Works (7)
Updated: December 18th, 2023 14:15
2023 journal article
Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (<i>Microtus ochrogaster</i>)
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 576.
author keywords: Pregnancy; EDCs; Endocrine disruptors; Neurotoxicology; Developmental toxicology; Organophosphate
TL;DR:
Prairie voles are used, a monogamous and bi-parental rodent, leveraged for decades to decipher the underpinnings of social behaviors, to examine the impact of fetal FR exposure on gene targets in the mid-gestational placenta and fetal brain and provide insights on the mechanisms by which FRs impair neurodevelopment and later in life social behaviors.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023
2022 journal article
Effects of developmental exposure to FireMaster (R) 550 (FM 550) on microglia density, reactivity and morphology in a prosocial animal model
NEUROTOXICOLOGY, 91, 140–154.
author keywords: Prefrontal cortex; Sex difference; Neurodevelopment; Endocrine disrupting chemicals; Flame retardants; Vole
MeSH headings : Animals; Arvicolinae; Female; Humans; Male; Mice; Microglia; Models, Animal; Organophosphates; Polybrominated Biphenyls; Pregnancy; Rats
TL;DR:
Overall, FM 550 exposure resulted in reduced numbers of microglia in most regions examined, with the 1000µg FM 550 exposed males particularly affected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 20, 2022
2022 journal article
Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles
TOXICS, 10(5).
author keywords: endocrine disruptors; flame retardants; sexual differentiation; pair bond
TL;DR:
Evidence is provided that chemical and social stressors can have unique behavioral effects that differ by sex but may not produce worse outcomes in combination.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 13, 2022
2021 journal article
Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture
ENDOCRINOLOGY, 162(8).
Contributors: S. Gillera n, W. Marinello n , K. Cao n, B. Horman n, H. Stapleton * & H. Patisaul n
author keywords: Social; anxiety; neurodevelopment; neural; endocrine disruptors; endocrine disrupting chemicals; oxytocin; vasopressin; dopamine
MeSH headings : Animals; Arginine Vasopressin / metabolism; Arvicolinae; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Male; Neurons / drug effects; Neurons / metabolism; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / drug effects; Sex Factors; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
Results expand on previous work showing evidence of endocrine disruption of OT/AVP pathways, including to subpopulations of PVN AVP neurons that coordinate osmoregulatory functions in the periphery, by testing the hypothesis that FM 550 sex-specifically alters AVP and OT neuronal populations in critical nuclei.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 12, 2021
2020 journal article
Developmental Exposure to Tetrabromobisphenol A Has Minimal Impact on Male Rat Reproductive Health.
Reproductive Toxicology (Elmsford, N.Y.).
author keywords: Tetrabromobisphenol A; Endocrine disruption; Bisphenol A; Male reproduction
MeSH headings : Animals; Female; Flame Retardants / toxicity; Male; Maternal-Fetal Exchange; Polybrominated Biphenyls / toxicity; Pregnancy; Prostate / drug effects; Rats, Wistar; Reproductive Health; Sperm Count; Spermatozoa / drug effects; Testis / drug effects; Testis / metabolism
TL;DR:
No differences in the morphology of testes, sperm, prostates, or secondary sex organs are found from post-natal day 21 through one-year of age, which may lead to the supposition that TBBPA is less harmful than its parent compound BPA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 29, 2022
2019 journal article
Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats
NEUROTOXICOLOGY, 75, 136–147.
author keywords: brain; anxiety; endocrine disruptions; sex differences; hyperactivity; neural; sexually dimorphic; neurotoxic; flame retardants; elevated plus maze; neurodevelopment
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Maze Learning / drug effects; Motor Activity / drug effects; Polybrominated Biphenyls / toxicity; Rats; Rats, Wistar / growth & development; Sex Factors
TL;DR:
It is demonstrated that exposure to environmental contaminants, like TBBPA, can have sex-specific effects on behavior highlighting the vulnerability of the developing brain.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 16, 2019
2019 journal article
Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles.
Neurotoxicology and Teratology, 79, 106840.
Contributors: S. Gillera n, W. Marinello n , B. Horman n, A. Phillips *, M. Ruis*, H. Stapleton *, D. Reif n , H. Patisaul n
author keywords: Social; Anxiety; Brain; Neurodevelopment; Neural; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Anxiety / chemically induced; Arvicolinae; Behavior, Animal / drug effects; Exploratory Behavior / drug effects; Female; Flame Retardants / toxicity; Male; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / psychology; Sex Characteristics; Social Behavior
TL;DR:
The utility of the prairie vole for investigating the impact of chemical exposures on social behavior is demonstrated and the hypothesis that developmental FR exposure impacts the social brain is supported.
(via Semantic Scholar)
Source: ORCID
Added: December 4, 2019
Employment
Updated: July 24th, 2023 18:07
2022 - present
ICF International (United States) Durham, North Carolina, US
Senior Toxicologist
2017 - 2022
NC State University Raleigh, NC, US
Graduate Student
Biological Sciences
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