Samantha Hollie Erwin
Also known as: Sam
Works (12)
Updated: July 5th, 2023 15:34
2023 journal article
Risk factors associated with an outbreak of equine coronavirus at a large farm in North Carolina
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: ECoV; coronavirus; colic; diarrhea; small colon impaction
TL;DR:
Clinical findings and risk factors for ECoV infection many of which were associated with intensive management of show horses were described, and clinicians should be aware that clinical signs vary and can include severe colic.
(via Semantic Scholar)
open access via www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023
2022 chapter
A Mathematical Framework for Evaluation of SOAR Tools with Limited Survey Data
author keywords: SOAR tools; User study; Cybersecurity
TL;DR:
This work provides a systematic method of downselecting a large pool of SoAR tools to a select few that merit next-step hands-on evaluation by SOC operators and helps to inform future development of SOAR tools.
(via Semantic Scholar)
Source: ORCID
Added: February 8, 2022
2020 journal article
Mathematical model of broadly reactive plasma cell production
Scientific Reports, 10(1).
Contributors: * , L. Childs * & S. Ciupe *
MeSH headings : Animals; Antibodies, Neutralizing / metabolism; Germinal Center / metabolism; HIV Antibodies / immunology; HIV Infections / immunology; Humans; Models, Theoretical; Mutation / genetics; Plasma Cells / cytology; Plasma Cells / metabolism; T-Lymphocytes, Helper-Inducer / metabolism
TL;DR:
A mathematical model of germinal center dynamics is developed and used to predict the events that lead to improved breadth of the plasma cell response and finds that the initial B-cell clonal composition, T-follicular helper cell signaling, increased rounds of productive somatic hypermutation, and B- cell selection strength are among the mechanisms differentiating between strain-specific and broadly reactive plasma cell production during infections.
(via Semantic Scholar)
Source: ORCID
Added: March 10, 2020
2020 journal article
The effect of enrofloxacin on enteric Escherichia coli: Fitting a mathematical model to in vivo data
PLOS ONE, 15(1), e0228138.
Contributors: n , D. Foster n, M. Jacob n, M. Papich n & C. Lanzas n
Ed(s): J. Loor
MeSH headings : Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Enrofloxacin / pharmacology; Escherichia coli / drug effects; Models, Statistical
TL;DR:
The initial E. coli susceptibility is a strong indicator of how steers respond to antimicrobial drug treatment, and faster removal of the antimicrobial drugs from the colon throughout the study leads to improved clearance of bacteria above the ECOFF in the low dose regimen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: February 5, 2020
2019 journal article
On modelling environmentally transmitted pathogens
Interface Focus, 10(1).
Contributors: C. Lanzas n , K. Davies n, n & D. Dawson n
author keywords: environmental transmission; mean-field models; individual-based models; infectious diseases
TL;DR:
A conceptual framework to organize microparasites based on the role that abiotic environments play in their lifecycle is presented, showing considerable divergence between both modelling approaches when conditions do not facilitate well mixing and for pathogens with fast dynamics in the environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: ORCID
Added: December 14, 2019
2018 chapter
Modeling the Argasid Tick (Ornithodoros moubata) Life Cycle
In Association for Women in Mathematics Series (Vol. 14, pp. 63–87).
Contributors: S. Clifton *, C. Davis *, n , G. Hamerlinck*, A. Veprauskas *, Y. Wang *, W. Zhang *, H. Gaff *
TL;DR:
The first mathematical models for an argasid tick are developed to explore the dynamics and identify knowledge gaps of these poorly studied ticks, and provide the basis for developing future models that include disease states to explore infection dynamics and possible management of ASF.
(via Semantic Scholar)
Source: ORCID
Added: January 14, 2021
2018 journal article
Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model
MSPHERE, 3(2).
