Works (38)

Updated: November 13th, 2023 08:07

2023 article

Development of a perfusable, hierarchical microvasculature-on-a-chip model

Chen, S. W., Blazeski, A., Zhang, S., Shelton, S. E., Offeddu, G. S., & Kamm, R. D. (2023, September 19). LAB ON A CHIP, Vol. 9.

By: S. Chen, A. Blazeski, S. Zhang, S. Shelton, G. Offeddu & R. Kamm

Sources: Web Of Science, ORCID
Added: October 10, 2023

2023 journal article

Development of a perfusable, hierarchical microvasculature-on-a-chip model

LAB ON A CHIP, 23(20), 4552–4564.

By: S. Chen*, A. Blazeski*, S. Zhang*, S. Shelton*, G. Offeddu* & R. Kamm*

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: October 23, 2023

2023 journal article

Impact of Fibrinogen, Fibrin Thrombi, and Thrombin on Cancer Cell Extravasation Using In Vitro Microvascular Networks

Advanced Healthcare Materials.

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 31, 2023

2023 journal article

Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors

Nature Communications, 14(1).

co-author countries: United States of America 🇺🇸
Sources: ORCID, Crossref
Added: August 31, 2023

2022 journal article

A Robust Method for Perfusable Microvascular Network Formation In Vitro

Small Methods, 6(6).

By: Z. Wan*, A. Zhong*, S. Zhang*, G. Pavlou*, M. Coughlin*, S. Shelton*, H. Nguyen*, J. Lorch*, D. Barbie*, R. Kamm*

co-author countries: United States of America 🇺🇸

Contributors: S. Shelton*

Sources: ORCID, Crossref
Added: August 31, 2023

2022 journal article

Engineered Microphysiological Systems for Testing Effectiveness of Cell-Based Cancer Immunotherapies

Cancers, 14(15), 3561.

co-author countries: United States of America 🇺🇸

Contributors: S. Shelton*

Sources: ORCID, Crossref
Added: August 31, 2023

2022 journal article

New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay

Advanced Healthcare Materials, 12(14).

By: Z. Wan*, M. Floryan*, M. Coughlin*, S. Zhang*, A. Zhong*, S. Shelton*, X. Wang*, C. Xu*, D. Barbie*, R. Kamm*

co-author countries: China 🇨🇳 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: September 3, 2023

2022 journal article

Preclinical models for development of immune–oncology therapies

Immuno Oncology Insights, 03(08), 396–398.

By: Y. Wang, S. Shelton*, G. Kastrunes, D. Barbie, G. Freeman & W. Marasco

Sources: Crossref, ORCID
Added: September 3, 2023

2021 journal article

A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts

Biomaterials, 276, 121032.

By: Z. Wan*, S. Zhang*, A. Zhong*, S. Shelton*, M. Campisi*, S. Sundararaman*, G. Offeddu*, E. Ko* ...

co-author countries: China 🇨🇳 Italy 🇮🇹 United States of America 🇺🇸
Sources: ORCID, Crossref
Added: August 31, 2023

2021 journal article

Engineering approaches for studying immune-tumor cell interactions and immunotherapy

IScience, 24(1), 101985.

By: S. Shelton*, H. Nguyen*, D. Barbie* & R. Kamm*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: August 31, 2023

2021 chapter

In vitro, primarily microfluidic models for atherosclerosis

In Biomechanics of Coronary Atherosclerotic Plaque (pp. 299–313).

By: S. Shelton* & R. Kamm*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 31, 2023

2021 journal article

Microheart: A microfluidic pump for functional vascular culture in microphysiological systems

Journal of Biomechanics, 119, 110330.

By: G. Offeddu*, J. Serrano*, S. Chen*, S. Shelton*, Y. Shin*, M. Floryan*, R. Kamm*

co-author countries: United States of America 🇺🇸
Sources: ORCID, Crossref
Added: August 31, 2023

2020 journal article

Microvascular Ultrasonic Imaging of Angiogenesis Identifies Tumors in a Murine Spontaneous Breast Cancer Model

International Journal of Biomedical Imaging, 2020, 1–10.

