Scott Alexander Baldwin

Graduate School

Works (2)

Updated: April 26th, 2024 09:54

2023 journal article

Semi-autonomous wound invasion via matrix-deposited, haptotactic cues


By: S. Baldwin n & J. Haugh n

author keywords: Cell migration; Wound healing; Gradient sensing; Tissue dynamics; Traveling wave
MeSH headings : Cues; Cell Movement / physiology; Chemotaxis / physiology; Wound Healing / physiology; Fibroblasts; Cytokines
TL;DR: In the present work, it is shown the plausibility of a hypothesis that fibroblasts themselves form and maintain haptotactic gradients in a semi-autonomous fashion, and a positive control scenario where FN is pre-deposited in the wound matrix, and fibro Blasts maintain haaptotaxis by removing FN at an appropriate rate is examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2021 journal article

Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration


By: S. Baldwin n, S. Van Bruggen n, J. Koelbl n, R. Appalabhotla n, J. Bear* & J. Haugh n

TL;DR: This work reports on the development of a passive pumping strategy, driven by the high capillary pressure and evaporative capacity of paper, and its application to study fibroblast chemotaxis, and how the orientation of signaling through the phosphoinositide 3-kinase pathway affects the cells' sensing of and response to conducive gradients. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2021

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