@article{guo_fudali_gimeno_digennaro_chang_williamson_bird_nielsen_2017, title={Networks Underpinning Symbiosis Revealed Through Cross-Species eQTL Mapping}, volume={206}, ISSN={["1943-2631"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85027059202&partnerID=MN8TOARS}, DOI={10.1534/genetics.117.202531}, abstractNote={AbstractInteractions between species are pervasive among plants, animals, and microbes, and identifying the molecular signals involved is an active area of research..Organisms engage in extensive cross-species molecular dialog, yet the underlying molecular actors are known for only a few interactions. Many techniques have been designed to uncover genes involved in signaling between organisms. Typically, these focus on only one of the partners. We developed an expression quantitative trait locus (eQTL) mapping-based approach to identify cause-and-effect relationships between genes from two partners engaged in an interspecific interaction. We demonstrated the approach by assaying expression of 98 isogenic plants (Medicago truncatula), each inoculated with a genetically distinct line of the diploid parasitic nematode Meloidogyne hapla. With this design, systematic differences in gene expression across host plants could be mapped to genetic polymorphisms of their infecting parasites. The effects of parasite genotypes on plant gene expression were often substantial, with up to 90-fold (P = 3.2 × 10−52) changes in expression levels caused by individual parasite loci. Mapped loci included a number of pleiotropic sites, including one 87-kb parasite locus that modulated expression of >60 host genes. The 213 host genes identified were substantially enriched for transcription factors. We distilled higher-order connections between polymorphisms and genes from both species via network inference. To replicate our results and test whether effects were conserved across a broader host range, we performed a confirmatory experiment using M. hapla-infected tomato. This revealed that homologous genes were similarly affected. Finally, to validate the broader utility of cross-species eQTL mapping, we applied the strategy to data from a Salmonella infection study, successfully identifying polymorphisms in the human genome affecting bacterial expression.}, number={4}, journal={Genetics}, author={Guo, Y. and Fudali, S. and Gimeno, J. and DiGennaro, P. and Chang, S. and Williamson, V.M. and Bird, D.M. and Nielsen, D.M.}, year={2017}, pages={2175–2184} }
 @inproceedings{robison_chang_birks_1999, title={The Hardwood Research Cooperative program at NC State University}, ISBN={0939970813}, booktitle={Proceedings of Portland '99, pioneering new trails : proceedings of the Society of American Foresters 1999 National Convention, Portland, Oregon, September 11-15, 1999.}, author={Robison, D. and Chang, S. and Birks, P.}, year={1999}, pages={558–559} }
 @article{chang_opperman_1992, title={Separation and characterization of Heterodera glycines acetylcholinesterase molecular forms}, volume={24}, number={1}, journal={Journal of Nematology}, author={Chang, S. and Opperman, C. H.}, year={1992}, pages={148} }
 @article{chang_opperman_1991, title={CHARACTERIZATION OF ACETYLCHOLINESTERASE MOLECULAR-FORMS OF THE ROOT-KNOT NEMATODE, MELOIDOGYNE}, volume={49}, ISSN={["1872-9428"]}, DOI={10.1016/0166-6851(91)90064-D}, abstractNote={Multiple molecular forms of acetylcholinesterase have been isolated and characterized from the root-knot nematodes Meloidogyne arenaria and Meloidogyne incognita. The forms of enzyme present in these 2 species are similar but not identical to those that occur in the free-living nematode Caenorhabditis elegans. The 5 enzyme forms exhibit differential solubilities and can be classified into 3 classes, A, B, and C, based on substrate affinity, inhibitor and detergent sensitivity, and thermal inactivation profiles. An unusual class of acetylcholinesterase has been isolated from Meloidogyne which has very high affinity for acetylcholine, but is highly resistant to carbamate and organophosphate inhibitors. The potential roles of the molecular forms in nematode behavior and sensitivity to nematicides are discussed.}, number={2}, journal={MOLECULAR AND BIOCHEMICAL PARASITOLOGY}, author={CHANG, S and OPPERMAN, CH}, year={1991}, month={Dec}, pages={205–214} }
 @article{chang_werner_1984, title={Relationship of seed germination and respiration during stratification with cultivar chilling requirement in peach}, volume={109}, number={1}, journal={Journal of the American Society for Horticultural Science}, author={Chang, S. and Werner, D. J.}, year={1984}, pages={42} }