Samuel Kit Bunn Lai
Works (24)
Updated: August 29th, 2023 11:25
2023 journal article
Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection
JOURNAL OF THEORETICAL BIOLOGY, 565.
author keywords: SARS-CoV-2; Nasal infection; Viral load; Mechanistic modeling
MeSH headings : Humans; SARS-CoV-2 / genetics; COVID-19; RNA, Viral / genetics; Viral Load; COVID-19 Testing
www.ncbi.nlm.nih.gov (repository)
Source: Web Of Science
Added: May 9, 2023
2022 journal article
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes
JOURNAL OF CONTROLLED RELEASE, 343, 518–527.
author keywords: PBPK model; Polyethylene glycol; PEGylated liposomes; Accelerated blood clearance; Anti-PEG antibodies
MeSH headings : Animals; Antibodies; Kinetics; Liposomes; Mice; Polyethylene Glycols / pharmacokinetics; Positron Emission Tomography Computed Tomography; Tissue Distribution
Source: Web Of Science
Added: May 23, 2022
2022 article
Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19
McSweeney, M., Stewart, I., Richardson, Z., Kang, H., Park, Y., Kim, C., … Lai, S. (2022, August 30). BIOENGINEERING & TRANSLATIONAL MEDICINE.
author keywords: antiviral; COVID-19; drug delivery; inhaled delivery; mAb; nebulization
Source: Web Of Science
Added: September 12, 2022
2021 journal article
Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(9).
author keywords: immunotherapy; cell engineering; receptors; chimeric antigen; antibody specificity
MeSH headings : Animals; Antibodies, Bispecific / metabolism; Disease Models, Animal; Humans; Lentivirus / pathogenicity; Mice; Receptors, Chimeric Antigen / metabolism; Tissue Engineering / methods
Source: Web Of Science
Added: October 4, 2021
2021 review
Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 169, 100–117.
MeSH headings : Angiotensin-Converting Enzyme 2 / antagonists & inhibitors; Angiotensin-Converting Enzyme 2 / metabolism; Animals; Antibodies, Monoclonal / chemistry; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / therapeutic use; Antiviral Agents / chemistry; Antiviral Agents / metabolism; Antiviral Agents / therapeutic use; COVID-19 / diagnosis; COVID-19 / metabolism; COVID-19 / therapy; Humans; Immunization, Passive; Immunologic Factors / chemistry; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Protein Structure, Secondary; Protein Structure, Tertiary; SARS-CoV-2 / chemistry; SARS-CoV-2 / drug effects; SARS-CoV-2 / metabolism; Virus Shedding / drug effects; Virus Shedding / physiology; COVID-19 Serotherapy
Source: Web Of Science
Added: March 15, 2021
2021 journal article
Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception
SCIENCE TRANSLATIONAL MEDICINE, 13(606).
MeSH headings : Animals; Contraception; Female; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Male; Pregnancy; Sheep; Sperm Motility; Spermatozoa
Source: Web Of Science
Added: August 30, 2021
2021 journal article
Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery
BULLETIN OF MATHEMATICAL BIOLOGY, 83(12).
author keywords: PBPK model; Latin hypercube sampling; Parameter optimization; Anti-PEG antibodies; PEGylated liposomes
MeSH headings : Animals; Drug Carriers; Mathematical Concepts; Mice; Models, Biological; Polyethylene Glycols / pharmacokinetics; Positron Emission Tomography Computed Tomography; Tissue Distribution
Source: Web Of Science
Added: November 23, 2021
2021 journal article
High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies
JOURNAL OF CONTROLLED RELEASE, 338, 804–812.
author keywords: Pegloticase; PEG; Anti-PEG antibodies
MeSH headings : Animals; Gout; Humans; Mice; Polyethylene Glycols; Tissue Distribution; Urate Oxidase; Uric Acid
Source: Web Of Science
Added: October 26, 2021
2021 journal article
Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19
JOURNAL OF CONTROLLED RELEASE, 329, 87–95.
