Works (44)
Updated: December 19th, 2024 11:15
2024 journal article
Engineering microvascular networks using a KLF2 reporter to probe flow-dependent endothelial cell function
Biomaterials.
open access via doi.org (repository)
Source: ORCID
Added: July 1, 2024
2024 journal article
Linking cell mechanical memory and cancer metastasis
Nature Reviews Cancer.
TL;DR:
It is suggested that biophysical adaptations favourable for metastasis are retained via mechanical memory, such that the extent of memory is influenced by both the magnitude and duration of the mechanical stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 28, 2024
2024 journal article
Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 15, 2024
2024 journal article
Transmural Flow Upregulates PD-L1 Expression in Microvascular Networks.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 15, 2024
2024 journal article
Utilizing convolutional neural networks for discriminating cancer and stromal cells in three-dimensional cell culture images with nuclei counterstain.
Journal of Biomedical Optics.
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: October 15, 2024
2024 journal article
Vascular microphysiological systems
CURRENT OPINION IN HEMATOLOGY, 31(3), 155–161.
author keywords: endothelial; microfluidic; microphysiological systems; organ-on-chip; vasculature
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2024
2023 article
Development of a perfusable, hierarchical microvasculature-on-a-chip model
Chen, S. W., Blazeski, A., Zhang, S., Shelton, S. E., Offeddu, G. S., & Kamm, R. D. (2023, September 19). LAB ON A CHIP, Vol. 9.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 10, 2023
2023 journal article
Development of a perfusable, hierarchical microvasculature-on-a-chip model
LAB ON A CHIP, 23(20), 4552–4564.
TL;DR:
A perfusable, multi-compartmental model that recapitulates the three microvascular compartments to assess various physiological properties such as vessel permeability, vasoconstriction dynamics, and circulating cell arrest and extravasation is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 23, 2023
2023 journal article
Impact of Fibrinogen, Fibrin Thrombi, and Thrombin on Cancer Cell Extravasation Using In Vitro Microvascular Networks
Advanced Healthcare Materials.
TL;DR:
This system presents a physiologically relevant model of fibrin clot formation in the human microvasculature, enabling in‐depth investigation of the cellular interactions between cancer cells and the coagulation system affecting cancer cell extravasation.
(via Semantic Scholar)
Source: ORCID
Added: August 31, 2023
2023 journal article
Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors
Nature Communications, 14(1).
TL;DR:
It is shown that conditional deletion of Dnmt1 in endothelial cells is sufficient to promote T cell infiltration, reduce tumor growth and enhance ICB response in preclinical models, suggesting an epigenetic pathway presumed to be targeted in cancer cells is also operative in the tumor vasculature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2022 journal article
A Robust Method for Perfusable Microvascular Network Formation In Vitro
Small Methods, 6(6).
TL;DR:
How initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two‐step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2022 journal article
Engineered Microphysiological Systems for Testing Effectiveness of Cell-Based Cancer Immunotherapies
Cancers, 14(15), 3561.
TL;DR:
Microphysiological systems (MPS) have the capability to predict therapeutic vulnerabilities and biological barriers while studying immune cell infiltration and killing in a more physiologically relevant context, thereby providing important insights into fundamental biologic mechanisms to expand the understanding of and treatments for currently incurable malignancies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2022 journal article
New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay
Advanced Healthcare Materials, 12(14).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023
2022 journal article
Preclinical models for development of immune–oncology therapies
Immuno Oncology Insights, 03(08), 396–398.
TL;DR:
Preclinical models, including cell lines, three dimensional cultures, and mouse models are reviewed to support the need for tools enabling the development of novel immune-oncology (I-O) therapies and to help research and development scientists utilize the appropriate tools and technologies to facilitate rapid transition from preclinical evaluation to clinical trials.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023
2021 journal article
A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts
Biomaterials, 276, 121032.
TL;DR:
This work immortalizes HUVECs and FBs by exogenously expressing human telomerase reverse transcriptase (hTERT) to obtain stable endothelial cell and FB sources for μVN formation in vitro and characterize the functions of Thy1 positive and negative FBs in vasculogenesis in vitro.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2021 journal article
Microheart: A microfluidic pump for functional vascular culture in microphysiological systems
Journal of Biomechanics, 119, 110330.
TL;DR:
The use of the pump for microvascular physiological studies demonstrated the utility of this system to recapitulate vascular fluid transport phenomena in microphysiological systems, which may find applications in disease models and drug screening.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2020 journal article
Engineering approaches for studying immune-tumor cell interactions and immunotherapy
IScience, 24(1), 101985.
