Works (12)
Updated: January 31st, 2024 05:01
2024 article
Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure
Rathod, M. L., Aw, W. Y., Huang, S., Lu, J., Doherty, E. L., Whithworth, C. P., … Polacheck, W. J. (2024, January 7). SMALL.
author keywords: blood-derived endothelial cell; cardiovascular; chronic kidney disease; indoxyl sulfate; microfluidics; organs-on-chip; uremic toxin
TL;DR:
The engineered microvessels presented here have the potential to be utilized to risk stratify and to direct personalized treatments for patients with chronic kidney disease and an increase in sensitivity compared to traditional 2D assays.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 29, 2024
2023 journal article
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation
SCIENCE ADVANCES, 9(7).
MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
TL;DR:
These findings demonstrate an in vitro platform for VMs and establish a role of dysregulated Rac1/PAK and mTORC1/2 signaling in PIK3CA-driven VMs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 27, 2023
2022 journal article
Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow
BIOFABRICATION, 14(2).
author keywords: microfluidics; vascular biology; interstitial flow; hemodynamics; biofluid mechanics; mechanotransduction
MeSH headings : Lymphatic Vessels; Microfluidics / methods; Stress, Mechanical
TL;DR:
A multi-layer microfluidic platform (MμLTI-Flow) is introduced that enables the culture of engineered blood and lymphatic microvessels and independent control of blood, lymphatic, and IFPs and will provide for analysis of key fluid mechanical parameters and cellular mechanisms that contribute to diseases in which fluid imbalances play a role in progression, including lymphedema and solid cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 31, 2022
2021 journal article
Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter
ACTA BIOMATERIALIA, 135, 260–273.
author keywords: Angiogenesis; Cell migration; Cell proliferation; Microfluidics; ECM; Endothelial cells; Chemotaxis; Hydrogels; Microvasculature; Sprouting Morphogenesis; Matrix porosity
MeSH headings : Animals; Biocompatible Materials / pharmacology; Endothelial Cells; Extracellular Matrix; Hydrogels / pharmacology; Mice; Neovascularization, Physiologic; Porosity
TL;DR:
Characterization of matrix properties and sprout morphometrics across these materials points to matrix porosity as a critical regulator of sprout invasion speed and diameter, supported by the observation that nanoporous DexVS hydrogels yielded endothelial cell sprouts that were not perfusable.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 29, 2021
2021 review
Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response
[Review of ]. CANCERS, 13(17).
author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
TL;DR:
The current understanding of malignant ascites is summarized, starting with an overview of ovarian cancer and ascites, followed by a description of the tools used to analyze the components of ascites and how these components modulate ovarian cancer biology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 20, 2021
2021 journal article
Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity
BIOMICROFLUIDICS, 15(5).
TL;DR:
A microfluidic approach is presented that enables the recreation of a three-dimensional, perfused endothelial vessel formed by human endothelial cells embedded within a collagen-rich matrix and demonstrates that extravasation of monocytes is highly regulated by the structural integrity of the endothelial monolayer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 4, 2021
2021 review
Myoelectric control of robotic lower limb prostheses: a review of electromyography interfaces, control paradigms, challenges and future directions
[Review of ]. JOURNAL OF NEURAL ENGINEERING, 18(4).
Contributors: A. Fleming n, N. Stafford *, n, X. Hu n, D. Ferris * & H. Huang n
author keywords: robotic lower limb protheses; neural-machine interface; EMG; gait and balance; human motor control
MeSH headings : Amputees; Artificial Limbs; Electromyography; Humans; Locomotion; Muscle, Skeletal; Robotic Surgical Procedures
TL;DR:
This review highlights the promise of EMG control for enabling new functionalities in robotic lower limb prostheses, as well as the existing challenges, knowledge gaps, and opportunities on this research topic from human motor control and clinical practice perspectives.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 16, 2021
2020 journal article
Microfluidics for the study of mechanotransduction
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22).
author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
TL;DR:
An overview of the main mechanotransduction pathways that function at sites of cell adhesion are given, and examples of how microfluidics can be used to apply both solid forces and fluid forces to cells are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2019 journal article
Proportional Myoelectric Control of a Virtual Inverted Pendulum Using Residual Antagonistic Muscles: Toward Voluntary Postural Control
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 27(7), 1473–1482.
Contributors: A. Fleming n, n & H. Huang n
author keywords: Electromyography; myoelectric control; postural control; volitional control; transtibial amputees; lower-limb amputees; residual muscles
MeSH headings : Adaptation, Psychological; Adult; Aged; Algorithms; Amputees; Ankle / physiology; Biomechanical Phenomena; Electromyography / methods; Female; Healthy Volunteers; Humans; Male; Middle Aged; Muscle Contraction / physiology; Muscle, Skeletal / physiology; Postural Balance; Posture / physiology; Psychomotor Performance; Virtual Reality
TL;DR:
The results suggest that after the training of transtibial amputees in coordinating antagonistic residual muscles in dynamic systems, it may be feasible to implement the proportional myoelectric control of the powered ankle prostheses in order to assist the postural control mechanisms, such as anticipatory and compensatory postural adjustments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 29, 2019
2018 journal article
Voluntary Control of Residual Antagonistic Muscles in Transtibial Amputees: Feedforward Ballistic Contractions and Implications for Direct Neural Control of Powered Lower Limb Prostheses
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 26(4), 894–903.
Contributors: n & H. Huang n
author keywords: Residual muscles; myoelectric control; lower limb amputee; powered prosthesis; postural control
MeSH headings : Adolescent; Adult; Aged; Amputees / psychology; Ankle / physiology; Artificial Limbs; Biomechanical Phenomena; Electromyography / statistics & numerical data; Electrophysiological Phenomena; Feedback, Physiological; Female; Humans; Lower Extremity; Male; Middle Aged; Muscle Contraction / physiology; Muscle, Skeletal / physiology; Prosthesis Design / methods; Psychomotor Performance; Recruitment, Neurophysiological; Task Performance and Analysis
TL;DR:
Results suggest that it is feasible for transtibial amputees to generate ballistic control signals using their residual muscles, and future work on volitional control of powered power ankle prostheses might consider anticipatory postural control based on ballistic-like residual muscle activation patterns and direct continuous proportional myoelectric control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2018 journal article
Voluntary Control of Residual Antagonistic Muscles in Transtibial Amputees: Reciprocal Activation, Coactivation, and Implications for Direct Neural Control of Powered Lower Limb Prostheses
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 27(1), 85–95.
Contributors: n & H. Huang n
author keywords: Residual muscles; volitional control; electromyography; myoelectric control; transtibial amputee; lower limb amputee; powered prosthesis
MeSH headings : Adolescent; Adult; Aged; Amputees; Ankle; Artificial Limbs; Biomechanical Phenomena; Electromyography; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Prosthesis Design; Psychomotor Performance
TL;DR:
The future development of powered lower limb prostheses using direct continuous proportional myoelectric control via residual muscles should consider how an amputee user’s immediately accessible residual muscle activation patterns and reachable 2-D control input space may affect their learning and performance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 4, 2019
2017 journal article
A new powered lower limb prosthesis control framework based on adaptive dynamic programming
IEEE Transactions on Neural Networks and Learning Systems, 28(9), 2215–2220.
Source: NC State University Libraries
Added: August 6, 2018
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