Shaobo Cai

Works (5)

Updated: July 5th, 2023 15:37

2019 journal article

Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells

SCIENTIFIC REPORTS, 9.

By: J. Bodle n, M. Hamouda n, S. Cai n, R. Williams n, S. Bernacki n & E. Loboa*

MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adipogenesis / genetics; Cell Differentiation / genetics; Cell Lineage / genetics; Cells, Cultured; Cilia / genetics; Core Binding Factor Alpha 1 Subunit / genetics; Gene Expression Regulation, Developmental / genetics; Humans; Mechanotransduction, Cellular / genetics; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / genetics; Tensile Strength; Tissue Engineering
TL;DR: This study demonstrates that hASC primary cilia exhibit mechanosensitivity to cyclic tensile strain and lineage-dependent expression, which may in part regulate signaling pathways localized to the primary cilium during the differentiation process. (via Semantic Scholar)
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Source: Web Of Science
Added: June 17, 2019

2018 journal article

Industrial-scale fabrication of an osteogenic and antibacterial PLA/silver-loaded calcium phosphate composite with significantly reduced cytotoxicity

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 107(4), 900–910.

By: S. Cai n, B. Pourdeyhimi n  & E. Loboa*

author keywords: industrial-scale fabrication; multifunctional scaffold; osteogenic; antibacterial; reduced cytotoxicity
MeSH headings : Adipose Tissue / cytology; Adipose Tissue / metabolism; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Calcium Phosphates / chemistry; Calcium Phosphates / pharmacology; Cell Differentiation / drug effects; Escherichia coli / growth & development; Humans; Osteogenesis / drug effects; Polyesters / chemical synthesis; Polyesters / chemistry; Polyesters / pharmacology; Silver / chemistry; Silver / pharmacology; Staphylococcus aureus / growth & development; Stem Cells / cytology; Stem Cells / metabolism; Tissue Scaffolds / chemistry
TL;DR: The results of this study indicate a promising alternative approach to produce multifunctional scaffolds at industrial-scale with higher throughput, lower cost, and enhanced reproducibility. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 22, 2019

2017 journal article

Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications

BIOMED RESEARCH INTERNATIONAL, 2017.

By: L. Mellor n, P. Huebner  n, S. Cai n, M. Mohiti-Asli  n, M. Taylor n, J. Spang *, R. Shirwaiker n , E. Loboa *

Contributors: L. Mellor n, P. Huebner  n, S. Cai n, M. Mohiti-Asli  n, M. Taylor n, J. Spang *, R. Shirwaiker n , E. Loboa *

MeSH headings : Animals; Cells, Cultured; Extracellular Matrix / chemistry; Humans; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / therapeutic use; Porosity; Printing, Three-Dimensional; Swine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR: The approach combining these two commonly used scaffold fabrication technologies allows for the creation of a scaffold with more close resemblance to heterogeneous tissue architecture, holding great potential for tissue engineering and regenerative medicine applications of osteochondral tissue and other heterogeneous tissues. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

High-Throughput Fabrication Method for Producing a Silver-Nanoparticles-Doped Nanoclay Polymer Composite with Novel Synergistic Antibacterial Effects at the Material Interface

ACS APPLIED MATERIALS & INTERFACES, 9(25), 21105–21115.

By: S. Cai n, B. Pourdeyhimi n  & E. Loboa *

author keywords: high-throughput; silver-nanoparticles-doped nanoclay; synergistic antibacterial effect; reduced bacterial adhesion; minimal silver content; in situ thermal reduction
MeSH headings : Anti-Bacterial Agents; Metal Nanoparticles; Nanocomposites; Polymers; Silver
TL;DR: This is the first report to show that altered material surface submicron structures created with the loading of nanoclay enables the creation of a nanocomposite with significantly lower affinity for bacterial adhesion. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Facilitating Teamwork in Adolescent and Young Adult Oncology

JOURNAL OF ONCOLOGY PRACTICE, 12(11), 1067-+.

By: R. Johnson *, C. Macpherson*, A. Smith *, R. Block * & J. Keyton *

MeSH headings : Adolescent; Adult; Communication; Cooperative Behavior; Humans; Interprofessional Relations; Male; Patient Care Team / organization & administration; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Trust; Young Adult
TL;DR: A case of a young adult patient in the days immediately after a cancer diagnosis illustrates the critical importance of three interrelated core coordinating mechanisms-closed-loop communication, shared mental models, and mutual trust-of teamwork in an adolescent and young adult multidisciplinary oncology team. (via Semantic Scholar)
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4. Quality Education (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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