Ran Zhang

Works (9)

Updated: April 24th, 2025 09:20

2023 article

Tolyporphins–Exotic Tetrapyrrole Pigments in a Cyanobacterium—A Review

Nguyen, K.-U., Zhang, Y., Liu, Q., Zhang, R., Jin, X., Taniguchi, M., … Lindsey, J. S. (2023, August 18). Molecules, Vol. 28.

By: K. Nguyen n, Y. Zhang n, Q. Liu n, R. Zhang n, X. Jin  n, M. Taniguchi n , E. Miller n , J. Lindsey n 

author keywords: bacteriochlorin; bioinformatics; biosynthesis; chlorophyll; cyanobacteria; field biology; gene cluster; genomics; natural products; tolyporphins
MeSH headings : Tetrapyrroles; Cyanobacteria / genetics; Porphyrins / pharmacology; Cardiac Glycosides
topics (OpenAlex): Marine Sponges and Natural Products; Porphyrin and Phthalocyanine Chemistry; Photosynthetic Processes and Mechanisms
TL;DR: The identification of putative biosynthetic gene clusters in the HT-58-2 cyanobacterial genome and accompanying studies suggest a new biosynthesis paradigm in the tetrapyrrole arena, which stands alone in the large pigments-of-life family. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 2, 2023

2022 article

Chasing the green echiuran worm Bonellia in tidal pools of Okinawa

Taniguchi, M., Taniguchi, M., Zhang, R., Goto, R., & Lindsey, J. S. (2022, March 4). FRONTIERS IN BIOLOGICAL DETECTION: FROM NANOSENSORS TO SYSTEMS XIV, Vol. 11979.

By: M. Taniguchi n , M. Taniguchi*, R. Zhang n, R. Goto * & J. Lindsey n 

Contributors: M. Taniguchi n , M. Taniguchi*, R. Zhang n, R. Goto * & J. Lindsey n 

author keywords: biodiversity; Bonellia viridis; bonellin; chlorophyll; spoon worms; tetrapyrrole; tides
topics (OpenAlex): Marine Biology and Ecology Research; Parasite Biology and Host Interactions; Environmental DNA in Biodiversity Studies
TL;DR: Assessment of information concerning tides at a wide shallow beach in Okinawa is reported, identifying narrowly restricted periods when acquisition of Bonellia specimens could be pursued without diving to expand study of the diversity of these unusual green worms. (via Semantic Scholar)
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14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 15, 2022

2021 article

Fluorescence Assay for Tolyporphins Amidst Abundant Chlorophyll in Crude Cyanobacterial Extracts

Nguyen, K. U., Zhang, R., Taniguchi, M., & Lindsey, J. S. (2021, June 21). Photochemistry and Photobiology, Vol. 7, pp. 1507–1515.

By: K. Nguyen n, R. Zhang n, M. Taniguchi n  & J. Lindsey n 

Contributors: K. Nguyen n, R. Zhang n, M. Taniguchi n  & J. Lindsey n 

MeSH headings : Chlorophyll / chemistry; Chlorophyll A; Cyanobacteria / chemistry; Fluorescence; Spectrometry, Fluorescence
topics (OpenAlex): Photosynthetic Processes and Mechanisms; Algal biology and biofuel production; Marine and coastal ecosystems
TL;DR: Tolyporphins were readily detected in cultures of HT‐58‐2 at reasonable growth periods in the absence of environmental stressors, which was not possible previously. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 26, 2021

2021 article

Identification of Putative Biosynthetic Gene Clusters for Tolyporphins in Multiple Filamentous Cyanobacteria

Jin, X., Zhang, Y., Zhang, R., Nguyen, K.-U., Lindsey, J. S., & Miller, E. S. (2021, July 28). Life, Vol. 8.

By: X. Jin n, Y. Zhang n, R. Zhang n, K. Nguyen n, J. Lindsey n  & E. Miller n 

author keywords: tolyporphins; tetrapyrroles; cyanobacteria; biosynthetic gene cluster; Brasilonema; Nostoc; Oculatella
topics (OpenAlex): Algal biology and biofuel production; Photosynthetic Processes and Mechanisms; Biocrusts and Microbial Ecology
TL;DR: Phylogenetic analysis based on 16S rRNA and a common component of the BGCs, TolD, points to a close evolutionary history between each strain and their respective tolyporphins BGC, and a collection of candidate cyanobacteria for genetic and biochemical analysis pertaining to these unusual tetrapyrrole macrocycles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2019 journal article

Cellular localization of tolyporphins, unusual tetrapyrroles, in a microbial photosynthetic community determined using hyperspectral confocal fluorescence microscopy

Photosynthesis Research, 141(3), 259–271.

By: M. Barnhart-Dailey *, Y. Zhang n, R. Zhang n, S. Anthony *, J. Aaron *, E. Miller n , J. Lindsey n , J. Timlin *

author keywords: Bacteriochlorin; Chlorophyll; Cyanobacteria; Membrane; Multivariate curve resolution
MeSH headings : Adaptation, Physiological; Bacteriochlorophyll A / chemistry; Chlorophyll A / chemistry; Cyanobacteria / metabolism; Cyanobacteria / ultrastructure; Darkness; Microscopy, Confocal; Microscopy, Fluorescence; Photosynthesis; Porphyrins / chemistry; Porphyrins / metabolism; Tetrapyrroles / chemistry; Tetrapyrroles / metabolism
topics (OpenAlex): Photosynthetic Processes and Mechanisms; Porphyrin and Phthalocyanine Chemistry; Algal biology and biofuel production
TL;DR: This work quantifies the relative abundance and envelope localization of tolyporphins in single cells, and illustrates the ability to identify novel tetrapyrroles in the presence of chlorophyll a in a photosynthetic microorganism within a non-axenic culture. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 23, 2019

2018 journal article

Genome sequence, metabolic properties and cyanobacterial attachment of Porphyrobacter sp. HT-58-2 isolated from a filamentous cyanobacterium–microbial consortium

Microbiology, 164(10), 1229–1239.

