@article{thrall_maccarini_stauffer_macfall_hauck_snyder_case_linder_lan_mccall_et al._2012, title={Thermal dose fractionation affects tumour physiological response}, volume={28}, ISSN={["0265-6736"]}, DOI={10.3109/02656736.2012.689087}, abstractNote={Purpose: It is unknown whether a thermal dose should be administered using a few large fractions with higher temperatures or a larger number of fractions with lower temperatures. To evaluate this we assessed the effect of administering the same total thermal dose, approximately 30 CEM43T90, in one versus three to four fractions per week, over 5 weeks. Materials and methods: Canine sarcomas were randomised to receive one of the hyperthermia fractionation schemes along with fractionated radiotherapy. Tumour response was based on changes in tumour volume, oxygenation, water diffusion quantified using MRI, and a panel of histological and immunohistochemical end points. Results: There was a greater reduction in tumour volume and water diffusion at the end of therapy in tumours receiving one hyperthermia fraction per week. There was a weak but significant association between improved tumour oxygenation 24 h after the first hyperthermia treatment and extent of volume reduction at the end of therapy. Finally, the direction of change of HIF-1α and CA-IX immunoreactivity after the first hyperthermia fraction was similar and there was an inverse relationship between temperature and the direction of change of CA-IX. There were no significant changes in interstitial fluid pressure, VEGF, vWF, apoptosis or necrosis as a function of treatment group or temperature. Conclusions: We did not identify an advantage to a three to four per week hyperthermia prescription, and response data pointed to a one per week prescription being superior.}, number={5}, journal={INTERNATIONAL JOURNAL OF HYPERTHERMIA}, author={Thrall, Donald E. and Maccarini, Paolo and Stauffer, Paul and Macfall, James and Hauck, Marlene and Snyder, Stacey and Case, Beth and Linder, Keith and Lan, Lan and Mccall, Linda and et al.}, year={2012}, pages={431–440} } @article{chi_thrall_jiang_snyder_fels_landon_mccall_lan_hauck_macfall_et al._2011, title={Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics}, volume={17}, ISSN={["1557-3265"]}, DOI={10.1158/1078-0432.ccr-10-2583}, abstractNote={Abstract}, number={8}, journal={CLINICAL CANCER RESEARCH}, author={Chi, Jen-Tsan and Thrall, Donald E. and Jiang, Chen and Snyder, Stacey and Fels, Diane and Landon, Chelsea and McCall, Linda and Lan, Lan and Hauck, Marlene and MacFall, James R. and et al.}, year={2011}, month={Apr}, pages={2549–2560} } @article{singh_snyder_lee_johnston_caruso_yingling_2010, title={Effect of Oligonucleotide Length on the Assembly of DNA Materials: Molecular Dynamics Simulations of Layer-by-Layer DNA Films}, volume={26}, ISSN={["0743-7463"]}, url={https://publons.com/publon/5454528/}, DOI={10.1021/la102762t}, abstractNote={DNA strand length has been found to be an important factor in many DNA-based nanoscale systems. Here, we apply molecular dynamics simulations in a synergistic effort with layer-by-layer experimental data to understand the effect of DNA strand length on the assembly of DNA films. The results indicate that short (less than 10 bases) and long (more than 30 bases) single-stranded DNAs do not exhibit optimal film growth, and this can be associated with the limited accessibility of the bases on the surface due to formation of self-protected interactions that prevent efficient hybridization. Interestingly, the presence of a duplex attached to a single strand significantly alters the persistence length of the polyT strands. Our study suggests that restrained polyT, compared to labile suspensions of free polyT, are more capable of hybridization and hence DNA-based assembly.}, number={22}, journal={LANGMUIR}, publisher={American Chemical Society (ACS)}, author={Singh, Abhishek and Snyder, Stacy and Lee, Lillian and Johnston, Angus P. R. and Caruso, Frank and Yingling, Yaroslava G.}, year={2010}, month={Nov}, pages={17339–17347} } @article{snyder_dewhirst_hauck_2008, title={The role of hypoxia in canine cancer}, volume={6}, ISSN={["1476-5829"]}, DOI={10.1111/j.1476-5829.2008.00163.x}, abstractNote={Abstract}, number={4}, journal={VETERINARY AND COMPARATIVE ONCOLOGY}, author={Snyder, S. A. and Dewhirst, M. W. and Hauck, M. L.}, year={2008}, month={Dec}, pages={213–223} }