmacology; Female; Fetus / metabolism; Gene Expression Regulation / drug effects; Liver / metabolism; Minerals; Pregnancy
TL;DR: Less expression of duodenal Ctr1 and a tendency for less CTR1 suggest that Simmentals have a lesser ability to absorb and utilize dietary Cu, and may explain why Simmental are more prone to Cu deficiency than Angus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Tolerance of cattle to increased dietary sulfur and effect of dietary cation-anion balance

JOURNAL OF ANIMAL SCIENCE, 89(8), 2502–2509.

By: J. Spears n, K. Lloyd n & R. Fry n

author keywords: cattle; copper; selenium; sulfur
MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Body Composition; Cattle / growth & development; Copper / blood; Copper / metabolism; Diet / veterinary; Liver; Male; Sulfur / adverse effects; Sulfur / metabolism; Zinc / blood
TL;DR: It is indicated that steers fed growing diets can tolerate up to 0.46% S with minimum effects on performance, and increasing DCAB did not prevent these depressions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cells in Vivo That Is Controlled at the Level of Protein Stability

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(42), 32385–32392.

By: Y. Nose*, L. Wood*, B. Kim *, J. Prohaska*, R. Fry n, J. Spears n, D. Thiele *

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Effect of dietary boron on physiological responses in growing steers inoculated with bovine herpesvirus type-1

RESEARCH IN VETERINARY SCIENCE, 90(1), 78–83.

By: R. Fry n, T. Brown n, K. Lloyd n, S. Hansen n, L. Legleiter n, W. Robarge n, J. Spears n

author keywords: Boron; Cattle; BHV-1; Acute phase proteins; Cytokines; Plasma B
MeSH headings : Acute-Phase Reaction; Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Body Temperature; Boron / pharmacology; Cattle; Cytokines / blood; Diet / veterinary; Dietary Supplements; Dose-Response Relationship, Drug; Eating / drug effects; Herpesvirus 1, Bovine; Infectious Bovine Rhinotracheitis / immunology; Male; Time Factors; Weight Gain / drug effects
TL;DR: Dairy B did not affect the duration and severity of clinical signs of BHV-1 and had minimal effects on plasma acute phase proteins and cytokines and Supplementation of B increased plasma B concentrations in a dose-responsive manner. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Effects of supplementing dairy cows with chromium propionate on milk and tissue chromium concentrations

JOURNAL OF DAIRY SCIENCE, 93(10), 4774–4780.

By: K. Lloyd n, V. Fellner n , S. McLeod n, R. Fry n, K. Krafka, A. Lamptey, J. Spears n

author keywords: chromium; dairy cattle; milk; tissue
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle / metabolism; Diet / veterinary; Dietary Supplements; Female; Milk / chemistry; Propionates / administration & dosage
TL;DR: Supplementation of Cr Prop at a level of 2 mg of Cr/kg of DM did not affect Cr concentration in milk, muscle, or fat, the major bovine products consumed by humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves

JOURNAL OF DAIRY SCIENCE, 93(2), 656–665.

By: S. Hansen n, M. Ashwell  n, A. Moeser n, R. Fry n, M. Knutson * & J. Spears n

author keywords: cattle; iron; manganese; metal transporter
MeSH headings : Animals; Body Weight / physiology; Cattle / metabolism; Cattle / physiology; Diet / veterinary; Duodenum / chemistry; Duodenum / drug effects; Gene Expression Regulation / drug effects; Heart / drug effects; Iron / analysis; Iron / blood; Iron / metabolism; Iron, Dietary / metabolism; Iron, Dietary / pharmacology; Liver / drug effects; Liver / metabolism; Male; Manganese / analysis; Manganese / blood; Manganese / metabolism; Membrane Transport Proteins / metabolism; Myocardium / chemistry; Oxidative Stress / drug effects
TL;DR: Feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Investigation of breed and sex effects on cytochrome P450 gene expression in cattle liver

RESEARCH IN VETERINARY SCIENCE, 90(2), 235–237.

By: M. Ashwell  n, R. Fry n, J. Spears n, A. O'Nan n & C. Maltecca n 

Contributors: M. Ashwell  n, R. Fry n, J. Spears n, . A.T. O'Nan n & C. Maltecca n 

author keywords: Cytochrome P450; Cattle; Gene expression; Liver
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Female; Gene Expression Regulation, Enzymologic / genetics; Gene Expression Regulation, Enzymologic / physiology; Liver / enzymology; Male; Sex Characteristics
TL;DR: Breed and/or sex of an animal may need to be considered before administering a dose of a xenobiotic due to the potential for harmful drug residues in foodstuffs as well as improper treatment of disease conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

Effect of dietary boron on immune function in growing beef steers*

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 94(3), 273–279.

By: R. Fry n, K. Lloyd n, S. Jacobi n, P. Siciliano n , W. Robarge n & J. Spears n

author keywords: cattle; boron; immunoglobulins; cytokines; lymphocytes
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Boron / administration & dosage; Boron / blood; Boron / pharmacology; Cattle / growth & development; Cattle / immunology; Diet / veterinary; Dietary Supplements; Dose-Response Relationship, Drug; Male; Phytohemagglutinins / immunology; Time Factors; Weight Gain
TL;DR: Results from this study indicate that supplemental B had minimal effects on immune function and did not affect performance of growing steers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle

BRITISH JOURNAL OF NUTRITION, 101(7), 1068–1078.

By: S. Hansen n, M. Ashwell  n, L. Legleiter n, R. Fry n, K. Lloyd n & J. Spears n

author keywords: Cattle; Copper; Growth; Manganese
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight / drug effects; Cattle / growth & development; Cattle / metabolism; Copper / deficiency; Cyclooxygenase 1 / genetics; Depression, Chemical; Female; Gene Expression / drug effects; Liver / metabolism; Male; Manganese / administration & dosage; Manganese / analysis; Nutritional Status; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / methods; Superoxide Dismutase / genetics; Superoxide Dismutase-1; Time Factors
TL;DR: In conclusion, feeding a Cu − deficient diet in combination with high Mn negatively affected the growth and Cu status of beef cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Exposure to low dietary copper or low copper coupled with high dietary manganese for one year does not alter brain prion protein characteristics in the mature cow

JOURNAL OF ANIMAL SCIENCE, 85(11), 2895–2903.

By: L. Legleiter n, H. Liu n, K. Lloyd n, S. Hansen n, R. Fry n & J. Spears n

author keywords: bovine; copper; manganese; prion
MeSH headings : Animals; Blotting, Western / veterinary; Brain / metabolism; Cattle; Copper / administration & dosage; Copper / deficiency; Dose-Response Relationship, Drug; Encephalopathy, Bovine Spongiform / metabolism; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Manganese / administration & dosage; Molecular Weight; Prions / drug effects; Prions / pathogenicity; Random Allocation
TL;DR: It is concluded that Cu deficiency, coupled with excessive Mn intake, in the bovine may decrease brain Cu and increase brain Mn. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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