TL;DR:
The importance of modeling and understanding the immune TME is highlighted and new tools for identifying new biological targets, drug testing, and strategies for personalized medicine are described.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 31, 2023
2020 chapter
In vitro, primarily microfluidic models for atherosclerosis
In Biomechanics of Coronary Atherosclerotic Plaque (pp. 299–313).
TL;DR:
This chapter explores the evolution of in-vitro models of atherosclerosis and the variety of hypotheses and results that have emerged from these efforts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 31, 2023
2020 journal article
Microvascular Ultrasonic Imaging of Angiogenesis Identifies Tumors in a Murine Spontaneous Breast Cancer Model
International Journal of Biomedical Imaging, 2020, 1–10.
TL;DR:
Application of microvascular tortuosity and spatial clustering techniques to clinical imaging could improve breast cancer diagnosis, as well as improve specificity in assessing cancer in other tissues.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2020 journal article
Tumor-Derived cGAMP Regulates Activation of the Vasculature
Frontiers in Immunology, 11.
TL;DR:
A novel microfluidic model is developed to study KL tumor-vascular interactions and shows that tumor cell cGAS-STING signaling not only produces T cell chemoattractants, but also primes tumor vasculature for immune cell escape.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2019 journal article
Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo
PHYSICS IN MEDICINE AND BIOLOGY, 64(11).
author keywords: multiple scattering; ultrasound imaging; diffusion constant; fibrosarcoma; contrast enhanced ultrasound; microbubbles
MeSH headings : Animals; Disease Models, Animal; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / pathology; Microbubbles; Neovascularization, Pathologic; Rats; Ultrasonography
TL;DR:
The diffusion constant and its anisotropy are shown to be significantly different between fibrosarcoma tumors and control tissue in a rat animal model in vivo, offering a promising way to quantitatively assess vascular networks when combined with contrast agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019
2018 journal article
ON THE RELATIONSHIP BETWEEN DYNAMIC CONTRAST-ENHANCED ULTRASOUND PARAMETERS AND THE UNDERLYING VASCULAR ARCHITECTURE EXTRACTED FROM ACOUSTIC ANGIOGRAPHY
ULTRASOUND IN MEDICINE AND BIOLOGY, 45(2), 539–548.
author keywords: Acoustic angiography; Dynamic contrast-enhanced ultrasound; Cancer; Dispersion; Perfusion; Ultrasound contrast agents
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media; Disease Models, Animal; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Imaging, Three-Dimensional / methods; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR:
It is hypothesize that dispersion characterizes vessels that are smaller than those visible with acoustic angiography, because dispersion provided better cancer classification than perfusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2020
2017 conference paper
Characterization of a prototype transmit 2 MHz receive 21 MHz array for superharmonic imaging
2017 IEEE International Ultrasonics Symposium (IUS). Presented at the 2017 IEEE International Ultrasonics Symposium (IUS).
Event: 2017 IEEE International Ultrasonics Symposium (IUS)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023
2017 journal article
First-in-Human Study of Acoustic Angiography in the Breast and Peripheral Vasculature
Ultrasound in Medicine & Biology, 43(12), 2939–2946.
author keywords: Contrast-enhanced ultrasound; Breast imaging; Angiography; Superharmonic; Microbubble; Micro-vasculature; Dual frequency
MeSH headings : Acoustics; Angiography; Breast / anatomy & histology; Breast / blood supply; Contrast Media; Feasibility Studies; Female; Fluorocarbons; Hand / anatomy & histology; Hand / blood supply; Humans; Image Enhancement / methods; Male; Microbubbles; Reference Values; Sensitivity and Specificity; Ultrasonography / methods; Wrist / anatomy & histology; Wrist / blood supply
TL;DR:
The translation of a contrast-enhanced ultrasound technique, acoustic angiography, to human imaging is described and results indicate that sensitivity and spatial resolution are sufficient to image vessels as small as 0.2 mm in diameter at depths of ~15mm in the human breast.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 conference paper
Which properties of the vascular architecture are reflected by dynamic contrast-enhanced ultrasound imaging of dispersion and wash-in rate? A comparison with acoustic angiography
2017 IEEE International Ultrasonics Symposium (IUS). Presented at the 2017 IEEE International Ultrasonics Symposium (IUS).
