Works (41)

Updated: April 15th, 2024 05:30

2024 article

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). NATURE NANOTECHNOLOGY, Vol. 1.

By: M. Liu*, S. Hu*, N. Yan*, K. Popowski n & K. Cheng*

TL;DR: The delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation is reported on and the immunotherapeutic potential of targeted cytokine mRNA therapy is demonstrated, showing the potential for locally delivered cytokine-based immunotherapies to address orthotopic and metastatic lung tumours. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 29, 2024

2024 journal article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

NATURE COMMUNICATIONS, 15(1).

By: Z. Wang*, S. Hu*, K. Popowski n, S. Liu*, D. Zhu*, X. Mei n, J. Li*, Y. Hu* ...

Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 journal article

A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus

SCIENCE ADVANCES, 9(25).

By: Z. Wang n, Z. Li n, W. Shi n, D. Zhu n, S. Hu n, P. Dinh n, K. Cheng n

MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
TL;DR: The Flu-RBD VLP vaccine is a promising candidate for combating COVID-19, influenza A, and coinfection and elicited a strong neutralization activity against both SARS-CoV-2 Delta pseudovirus and wild-type influenza A H1N1 inactivated virus in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2023

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n, K. Huang n, S. Hu n, K. Popowski n, K. Cheng n

TL;DR: A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

NANO RESEARCH, 16(5), 7248–7259.

By: X. Wang*, S. Hu n, D. Zhu n, J. Li n, K. Cheng n & G. Liu

author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
TL;DR: Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs, and microRNAs in NVs are related to cardiac repair, fibrosis repression, and angiogenesis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 article

Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy

Cheng, X., Hu, S., & Cheng, K. (2023, June 9). ACS NANO, Vol. 6.

By: X. Cheng n, S. Hu n & K. Cheng n

author keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer
MeSH headings : Humans; Female; Estrogen Receptor alpha / metabolism; Proteolysis Targeting Chimera; Breast Neoplasms / pathology; Drug Delivery Systems / methods; Proteolysis
TL;DR: The work demonstrates the feasibility and proof-of-concept therapeutic potential of using microneedle patches to directly deliver PROTACs into tumors and can sufficiently degrade ERα in MCF7 cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023

2022 article

Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS NANO, Vol. 9.

By: S. Hu n, D. Zhu n, Z. Li n & K. Cheng n

author keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair
MeSH headings : Animals; Rats; Elastin; Polylactic Acid-Polyglycolic Acid Copolymer; Hyaluronic Acid; Mesenchymal Stem Cells; Myocytes, Cardiac; Myocardium; Nanoparticles; Peptides
TL;DR: A detachable therapeutic microneedle patch, which is comprised of mesenchymal stromal cell-secreted factors (MSCF)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) in MN tips made of elastin-like polypeptide gel, provides a promising treatment approach for cardiac diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022

2022 journal article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

CIRCULATION RESEARCH, 131(10), E135–E150.

By: D. Zhu n, S. Liu n, K. Huang n, Z. Wang n, S. Hu n, J. Li n, Z. Li n, K. Cheng n

author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
TL;DR: A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 14, 2022

2022 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2021 journal article

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

ACS NANO, 15(7), 11099–11111.

By: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan ...

Contributors: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan ...

author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
TL;DR: In a mouse model of acute myocardial infarction, EXOS improved cardiac function and reduced fibrosis, and promoted endogenous angiomyogenesis in the post-injury heart, indicating that EXOS is a promising strategy to deliver therapeutic exosomes for heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 23, 2021

2021 journal article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

MED, 2(11), 1253-+.

By: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Abad n, K. Cheng n

Contributors: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Juan Abad n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
TL;DR: A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 3, 2021

2021 journal article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894–8908.

By: S. Zhang n, D. Zhu n, Z. Li n, K. Huang n, S. Hu n, H. Lutz n, M. Xie n, X. Mei n ...

Contributors: S. Zhang n, D. Zhu n, Z. Li n, K. Huang n, S. Hu n, H. Lutz n, M. Xie n, X. Mei n ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
TL;DR: In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021

2021 review

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).

