Works (39)
Updated: September 1st, 2023 05:01
2023 journal article
A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus
SCIENCE ADVANCES, 9(25).
MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
www.science.org (publisher PDF)
Sources: Web Of Science, ORCID
Added: June 24, 2023
2023 journal article
An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection
Nature Materials, 2.
Sources: Web Of Science, ORCID, Crossref
Added: March 6, 2023
2023 journal article
Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials
NANO RESEARCH, 16(5), 7248–7259.
author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
Sources: Web Of Science, ORCID
Added: August 28, 2023
2023 article
Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy
Cheng, X., Hu, S., & Cheng, K. (2023, June 9). ACS NANO, Vol. 6.
author keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer
MeSH headings : Humans; Female; Estrogen Receptor alpha / metabolism; Proteolysis Targeting Chimera; Breast Neoplasms / pathology; Drug Delivery Systems / methods; Proteolysis
Sources: Web Of Science, ORCID
Added: June 26, 2023
2022 article
Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair
Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS NANO, Vol. 9.
author keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair
MeSH headings : Animals; Rats; Elastin; Polylactic Acid-Polyglycolic Acid Copolymer; Hyaluronic Acid; Mesenchymal Stem Cells; Myocytes, Cardiac; Myocardium; Nanoparticles; Peptides
Sources: Web Of Science, ORCID
Added: October 11, 2022
2022 journal article
Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3
CIRCULATION RESEARCH, 131(10), E135–E150.
author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
Sources: Web Of Science, ORCID
Added: November 14, 2022
2022 journal article
Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction
CHEMICAL ENGINEERING JOURNAL, 427.
author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
Sources: Web Of Science, ORCID
Added: January 3, 2022
2021 journal article
A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction
ACS NANO, 15(7), 11099–11111.
author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
Sources: Web Of Science, ORCID
Added: August 23, 2021
2021 journal article
A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs
MED, 2(11), 1253-+.
MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
Sources: Web Of Science, ORCID
Added: November 3, 2021
2021 journal article
A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency
THERANOSTICS, 11(18), 8894–8908.
author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
Sources: Web Of Science, ORCID
Added: October 12, 2021
2021 review
All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart
[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).
author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
Sources: Web Of Science, ORCID
Added: June 10, 2021
2021 journal article
Exosome-eluting stents for vascular healing after ischaemic injury
NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.
MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
Sources: Web Of Science, ORCID
Added: April 6, 2021
2021 journal article
Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair
ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.
author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
Sources: Web Of Science, ORCID
Added: February 21, 2022
2021 article
Generation and Manipulation of Exosomes
CARDIAC REGENERATION, Vol. 2158, pp. 295–305.
author keywords: Exosome generation; Exosome manipulation; Myocardial infarction; Cardiac homing peptide; Platelet membrane; Intravenous injection
MeSH headings : Animals; Blood Platelets / chemistry; Cell Culture Techniques / methods; Cell Fractionation / methods; Cell Membrane / chemistry; Cell Membrane / metabolism; Exosomes / ultrastructure; Humans; Mice; Molecular Targeted Therapy; Myocardium / cytology; Peptides / analysis; Peptides / metabolism; Rats; Technology, Pharmaceutical / methods; Ultracentrifugation; Ultrasonic Waves
Sources: Web Of Science, ORCID
Added: August 30, 2021
2021 journal article
Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair
ADVANCED FUNCTIONAL MATERIALS, 31(15).
author keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels
Sources: Web Of Science, ORCID
Added: February 22, 2021
2021 journal article
Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury
NANO TODAY, 39.
author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
Sources: Web Of Science, ORCID
Added: September 7, 2021
2021 journal article
Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy
ACS NANO, 15(1), 1100–1110.
MeSH headings : Drug Delivery Systems; Humans; Hyperthermia, Induced; Hypoxia; Neoplasms / drug therapy; Phototherapy
Sources: Web Of Science, ORCID
Added: March 29, 2021
2020 journal article
Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs
ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.
author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
Sources: Web Of Science, ORCID
Added: December 11, 2020
2020 journal article
Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling
SCIENCE ADVANCES, 6(30).
MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
Sources: Web Of Science, ORCID
Added: August 10, 2020
2020 review
Engineering better stem cell therapies for treating heart diseases
[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).
author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
Sources: Web Of Science, ORCID
Added: May 26, 2020
2020 review
Exosome therapeutics for lung regenerative medicine
[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).
author keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell
Sources: Web Of Science, ORCID
Added: July 20, 2020
2020 journal article
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
NATURE COMMUNICATIONS, 11(1).
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
Sources: Web Of Science, ORCID
Added: March 23, 2020
2020 journal article
Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis
NANO RESEARCH, 13(8), 2197–2202.
author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
Sources: Web Of Science, ORCID
Added: June 29, 2020
2020 journal article
Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair
SCIENCE ADVANCES, 6(6).
MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
Sources: Web Of Science, ORCID
Added: March 2, 2020
2020 journal article
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs
THERANOSTICS, 10(8), 3474–3487.
author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
Sources: Web Of Science, ORCID
Added: March 30, 2020
2019 journal article
Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells
NANO LETTERS, 19(3), 1883–1891.
author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: April 2, 2019
2019 journal article
Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells
ADVANCED THERAPEUTICS, 2(10).
author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
Sources: Web Of Science, ORCID
Added: January 27, 2020
2019 review
Cell and biomaterial-based approaches to uterus regeneration
[Review of ]. REGENERATIVE BIOMATERIALS, 6(3), 141–148.
author keywords: Asherman's syndrome; intrauterine adhesions; endometrium; stem cells
Sources: Web Of Science, ORCID
Added: September 16, 2019
2019 review
Chemical Engineering of Cell Therapy for Heart Diseases
[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 52(6), 1687–1696.
MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics / methods; Cardiomyopathy, Dilated / therapy; Cell- and Tissue-Based Therapy / methods; Chemical Engineering / methods; Exosomes; Humans; Hydrogels / chemistry; Myocardial Infarction / therapy; Stem Cells / chemistry; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: July 15, 2019
2019 journal article
Excipient-free nanodispersion of 7-ethyl-10-hydroxycamptothecin exerts potent therapeutic effects against pancreatic cancer cell lines and patient-derived xenografts
CANCER LETTERS, 465, 36–44.
author keywords: Excipient-free nanodispersion; Pancreatic cancer; 7-Ethyl-10-hydroxycamptothecin (SN-38); Patient-derived xenograft (PDX); Irinotecan (CPT-11)
MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Drug Compounding; Excipients / chemistry; Humans; Irinotecan / administration & dosage; Irinotecan / chemistry; Irinotecan / pharmacology; Mice; Nanomedicine; Nanoparticles; Pancreatic Neoplasms / drug therapy; Topoisomerase I Inhibitors / administration & dosage; Topoisomerase I Inhibitors / chemistry; Topoisomerase I Inhibitors / pharmacology; Xenograft Model Antitumor Assays
Sources: Web Of Science, ORCID
Added: November 11, 2019
2019 journal article
Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome
ADVANCED HEALTHCARE MATERIALS, 8(14).
author keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome
MeSH headings : Animals; Disease Models, Animal; Electrocoagulation; Endometrium / injuries; Female; Gynatresia / therapy; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Mesenchymal Stem Cells / metabolism; Pregnancy; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 12, 2019
2019 journal article
Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging
ACS NANO, 13(10), 11273–11282.
author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
Sources: Web Of Science, ORCID
Added: November 11, 2019
2019 journal article
Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury
ADVANCED FUNCTIONAL MATERIALS, 29(4).
author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
Sources: Web Of Science, ORCID
Added: February 4, 2019
2019 journal article
microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential
JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.
MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
Sources: Web Of Science, ORCID
Added: June 24, 2019
2018 journal article
A New Era of Cardiac Cell Therapy: Opportunities and Challenges
Advanced Healthcare Materials, 8(2), 1801011.
author keywords: cardiac patches; cell therapy; exosomes; injury targeting; microRNA; myocardial infarction; synthetic stem cells
MeSH headings : Animals; Biocompatible Materials / metabolism; Cell- and Tissue-Based Therapy / methods; Endocarditis / metabolism; Endocarditis / therapy; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / physiology; Myocarditis / metabolism; Myocarditis / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanomedicine / methods; Paracrine Communication; Tissue Engineering / methods
Sources: Web Of Science, ORCID, Crossref
Added: February 11, 2019
2018 review
Body builder: from synthetic cells to engineered tissues
[Review of ]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42.
MeSH headings : Artificial Cells / metabolism; Humans; Models, Biological; Regenerative Medicine; Tissue Engineering / methods
Sources: Web Of Science, ORCID
Added: November 12, 2018
2018 review
Platelets and their biomimetics for regenerative medicine and cancer therapies
[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365.
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Blood Platelets / chemistry; Blood Platelets / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Regenerative Medicine / methods
Sources: Web Of Science, ORCID
Added: December 10, 2018
2018 journal article
Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair
ACS NANO, 12(12), 12193–12200.
author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: January 14, 2019
2018 journal article
Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide
THERANOSTICS, 8(7), 1869–1878.
author keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction
MeSH headings : Administration, Intravenous; Animals; Biological Products / administration & dosage; Biological Products / pharmacokinetics; Biological Therapy / methods; Cell Survival; Disease Models, Animal; Echocardiography; Exosomes; Molecular Targeted Therapy / methods; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Peptides / administration & dosage; Peptides / pharmacokinetics; Rats; Treatment Outcome
Sources: Web Of Science, ORCID
Added: August 6, 2018
