@article{mccance_teeter_blanchard_venditti_2023, title={Using Activity Theory to understand the interactions of a university interdisciplinary team of scientists and science educators}, volume={2}, ISSN={["1470-174X"]}, url={https://doi.org/10.1080/03075079.2023.2172564}, DOI={10.1080/03075079.2023.2172564}, abstractNote={ABSTRACT Interdisciplinary collaborations between different academic disciplines can create knowledge and solutions to challenges that are beyond the scope of what a single discipline can achieve. However, little is known about how interdisciplinary teams of faculty and graduate students function as a whole and the processes that guide them as they work on collaborative tasks. Using Activity Theory, this qualitative study analyzed team meeting transcripts to examine interdisciplinary team interactions involving Science/Engineering and Science Education graduate students and faculty members as they co-developed laboratory activities for a grant-funded project. Several factors contributed to the team’s success: shared goals (Object), environment (Community), and clear Division of Labor. Differences (contradictions) were found in the Tools, Rules, and Division of Labor; the PI and Science/Engineering graduate students tended to focus on the needed lab materials, and the Science Education members focused more on educational standards and teachers’ ideas in the lab development (Tools). The PI and Science Education members set and enforced the team meeting agendas and deadlines (Rules). The Science/Engineering grad students focused on practical considerations to ensure the labs could successfully be implemented in a class setting (Rules) and were assigned the most tasks to complete (Division of Labor). The findings provide insight into the nature of interdisciplinary team dynamics between a Science/Engineering and Education grant team. The findings also suggest the importance of shared goals (Object), community development (Rules: Team Building), and the potential of capitalizing on different strengths and knowledge (contradictions) in an interdisciplinary team.}, journal={STUDIES IN HIGHER EDUCATION}, author={McCance, Katherine R. and Teeter, Stephanie D. and Blanchard, Margaret R. and Venditti, Richard A.}, year={2023}, month={Feb} } @article{howe_thompson_teeter_easson_barlow_griffith_schnabel_spang_fisher_2022, title={Degenerative changes are associated with severity of anterior cruciate ligament injury within the skeletally immature joint}, url={https://doi.org/10.1101/2022.11.12.516262}, DOI={10.1101/2022.11.12.516262}, abstractNote={Anterior cruciate ligament (ACL) injuries are a major problem in the pediatric and adolescent populations. Some of these injuries extend only partially through the tissue cross-section; yet, there is limited data to inform clinical treatment of such partial tears. In particular, it is unknown how injury severity impacts long-term degenerative changes in the joint. Here, we leverage a skeletally immature preclinical porcine model to evaluate joint biomechanics and degeneration after partial (isolated anteromedial (AM) or posterolateral (PL) bundle) or complete ACL injury. Six months after injury, joint laxity increases were minimal after PL bundle injury, minor after AM bundle injury, and major after ACL injury. Joint degeneration (evaluated in the cartilage and meniscus) was minimal after PL bundle injury, moderate after AM bundle injury, and substantial after ACL injury. With subjects grouped by clinical Lachman grade (indicating the extent of joint destabilization), degeneration was associated with increasing grade, irrespective of injury type. These findings point to the importance of considering joint laxity as a factor when treating young patients, particularly those with partial ACL injuries.}, author={Howe, Danielle and Thompson, Jacob D. and Teeter, Stephanie D. and Easson, Margaret and Barlow, Olivia and Griffith, Emily H. and Schnabel, Lauren V. and Spang, Jeffrey T. and Fisher, Matthew B.}, year={2022}, month={Nov} } @inproceedings{teeter_painter_2022, place={Braga}, title={Exploring a Scientist-Teacher Partnership Model to Support Scientists’ Outreach Efforts}, url={https://www.researchgate.net/publication/367962482_Exploring_a_Scientist-Teacher_Partnership_Model_to_Support_Scientists%27_Outreach_Efforts_ESERA_2021_Fostering_Scientific_Citizenship_in_an_Uncertain_World_Proceedings_of_ESERA_2021}, booktitle={ESERA 2021}, publisher={CIEC, University of Minho}, author={Teeter, S.D. and Painter, J.}, editor={Carvalho, G.S. and ASAfonso and Anastácio, Z.Editors}, year={2022}, pages={591–599} } @book{rende_teeter_owen_2021, title={Synergies: University-Museum Collaborations}, volume={9}, url={http://dx.doi.org/10.35542/osf.io/3wpb9}, DOI={10.35542/osf.io/3wpb9}, abstractNote={The purpose of this report is to provide documentation of the University-Museums Synergies Initiative between a Department of Marine, Earth, and Atmospheric Sciences and a Museum of Natural Sciences.The goals of this initiative were to 1)identify specific projects and opportunities might be developed to strengthen the collaboration between institutions and 2) gain a betterunderstanding of MEAS researchers’ and Museum employees' perspectives onuniversity-museum partnerships.