Samantha Carol Catherine Kisthardt

College of Agriculture and Life Sciences

Works (4)

Updated: April 24th, 2025 02:34

2023 journal article

The microbial-derived bile acid lithocholate and its epimers inhibit <i>Clostridioides difficile</i> growth and pathogenicity while sparing members of the gut microbiota

JOURNAL OF BACTERIOLOGY, 205(9).

By: S. Kisthardt n, R. Thanissery  n, C. Pike n, M. Foley n & C. Theriot n

author keywords: lithocholate; Clostridioides difficile; epimers; secondary bile acids; gut microbiota
MeSH headings : Humans; Virulence; Gastrointestinal Microbiome; Clostridioides difficile; Caco-2 Cells; Bile Acids and Salts / pharmacology; Lithocholic Acid
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Gastrointestinal motility and disorders
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Source: Web Of Science
Added: April 8, 2024

2022 journal article

<p>Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E</p>

VIROLOGY, 571, 21–33.

By: Y. Zhu n, F. Scholle n , S. Kisthardt n & D. Xie n 

Contributors: Y. Zhu n, F. Scholle n , S. Kisthardt n & D. Xie n 

author keywords: (+)-dihydrokaempferol; <p>(+)-dihydroquercetin (taxifolin)</p>; (+)-dihydromyricetin; Kaempferol; Quercetin; Myricentin; Isoquercitrin; Rutin; Flavan-3-ols
MeSH headings : COVID-19; Coronavirus 229E, Human / drug effects; Coronavirus 229E, Human / physiology; Coronavirus 3C Proteases / antagonists & inhibitors; Flavonols / pharmacology; Humans; Molecular Docking Simulation; SARS-CoV-2 / drug effects; Virus Replication / drug effects
topics (OpenAlex): Computational Drug Discovery Methods; Essential Oils and Antimicrobial Activity; Phytochemicals and Medicinal Plants
TL;DR: In vitro inhibition assays showed that seven available compounds effectively inhibited the SARS-CoV-2 Mpro activity and their IC50 values ranged from 0.125 to 12.9 µM, which indicates that these antioxidative flavonols and dihydroflavonols are promising candidates for curbing the two viruses. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 23, 2022

2022 article

A standardized procedure for quantitative evaluation of residual viral activity on antiviral treated textiles

Wang, Z., Amanah, A. Y., Ali, K. M., Payne, L. C., Kisthardt, S., Scholle, F., … Gluck, J. M. (2022, November 2). TEXTILE RESEARCH JOURNAL, Vol. 11.

By: Z. Wang n , A. Amanah  n, K. Ali n, L. Payne n, S. Kisthardt n, F. Scholle n , R. Ormond n , K. Mathur n , J. Gluck n 

author keywords: SARS-CoV-2; antiviral textiles; Tissue Culture Infectious Dose 50
topics (OpenAlex): Infection Control and Ventilation; Infection Control in Healthcare; COVID-19 and healthcare impacts
TL;DR: This pilot study aims to develop and refine a standardized protocol to quantitatively evaluate residual viral activity on antiviral textiles and used HCoV-229E and Huh-7 human liver cancer cells for this investigation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2022

2021 journal article

Toward Universal Photodynamic Coatings for Infection Control

FRONTIERS IN MEDICINE, 8.

By: C. Ghareeb n, B. Peddinti n, S. Kisthardt n, F. Scholle n , R. Spontak n  & R. Ghiladi n 

author keywords: antimicrobial; Coronavirus; coatings; photodynamic inactivation; photosensitizer; polymer; singlet oxygen; Staphylococcus aureus
topics (OpenAlex): Photodynamic Therapy Research Studies; Antimicrobial agents and applications; Nanoplatforms for cancer theranostics
TL;DR: The antimicrobial efficacy of a simple bicomponent spray coating composed of the commercially-available UV-photocrosslinkable polymer N-methyl-4(4'-formyl-styryl)pyridinium methosulfate acetal poly(vinyl alcohol) (SbQ-PVA) and one of three aPDI photosensitizers (PSs) is evaluated. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021

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