Works (6)

Updated: July 5th, 2023 15:40

2019 journal article

Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study


By: S. Ehling n, W. Baeumer & M. Papich n

MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Cross-Over Studies; Dimenhydrinate / administration & dosage; Dimenhydrinate / blood; Dimenhydrinate / pharmacokinetics; Diphenhydramine / administration & dosage; Diphenhydramine / blood; Diphenhydramine / pharmacokinetics; Dogs; Female; Half-Life; Histamine / adverse effects; Histamine Antagonists / pharmacokinetics; Male; Pilot Projects; Theophylline / blood; Urticaria / chemically induced; Urticaria / drug therapy
TL;DR: Oral absorption of diphenhydramine was approximately three times greater with a longer half-life when it was administered as the combination product dimenhydrinate, and theophylline reached plasma concentrations considered to be therapeutic for dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons

Acta Dermato Venereologica, 99(6), 587–893.

By: S. Ehling n, T. Fukuyama n, M. Ko*, T. Olivry n & W. Bäumer n

Contributors: S. Ehling n, T. Fukuyama n, M. Ko*, T. Olivry n & W. Bäumer n

author keywords: acute itch; dorsal root ganglia; mast cells; neuromedin B; allergic dermatitis.
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation; Cells, Cultured; Dermatitis, Allergic Contact / etiology; Female; Ganglia, Spinal / cytology; Ganglia, Spinal / metabolism; Gene Expression; Indoles / pharmacology; Injections, Intradermal; Macaca mulatta; Male; Mast Cells / metabolism; Mast Cells / physiology; Mice; Neurokinin B / administration & dosage; Neurokinin B / analogs & derivatives; Pruritus / chemically induced; Pyridines / pharmacology; RNA, Messenger / metabolism; Receptors, Bombesin / antagonists & inhibitors; Receptors, Bombesin / genetics; Receptors, Bombesin / metabolism; Sensory Receptor Cells / physiology; Single-Cell Analysis; Toluene 2,4-Diisocyanate
TL;DR: In vitro real time PCR analysis for neuromedin B and its receptor expression in murine mast cells and dorsal root ganglia as well as functional calcium imaging in the ganglia found that the peripheral signal is likely transmitted through the activation of dorsalRoot ganglia. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: May 20, 2019

2017 journal article

Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia


By: R. Butler n, S. Ehling n, M. Barbar n, J. Thomas n, M. Hughes n, C. Smith n, V. Pogorelov*, D. Aryal* ...

author keywords: Nociception; Contextual fear; Fear-conditioned analgesia; Amygdala; cFos; Neural circuits
MeSH headings : Acute Pain / physiopathology; Amygdala / physiopathology; Analgesia / methods; Animals; Central Amygdaloid Nucleus / metabolism; Conditioning, Psychological / physiology; Fear / physiology; Male; Mice, Inbred C57BL; Neurons / metabolism; Pain Management; Periaqueductal Gray / metabolism; Periaqueductal Gray / physiopathology
TL;DR: The results show that amygdala processing of conditioned contextual aversive, nociceptive, and FCA behaviors involve different neuronal phenotypes and neural circuits between, within, and from various amygdala nuclei. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo


By: S. Ehling n, K. Rossbach*, S. Dunston n, H. Stark* & W. Baumer n

author keywords: Natural killer cells; Histamine H4 receptor; CCL17/TARC; Dermal dendritic cells; Allergic contact dermatitis
MeSH headings : Animals; Chemokine CCL17 / metabolism; Chemotaxis / drug effects; Coculture Techniques; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Atopic / immunology; Dermatitis, Atopic / metabolism; Disease Models, Animal; Female; Histamine / metabolism; Humans; Indoles / pharmacology; Killer Cells, Natural / drug effects; Killer Cells, Natural / metabolism; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Piperazines / pharmacology; Pyrimidines / pharmacology; Receptors, G-Protein-Coupled / agonists; Receptors, G-Protein-Coupled / antagonists & inhibitors; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Receptors, Histamine / genetics; Receptors, Histamine / metabolism; Receptors, Histamine H4; Skin / cytology; Skin / drug effects; Skin / metabolism; Toluene 2,4-Diisocyanate / toxicity
TL;DR: The H4R is identified as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation and is suggested to be beneficial in diseases like AD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes


By: K. LaDuke n, S. Ehling n, J. Cullen n & W. Baeumer

MeSH headings : Animals; Azathioprine / administration & dosage; Azathioprine / pharmacology; Cell Line; Cell Survival / drug effects; Dogs; Dose-Response Relationship, Drug; Hepatocytes / drug effects; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / pharmacology; Mercaptopurine / administration & dosage; Mercaptopurine / pharmacology; Thioguanine / administration & dosage; Thioguanine / pharmacology
TL;DR: Results indicated that thiopurines adversely affected the viability of canine hepatocytes in a time- and concentration-dependent manner but had a nonsignificant effect on the LDH and ALT activities and free glutathione depletion of those hepatocytes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis


By: T. Fukuyama n, S. Ehling n, E. Cook n & W. Baeumer

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
TL;DR: Oral treatment with JAK inhibitors reduced itch behavior dramatically but had only little effect on the inflammatory response, whereas topical treatment improved both itch and inflammatory response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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