MeSH headings : Administration, Inhalation; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / therapeutic use; Antibodies, Neutralizing / immunology; Antibodies, Viral / immunology; Antiviral Agents / administration & dosage; Antiviral Agents / therapeutic use; Humans; Immunotherapy / methods; Injections, Intravenous; Nebulizers and Vaporizers; SARS-CoV-2 / drug effects; Secondary Prevention; Treatment Outcome; COVID-19 Drug Treatment
Source: Web Of Science
Added: June 10, 2021
2021 journal article
Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice
JOURNAL OF CONTROLLED RELEASE, 329, 774–781.
author keywords: Polyethylene glycol antibodies; Anti-PEG antibodies; PEGylation; Polyethylene glycol; Anti-drug antibodies; Drug delivery; Accelerated blood clearance; Nanoparticles; Tolerogenesis
MeSH headings : Animals; Humans; Liposomes; Mice; Polyethylene Glycols
Source: Web Of Science
Added: June 10, 2021
2021 article
The biophysical principles underpinning muco-trapping functions of antibodies
Schaefer, A., & Lai, S. K. (2021, June 26). HUMAN VACCINES & IMMUNOTHERAPEUTICS.
author keywords: Passive immunization; antibodies; mucus
MeSH headings : Antibody-Dependent Cell Cytotoxicity; Immunoglobulin G; Mucins; Mucus / metabolism
Source: Web Of Science
Added: August 2, 2021
2020 journal article
Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds
ACTA BIOMATERIALIA, 107, 91–101.
author keywords: Biological hydrogels; Glycosylation; Antibodies; Hydrogen bonds
MeSH headings : Alginates / chemistry; Chitosan / chemistry; Hydrogels / chemistry; Hydrogen Bonding; Immunoglobulin G / immunology; Immunoglobulin G / metabolism; Immunoglobulin M / immunology; Immunoglobulin M / metabolism; Nanoparticles / chemistry; Polyethylene Glycols / chemistry; Polyethylene Glycols / metabolism; Polystyrenes / chemistry; Protein Binding; Sepharose / chemistry
Source: Web Of Science
Added: May 8, 2020
2020 review
Challenges & opportunities for phage-based in situ microbiome engineering in the gut
[Review of Challenges & opportunities for phage-based in situ microbiome engineering in the gut]. JOURNAL OF CONTROLLED RELEASE, 326, 106–119.
author keywords: Bacteriophage; Phage; Microbiome; Microbiome engineering; in situ engineering; Microbiome gene therapy
MeSH headings : Bacteria; Bacteriophages; Gastrointestinal Microbiome; Humans; Microbiota
Source: Web Of Science
Added: October 12, 2020
2020 journal article
Engineering tetravalent IgGs with enhanced agglutination potencies for trapping vigorously motile sperm in mucin matrix
ACTA BIOMATERIALIA, 117, 226–234.
author keywords: Agglutination; Antibodies; Antibody engineering; Contraception; Sperm; Tetravalent IgG
MeSH headings : Agglutination; Antibodies; Female; Humans; Male; Mucins; Sperm Agglutination; Spermatozoa
Source: Web Of Science
Added: November 30, 2020
2020 journal article
LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus
MUCOSAL IMMUNOLOGY, 13(5), 814–823.
MeSH headings : Animals; Antibodies, Bacterial / immunology; Disease Models, Animal; Immunoglobulin Fab Fragments / immunology; Immunoglobulin Fc Fragments / immunology; Immunoglobulin G / immunology; Intestinal Mucosa; Lipopolysaccharides / immunology; Mice; Mucus / immunology; Mucus / microbiology; Polysaccharides / immunology; Protein Binding / immunology; Salmonella Infections / immunology; Salmonella Infections / microbiology; Salmonella typhimurium / immunology
Source: Web Of Science
Added: March 23, 2020
2020 journal article
Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers
COMMUNICATIONS CHEMISTRY, 3(1).