By: S. Shelton n, J. Stone n, F. Gao*, D. Zeng* & P. Dayton n

co-author countries: United States of America 🇺🇸
Sources: ORCID, Crossref
Added: August 31, 2023

2020 journal article

Tumor-Derived cGAMP Regulates Activation of the Vasculature

Frontiers in Immunology, 11.

co-author countries: Italy 🇮🇹 Japan 🇯🇵 Singapore 🇸🇬 United States of America 🇺🇸
Sources: ORCID, Crossref
Added: August 31, 2023

2019 journal article

ON THE RELATIONSHIP BETWEEN DYNAMIC CONTRAST-ENHANCED ULTRASOUND PARAMETERS AND THE UNDERLYING VASCULAR ARCHITECTURE EXTRACTED FROM ACOUSTIC ANGIOGRAPHY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(2), 539–548.

By: A. Panfilova*, S. Shelton n, C. Caresio*, R. Sloun*, F. Molinari*, H. Wijkstra*, P. Dayton n, M. Mischi*

co-author countries: Italy 🇮🇹 Netherlands 🇳🇱 United States of America 🇺🇸
author keywords: Acoustic angiography; Dynamic contrast-enhanced ultrasound; Cancer; Dispersion; Perfusion; Ultrasound contrast agents
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media; Disease Models, Animal; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Imaging, Three-Dimensional / methods; Rats; Rats, Inbred F344; Ultrasonography / methods
Sources: Web Of Science, ORCID
Added: April 20, 2020

2019 journal article

Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo

PHYSICS IN MEDICINE AND BIOLOGY, 64(11).

co-author countries: United States of America 🇺🇸
author keywords: multiple scattering; ultrasound imaging; diffusion constant; fibrosarcoma; contrast enhanced ultrasound; microbubbles
MeSH headings : Animals; Disease Models, Animal; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / pathology; Microbubbles; Neovascularization, Pathologic; Rats; Ultrasonography
Sources: Web Of Science, ORCID
Added: June 24, 2019

2017 journal article

3-D Ultrasound Localization Microscopy for Identifying Microvascular Morphology Features of Tumor Angiogenesis at a Resolution Beyond the Diffraction Limit of Conventional Ultrasound

Theranostics, 7(1), 196–204.

By: F. Lin, S. Shelton*, D. Espíndola, J. Rojas, G. Pinton & P. Dayton*

author keywords: Angiogenesis; super-resolution; ultrasound localization microscopy; microbubble contrast agent; acoustic angiography; biomarker
MeSH headings : Animals; Disease Models, Animal; Female; Fibrosarcoma / pathology; Imaging, Three-Dimensional / methods; Microscopy / methods; Microvessels / pathology; Neovascularization, Pathologic; Pilot Projects; Rats, Inbred F344; Ultrasonography / methods
Sources: ORCID, Crossref, Web Of Science
Added: August 6, 2018

2017 journal article

Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models

Molecular Imaging and Biology, 19(2), 194–202.

By: B. Lindsey n, S. Shelton n, F. Foster* & P. Dayton n

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Microbubble; Superharmonic; Microvasculature; Angiogenesis; Tortuosity; Targeted imaging; Ultrasound; Contrast imaging; VEGFR2; Selectin
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media / chemistry; Disease Models, Animal; Image Processing, Computer-Assisted; Microvessels / pathology; Molecular Imaging / methods; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Rats, Inbred F344
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 conference paper

Characterization of a prototype transmit 2 MHz receive 21 MHz array for superharmonic imaging

2017 IEEE International Ultrasonics Symposium (IUS). Presented at the 2017 IEEE International Ultrasonics Symposium (IUS).

By: I. Newsome, B. Lindsey, S. Shelton*, E. Cherin, J. Yin, F. Foster, P. Dayton

Event: 2017 IEEE International Ultrasonics Symposium (IUS)

Sources: Crossref, ORCID
Added: September 3, 2023

2017 journal article

First-in-Human Study of Acoustic Angiography in the Breast and Peripheral Vasculature

Ultrasound in Medicine & Biology, 43(12), 2939–2946.