}, journal={North Carolina State University}, institution={Center for Open Science}, author={Rende, Kathryn and Teeter, Stephanie Dawn and Owen, Lewis}, year={2021}, month={Sep} } @article{teeter_husseini_cole_2020, title={Assessing changes in attitudes toward engineering and biomechanics resulting from a high school outreach event}, volume={103}, ISSN={0021-9290}, url={http://dx.doi.org/10.1016/j.jbiomech.2020.109683}, DOI={10.1016/j.jbiomech.2020.109683}, abstractNote={National Biomechanics Day aims to introduce students to the emerging field of biomechanics and improve their perception of engineering and engineers. This quantitative study examines participants’ attitude changes following one such event. By prioritizing increasing excitement and engagement over teaching content, we anticipate that students’ opinions of engineering and biomechanics will improve following the event. Pre- and post-test surveys consisting of Likert scale and semantic differential (SD) items assessed changes in three key areas: self-identity as a scientist and engineer, attitudes toward engineering, and attitudes toward biomechanics. Based on unpaired and paired student responses, we found significant gains in all three areas. Students agreed more strongly with statements regarding whether they saw themselves as scientists and engineers, and they had improved attitudes toward engineering in general and biomechanics specifically. The SD scales also reflected improved opinions of both science and biomechanics. These more positive attitudes could eventually lead to more students recruited to study a variety of engineering disciplines, ultimately addressing the ongoing national shortage of qualified engineers.}, journal={Journal of Biomechanics}, publisher={Elsevier BV}, author={Teeter, Stephanie D. and Husseini, Naji S. and Cole, Jacqueline H.}, year={2020}, month={Apr}, pages={109683} } @misc{teeter_malekipour_2020, title={Meet the First Author: Assessing changes in attitudes toward engineering and biomechanics resulting from a high school outreach event}, url={https://www.huble.org/meet-the-first-author/mtfa-024/}, journal={Huble: The IFMRS Learning Environment}, author={Teeter, Stephanie D. and Malekipour, Fatemeh}, year={2020}, month={Aug} } @article{sano_dewitt_teeter_xing_2018, title={Optimization of a single insertion electrode array for the creation of clinically relevant ablations using high-frequency irreversible electroporation}, volume={95}, ISSN={0010-4825}, url={http://dx.doi.org/10.1016/j.compbiomed.2018.02.009}, DOI={10.1016/j.compbiomed.2018.02.009}, abstractNote={High-frequency irreversible electroporation (H-FIRE) is an emerging ablation modality, delivering rapid bursts of bipolar microsecond-duration electrical pulses to non-thermally ablate tissue including tumors. With advantages over current electroporation techniques including mitigation of muscle stimulation and reduced susceptibility to heterogeneous tissue properties, H-FIRE may produce more uniform and predictable ablations and can potentially be delivered with a single applicator device. However, the resulting ablations tend to be smaller than those provided with equivalent energy monopolar pulse protocols. Here, we develop numerical simulations that demonstrate the potential for clinically relevant ablations with H-FIRE delivered via a single insertion technique comprised of an expandable array and a distally placed grounding pad. Based on existing in vivo data and new in vitro results, delivery of H-FIRE with a clinical IRE single electrode probe (1 cm long) is predicted to produce a 2.2 cm3 ablation while an optimized eight tine array produces a 3.2 cm3 ablation when the same H-FIRE bursts are delivered (5000 V). We demonstrate that alternative pulse protocols can be used to increase ablation volumes with this optimized array and these results indicate that in vivo investigation of a single insertion array and grounding pad are warranted.}, journal={Computers in Biology and Medicine}, publisher={Elsevier BV}, author={Sano, Michael B. and DeWitt, Matthew R. and Teeter, Stephanie D. and Xing, Lei}, year={2018}, month={Apr}, pages={107–117} } @article{bodle_teeter_hluck_hardin_bernacki_loboa_2014, title={Age-Related Effects on the Potency of Human Adipose-Derived Stem Cells: Creation and Evaluation of Superlots and Implications for Musculoskeletal Tissue Engineering Applications}, volume={20}, ISSN={1937-3384 1937-3392}, url={http://dx.doi.org/10.1089/ten.TEC.2013.0683}, DOI={10.1089/ten.tec.2013.0683}, abstractNote={Human adipose-derived stem cells (hASC) are now a prevalent source of adult stem cells for studies in tissue engineering and regenerative medicine. However, researchers utilizing hASC in their investigations often encounter high levels of donor-to-donor variability in hASC differentiation potential. Because of this, conducting studies with this primary cell type can require extensive resources to generate statistically significant data. We present a method to generate pooled donor cell