Stephanie Huang

Works (13)

Updated: July 21st, 2025 14:37

2025 article

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

Rathod, M., Stack, R. N., Kubik, S. E., Huang, S. A., Whitworth, C. P., Aw, W. Y., … Polacheck, W. J. (2025, June 20). Advanced Science.

By: M. Rathod n, R. Stack n, S. Kubik n, S. Huang n, C. Whitworth *, W. Aw n, E. Doherty  n, S. Meehan n, P. Roy‐Chaudhury *, W. Polacheck n

author keywords: cardiovascular disease; chronic kidney disease; mechanobiology; microfluidics; organ-on-chip; uremic toxin; vascular endothelium
topics (OpenAlex): Dialysis and Renal Disease Management; Blood properties and coagulation; Erythropoietin and Anemia Treatment
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: June 30, 2025

2024 article

Donor‐Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure

Rathod, M. L., Aw, W. Y., Huang, S., Lu, J., Doherty, E. L., Whithworth, C. P., … Polacheck, W. J. (2024, January 7). Small.

By: M. Rathod n, W. Aw n, S. Huang n, J. Lu  n, E. Doherty  n, C. Whithworth*, P. Roy‐Chaudhury *, W. Polacheck n

author keywords: blood-derived endothelial cell; cardiovascular; chronic kidney disease; indoxyl sulfate; microfluidics; organs-on-chip; uremic toxin
MeSH headings : Humans; Microvessels / pathology; Cardiovascular Diseases; Animals; Swine; Renal Insufficiency / therapy; Risk Assessment; Tissue Donors; Tissue Engineering / methods; Indican / blood
topics (OpenAlex): Dialysis and Renal Disease Management; Erythropoietin and Anemia Treatment; 3D Printing in Biomedical Research
TL;DR: The engineered microvessels presented here have the potential to be utilized to risk stratify and to direct personalized treatments for patients with chronic kidney disease and an increase in sensitivity compared to traditional 2D assays. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 29, 2024

2023 article

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

Aw, W. Y., Cho, C., Wang, H., Cooper, A. H., Doherty, E. L., Rocco, D., … Polacheck, W. J. (2023, February 15). Science Advances.

By: W. Aw  n, C. Cho  n, H. Wang  n, A. Cooper n, E. Doherty  n, D. Rocco *, S. Huang n, S. Kubik n ...

MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
topics (OpenAlex): Vascular Malformations and Hemangiomas; Vascular Malformations Diagnosis and Treatment; Vascular Tumors and Angiosarcomas
TL;DR: These findings demonstrate an in vitro platform for VMs and establish a role of dysregulated Rac1/PAK and mTORC1/2 signaling in PIK3CA-driven VMs. (via Semantic Scholar)
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Source: Web Of Science
Added: March 27, 2023

2022 article

Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow

Lee, G.-hun, Huang, S. A., Aw, W. Y., Rathod, M. L., Cho, C., Ligler, F. S., & Polacheck, W. J. (2022, January 6). Biofabrication.

By: G. Lee  n, S. Huang n, W. Aw  n, M. Rathod  n, C. Cho  n, F. Ligler n, W. Polacheck n

author keywords: microfluidics; vascular biology; interstitial flow; hemodynamics; biofluid mechanics; mechanotransduction
MeSH headings : Lymphatic Vessels; Microfluidics / methods; Stress, Mechanical
topics (OpenAlex): 3D Printing in Biomedical Research; Spaceflight effects on biology; Lymphatic System and Diseases
TL;DR: A multi-layer microfluidic platform (MμLTI-Flow) is introduced that enables the culture of engineered blood and lymphatic microvessels and independent control of blood, lymphatic, and IFPs and will provide for analysis of key fluid mechanical parameters and cellular mechanisms that contribute to diseases in which fluid imbalances play a role in progression, including lymphedema and solid cancer. (via Semantic Scholar)
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Source: Web Of Science
Added: January 31, 2022

2021 article

Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter

Wang, W. Y., Kent, R. N., Huang, S. A., Jarman, E. H., Shikanov, E. H., Davidson, C. D., … Baker, B. M. (2021, August 29). Acta Biomaterialia.