Contributors: J. Fletcher n, n , C. Lanzas n & C. Theriot n
author keywords: Clostridium difficile; amino acids; intestinal colonization; metabolomics; peptides; transcriptomics
MeSH headings : Amino Acids, Branched-Chain / metabolism; Animals; Anti-Bacterial Agents / administration & dosage; Carbohydrate Metabolism; Cecum / microbiology; Clostridioides difficile / metabolism; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Female; Gastrointestinal Microbiome; Gene Expression Profiling; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Peptide Hydrolases / genetics; Proline / metabolism; Sequence Analysis, RNA; Transcriptome
TL;DR:
The gut environment after antibiotics and during the initial stages of C. difficile colonization and infection is defined and amino acids, in particular, proline and branched-chain amino acids and carbohydrates decrease in abundance over time and that C.difficile gene expression is consistent with their utilization in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Germinal center dynamics during acute and chronic infection
Mathematical Biosciences and Engineering, 14(3), 655–671.
Contributors: * & S. Ciupe *
author keywords: B cells; Tfh cells; germinal centers; somatic hypermutations; mathematical models
MeSH headings : Acute Disease; Antigens / genetics; Antigens / immunology; B-Lymphocytes / immunology; B-Lymphocytes / physiology; Chronic Disease; Germinal Center / immunology; Humans; Infections / immunology; Infections / pathology; Models, Biological; Mutation; T-Lymphocytes, Helper-Inducer / immunology
TL;DR:
It is predicted that the T follicular helper cells are a limiting resource in driving large numbers of somatic hypermutations and possible mechanisms that can revert this limitation in the presence of non-mutating and mutating antigen are presented.
(via Semantic Scholar)
Source: ORCID
Added: June 19, 2019
2017 thesis
Mathematical models of immune responses to infectious diseases
http://hdl.handle.net/10919/77026
Source: ORCID
Added: June 19, 2019
2017 journal article
Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa
PLOS ONE, 12(1).
Contributors: M. Verma *, * , V. Abedi *, R. Hontecillas *, S. Hoops *, A. Leber *, J. Bassaganya-Riera *, S. Ciupe *
MeSH headings : Anti-HIV Agents / therapeutic use; CD4-Positive T-Lymphocytes / immunology; Coinfection / immunology; Coinfection / virology; HIV Infections / complications; HIV Infections / drug therapy; HIV Infections / immunology; Humans; Immunocompromised Host; Models, Biological; Mouth Mucosa / virology; Oncogenes; Papillomaviridae; Papillomavirus Infections / complications; Papillomavirus Infections / drug therapy; Papillomavirus Infections / immunology; Prognosis; tat Gene Products, Human Immunodeficiency Virus / genetics
TL;DR:
A mathematical model of HIV/HPV co-infection is developed and predicts that, under efficacious antiretroviral treatment, HPV infections will decrease in the long run due to the restoration of CD4+ T cell numbers and protective immune responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 19, 2019
2013 thesis
Modeling of Passive Chilled Beams for use in Efficient Control of Indoor-Air Environments
Source: ORCID
Added: June 19, 2019
2012 journal article
Matrix analysis to model the invasion of alligatorweed (Alternanthera philoxeroides) on Kentucky lakes
Journal of Plant Ecology, 6(2), 150–157.
Contributors: * , A. Huckaba *, K. He* & M. McCarthy *
author keywords: matrix model; population projection matrices; sensitivity analysis; life stage; invasive plant
TL;DR:
The results of this study indicate that in the aquatic habitat, plants at their early life cycle stage are most sensitive to potential control measures, and in the terrestrial habitat, the most sensitive stage of alligatorweed is at its latelife cycle stage, characterized with large-sized plants, thus suggesting the best timing for management and eradication of this invasive species.
(via Semantic Scholar)
Source: ORCID
Added: June 19, 2019
Employment
Updated: May 11th, 2022 15:37
2022 - present
Pacific Northwest National Laboratory Richland, Washington, US
2019 - 2022
Oak Ridge National Laboratory Oak Ridge, TN, US
Research Scientist
Biomedical Science, Engineering, and Computing
2017 - 2019
North Carolina State University Raleigh, NC, US
Postdoc
Population Health and Pathobiology
2011 - 2017
Virginia Tech Blacksburg, Virginia, US
Graduate Assistant
Mathematics
Education
Updated: October 4th, 2019 13:00
2013 - 2017
Virginia Tech Blacksburg, Virginia, US
Ph.D.
Mathematics
2011 - 2013
Virginia Tech Blacksburg, Virginia, US
MS
Mathematics
2006 - 2011
Murray State University Murray, Kentucky, US
BS
Mathematics
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