Event: 2017 IEEE International Ultrasonics Symposium (IUS)
TL;DR:
This paper looks at longitudinal trends of wash-in-rate (WIR), a perfusion parameter, and correlation coefficient, a dispersion parameter, in 3 fibrosarcoma xenograft models and hypothesizes that the correlation coefficient reflects properties of smaller vessels than those visible with AA.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023
2016 journal article
3-D Ultrasound Localization Microscopy for Identifying Microvascular Morphology Features of Tumor Angiogenesis at a Resolution Beyond the Diffraction Limit of Conventional Ultrasound
Theranostics, 7(1), 196–204.
author keywords: Angiogenesis; super-resolution; ultrasound localization microscopy; microbubble contrast agent; acoustic angiography; biomarker
MeSH headings : Animals; Disease Models, Animal; Female; Fibrosarcoma / pathology; Imaging, Three-Dimensional / methods; Microscopy / methods; Microvessels / pathology; Neovascularization, Pathologic; Pilot Projects; Rats, Inbred F344; Ultrasonography / methods
TL;DR:
The ability to image complex microvascular patterns associated with tumor angiogenesis in-vivo at a resolution of tens of microns is demonstrated - substantially better than the diffraction limit of traditional clinical ultrasound, yet using an 8 MHz clinical ultrasound probe.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2016 article
Acoustic angiography: A new high frequency contrast ultrasound technique for biomedical imaging
SENSING AND ANALYSIS TECHNOLOGIES FOR BIOMEDICAL AND COGNITIVE APPLICATIONS 2016, Vol. 9871.
author keywords: Ultrasound; contrast agent; microbubble; microvasculature; angiogenesis; broadband; superharmonic; transducer; dual-frequency; acoustic angiography
TL;DR:
Data shows that acoustic angiography can provide important information about the presence of disease based on vascular patterns, and may enable a new paradigm in medical imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models
Molecular Imaging and Biology, 19(2), 194–202.
author keywords: Microbubble; Superharmonic; Microvasculature; Angiogenesis; Tortuosity; Targeted imaging; Ultrasound; Contrast imaging; VEGFR2; Selectin
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media / chemistry; Disease Models, Animal; Image Processing, Computer-Assisted; Microvessels / pathology; Molecular Imaging / methods; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Rats, Inbred F344
TL;DR:
Analysis of registered microvascular and molecular imaging volumes indicated that vessel tortuosity decreases with increasing distance from both VEGFR2- and selectin-targeting sites, and superharmonic imaging had significantly higher contrast-to-tissue ratio (CTR) than multi-pulse imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 conference paper
Does contrast ultrasound dispersion imaging reveal changes in tortuosity? A comparison with acoustic angiography
IEEE International Ultrasound Symposium. Presented at the IEEE International Ultrasound Symposium, Tours, France.
Event: IEEE International Ultrasound Symposium at Tours, France on September 18-21, 2016
Source: NC State University Libraries
Added: September 10, 2023
2016 journal article
High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography
ANNALS OF BIOMEDICAL ENGINEERING, 45(4), 939–948.
author keywords: Ultrasound; Perfusion; Microbubble; High frequency; Low flow imaging; Quantitative imaging; Angiogenesis; Superharmonic
MeSH headings : Angiography / methods; Animals; Chick Embryo; Chorioallantoic Membrane / blood supply; Chorioallantoic Membrane / diagnostic imaging; Contrast Media / pharmacology; Microbubbles / therapeutic use; Perfusion Imaging / methods; Ultrasonography / methods
TL;DR:
The feasibility of dynamic contrast-enhanced superharmonic perfusion imaging at low flow rates is demonstrated and the feasibility of quantitatively mapping perfusion rate in 2D in a mouse model with spatial resolution of ~100 μm is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
In-vivo</i> quantitative analysis of the angiogenic microvasculature in tumor-bearing rats using multiple scattering: A preliminary study
Journal of the Acoustical Society of America, 140(4_Supplement), 3187–3187.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023
2016 conference paper
Molecular acoustic angiography: Comparison of contrast-to-tissue ratio with multi-pulse techniques and imaging multiple targeted microbubbles
2016 IEEE International Ultrasonics Symposium (IUS). Presented at the 2016 IEEE International Ultrasonics Symposium (IUS).
Event: 2016 IEEE International Ultrasonics Symposium (IUS)
TL;DR:
The contrast-to-tissue ratio (CTR) between superharmonic and multi-pulse molecular imaging is compared and images of microbubbles targeted to different biomarkers expressed by the vascular endothelial cells are presented.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2016 conference paper
The application of acoustic angiography to assess the progression of angiogenesis in a spontaneous mouse model of breast cancer
2016 IEEE International Ultrasonics Symposium (IUS). Presented at the 2016 IEEE International Ultrasonics Symposium (IUS).