By: S. Shelton n, B. Lindsey n, P. Dayton n & Y. Lee*

co-author countries: United States of America 🇺🇸
author keywords: Contrast-enhanced ultrasound; Breast imaging; Angiography; Superharmonic; Microbubble; Micro-vasculature; Dual frequency
MeSH headings : Acoustics; Angiography; Breast / anatomy & histology; Breast / blood supply; Contrast Media; Feasibility Studies; Female; Fluorocarbons; Hand / anatomy & histology; Hand / blood supply; Humans; Image Enhancement / methods; Male; Microbubbles; Reference Values; Sensitivity and Specificity; Ultrasonography / methods; Wrist / anatomy & histology; Wrist / blood supply
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography

ANNALS OF BIOMEDICAL ENGINEERING, 45(4), 939–948.

By: B. Lindsey n, S. Shelton n, K. Martin n, K. Ozgun n, J. Rojas n, F. Foster*, P. Dayton n

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Ultrasound; Perfusion; Microbubble; High frequency; Low flow imaging; Quantitative imaging; Angiogenesis; Superharmonic
MeSH headings : Angiography / methods; Animals; Chick Embryo; Chorioallantoic Membrane / blood supply; Chorioallantoic Membrane / diagnostic imaging; Contrast Media / pharmacology; Microbubbles / therapeutic use; Perfusion Imaging / methods; Ultrasonography / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 conference paper

Which properties of the vascular architecture are reflected by dynamic contrast-enhanced ultrasound imaging of dispersion and wash-in rate? A comparison with acoustic angiography

2017 IEEE International Ultrasonics Symposium (IUS). Presented at the 2017 IEEE International Ultrasonics Symposium (IUS).

By: A. Panfilova*, S. Shelton n, R. van Sloun*, C. Caresio*, H. Wijkstra*, P. Dayton n, M. Mischi*

co-author countries: Italy 🇮🇹 Netherlands 🇳🇱 United States of America 🇺🇸

Event: 2017 IEEE International Ultrasonics Symposium (IUS)

Sources: Crossref, ORCID
Added: September 3, 2023

2016 article

Acoustic angiography: A new high frequency contrast ultrasound technique for biomedical imaging

SENSING AND ANALYSIS TECHNOLOGIES FOR BIOMEDICAL AND COGNITIVE APPLICATIONS 2016, Vol. 9871.

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Ultrasound; contrast agent; microbubble; microvasculature; angiogenesis; broadband; superharmonic; transducer; dual-frequency; acoustic angiography
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 conference paper

Does contrast ultrasound dispersion imaging reveal changes in tortuosity? A comparison with acoustic angiography

IEEE International Ultrasound Symposium. Presented at the IEEE International Ultrasound Symposium, Tours, France.

By: A. Panfilova, S. Shelton, R. van Sloun, L. Demi, H. Wijkstra, P. Dayton, M. Mischi

Event: IEEE International Ultrasound Symposium at Tours, France on September 18-21, 2016

Source: NC State University Libraries
Added: September 10, 2023

2016 journal article

In-vivo quantitative analysis of the angiogenic microvasculature in tumor-bearing rats using multiple scattering: A preliminary study

Journal of the Acoustical Society of America, 140(4_Supplement), 3187–3187.

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: September 3, 2023

2016 journal article

MOLECULAR ACOUSTIC ANGIOGRAPHY: A NEW TECHNIQUE FOR HIGH-RESOLUTION SUPERHARMONIC ULTRASOUND MOLECULAR IMAGING

ULTRASOUND IN MEDICINE AND BIOLOGY, 42(3), 769–781.

