Samuel Kit Bunn Lai

Works (23)

2022 journal article

A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes

JOURNAL OF CONTROLLED RELEASE.

By: A. Talkington, M. McSweeney, T. Wessler, M. Rath, Z. Li, T. Zhang, H. Yuan, J. Frank ...

Source: Web Of Science
Added: May 23, 2022

2022 article

Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19

McSweeney, M., Stewart, I., Richardson, Z., Kang, H., Park, Y., Kim, C., … Lai, S. (2022, August 30). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: M. McSweeney, I. Stewart, Z. Richardson, H. Kang, Y. Park, C. Kim, K. Tiruthani, W. Wolf ...

Source: Web Of Science
Added: September 12, 2022

2021 journal article

Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells

JOURNAL FOR IMMUNOTHERAPY OF CANCER.

By: J. Huckaby, E. Landoni, T. Jacobs, B. Savoldo, G. Dotti & S. Lai

Source: Web Of Science
Added: October 4, 2021

2021 review

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 169, 100–117.

By: C. Cruz-Teran, K. Tiruthani, M. McSweeney, A. Ma, R. Pickles & S. Lai

Source: Web Of Science
Added: March 15, 2021

2021 journal article

Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception

SCIENCE TRANSLATIONAL MEDICINE.

By: B. Shrestha, A. Schaefer, Y. Zhu, J. Saada, T. Jacobs, E. Chavez, S. Omsted, C. Cruz-Teran ...

Source: Web Of Science
Added: August 30, 2021

2021 journal article

Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery

BULLETIN OF MATHEMATICAL BIOLOGY.

By: A. Talkington, T. Wessler, S. Lai, Y. Cao & M. Forest

Source: Web Of Science
Added: November 23, 2021

2021 journal article

High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies

JOURNAL OF CONTROLLED RELEASE.

By: A. Talkington, M. McSweeney, T. Zhang, Z. Li, A. Nyborg, B. LaMoreaux, E. Livingston, J. Frank, H. Yuan, S. Lai

Source: Web Of Science
Added: October 26, 2021

2021 journal article

Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19

JOURNAL OF CONTROLLED RELEASE.

By: S. Lai, M. McSweeney & R. Pickles

Source: Web Of Science
Added: June 10, 2021

2021 journal article

Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice

JOURNAL OF CONTROLLED RELEASE.

By: M. McSweeney, L. Shen, A. DeWalle, J. Joiner, E. Ciociola, D. Raghuwanshi, M. Macauley, S. Lai

Source: Web Of Science
Added: June 10, 2021

2021 article

The biophysical principles underpinning muco-trapping functions of antibodies

Schaefer, A., & Lai, S. K. (2021, June 26). HUMAN VACCINES & IMMUNOTHERAPEUTICS.

By: A. Schaefer & S. Lai

Source: Web Of Science
Added: August 2, 2021

2020 journal article

Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds

ACTA BIOMATERIALIA, 107, 91–101.

By: J. Schiller, M. Fogle, O. Bussey, W. Kissner, D. Hill & S. Lai

Source: Web Of Science
Added: May 8, 2020

2020 review

Challenges & opportunities for phage-based in situ microbiome engineering in the gut

[Review of Challenges & opportunities for phage-based in situ microbiome engineering in the gut]. JOURNAL OF CONTROLLED RELEASE, 326, 106–119.

By: P. Voorhees, C. Cruz-Teran, J. Edelstein & S. Lai

Source: Web Of Science
Added: October 12, 2020

2020 journal article

Engineering tetravalent IgGs with enhanced agglutination potencies for trapping vigorously motile sperm in mucin matrix

ACTA BIOMATERIALIA, 117, 226–234.

By: B. Shrestha, A. Schaefer, E. Chavez, A. Kopp, T. Jacobs, T. Moench, S. Lai

Source: Web Of Science
Added: November 30, 2020

2020 article

LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus

MUCOSAL IMMUNOLOGY.

By: H. Schroeder, J. Newby, A. Schaefer, B. Subramani, A. Tubbs, M. Gregory Forest, E. Miao, S. Lai

Source: Web Of Science
Added: March 23, 2020

2020 journal article

Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers

COMMUNICATIONS CHEMISTRY, 3(1).

By: J. Huckaby, T. Jacobs, Z. Li, R. Perna, A. Wang, N. Nicely, S. Lai

Source: Web Of Science
Added: September 28, 2020

2020 journal article

The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis

PLOS PATHOGENS, 16(1).

By: T. Hoang, E. Toler, K. DeLong, N. Mafunda, S. Bloom, H. Zierden, T. Moench, J. Coleman ...

Source: Web Of Science
Added: February 17, 2020

2020 review

Tuning Barrier Properties of Biological Hydrogels

[Review of ]. ACS APPLIED BIO MATERIALS, 3(5), 2875–2890.

By: J. Schiller & S. Lai

Source: Web Of Science
Added: February 1, 2021

2019 journal article

Engineering Polymer-Binding Bispecific Antibodies for Enhanced Pretargeted Delivery of Nanoparticles to Mucus-Covered Epithelium

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(17), 5604–5608.

By: J. Huckaby, C. Parker, T. Jacobs, A. Schaefer, D. Wadsworth, A. Nguyen, A. Wang, J. Newby, S. Lai

Source: Web Of Science
Added: June 4, 2019

2019 journal article

Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes

PHYSICAL REVIEW E, 100(2).

By: K. Patel, S. Mao, M. Forest, S. Lai & J. Newby

Source: Web Of Science
Added: August 26, 2019

2019 journal article

Modeling Barrier Properties of Intestinal Mucus Reinforced with IgG and Secretory IgA against Motile Bacteria

ACS INFECTIOUS DISEASES, 5(9), 1570–1580.

By: F. Xu, J. Newby, J. Schiller, H. Schroeder, T. Wessler, A. Chen, M. Forest, S. Lai

Source: Web Of Science
Added: October 7, 2019

2019 journal article

Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

JOURNAL OF CONTROLLED RELEASE, 311, 138–146.

By: M. McSweeney, L. Price, T. Wessler, E. Ciociola, L. Herity, J. Piscitelli, A. DeWalle, T. Harris ...

Source: Web Of Science
Added: December 9, 2019

2019 journal article

Robust antigen-specific tuning of the nanoscale barrier properties of biogels using matrix-associating IgG and IgM antibodies

ACTA BIOMATERIALIA, 89, 95–103.

By: J. Schiller, A. Marvin, J. McCallen & S. Lai

Source: Web Of Science
Added: May 20, 2019

2014 journal article

Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion

Biophysical Journal, 106(9), 2028–2036.

By: A. Chen, S. McKinley, S. Wang, F. Shi, P. Mucha, M. Forest, S. Lai

Source: NC State University Libraries
Added: August 6, 2018