Works (12)
Updated: July 6th, 2023 21:17
2019 journal article
Enrofloxacin Pharmacokinetics and Sampling Techniques in California Sea Hares (Aplysia californica)
Journal of the American Association for Laboratory Animal Science, 58(2), 231–234.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Aplysia / metabolism; Chromatography, High Pressure Liquid; Enrofloxacin / administration & dosage; Enrofloxacin / pharmacokinetics; Laboratory Animal Science
TL;DR:
Hemocoel injection appears to be an effective way to administer enrofloxacin to Aplysia and reach clinically relevant concentrations, and reached therapeutic target concentrations in A. californica when dosed according to the regimen described in the current report.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 22, 2019
2018 journal article
Comparison of the pharmacokinetics of plant-based treatments in milk and plasma of USDA organic dairy cattle with and without mastitis
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 35(9), 1716–1727.
author keywords: Pharmacology; milk; organic; thymol; carvacrol; bovine; cattle
MeSH headings : Animals; Cattle; Cymenes; Dairying; Female; Food, Organic / analysis; Garlic / chemistry; Milk / chemistry; Monoterpenes / blood; Thymol / blood; United States; United States Department of Agriculture
TL;DR:
Study of the pharmacokinetics of 3 compounds used on organic both healthy and mastitic organic dairy cattle found levels remained below the limit of detection in milk and plasma and thus no withdrawal time appears to be needed for milk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2017 journal article
Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle
Food Additives & Contaminants: Part A, 34(5), 1–10.
author keywords: Mastitis; organic; generally recognised as safe (GRAS); bovine; residue
MeSH headings : Administration, Topical; Allyl Compounds / administration & dosage; Allyl Compounds / pharmacokinetics; Animals; Cattle; Cymenes; Dairying; Disulfides / administration & dosage; Disulfides / pharmacokinetics; Female; Health; Limit of Detection; Mammary Glands, Animal / metabolism; Monoterpenes / administration & dosage; Monoterpenes / pharmacokinetics; Thymol / administration & dosage; Thymol / pharmacokinetics
TL;DR:
The plasma pharmacokinetics of three organic mastitis products currently used by organic producers and organic dairy veterinarians are investigated, finding that levels were measurable in the plasma, liver, kidney and fat up to 72 h after the last dose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Evaluation of factors important in modeling plasma concentrations of tetracycline hydrochloride administered in water in swine
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1641–1649.
TL;DR:
The factors found to be of importance, combined with knowledge of the individual pharmacokinetic and chemical properties of medications currently approved for administration in water, may be useful in more prudent administration of approved medications administered to swine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Hot topic: Milk and plasma disposition of thymol following intramammary administration of a phytoceutical mastitis treatment
JOURNAL OF DAIRY SCIENCE, 94(4), 1738–1743.
author keywords: Phyto-Mast; organic production; thymol; mastitis treatment
MeSH headings : Angelica sinensis; Animals; Anti-Infective Agents, Local / analysis; Anti-Infective Agents, Local / blood; Anti-Infective Agents, Local / therapeutic use; Dairying / methods; Drug Administration Routes; Drug Residues / analysis; Female; Gaultheria; Glycyrrhiza uralensis; Goats; Mammary Glands, Animal / metabolism; Mastitis / drug therapy; Mastitis / metabolism; Mastitis / veterinary; Milk / chemistry; Phytotherapy / veterinary; Pilot Projects; Thymol / analysis; Thymol / blood; Thymol / therapeutic use; Thymus Plant
TL;DR:
This study developed an assay to quantify thymol (one of the active ingredients in Phyto-Mast), a plant-based mastitis treatment used on organic dairy farms, in milk and plasma using gas chromatography and mass spectrometry (GC-MS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine
FOOD AND CHEMICAL TOXICOLOGY, 48(8-9), 2542–2546.
author keywords: Triazines; Melamine; Ruminants; Pharmacokinetics
MeSH headings : Animals; Chromatography, High Pressure Liquid; Dairying; Female; Food Contamination; Goats / metabolism; Half-Life; Linear Models; Mass Spectrometry; Milk / chemistry; Tissue Distribution; Triazines / blood; Triazines / pharmacokinetics
TL;DR:
The pharmacokinetics of melamine in ruminants is not predictive from monogastrics and milk from similarly exposed animals should be condemned for at least 4days after the last exposure to avoid violation of proposed MRLs or safe levels for milk.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats
RESEARCH IN VETERINARY SCIENCE, 90(3), 477–479.
author keywords: Tulathromycin; Goats; Pharmacokinetics; Respiratory disease; Antibiotics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Half-Life; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Tandem Mass Spectrometry / veterinary
TL;DR:
The pharmacokinetics of tulathromycin after a single 2.5 mg/kg SC injection in goats were very similar to what has been previously reported in cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model
Nano Letters, 9(2), 794–799.
Contributors: H. Lee n, T. Leavens n, n, N. Monteiro-Riviere n & J. Riviere n
MeSH headings : Animals; Hemodynamics; Mice; Models, Biological; Organ Specificity; Pharmacokinetics; Quantum Dots; Rats; Tissue Distribution
TL;DR:
The physiologically based pharmacokinetic model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution, suggesting more complex models will be needed to better predict QD biodiversity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Pharmacology of tetracycline water medication in swine
JOURNAL OF ANIMAL SCIENCE, 87(10), 3179–3186.
author keywords: pharmacokinetics; plasma concentration; swine; tetracycline; water medication
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Male; Microbial Sensitivity Tests / veterinary; Random Allocation; Swine / metabolism; Tetracycline / administration & dosage; Tetracycline / blood; Tetracycline / pharmacokinetics; Tetracycline / urine
TL;DR:
The study showed that tetracycline oral bioavailability is very small and the dose response curve shows that concentrations of plasma tetrACYcline increase linearly, yet not in a 1 to 1 ratio, to the direct increase in water medication dose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unit
JOURNAL OF FOOD PROTECTION, 71(3), 584–589.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Chromatography, High Pressure Liquid / methods; Consumer Product Safety; Dose-Response Relationship, Drug; Drug Residues / analysis; Food Contamination / analysis; Half-Life; Humans; Metabolic Clearance Rate; Pilot Projects; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Water / chemistry
TL;DR:
Plasma levels in pigs treated with an oral bolus, which is equivalent to the total drug consumed within a 24-h period, achieved therapeutic concentrations and noncompartmental-based pharmacokinetic model parameters were consistent with previously published values in swine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Pharmacokinetics of melamine in pigs following intravenous administration
Food and Chemical Toxicology, 46(3), 1196–1200.
MeSH headings : Animals; Chromatography, High Pressure Liquid; Infusions, Intravenous; Kidney / metabolism; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Swine; Triazines / administration & dosage; Triazines / blood; Triazines / pharmacokinetics
TL;DR:
The pharmacokinetic parameters for melamine obtained in pigs are comparable to the only mammalian study in rats and suggests that melamine is readily cleared by the kidney and there is unlikely to be significant tissue binding.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
journal article
Stability and bioactivity of tetracycline hydrochloride water medication in a swine production unit
Mason, S. E., Suyemoto, M., Baynes, R., & Almond, G. Journal of Swine Health and Production, 19(2), 107–111.
Source: NC State University Libraries
Added: August 6, 2018
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