@article{young_pallerla_cottrell_maturavongsadit_prasher_shrivastava_cruz_montgomery_schauer_sykes_et al._2023, title={Long-acting injectable multipurpose prevention technology for prevention of HIV and unplanned pregnancy}, volume={363}, ISSN={["1873-4995"]}, DOI={10.1016/j.jconrel.2023.10.006}, abstractNote={Only condoms are proven to protect against both HIV and unplanned pregnancy, however, poor user acceptability and lack of partner cooperation impede effectiveness. We developed an injectable ultra-long-acting, biodegradable, and removable in-situ forming implant (ISFI) as multipurpose prevention technology (MPT). MPT ISFIs co-formulated an antiretroviral (dolutegravir (DTG)) or cabotegravir (CAB)), and a hormonal contraceptive (etonogestrel (ENG) or medroxyprogesterone acetate (MPA)). All formulations were well-tolerated in mice with no signs of chronic local or systemic inflammation. Plasma CAB and DTG concentrations were above 4× PA-IC90 for 90 days with zero-order and diffusion-controlled absorption, respectively, and no differences when co-formulated with either hormone. Plasma ENG and MPA concentrations were quantifiable for 90 days. Complete removal of CAB/MPA ISFIs resulted in MPA concentrations falling below the limit of quantification after 24 h post-removal, but incomplete CAB elimination from plasma. Collectively, we demonstrated the ability to co-formulate antiretrovirals with contraceptives in an ISFI that is well-tolerated with sustained plasma concentrations up to 90 days.}, journal={JOURNAL OF CONTROLLED RELEASE}, author={Young, Isabella C. and Pallerla, Aryani and Cottrell, Mackenzie L. and Maturavongsadit, Panita and Prasher, Alka and Shrivastava, Roopali and Cruz, Gabriela De la and Montgomery, Stephanie A. and Schauer, Amanda and Sykes, Craig and et al.}, year={2023}, month={Nov}, pages={606–620} }
 @article{cole_roshankhah_blackwell_montgomery_egan_muller_2023, title={Random matrix theory to quantify micro-structural changes in rodent lungs due to pulmonary diseases}, volume={153}, ISSN={["1520-8524"]}, DOI={10.1121/10.0018613}, abstractNote={We exploit the random matrix theory to detect changes in rodent lungs exhibiting pulmonary fibrosis and edema. Coherences in the backscattered signals are stronger when single scattering dominates (fibrosis/edema). On the contrary, healthy lungs exhibit more apparent randomness due to multiple scattering. This leads to differences in the distribution of eigenvalues, which can be retrieved using Singular Value Decomposition of the Inter-elementResponse Matrix (IRM). We use features of the eigenvalue distribution (E(x), the expected value, and, the eigenvalue with the highest probability) to quantify changes in lung parenchyma and investigate whether they can improve the specificity of quantitative ultrasound to lung diseases. IRMs were acquired from 51 rat lungs (10 controls, 18 edematous, 17 fibrotic, 6 fibrotic rats, which were treated with Nintedanib) using a 128-element linear array (Verasonics L11-4v, 7.8 MHz). Severity of fibrosis and edema were quantified by histology and the ratio of wet to dry weight. Both parameters showed significant differences between edematous and fibrotic lungs, and between control and fibrotic lungs, which was significantly correlated to both the severity of fibrosis and edema. E(x) was significantly correlated to the severity of fibrosis. This suggests that these parameters could be part of a toolkit for the quantitative assessment of lung diseases.}, number={3}, journal={JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA}, author={Cole, Azadeh D. and Roshankhah, Roshan and Blackwell, John and Montgomery, Stephanie A. and Egan, Thomas M. and Muller, Marie}, year={2023}, month={Mar} }