Works (12)

Updated: July 5th, 2023 15:34

2023 journal article

Risk factors associated with an outbreak of equine coronavirus at a large farm in North Carolina


By: K. Hepworth-Warren n, S. Erwin n, C. Moore, J. Talbot, K. Young n, M. Neault*, J. Haugland*, J. Robertson n, A. Blikslager n

author keywords: ECoV; coronavirus; colic; diarrhea; small colon impaction
TL;DR: Clinical findings and risk factors for ECoV infection many of which were associated with intensive management of show horses were described, and clinicians should be aware that clinical signs vary and can include severe colic. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2022 chapter

A Mathematical Framework for Evaluation of SOAR Tools with Limited Survey Data

By: S. Norem*, A. Rice*, S. Erwin*, R. Bridges*, S. Oesch* & B. Weber*

author keywords: SOAR tools; User study; Cybersecurity
TL;DR: This work provides a systematic method of downselecting a large pool of SoAR tools to a select few that merit next-step hands-on evaluation by SOC operators and helps to inform future development of SOAR tools. (via Semantic Scholar)
Source: ORCID
Added: February 8, 2022

2020 journal article

Mathematical model of broadly reactive plasma cell production

Scientific Reports, 10(1).

By: S. Erwin*, L. Childs* & S. Ciupe*

Contributors: S. Erwin*, L. Childs* & S. Ciupe*

MeSH headings : Animals; Antibodies, Neutralizing / metabolism; Germinal Center / metabolism; HIV Antibodies / immunology; HIV Infections / immunology; Humans; Models, Theoretical; Mutation / genetics; Plasma Cells / cytology; Plasma Cells / metabolism; T-Lymphocytes, Helper-Inducer / metabolism
TL;DR: A mathematical model of germinal center dynamics is developed and used to predict the events that lead to improved breadth of the plasma cell response and finds that the initial B-cell clonal composition, T-follicular helper cell signaling, increased rounds of productive somatic hypermutation, and B- cell selection strength are among the mechanisms differentiating between strain-specific and broadly reactive plasma cell production during infections. (via Semantic Scholar)
Source: ORCID
Added: March 10, 2020

2020 journal article

On modelling environmentally transmitted pathogens

Interface Focus, 10(1).

By: C. Lanzas n, K. Davies n, S. Erwin n & D. Dawson n

Contributors: C. Lanzas n, K. Davies n, S. Erwin n & D. Dawson n

author keywords: environmental transmission; mean-field models; individual-based models; infectious diseases
TL;DR: A conceptual framework to organize microparasites based on the role that abiotic environments play in their lifecycle is presented, showing considerable divergence between both modelling approaches when conditions do not facilitate well mixing and for pathogens with fast dynamics in the environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: December 14, 2019

2020 journal article

The effect of enrofloxacin on enteric Escherichia coli: Fitting a mathematical model to in vivo data

PLOS ONE, 15(1), e0228138.

By: S. Erwin n, D. Foster n, M. Jacob n, M. Papich n & C. Lanzas n

Contributors: S. Erwin n, D. Foster n, M. Jacob n, M. Papich n & C. Lanzas n

Ed(s): J. Loor

MeSH headings : Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Enrofloxacin / pharmacology; Escherichia coli / drug effects; Models, Statistical
TL;DR: The initial E. coli susceptibility is a strong indicator of how steers respond to antimicrobial drug treatment, and faster removal of the antimicrobial drugs from the colon throughout the study leads to improved clearance of bacteria above the ECOFF in the low dose regimen. (via Semantic Scholar)
Source: ORCID
Added: February 5, 2020

2018 chapter

Modeling the Argasid Tick (Ornithodoros moubata) Life Cycle

In Association for Women in Mathematics Series (Vol. 14, pp. 63–87).

Contributors: S. Clifton*, C. Davis*, S. Erwin n, G. Hamerlinck*, A. Veprauskas*, Y. Wang*, W. Zhang*, H. Gaff*

TL;DR: The first mathematical models for an argasid tick are developed to explore the dynamics and identify knowledge gaps of these poorly studied ticks, and provide the basis for developing future models that include disease states to explore infection dynamics and possible management of ASF. (via Semantic Scholar)
Source: ORCID
Added: January 14, 2021

2018 journal article

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model

MSPHERE, 3(2).