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Microbubble; Targeted imaging; Angiogenesis; Microvasculature; Biomarker
MeSH headings : Angiography; Animals; Cell Line, Tumor; Contrast Media / pharmacokinetics; Elasticity Imaging Techniques / instrumentation; Elasticity Imaging Techniques / methods; Equipment Design; Equipment Failure Analysis; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / metabolism; Fluorocarbons; Image Enhancement / instrumentation; Image Enhancement / methods; Image Interpretation, Computer-Assisted / instrumentation; Image Interpretation, Computer-Assisted / methods; Integrin alphaVbeta3 / metabolism; Molecular Imaging; Oligopeptides / pharmacokinetics; Phantoms, Imaging; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 conference paper

Molecular acoustic angiography: Comparison of contrast-to-tissue ratio with multi-pulse techniques and imaging multiple targeted microbubbles

2016 IEEE International Ultrasonics Symposium (IUS). Presented at the 2016 IEEE International Ultrasonics Symposium (IUS).

By: S. Shelton*, B. Lindsey*, P. Dayton* & F. Foster*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸

Event: 2016 IEEE International Ultrasonics Symposium (IUS)

Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 journal article

The "Fingerprint" of Cancer Extends Beyond Solid Tumor Boundaries: Assessment With a Novel Ultrasound Imaging Approach

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(5), 1082–1086.

By: S. Rao n, S. Shelton n & P. Dayton

co-author countries: United States of America 🇺🇸
author keywords: Acoustic angiography; angiogenesis; spatial heterogeneity; tortuosity; ultrasound
MeSH headings : Angiography; Animals; Image Interpretation, Computer-Assisted / methods; Imaging, Three-Dimensional / methods; Mice; Microvessels / diagnostic imaging; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Neovascularization, Pathologic / diagnostic imaging; Ultrasonography / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 conference paper

The application of acoustic angiography to assess the progression of angiogenesis in a spontaneous mouse model of breast cancer

2016 IEEE International Ultrasonics Symposium (IUS). Presented at the 2016 IEEE International Ultrasonics Symposium (IUS).

By: S. Shelton*, P. Dayton*, S. Aylward* & F. Foster*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸

Event: 2016 IEEE International Ultrasonics Symposium (IUS)

Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2015 conference paper

Molecular acoustic angiography: Demonstration of in vivo feasibility for high resolution superharmonic ultrasound molecular imaging

2015 IEEE International Ultrasonics Symposium (IUS). Presented at the 2015 IEEE International Ultrasonics Symposium (IUS).

co-author countries: Canada 🇨🇦 United States of America 🇺🇸

Event: 2015 IEEE International Ultrasonics Symposium (IUS)

Sources: Crossref, ORCID
Added: September 3, 2023

2015 journal article

Optimization of Contrast-to-Tissue Ratio Through Pulse Windowing in Dual-Frequency “Acoustic Angiography” Imaging

Ultrasound in Medicine & Biology, 41(7), 1884–1895.

By: B. Lindsey n, S. Shelton n & P. Dayton n

co-author countries: United States of America 🇺🇸
author keywords: Microbubbles; Superharmonic; Harmonic; Pulse shape; Pulse window; High-frequency ultrasound; Acoustic angiography; Contrast agent
Sources: ORCID, Crossref, Web Of Science
Added: August 6, 2018

2015 journal article

QUANTIFICATION OF MICROVASCULAR TORTUOSITY DURING TUMOR EVOLUTION USING ACOUSTIC ANGIOGRAPHY

ULTRASOUND IN MEDICINE AND BIOLOGY, 41(7), 1896–1904.

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Tortuosity; Contrast agent; Microbubble; Ultrasound; Acoustic angiography; Microvasculature; Angiogenesis; Superharmonic imaging
MeSH headings : Algorithms; Angiography / methods; Animals; Breast Neoplasms / blood supply; Breast Neoplasms / complications; Breast Neoplasms / pathology; Elasticity Imaging Techniques / methods; Female; Humans; Image Enhancement / methods; Image Interpretation, Computer-Assisted / methods; Male; Mice; Microvessels / diagnostic imaging; Neovascularization, Pathologic / complications; Neovascularization, Pathologic / pathology; Reproducibility of Results; Sensitivity and Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Acoustic Characterization of Contrast-to-issue Ratio and Axial Resolution for Dual-Frequency Contrast-Specific Acoustic Angiography Imaging

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 61(10), 1668–1687.

