Rie Kajino-Sakamoto

Works (3)

Updated: July 6th, 2023 21:16

2016 journal article

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.

By: K. Hashimoto n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n  & J. Ninomiya-Tsuji n 

Contributors: K. Hashimoto n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n  & J. Ninomiya-Tsuji n 

author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
TL;DR: The results identify for the first time that TAK1 is a modulator of p62/SQSTM1-dependent Keap1 degradation and maintains the steady state-level of Nrf2, important for homeostatic antioxidant protection in the intestinal epithelium. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

PLOS ONE, 4(2).

By: J. Kim n, R. Kajino-Sakamoto n, E. Omori n, C. Jobin * & J. Ninomiya-Tsuji n 

Contributors: J. Kim n, R. Kajino-Sakamoto n, E. Omori n, C. Jobin * & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Apoptosis; Cell Proliferation; Colitis / chemically induced; Colitis / etiology; Cyclooxygenase 2; Dextran Sulfate; Interleukin-6; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Receptors, Tumor Necrosis Factor, Type I / deficiency; Signal Transduction
TL;DR: It is shown that TAK1 is essential for interleukin 1- and bacterial components-induced expression of cytoprotective factors and cell proliferation, which is pivotal for protecting the intestinal epithelium against injury. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

ONCOGENE, 28(23), 2257–2265.

By: S. Morioka*, E. Omori n, T. Kajino *, R. Kajino-Sakamoto n, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: S. Morioka*, E. Omori n, T. Kajino *, R. Kajino-Sakamoto n, K. Matsumoto * & J. Ninomiya-Tsuji n 

author keywords: TAK1; TRAIL; reactive oxygen species; cIAP; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Caspase 3 / metabolism; Cell Line; Cell Line, Tumor; Cell Survival / drug effects; Electrophoretic Mobility Shift Assay; Flow Cytometry; HeLa Cells; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Microscopy, Fluorescence; NF-kappa B / metabolism; RNA, Small Interfering / genetics; Reactive Oxygen Species / metabolism; Recombinant Proteins / pharmacology; TNF-Related Apoptosis-Inducing Ligand / genetics; TNF-Related Apoptosis-Inducing Ligand / pharmacology; Transfection
TL;DR: It is reported that deletion of TAK1 kinase greatly increased activation of caspase-3 and cell death after TRAIL stimulation in keratinocytes, fibroblasts and cancer cells, and inhibition of Tak1 can be an effective approach to increase TRAIL sensitivity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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