populations, termed "superlots," containing cell populations derived from four to five age-clustered donors. The goal of generating these superlots was to 1) increase experimental throughput, 2) to utilize assay resources more efficiently, and 3) to begin to establish global hASC differentiation behaviors that may be associated with donor age. With our superlot approach, we have validated that pooled donor cell populations exhibit proliferative activity representing the combined behavior of each individual donor cell line. Further, the superlots also exhibit differentiation levels roughly approximating the average combined differentiation levels of each individual donor cell line. We established that high donor-to-donor variability exists between the pre-, peri-, and postmenopausal age groupings and that proliferation and differentiation characteristics can vary widely, independent of age. Interestingly, we did observe that cell lines derived from postmenopausal donors demonstrated a relatively high proclivity for osteogenic differentiation and a relatively lowered proclivity for adipogenic differentiation as compared with cells derived from pre- and perimenopausal donors. In general, superlots effectively represented the average differentiation behavior of each of their contributing cell populations and could provide a powerful tool for increasing experimental throughput to more efficiently utilize resources when studying hASC differentiation.}, number={12}, journal={Tissue Engineering Part C: Methods}, publisher={Mary Ann Liebert Inc}, author={Bodle, Josephine C. and Teeter, Stephanie D. and Hluck, Brandon H. and Hardin, Joseph W. and Bernacki, Susan H. and Loboa, Elizabeth G.}, year={2014}, month={Dec}, pages={972–983} } @article{gamcsik_kasibhatla_teeter_colvin_2012, title={Glutathione levels in human tumors}, volume={17}, ISSN={1354-750X 1366-5804}, url={http://dx.doi.org/10.3109/1354750X.2012.715672}, DOI={10.3109/1354750x.2012.715672}, abstractNote={This review summarizes clinical studies in which glutathione was measured in tumor tissue from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung cancer. Glutathione tends to be elevated in breast, ovarian, head and neck, and lung cancer and lower in brain and liver tumors compared to disease-free tissue. Cervical, colorectal, gastric, and esophageal cancers show both higher and lower levels of tumor glutathione. Some studies show an inverse relationship between patient survival and tumor glutathione. Based on this survey, we recommend approaches that may improve the clinical value of glutathione as a biomarker.}, number={8}, journal={Biomarkers}, publisher={Informa UK Limited}, author={Gamcsik, Michael P. and Kasibhatla, Mohit S. and Teeter, Stephanie D. and Colvin, O. Michael}, year={2012}, month={Aug}, pages={671–691} } @article{gamcsik_daniel clark_ludeman_springer_d’alessandro_simpson_pourdeyhimi_bryce johnson_teeter_blackband_et al._2011, title={Non-invasive Monitoring of L-2-Oxothiazolidine-4-Carboxylate Metabolism in the Rat Brain by In vivo 13C Magnetic Resonance Spectroscopy}, volume={36}, ISSN={0364-3190 1573-6903}, url={http://dx.doi.org/10.1007/s11064-010-0362-5}, DOI={10.1007/s11064-010-0362-5}, abstractNote={The cysteine precursor L-2-oxothiazolidine-4-carboxylate (OTZ, procysteine) can raise cysteine concentration, and thus glutathione levels, in some tissues. OTZ has therefore been proposed as a prodrug for combating oxidative stress. We have synthesized stable isotope labeled OTZ (i.e. L-2-oxo-[5-13C]-thiazolidine-4-carboxylate, 13C-OTZ) and tracked its uptake and metabolism in vivo in rat brain by 13C magnetic resonance spectroscopy. Although uptake and clearance of 13C-OTZ was detectable in rat brain following a bolus dose by in vivo spectroscopy, no incorporation of isotope label into brain glutathione was detectable. Continuous infusion of 13C-OTZ over 20 h, however, resulted in 13C-label incorporation into glutathione, taurine, hypotaurine and lactate at levels sufficient for detection by in vivo magnetic resonance spectroscopy. Examination of brain tissue extracts by mass spectrometry confirmed only low levels of isotope incorporation into glutathione in rats treated with a bolus dose and much higher levels after 20 h of continuous infusion. In contrast to some previous studies, bolus administration of OTZ did not alter brain glutathione levels. Even a continuous infusion of OTZ over 20 h failed to raise brain glutathione levels. These studies demonstrate the utility of in vivo magnetic resonance for non-invasive monitoring of antioxidant uptake and metabolism in intact brain. These types of experiments can be used to evaluate the efficacy of various interventions for maintenance of brain glutathione.}, number={3}, journal={Neurochemical Research}, publisher={Springer Science and Business Media LLC}, author={Gamcsik, Michael P. and Daniel Clark, M. and Ludeman, Susan M. and Springer, James B. and D’Alessandro, Michael A. and Simpson, Nicholas E. and Pourdeyhimi, Roxana and Bryce Johnson, C. and Teeter, Stephanie D. and Blackband, Stephen J. and et al.}, year={2011}, month={Mar}, pages={443–451} }