Event: 2016 IEEE International Ultrasonics Symposium (IUS)
TL;DR:
Results indicate that acoustic angiography images can reveal microvasculature in sufficient detail for vascular morphology to be used as a biomarker for cancer imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
MOLECULAR ACOUSTIC ANGIOGRAPHY: A NEW TECHNIQUE FOR HIGH-RESOLUTION SUPERHARMONIC ULTRASOUND MOLECULAR IMAGING
ULTRASOUND IN MEDICINE AND BIOLOGY, 42(3), 769–781.
author keywords: Microbubble; Targeted imaging; Angiogenesis; Microvasculature; Biomarker
MeSH headings : Angiography; Animals; Cell Line, Tumor; Contrast Media / pharmacokinetics; Elasticity Imaging Techniques / instrumentation; Elasticity Imaging Techniques / methods; Equipment Design; Equipment Failure Analysis; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / metabolism; Fluorocarbons; Image Enhancement / instrumentation; Image Enhancement / methods; Image Interpretation, Computer-Assisted / instrumentation; Image Interpretation, Computer-Assisted / methods; Integrin alphaVbeta3 / metabolism; Molecular Imaging; Oligopeptides / pharmacokinetics; Phantoms, Imaging; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution
TL;DR:
The combined information provided by these scans may present new opportunities for analyzing relationships between microvascular anatomy and vascular targets, subject only to limitations of the current mechanically scanned system and microbubble persistence to repeated imaging at moderate mechanical indices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 conference paper
Molecular acoustic angiography: Demonstration of in vivo feasibility for high resolution superharmonic ultrasound molecular imaging
2015 IEEE International Ultrasonics Symposium (IUS). Presented at the 2015 IEEE International Ultrasonics Symposium (IUS).
Event: 2015 IEEE International Ultrasonics Symposium (IUS)
TL;DR:
The feasibility ofsuperharmonic molecular imaging was shown using microbubbles targeted to the αvβ3 integrin in a rat fibrosarcoma model and combined with superharmonic images of free microbubble to produce high contrast, high resolution 3D volumes of both microvascular anatomy and molecular targeting.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023
2015 journal article
Optimization of Contrast-to-Tissue Ratio Through Pulse Windowing in Dual-Frequency “Acoustic Angiography” Imaging
Ultrasound in Medicine & Biology, 41(7), 1884–1895.
author keywords: Microbubbles; Superharmonic; Harmonic; Pulse shape; Pulse window; High-frequency ultrasound; Acoustic angiography; Contrast agent
TL;DR:
In this study, shaped transmit pulses were used to image the higher broadband harmonic echoes of microbubble contrast agents, and the effects of varying pulse window and phasing on microbubbles and tissue harmonic echoes were evaluated using a dual-frequency transducer in vitro and in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2015 journal article
QUANTIFICATION OF MICROVASCULAR TORTUOSITY DURING TUMOR EVOLUTION USING ACOUSTIC ANGIOGRAPHY
ULTRASOUND IN MEDICINE AND BIOLOGY, 41(7), 1896–1904.
author keywords: Tortuosity; Contrast agent; Microbubble; Ultrasound; Acoustic angiography; Microvasculature; Angiogenesis; Superharmonic imaging
MeSH headings : Algorithms; Angiography / methods; Animals; Breast Neoplasms / blood supply; Breast Neoplasms / complications; Breast Neoplasms / pathology; Elasticity Imaging Techniques / methods; Female; Humans; Image Enhancement / methods; Image Interpretation, Computer-Assisted / methods; Male; Mice; Microvessels / diagnostic imaging; Neovascularization, Pathologic / complications; Neovascularization, Pathologic / pathology; Reproducibility of Results; Sensitivity and Specificity
TL;DR:
Quantitative morphologic analysis of tumor vessels revealed significantly increased vascular tortuosity abnormalities associated with tumor growth, with the distance metric elevated approximately 14% and the sum of angles metric increased 60% in tumor vessels versus controls.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
The "Fingerprint" of Cancer Extends Beyond Solid Tumor Boundaries: Assessment With a Novel Ultrasound Imaging Approach
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(5), 1082–1086.
author keywords: Acoustic angiography; angiogenesis; spatial heterogeneity; tortuosity; ultrasound
MeSH headings : Angiography; Animals; Image Interpretation, Computer-Assisted / methods; Imaging, Three-Dimensional / methods; Mice; Microvessels / diagnostic imaging; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Neovascularization, Pathologic / diagnostic imaging; Ultrasonography / methods
TL;DR:
Visualization of abnormal vascular tortuosity may make acoustic angiography an invaluable tool for early tumor detection based on quantifying the vascular footprint of small tumors and a sensitive method for understanding changes in the vascular microenvironment during tumor progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Acoustic Characterization of Contrast-to-issue Ratio and Axial Resolution for Dual-Frequency Contrast-Specific Acoustic Angiography Imaging
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 61(10), 1668–1687.