By: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng

Contributors: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng

author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
TL;DR: An in‐depth study of primary theories of cell loss, including low efficiency in cell injection, “washout” effects, and cell death, is undertaken and the literature from the past decade that focuses on cell transplantation to the heart using various cell delivery routes is organized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021

2021 journal article

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.

By: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

Contributors: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
TL;DR: It is shown that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 6, 2021

2021 journal article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.

By: X. Wang*, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang

Contributors: X. Wang*, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 21, 2022

2021 article

Generation and Manipulation of Exosomes

CARDIAC REGENERATION, Vol. 2158, pp. 295–305.

By: S. Hu n, L. Qiao n & K. Cheng n

author keywords: Exosome generation; Exosome manipulation; Myocardial infarction; Cardiac homing peptide; Platelet membrane; Intravenous injection
MeSH headings : Animals; Blood Platelets / chemistry; Cell Culture Techniques / methods; Cell Fractionation / methods; Cell Membrane / chemistry; Cell Membrane / metabolism; Exosomes / ultrastructure; Humans; Mice; Molecular Targeted Therapy; Myocardium / cytology; Peptides / analysis; Peptides / metabolism; Rats; Technology, Pharmaceutical / methods; Ultracentrifugation; Ultrasonic Waves
TL;DR: Generation of exosomes from biopsy, isolation ofExosomes by centrifugal ultrafiltration method, and approaches for manipulation of cardiac homing exosome by chemical engineering for the treatment of myocardial infarction are described. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 30, 2021

2021 journal article

Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

ADVANCED FUNCTIONAL MATERIALS, 31(15).

By: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

Contributors: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

author keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels
TL;DR: A ROS‐sensitive cross‐linked poly(vinyl alcohol) (PVA) hydrogel is synthesized to deliver basic fibroblast growth factor (bFGF) for myocardial repair and protects cardiac function and reduces fibrosis in the post‐I/R heart, with enhanced angiomyogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 22, 2021

2021 journal article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

By: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2021 journal article

Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy

ACS NANO, 15(1), 1100–1110.

By: P. Zheng*, M. Fan*, H. Liu*, Y. Zhang*, X. Dai*, H. Li*, X. Zhou*, S. Hu n ...

MeSH headings : Drug Delivery Systems; Humans; Hyperthermia, Induced; Hypoxia; Neoplasms / drug therapy; Phototherapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 29, 2021

2020 journal article

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.

By: T. Su n, K. Huang n, K. Mathews n, V. Scharf n, S. Hu n, Z. Li n, B. Frame*, J. Cores n ...

author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
TL;DR: It is shown that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020

2020 journal article

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling

SCIENCE ADVANCES, 6(30).

By: S. Hu n, Z. Li n, H. Lutz n, K. Huang n, T. Su n, J. Cores n, P. Dinh n, K. Cheng n

MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
TL;DR: Results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment, and it was demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 10, 2020

2020 review

Engineering better stem cell therapies for treating heart diseases

[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).

By: J. Li n, S. Hu n & K. Cheng n

author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
TL;DR: This review will provide a brief summary of stem cell therapies for ischemic heart disease, the investigation of mechanisms behind stem-cell based cardiac regeneration and also, what bioengineers can do and have been doing on the translational stage of stem Cell therapies for heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2020 review

Exosome therapeutics for lung regenerative medicine

[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).

By: K. Popowski n, H. Lutz n, S. Hu n, A. George n, P. Dinh n & K. Cheng n

author keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell
TL;DR: The uses of exosomes as a therapy and their roles in lung regenerative medicine, as well as current challenges in exosome therapies are underline. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 20, 2020

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 23, 2020

2020 journal article

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

NANO RESEARCH, 13(8), 2197–2202.

By: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

Contributors: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
TL;DR: A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020

2020 journal article

Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair

SCIENCE ADVANCES, 6(6).