By: J. Fletcher n, S. Erwin n, C. Lanzas n & C. Theriot n

Contributors: J. Fletcher n, S. Erwin n, C. Lanzas n & C. Theriot n

author keywords: Clostridium difficile; amino acids; intestinal colonization; metabolomics; peptides; transcriptomics
MeSH headings : Amino Acids, Branched-Chain / metabolism; Animals; Anti-Bacterial Agents / administration & dosage; Carbohydrate Metabolism; Cecum / microbiology; Clostridioides difficile / metabolism; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Female; Gastrointestinal Microbiome; Gene Expression Profiling; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Peptide Hydrolases / genetics; Proline / metabolism; Sequence Analysis, RNA; Transcriptome
TL;DR: The gut environment after antibiotics and during the initial stages of C. difficile colonization and infection is defined and amino acids, in particular, proline and branched-chain amino acids and carbohydrates decrease in abundance over time and that C.difficile gene expression is consistent with their utilization in vivo. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Germinal center dynamics during acute and chronic infection

Mathematical Biosciences and Engineering, 14(3), 655–671.

By: S. Erwin* & S. Ciupe*

Contributors: S. Erwin* & S. Ciupe*

author keywords: B cells; Tfh cells; germinal centers; somatic hypermutations; mathematical models
MeSH headings : Acute Disease; Antigens / genetics; Antigens / immunology; B-Lymphocytes / immunology; B-Lymphocytes / physiology; Chronic Disease; Germinal Center / immunology; Humans; Infections / immunology; Infections / pathology; Models, Biological; Mutation; T-Lymphocytes, Helper-Inducer / immunology
TL;DR: It is predicted that the T follicular helper cells are a limiting resource in driving large numbers of somatic hypermutations and possible mechanisms that can revert this limitation in the presence of non-mutating and mutating antigen are presented. (via Semantic Scholar)
Source: ORCID
Added: June 19, 2019

2017 thesis

Mathematical models of immune responses to infectious diseases

Samantha Erwin

Source: ORCID
Added: June 19, 2019

2017 journal article

Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa

PLOS ONE, 12(1).

MeSH headings : Anti-HIV Agents / therapeutic use; CD4-Positive T-Lymphocytes / immunology; Coinfection / immunology; Coinfection / virology; HIV Infections / complications; HIV Infections / drug therapy; HIV Infections / immunology; Humans; Immunocompromised Host; Models, Biological; Mouth Mucosa / virology; Oncogenes; Papillomaviridae; Papillomavirus Infections / complications; Papillomavirus Infections / drug therapy; Papillomavirus Infections / immunology; Prognosis; tat Gene Products, Human Immunodeficiency Virus / genetics
TL;DR: A mathematical model of HIV/HPV co-infection is developed and predicts that, under efficacious antiretroviral treatment, HPV infections will decrease in the long run due to the restoration of CD4+ T cell numbers and protective immune responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 19, 2019

2013 journal article

Matrix analysis to model the invasion of alligatorweed (Alternanthera philoxeroides) on Kentucky lakes

Journal of Plant Ecology, 6(2), 150–157.

By: S. Erwin*, A. Huckaba*, K. He* & M. McCarthy*

Contributors: S. Erwin*, A. Huckaba*, K. He* & M. McCarthy*

author keywords: matrix model; population projection matrices; sensitivity analysis; life stage; invasive plant
TL;DR: The results of this study indicate that in the aquatic habitat, plants at their early life cycle stage are most sensitive to potential control measures, and in the terrestrial habitat, the most sensitive stage of alligatorweed is at its latelife cycle stage, characterized with large-sized plants, thus suggesting the best timing for management and eradication of this invasive species. (via Semantic Scholar)
Source: ORCID
Added: June 19, 2019

2013 thesis

Modeling of Passive Chilled Beams for use in Efficient Control of Indoor-Air Environments

Samantha Erwin

Source: ORCID
Added: June 19, 2019


Updated: May 11th, 2022 15:37

2022 - present

Pacific Northwest National Laboratory Richland, Washington, US

2019 - 2022

Oak Ridge National Laboratory Oak Ridge, TN, US
Research Scientist Biomedical Science, Engineering, and Computing

2017 - 2019

North Carolina State University Raleigh, NC, US
Postdoc Population Health and Pathobiology

2011 - 2017

Virginia Tech Blacksburg, Virginia, US
Graduate Assistant Mathematics


Updated: October 4th, 2019 13:00

2013 - 2017

Virginia Tech Blacksburg, Virginia, US
Ph.D. Mathematics

2011 - 2013

Virginia Tech Blacksburg, Virginia, US
MS Mathematics

2006 - 2011

Murray State University Murray, Kentucky, US
BS Mathematics

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