MeSH headings : Angiography / methods; Animals; Cattle; Contrast Media / chemistry; Iliac Artery / diagnostic imaging; Mice; Microbubbles; Muscles / diagnostic imaging; Particle Size; Pressure; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Transducers; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods
TL;DR:
CTR dependence on transmit frequency and peak pressure were confirmed through in vivo imaging in two rodents and may lead to improved imaging of vascular remodeling in superficial or luminal cancers such as those of the breast, prostate, and colon.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 article
Optimization of Contrast-to-tissue Ratio and Role of Bubble Destruction in Dual-Frequency Contrast-Specific "Acoustic Angiography" Imaging
2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1774–1777.
author keywords: superharmonic; microbubble; high frequency ultrasound; cavitation; dual-frequency; contrast-to-tissue ratio
TL;DR:
This work examines the imaging parameters for optimizing contrast-to-tissue ratio (CTR) for dual-frequency imaging and the relationship between bubble destruction and broadband harmonic signal production and indicates that superharmonic signals having the broadest bandwidth and highest energy are associated with shell fragmentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 conference paper
The implementation of acoustic angiography for microvascular and angiogenesis imaging
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Presented at the 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
Event: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
TL;DR:
Because microbubbles are strictly an intravascular agent, this approach enables visualization of microvascular morphology with unique clarity, providing insight into angiogenesis associated with tumor development.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023
2014 journal article
Vascular channels formed by subpopulations of PECAM1+ melanoma cells
Nature Communications, 5(1).
MeSH headings : Angiogenesis Inhibitors / chemistry; Animals; Cell Line, Tumor; Female; Flow Cytometry; Green Fluorescent Proteins / metabolism; Humans; Melanoma / metabolism; Melanoma, Experimental / metabolism; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic / metabolism; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; RNA, Small Interfering / metabolism; Skin Neoplasms / metabolism; Transcription Factor AP-2 / metabolism; Up-Regulation; Vascular Endothelial Growth Factor A / metabolism; Vascular Endothelial Growth Factor Receptor-2 / metabolism
TL;DR:
VM-competent subpopulations, rather than all cells within a tumour, may instigate VM, supplant host-derived endothelium, and form PECAM1-dependent conduits that are not diminished by neutralizing VEGF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
A multiphase model for three-dimensional tumor growth
New Journal of Physics, 15(1), 015005.
TL;DR:
This model can predict and optimize the efficacy of anticancer therapeutic strategies and be further developed to answer questions on tumor biophysics, related to the effects of ECM stiffness and cell adhesion on TC proliferation.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023
2012 journal article
Tumor growth modeling from the perspective of multiphase porous media mechanics.
Molecular & Cellular Biomechanics : MCB. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285734/?tool=EBI
Source: ORCID
Added: August 31, 2023
Employment
Updated: August 31st, 2023 11:04
2023 - present
University of North Carolina NC, US
Assistant Professor
Biomedical Engineering
2023 - present
North Carolina State University Raleigh, US
Assistant Professor
Biomedical Engineering
2019 - 2023
Dana-Farber Cancer Institute Boston, MA, US
Postdoctoral Fellow
Medical Oncology
2018 - 2023
Massachusetts Institute of Technology Cambridge, Massachusetts, US
Postdoctoral Fellow
Biological Engineering
2012 - 2017
North Carolina State University Raleigh, North Carolina, US
Graduate Student
Biomedical Engineering
2012 - 2017
University of North Carolina Chapel Hill, North Carolina, US
Graduate student
Biomedical Engineering
Funding History
Funding history based on the linked ORCID record. Updated: August 31st, 2023 10:57
grant
February 1, 2018 - January 31, 2023
Imaging Cancer Angiogenesis with Acoustic Angiography Ultrasound
National Cancer Institute
grant
September 21, 2016 - December 31, 2017
Imaging Cancer Angiogenesis with Acoustic Angiography Ultrasound
National Cancer Institute
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