By: Z. Li n, S. Hu n, K. Huang n, T. Su n, J. Cores n & K. Cheng n

MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
TL;DR: IL1-PM is a promising cardiac detoxification agent that removes cytotoxic IL-1β during AMI and induces therapeutic cardiac repair and protects the cardiomyocytes from apoptosis by neutralizing IL–1β and decreasing IL- 1β–driven caspase-3 activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 2, 2020

2020 journal article

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

THERANOSTICS, 10(8), 3474–3487.

By: L. Qiao n, S. Hu n, K. Huang n, T. Su n, Z. Li*, A. Vandergriff n, J. Cores n, P. Dinh n ...

author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
TL;DR: It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2019 journal article

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells

NANO LETTERS, 19(3), 1883–1891.

By: D. Shen n, Z. Li n, S. Hu n, K. Huang n, T. Su n, H. Liang n, F. Liu n, K. Cheng n

author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
TL;DR: Taking advantage of the natural infarct-homing ability of platelets, CD34 antibody-linked platelets (P-CD34) are engineered to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart for effective heart repair. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

ADVANCED THERAPEUTICS, 2(10).

By: K. Huang*, Z. Li n, T. Su n, D. Shen*, S. Hu n & K. Cheng n

author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
TL;DR: In vivo studies in a mouse model with heart ischemia/reperfusion injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020

2019 review

Cell and biomaterial-based approaches to uterus regeneration

[Review of ]. REGENERATIVE BIOMATERIALS, 6(3), 141–148.

By: F. Liu n, S. Hu n, S. Wang* & K. Cheng n

author keywords: Asherman's syndrome; intrauterine adhesions; endometrium; stem cells
TL;DR: This review is a recapitulation of the literature focused on cellular therapies for treating Asherman’s syndrome, exploring the use of cell-based therapeutics, in conjunction with biomaterials, to treat AS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019

2019 review

Chemical Engineering of Cell Therapy for Heart Diseases

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 52(6), 1687–1696.

By: Z. Li n, S. Hu n & K. Cheng n

MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics / methods; Cardiomyopathy, Dilated / therapy; Cell- and Tissue-Based Therapy / methods; Chemical Engineering / methods; Exosomes; Humans; Hydrogels / chemistry; Myocardial Infarction / therapy; Stem Cells / chemistry; Stem Cells / metabolism
TL;DR: The third generation of therapeutic strategies are developed, which utilize cell-free approaches for cardiac cell therapies, and it is hoped that the designs will promote the use of chemical engineering approaches to transform, transport, and fabricate cell- free systems as novel cardiac cell therapeutic agents for clinical applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019

2019 journal article

Excipient-free nanodispersion of 7-ethyl-10-hydroxycamptothecin exerts potent therapeutic effects against pancreatic cancer cell lines and patient-derived xenografts

CANCER LETTERS, 465, 36–44.

author keywords: Excipient-free nanodispersion; Pancreatic cancer; 7-Ethyl-10-hydroxycamptothecin (SN-38); Patient-derived xenograft (PDX); Irinotecan (CPT-11)
MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Drug Compounding; Excipients / chemistry; Humans; Irinotecan / administration & dosage; Irinotecan / chemistry; Irinotecan / pharmacology; Mice; Nanomedicine; Nanoparticles; Pancreatic Neoplasms / drug therapy; Topoisomerase I Inhibitors / administration & dosage; Topoisomerase I Inhibitors / chemistry; Topoisomerase I Inhibitors / pharmacology; Xenograft Model Antitumor Assays
TL;DR: SN-38 and CPT-11 showed potent cytotoxicity against PC cells in vitro, slowed tumor growth in vivo, namely subcutaneously and orthotopically xenografted mice, with minimal adverse effects, and prolonged their overall survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019

2019 journal article

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

ADVANCED HEALTHCARE MATERIALS, 8(14).

