Sarah O'Flaherty

Gilfillan, D., Vilander, A. C., Pan, M., Goh, Y. J., O'Flaherty, S., Feng, N., … Dean, G. A. (2023). <i>Lactobacillus acidophilus</i> Expressing Murine Rotavirus VP8 and Mucosal Adjuvants Induce Virus-Specific Immune Responses. VACCINES, 11(12). https://doi.org/10.3390/vaccines11121774

Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut. NATURE MICROBIOLOGY, Vol. 3. https://doi.org/10.1038/s41564-023-01337-7

O'Flaherty, S., Cobian, N., & Barrangou, R. (2023). Impact of Pomegranate on Probiotic Growth, Viability, Transcriptome and Metabolism. MICROORGANISMS, 11(2). https://doi.org/10.3390/microorganisms11020404

Chamberlain, M. C., O'Flaherty, S., Cobian, N., & Barrangou, R. (2022). Metabolomic Analysis of Lactobacillus acidophilus, L. gasseri, L. crispatus, and Lacticaseibacillus rhamnosus Strains in the Presence of Pomegranate Extract. FRONTIERS IN MICROBIOLOGY, 13. https://doi.org/10.3389/fmicb.2022.863228

Foley, M. H., O'Flaherty, S., Allen, G., Rivera, A. J., Stewart, A. K., Barrangou, R., & Theriot, C. M. (2021). Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6). https://doi.org/10.1073/pnas.2017709118

Klotz, C., Goh, Y. J., O'Flaherty, S., Johnson, B., & Barrangou, R. (2020). Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface. FRONTIERS IN MICROBIOLOGY, 11. https://doi.org/10.3389/fmicb.2020.00345

Foley, M. H., O'Flaherty, S., Barrangou, R., & Theriot, C. M. (2019). Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract. PLOS PATHOGENS, 15(3). https://doi.org/10.1371/journal.ppat.1007581

O'Flaherty, S., Crawley, A. B., Theriot, C. M., & Barrangou, R. (2018). The Lactobacillus Bile Salt Hydrolase Repertoire Reveals Niche-Specific Adaptation. MSPHERE, 3(3). https://doi.org/10.1128/msphere.00140-18

Hidalgo-Cantabrana, C., O'Flaherty, S., & Barrangou, R. (2017). [Review of CRISPR-based engineering of next-generation lactic acid bacteria]. CURRENT OPINION IN MICROBIOLOGY, 37, 79–87. https://doi.org/10.1016/j.mib.2017.05.015

Selle, K., Goh, Y. J., Johnson, B. R., Sarah, O. F., Andersen, J. M., Barrangou, R., & Klaenhammer, T. R. (2017). Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus. Frontiers in Microbiology, 8. https://doi.org/10.3389/fmicb.2017.00553

Klotz, C., O'Flaherty, S., Goh, Y. J., & Barrangou, R. (2017). Investigating the Effect of Growth Phase on the Surface-Layer Associated Proteome of Lactobacillus acidophilus Using Quantitative Proteomics. FRONTIERS IN MICROBIOLOGY, 8. https://doi.org/10.3389/fmicb.2017.02174

Johnson, B. R., O'Flaherty, S., Goh, Y. J., Carroll, I., Barrangou, R., & Klaenhammer, T. R. (2017). The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM. FRONTIERS IN MICROBIOLOGY, 8. https://doi.org/10.3389/fmicb.2017.01185

Celebioglu, H. U., Ejby, M., Majumder, A., Kobler, C., Goh, Y. J., Thorsen, K., … Svensson, B. (2016). Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic. PROTEOMICS, 16(9), 1361–1375. https://doi.org/10.1002/pmic.201500212

O'Flaherty, S., & Klaenhammer, T. R. (2016). Multivalent Chromosomal Expression of the Clostridium botulinum Serotype A Neurotoxin Heavy-Chain Antigen and the Bacillus anthracis Protective Antigen in Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(20), 6091–6101. https://doi.org/10.1128/aem.01533-16

Sanozky-Dawes, R., Selle, K., O'Flaherty, S., Klaenhammer, T., & Barrangou, R. (2015). Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri. MICROBIOLOGY-SGM, 161, 1752–1761. https://doi.org/10.1099/mic.0.000129

Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & O'Flaherty, S. (2015, February). Sortase-deficient lactobacilli: effect on immunomodulation and gut retention. MICROBIOLOGY-SGM, Vol. 161, pp. 311–321. https://doi.org/10.1099/mic.0.000007

O'Flaherty, S. (2014). Probiotic-mediated modulation of host gene expression. Interactive Probiotics, 81–98. https://doi.org/10.1201/b16439-5

Johnson, B., Selle, K., O'Flaherty, S., Goh, Y. J., & Klaenhammer, T. (2013). Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM. MICROBIOLOGY-SGM, 159, 2269–2282. https://doi.org/10.1099/mic.0.070755-0

O'Flaherty, S., & Klaenhammer, T. R. (2012). Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(14), 5028–5032. https://doi.org/10.1128/aem.00504-12

Mohamadzadeh, M., Pfeiler, E. A., Brown, J. B., Zadeh, M., Gramarossa, M., Managlia, E., … Klaenhammer, T. R. (2011). Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 4623–4630. https://doi.org/10.1073/pnas.1005066107

Goh, Y. J., Goin, C., O'Flaherty, S., Altermann, E., & Hutkins, R. (2011, August 30). Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9. MICROBIAL CELL FACTORIES, Vol. 10. https://doi.org/10.1186/1475-2859-10-s1-s22

O'Flaherty, S., & Klaenhammer, T. R. (2011). The Impact of Omic Technologies on the Study of Food Microbes. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2, Vol. 2, pp. 353–371. https://doi.org/10.1146/annurev-food-030810-110338

Sarah J. O'Flaherty, & Klaenhammer, T. R. (2010). Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells. MICROBIOLOGY-SGM, 156, 3360–3367. https://doi.org/10.1099/mic.0.043158-0

O'Flaherty, S., & Klaenhammer, T. R. (2010, April). The role and potential of probiotic bacteria in the gut, and the communication between gut microflora and gut/host. INTERNATIONAL DAIRY JOURNAL, Vol. 20, pp. 262–268. https://doi.org/10.1016/j.idairyj.2009.11.011

Goh, Y. J., Azcarate-Peril, M. A., O'Flaherty, S., Durmaz, E., Valence, F., Jardin, J., … Klaenhammer, T. R. (2009). Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105. https://doi.org/10.1128/AEM.02502-08

Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., Sinderen, D., & Paul W. O'Toole. (2009). [Review of Genome-scale analyses of health-promoting bacteria: probiogenomics]. NATURE REVIEWS MICROBIOLOGY, 7(1), 61–U77. https://doi.org/10.1038/nrmicro2047

Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625. https://doi.org/10.1128/AEM.00054-08

Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). Functional genomics of probiotic Lactobacilli. JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162. https://doi.org/10.1097/MCG.0b013e31817da140