By: R. Hughes n, X. Jin n, Y. Zhang n, R. Zhang n, S. Tran n, P. Williams *, J. Lindsey n , E. Miller n 

author keywords: alphaproteobacteria; fluorescence in situ hybridization (FISH); tolyporphins; bacteriochlorin; photosynthetic gene cluster
MeSH headings : Alphaproteobacteria / classification; Alphaproteobacteria / genetics; Alphaproteobacteria / metabolism; Alphaproteobacteria / physiology; Bacterial Proteins / genetics; Base Sequence; Chromosome Mapping; Cyanobacteria / metabolism; DNA, Bacterial / genetics; Genome, Bacterial / genetics; In Situ Hybridization, Fluorescence; Microbial Consortia; Phylogeny; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA
topics (OpenAlex): Microbial Community Ecology and Physiology; Genomics and Phylogenetic Studies; Photosynthetic Processes and Mechanisms
TL;DR: The studies reported herein expand the description of the community of predominantly alphaproteobacteria associated with the filamentous HT- 58-2 cyanobacterium and isolate a dominant bacterium, Porphyrobacter sp. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 7, 2019

2017 article

Genome Sequence and Composition of a Tolyporphin-Producing Cyanobacterium-Microbial Community

Hughes, R.-A., Zhang, Y., Zhang, R., Williams, P. G., Lindsey, J. S., & Miller, E. S. (2017, July 29). Applied and Environmental Microbiology, Vol. 83.

By: R. Hughes n, Y. Zhang n, R. Zhang n, P. Williams *, J. Lindsey n  & E. Miller n 

author keywords: cyanobacteria; genome analysis; phylogenetic analysis; tetrapyrroles; tolyporphin
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biosynthetic Pathways; Cyanobacteria / chemistry; Cyanobacteria / genetics; Cyanobacteria / growth & development; Cyanobacteria / metabolism; Genome, Bacterial; Metagenomics; Multigene Family; Phylogeny; Porphyrins / biosynthesis; Porphyrins / chemistry
topics (OpenAlex): Porphyrin Metabolism and Disorders; Photosynthetic Processes and Mechanisms; Microbial Community Ecology and Physiology
TL;DR: It is found that the HT-58-2 culture is composed of the cyanobacterium and a community of associated bacteria, complicating the question of which organisms make tolyporphins, and an intriguing gene cluster that contains tetrapyrrole biosynthesis genes and a collection of unknown genes suggests a possible role in toly porphin biosynthesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Mass spectrometric detection of chlorophyll a and the tetrapyrrole secondary metabolite tolyporphin A in the filamentous cyanobacterium HT-58-2. Approaches to high-throughput screening of intact cyanobacteria

Zhang, Y., Zhang, R., Nazari, M., Bagley, M. C., Miller, E. S., Williams, P. G., … Lindsey, J. S. (2017, November 1). Journal of Porphyrins and Phthalocyanines, Vol. 21, pp. 759–768.

By: Y. Zhang n, R. Zhang n, M. Nazari  n, M. Bagley n, E. Miller n , P. Williams *, D. Muddiman n , J. Lindsey n 

author keywords: IR-MALDESI-FTMS; MS/MS; MALDI-TOF-MS; chlorophyll; bacteriochlorin; high-throughput screening
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Marine and coastal ecosystems; Marine Toxins and Detection Methods
TL;DR: Examination by MALDI-TOF-MS of lipophilic crude extracts of small-scale HT-58-2 samples without chromatographic fractionation enabled semi-quantitation of tolyporphin A over a 41-day growth period. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Quantitation of Tolyporphins, Diverse Tetrapyrrole Secondary Metabolites with Chlorophyll-Like Absorption, from a Filamentous Cyanobacterium-Microbial Community

Phytochemical Analysis, 29(2), 205–216.

By: Y. Zhang n, R. Zhang n, R. Hughes n, J. Dai *, J. Gurr*, P. Williams *, E. Miller n , J. Lindsey n 

author keywords: HPLC; mass spectrometry; absorption spectroscopy with multicomponent analysis; nitrogen deprivation; growth curve
MeSH headings : Chlorophyll / chemistry; Chlorophyll A; Chromatography, High Pressure Liquid / methods; Cyanobacteria / growth & development; Cyanobacteria / metabolism; Porphyrins / analysis; Porphyrins / chemistry; Reference Standards; Reproducibility of Results; Spectrum Analysis / methods; Tetrapyrroles / analysis
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Photosynthetic Processes and Mechanisms; Algal biology and biofuel production
TL;DR: The quantitative methods developed herein should facilitate investigation of the biosynthesis of tolyporphins (and other tetrapyrroles) as well as examination of other strains for production of tolporph Ins. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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