By: F. Liu n, S. Hu n, H. Yang n, Z. Li n, K. Huang n, T. Su n, S. Wang*, K. Cheng n

author keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome
MeSH headings : Animals; Disease Models, Animal; Electrocoagulation; Endometrium / injuries; Female; Gynatresia / therapy; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Mesenchymal Stem Cells / metabolism; Pregnancy; Rats, Sprague-Dawley
TL;DR: The HA gel/MSC‐Sec treatment paradigm creates a sustained release system that repairs endometrial injury in rats and promotes viable pregnancy, and holds great potential for the treatment of AS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 journal article

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

ACS NANO, 13(10), 11273–11282.

By: S. Hu n, Z. Li n, J. Cores n, K. Huang n, T. Su n, P. Dinh n, K. Cheng n

author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
TL;DR: Results indicate that exosomes from 3D cultured HDF spheroids have anti-skin-aging properties and the potential to prevent and treat cutaneous aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019

2019 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang n, H. Ma*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2019 journal article

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.

By: L. Qiao n, S. Hu n, S. Liu*, H. Zhang*, H. Ma*, K. Huang n, Z. Li n, T. Su n ...

MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
TL;DR: The heart failure pathological condition altered the miR cargos of cardiac-derived exosomes and impaired their regenerative activities, and mechanistic studies revealed that miR-21-5p augmented Akt kinase activity through the inhibition of phosphatase and tensin homolog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 journal article

A New Era of Cardiac Cell Therapy: Opportunities and Challenges

Advanced Healthcare Materials, 8(2), 1801011.

By: K. Huang n, S. Hu n & K. Cheng n

author keywords: cardiac patches; cell therapy; exosomes; injury targeting; microRNA; myocardial infarction; synthetic stem cells
MeSH headings : Animals; Biocompatible Materials / metabolism; Cell- and Tissue-Based Therapy / methods; Endocarditis / metabolism; Endocarditis / therapy; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / physiology; Myocarditis / metabolism; Myocarditis / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanomedicine / methods; Paracrine Communication; Tissue Engineering / methods
TL;DR: The next generation of cell‐based MI therapies will identify and isolate cell products and derivatives, integrate them with biocompatible materials and technologies, and use them for the regeneration of damaged myocardial tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: February 11, 2019

2018 review

Body builder: from synthetic cells to engineered tissues

[Review of ]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42.

By: S. Hu n, B. Ogle* & K. Cheng n

MeSH headings : Artificial Cells / metabolism; Humans; Models, Biological; Regenerative Medicine; Tissue Engineering / methods
TL;DR: This review summarized recent advances in fabricating synthetic cells, with a specific focus on their application to cardiac regenerative medicine and tissue engineering, and pointed to challenges and future directions for the field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2018

2018 review

Platelets and their biomimetics for regenerative medicine and cancer therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365.

By: Z. Li n, S. Hu n & K. Cheng n

MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Blood Platelets / chemistry; Blood Platelets / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Regenerative Medicine / methods
TL;DR: This review will highlight the recent progress made in the development of disease-targeting platelets- and platelet-mimicking-vehicles as therapeutic platforms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018

2018 journal article

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

ACS NANO, 12(12), 12193–12200.

By: Z. Li n, D. Shen*, S. Hu n, T. Su n, K. Huang n, F. Liu n, L. Hou*, K. Cheng n

author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
TL;DR: In a mouse model of acute myocardial infarction, the in vivo results of cardiac function, heart morphometry, and immunohistochemistry assessment all confirmed effective heart repair by the PTBC system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2018 journal article

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

THERANOSTICS, 8(7), 1869–1878.

author keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction
MeSH headings : Administration, Intravenous; Animals; Biological Products / administration & dosage; Biological Products / pharmacokinetics; Biological Therapy / methods; Cell Survival; Disease Models, Animal; Echocardiography; Exosomes; Molecular Targeted Therapy / methods; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Peptides / administration & dosage; Peptides / pharmacokinetics; Rats; Treatment Outcome
TL;DR: By targeting exosomes to the infarcted heart, there was a significant improvement in outcomes with reduced fibrosis and scar size, and increased cellular proliferation and angiogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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