Source: Web Of Science
Added: September 28, 2020
2020 journal article
The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis
PLOS PATHOGENS, 16(1).
MeSH headings : Adult; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Cervix Uteri / microbiology; Cervix Uteri / virology; Coinfection / microbiology; Coinfection / virology; Female; HIV Infections / virology; HIV-1 / physiology; Humans; Microbiota; Middle Aged; Mucus / microbiology; Mucus / virology; Vagina / microbiology; Vagina / virology; Vaginosis, Bacterial / microbiology; Young Adult
Source: Web Of Science
Added: February 17, 2020
2020 review
Tuning Barrier Properties of Biological Hydrogels
[Review of ]. ACS APPLIED BIO MATERIALS, 3(5), 2875–2890.
author keywords: biological hydrogels; barriers; steric hindrance; adhesion; antibodies; agglutination; cross-linking; third-party modulators
Source: Web Of Science
Added: February 1, 2021
2019 journal article
Engineering Polymer-Binding Bispecific Antibodies for Enhanced Pretargeted Delivery of Nanoparticles to Mucus-Covered Epithelium
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(17), 5604–5608.
author keywords: antibodies; drug delivery; mucus; nanoparticles; PEGylation
MeSH headings : Antibodies, Bispecific / metabolism; Humans; Nanoparticles / metabolism; Polymers / metabolism
Source: Web Of Science
Added: June 4, 2019
2019 journal article
Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes
PHYSICAL REVIEW E, 100(2).
MeSH headings : Biological Transport; Kinetics; Models, Biological; Molecular Motor Proteins / metabolism; Monte Carlo Method; Protein Binding
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Modeling Barrier Properties of Intestinal Mucus Reinforced with IgG and Secretory IgA against Motile Bacteria
ACS INFECTIOUS DISEASES, 5(9), 1570–1580.
author keywords: mucin; immunoglobulins; mucosal immunity; pathogen
MeSH headings : Agglutination; Animals; Bacteria / immunology; Bacteria / pathogenicity; Binding Sites; Humans; Immunoglobulin A, Secretory / chemistry; Immunoglobulin A, Secretory / metabolism; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Intestinal Mucosa / immunology; Models, Theoretical; Mucins / chemistry; Mucins / immunology; Protein Binding
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG
JOURNAL OF CONTROLLED RELEASE, 311, 138–146.
author keywords: Polyethylene glycol antibodies; Anti-PEG antibodies; PEGylation; Polyethylene glycol; Anti-drug antibodies; Drug delivery; Accelerated blood clearance; Nanoparticles
MeSH headings : Administration, Intravenous; Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / pharmacokinetics; Antibodies / immunology; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Female; Liposomes; Liver / metabolism; Mice, Inbred BALB C; Molecular Weight; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Robust antigen-specific tuning of the nanoscale barrier properties of biogels using matrix-associating IgG and IgM antibodies
ACTA BIOMATERIALIA, 89, 95–103.
author keywords: Basement membrane; Extracellular matrix; Antibodies; Laminin; Particle tracking; PEG
MeSH headings : Animals; Antigens / chemistry; Collagen / chemistry; Drug Combinations; Hydrogels / chemistry; Immunoglobulin G / chemistry; Immunoglobulin M / chemistry; Laminin / chemistry; Membranes, Artificial; Nanoparticles / chemistry; Proteoglycans / chemistry
Source: Web Of Science
Added: May 20, 2019
2014 journal article
Transient Antibody-Mucin Interactions Produce a Dynamic Molecular Shield against Viral Invasion
BIOPHYSICAL JOURNAL, 106(9), 2028–2036.
MeSH headings : Antibodies, Neutralizing / immunology; Antibodies, Neutralizing / metabolism; Antibodies, Viral / metabolism; Antibody Specificity; Cervix Uteri / virology; Female; HIV-1 / physiology; Humans; Immunoglobulin G / immunology; Kinetics; Mucins / metabolism; Mucus / virology; Protein Binding; Vagina / virology
Source: Web Of Science
Added: August 6, 2018