By: B. Lindsey n, J. Rojas n, K. Martin n, S. Shelton n & P. Dayton n

co-author countries: United States of America 🇺🇸
MeSH headings : Angiography / methods; Animals; Cattle; Contrast Media / chemistry; Iliac Artery / diagnostic imaging; Mice; Microbubbles; Muscles / diagnostic imaging; Particle Size; Pressure; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Transducers; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 article

Optimization of Contrast-to-tissue Ratio and Role of Bubble Destruction in Dual-Frequency Contrast-Specific "Acoustic Angiography" Imaging

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1774–1777.

By: B. Lindsey*, J. Rojas*, K. Martin*, S. Shelton* & P. Dayton*

co-author countries: United States of America 🇺🇸
author keywords: superharmonic; microbubble; high frequency ultrasound; cavitation; dual-frequency; contrast-to-tissue ratio
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 conference paper

The implementation of acoustic angiography for microvascular and angiogenesis imaging

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Presented at the 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

By: P. Dayton*, R. Gessner*, L. Phillips*, S. Shelton*, K. Martin*, M. Lee*, F. Foster*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸

Event: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Sources: Crossref, ORCID
Added: September 3, 2023

2014 journal article

Vascular channels formed by subpopulations of PECAM1+ melanoma cells

Nature Communications, 5(1).

By: J. Dunleavey*, L. Xiao*, J. Thompson*, M. Kim*, J. Shields*, S. Shelton n, D. Irvin*, V. Brings* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Angiogenesis Inhibitors / chemistry; Animals; Cell Line, Tumor; Female; Flow Cytometry; Green Fluorescent Proteins / metabolism; Humans; Melanoma / metabolism; Melanoma, Experimental / metabolism; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic / metabolism; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; RNA, Small Interfering / metabolism; Skin Neoplasms / metabolism; Transcription Factor AP-2 / metabolism; Up-Regulation; Vascular Endothelial Growth Factor A / metabolism; Vascular Endothelial Growth Factor Receptor-2 / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2013 journal article

A multiphase model for three-dimensional tumor growth

New Journal of Physics, 15(1), 015005.

By: G. Sciumè*, S. Shelton*, W. Gray*, C. Miller*, F. Hussain*, M. Ferrari*, P. Decuzzi*, B. Schrefler*

co-author countries: France 🇫🇷 Italy 🇮🇹 United States of America 🇺🇸
Sources: ORCID, Crossref
Added: August 31, 2023

2012 journal article

Tumor growth modeling from the perspective of multiphase porous media mechanics.

Molecular & Cellular Biomechanics : MCB. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285734/?tool=EBI

Source: ORCID
Added: August 31, 2023

Employment

Updated: August 31st, 2023 11:04

2023 - present

University of North Carolina NC, US
Assistant Professor Biomedical Engineering

2023 - present

North Carolina State University Raleigh, US
Assistant Professor Biomedical Engineering

2019 - 2023

Dana-Farber Cancer Institute Boston, MA, US
Postdoctoral Fellow Medical Oncology

2018 - 2023

Massachusetts Institute of Technology Cambridge, Massachusetts, US
Postdoctoral Fellow Biological Engineering

2012 - 2017

North Carolina State University Raleigh, North Carolina, US
Graduate Student Biomedical Engineering

2012 - 2017

University of North Carolina Chapel Hill, North Carolina, US
Graduate student Biomedical Engineering

Funding History

Funding history based on the linked ORCID record. Updated: August 31st, 2023 10:57

grant February 1, 2018 - January 31, 2023
Imaging Cancer Angiogenesis with Acoustic Angiography Ultrasound
National Cancer Institute
grant September 21, 2016 - December 31, 2017
Imaging Cancer Angiogenesis with Acoustic Angiography Ultrasound
National Cancer Institute