By: W. Wang *, R. Kent *, S. Huang n, E. Jarman*, E. Shikanov*, C. Davidson *, H. Hiraki *, D. Lin* ...

author keywords: Angiogenesis; Cell migration; Cell proliferation; Microfluidics; ECM; Endothelial cells; Chemotaxis; Hydrogels; Microvasculature; Sprouting Morphogenesis; Matrix porosity
MeSH headings : Animals; Biocompatible Materials / pharmacology; Endothelial Cells; Extracellular Matrix; Hydrogels / pharmacology; Mice; Neovascularization, Physiologic; Porosity
topics (OpenAlex): Cellular Mechanics and Interactions; Angiogenesis and VEGF in Cancer; 3D Printing in Biomedical Research
TL;DR: Characterization of matrix properties and sprout morphometrics across these materials points to matrix porosity as a critical regulator of sprout invasion speed and diameter, supported by the observation that nanoporous DexVS hydrogels yielded endothelial cell sprouts that were not perfusable. (via Semantic Scholar)
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Source: Web Of Science
Added: November 29, 2021

2021 article

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

Rickard, B. P., Conrad, C., Sorrin, A. J., Ruhi, M. K., Reader, J. C., Huang, S. A., … Rizvi, I. (2021, August 26). Cancers, Vol. 13, p. 4318.

By: B. Rickard n , C. Conrad *, A. Sorrin*, M. Ruhi  n, J. Reader *, S. Huang n, W. Franco *, G. Scarcelli * ...

author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
topics (OpenAlex): Ovarian cancer diagnosis and treatment; Intraperitoneal and Appendiceal Malignancies; Endometriosis Research and Treatment
TL;DR: The current understanding of malignant ascites is summarized, starting with an overview of ovarian cancer and ascites, followed by a description of the tools used to analyze the components of ascites and how these components modulate ovarian cancer biology. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 20, 2021

2021 article

Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity

Pérez-Rodríguez, S., Huang, S. A., Borau, C., García-Aznar, J. M., & Polacheck, W. J. (2021, September 1). Biomicrofluidics.

By: S. Pérez-Rodríguez *, S. Huang n, C. Borau *, J. García-Aznar * & W. Polacheck n

topics (OpenAlex): Angiogenesis and VEGF in Cancer; 3D Printing in Biomedical Research; Lymphatic System and Diseases
TL;DR: A microfluidic approach is presented that enables the recreation of a three-dimensional, perfused endothelial vessel formed by human endothelial cells embedded within a collagen-rich matrix and demonstrates that extravasation of monocytes is highly regulated by the structural integrity of the endothelial monolayer. (via Semantic Scholar)
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Source: Web Of Science
Added: October 4, 2021

2021 article

Myoelectric control of robotic lower limb prostheses: a review of electromyography interfaces, control paradigms, challenges and future directions

Fleming, A., Stafford, N., Huang, S., Hu, X., Ferris, D. P., & Huang, H. (2021, July 6). Journal of Neural Engineering, Vol. 7.

By: A. Fleming n, N. Stafford *, S. Huang n, X. Hu n, D. Ferris * & H. Huang n 

Contributors: A. Fleming n, N. Stafford *, S. Huang n, X. Hu n, D. Ferris * & H. Huang n 

author keywords: robotic lower limb protheses; neural-machine interface; EMG; gait and balance; human motor control
MeSH headings : Amputees; Artificial Limbs; Electromyography; Humans; Locomotion; Muscle, Skeletal; Robotic Surgical Procedures
topics (OpenAlex): Muscle activation and electromyography studies; Neuroscience and Neural Engineering; Prosthetics and Rehabilitation Robotics
TL;DR: This review highlights the promise of EMG control for enabling new functionalities in robotic lower limb prostheses, as well as the existing challenges, knowledge gaps, and opportunities on this research topic from human motor control and clinical practice perspectives. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 16, 2021

2020 article

Microfluidics for the study of mechanotransduction

Griffith, C. M., Huang, S. A., Cho, C., Khare, T. M., Rich, M., Lee, G.-hun, … Polacheck, W. J. (2020, February 21). Journal of Physics D Applied Physics.

By: C. Griffith  n, S. Huang n, C. Cho  n, T. Khare  n, M. Rich  n, G. Lee*, F. Ligler n, B. Diekman n, W. Polacheck n

author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
topics (OpenAlex): Cellular Mechanics and Interactions; 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies
TL;DR: An overview of the main mechanotransduction pathways that function at sites of cell adhesion are given, and examples of how microfluidics can be used to apply both solid forces and fluid forces to cells are presented. (via Semantic Scholar)
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Source: Web Of Science
Added: April 20, 2020

2019 article

Proportional Myoelectric Control of a Virtual Inverted Pendulum Using Residual Antagonistic Muscles: Toward Voluntary Postural Control

Fleming, A., Huang, S., & Huang, H. (2019, June 10). IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 27, pp. 1473–1482.

By: A. Fleming n, S. Huang n & H. Huang n 

Contributors: A. Fleming n, S. Huang n & H. Huang n 

author keywords: Electromyography; myoelectric control; postural control; volitional control; transtibial amputees; lower-limb amputees; residual muscles
MeSH headings : Adaptation, Psychological; Adult; Aged; Algorithms; Amputees; Ankle / physiology; Biomechanical Phenomena; Electromyography / methods; Female; Healthy Volunteers; Humans; Male; Middle Aged; Muscle Contraction / physiology; Muscle, Skeletal / physiology; Postural Balance; Posture / physiology; Psychomotor Performance; Virtual Reality
topics (OpenAlex): Muscle activation and electromyography studies; Prosthetics and Rehabilitation Robotics; Balance, Gait, and Falls Prevention
TL;DR: The results suggest that after the training of transtibial amputees in coordinating antagonistic residual muscles in dynamic systems, it may be feasible to implement the proportional myoelectric control of the powered ankle prostheses in order to assist the postural control mechanisms, such as anticipatory and compensatory postural adjustments. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 29, 2019

2018 article

Voluntary Control of Residual Antagonistic Muscles in Transtibial Amputees: Feedforward Ballistic Contractions and Implications for Direct Neural Control of Powered Lower Limb Prostheses

Huang, S., & Huang, H. (2018, March 2). IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 26, pp. 894–903.

By: S. Huang n & H. Huang n 

Contributors: S. Huang n & H. Huang n 

author keywords: Residual muscles; myoelectric control; lower limb amputee; powered prosthesis; postural control
MeSH headings : Adolescent; Adult; Aged; Amputees / psychology; Ankle / physiology; Artificial Limbs; Biomechanical Phenomena; Electromyography / statistics & numerical data; Electrophysiological Phenomena; Feedback, Physiological; Female; Humans; Lower Extremity; Male; Middle Aged; Muscle Contraction / physiology; Muscle, Skeletal / physiology; Prosthesis Design / methods; Psychomotor Performance; Recruitment, Neurophysiological; Task Performance and Analysis
topics (OpenAlex): Muscle activation and electromyography studies; Prosthetics and Rehabilitation Robotics; Neuroscience and Neural Engineering
TL;DR: Results suggest that it is feasible for transtibial amputees to generate ballistic control signals using their residual muscles, and future work on volitional control of powered power ankle prostheses might consider anticipatory postural control based on ballistic-like residual muscle activation patterns and direct continuous proportional myoelectric control. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2018 article

Voluntary Control of Residual Antagonistic Muscles in Transtibial Amputees: Reciprocal Activation, Coactivation, and Implications for Direct Neural Control of Powered Lower Limb Prostheses

Huang, S., & Huang, H. (2018, December 7). IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 27, pp. 85–95.

By: S. Huang n & H. Huang n 

Contributors: S. Huang n & H. Huang n 

author keywords: Residual muscles; volitional control; electromyography; myoelectric control; transtibial amputee; lower limb amputee; powered prosthesis
MeSH headings : Adolescent; Adult; Aged; Amputees; Ankle; Artificial Limbs; Biomechanical Phenomena; Electromyography; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Prosthesis Design; Psychomotor Performance
topics (OpenAlex): Muscle activation and electromyography studies; Prosthetics and Rehabilitation Robotics; Neuroscience and Neural Engineering
TL;DR: The future development of powered lower limb prostheses using direct continuous proportional myoelectric control via residual muscles should consider how an amputee user’s immediately accessible residual muscle activation patterns and reachable 2-D control input space may affect their learning and performance. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 4, 2019

2017 journal article

A new powered lower limb prosthesis control framework based on adaptive dynamic programming

IEEE Transactions on Neural Networks and Learning Systems, 28(9), 2215–2220.

By: Y. Wen, J. Si, X. Gao, S. Huang & H. Huang 

Source: NC State University Libraries
Added: August 6, 2018

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