Works (25)

Updated: February 21st, 2024 05:01

2024 article

Engineering a "muco-trapping" ACE2-immunoglobulin hybrid with picomolar affinity as an inhaled, pan-variant immunotherapy for COVID-19

Tiruthani, K., Cruz-Teran, C., Chan, J. F. W., Ma, A., Mcsweeney, M., Wolf, W., … Lai, S. K. (2024, February 7). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: K. Tiruthani*, C. Cruz-Teran*, J. Chan*, A. Ma n, M. Mcsweeney, W. Wolf*, S. Yuan*, V. Poon* ...

co-author countries: China 🇨🇳 Hong Kong 🇭🇰 United States of America 🇺🇸
author keywords: ACE2; antibody; COVID-19; drug delivery; immunodecoy; inhaled delivery; monoclonal antibody; SARS-CoV-2
Source: Web Of Science
Added: February 19, 2024

2023 journal article

Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection

JOURNAL OF THEORETICAL BIOLOGY, 565.

co-author countries: United States of America 🇺🇸
author keywords: SARS-CoV-2; Nasal infection; Viral load; Mechanistic modeling
MeSH headings : Humans; SARS-CoV-2 / genetics; COVID-19; RNA, Viral / genetics; Viral Load; COVID-19 Testing
Source: Web Of Science
Added: May 9, 2023

2022 journal article

A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes

JOURNAL OF CONTROLLED RELEASE, 343, 518–527.

By: A. Talkington*, M. McSweeney*, T. Wessler*, M. Rath*, Z. Li*, T. Zhang*, H. Yuan*, J. Frank* ...

co-author countries: United States of America 🇺🇸
author keywords: PBPK model; Polyethylene glycol; PEGylated liposomes; Accelerated blood clearance; Anti-PEG antibodies
MeSH headings : Animals; Antibodies; Kinetics; Liposomes; Mice; Polyethylene Glycols / pharmacokinetics; Positron Emission Tomography Computed Tomography; Tissue Distribution
Source: Web Of Science
Added: May 23, 2022

2022 article

Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19

McSweeney, M., Stewart, I., Richardson, Z., Kang, H., Park, Y., Kim, C., … Lai, S. (2022, August 30). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: M. McSweeney*, I. Stewart*, Z. Richardson*, H. Kang*, Y. Park*, C. Kim*, K. Tiruthani*, W. Wolf* ...

co-author countries: Korea (Republic of) 🇰🇷 United States of America 🇺🇸
author keywords: antiviral; COVID-19; drug delivery; inhaled delivery; mAb; nebulization
Source: Web Of Science
Added: September 12, 2022

2021 journal article

Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(9).

By: J. Huckaby n, E. Landoni*, T. Jacobs*, B. Savoldo*, G. Dotti* & S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: immunotherapy; cell engineering; receptors; chimeric antigen; antibody specificity
MeSH headings : Animals; Antibodies, Bispecific / metabolism; Disease Models, Animal; Humans; Lentivirus / pathogenicity; Mice; Receptors, Chimeric Antigen / metabolism; Tissue Engineering / methods
Source: Web Of Science
Added: October 4, 2021

2021 review

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 169, 100–117.

By: C. Cruz-Teran*, K. Tiruthani*, M. McSweeney, A. Ma n, R. Pickles* & S. Lai n

co-author countries: United States of America 🇺🇸
MeSH headings : Angiotensin-Converting Enzyme 2 / antagonists & inhibitors; Angiotensin-Converting Enzyme 2 / metabolism; Animals; Antibodies, Monoclonal / chemistry; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / therapeutic use; Antiviral Agents / chemistry; Antiviral Agents / metabolism; Antiviral Agents / therapeutic use; COVID-19 / diagnosis; COVID-19 / metabolism; COVID-19 / therapy; Humans; Immunization, Passive; Immunologic Factors / chemistry; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Protein Structure, Secondary; Protein Structure, Tertiary; SARS-CoV-2 / chemistry; SARS-CoV-2 / drug effects; SARS-CoV-2 / metabolism; Virus Shedding / drug effects; Virus Shedding / physiology; COVID-19 Serotherapy
Source: Web Of Science
Added: March 15, 2021

2021 journal article

Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception

SCIENCE TRANSLATIONAL MEDICINE, 13(606).

By: B. Shrestha*, A. Schaefer n, Y. Zhu*, J. Saada*, T. Jacobs*, E. Chavez*, S. Omsted*, C. Cruz-Teran* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Contraception; Female; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Male; Pregnancy; Sheep; Sperm Motility; Spermatozoa
Source: Web Of Science
Added: August 30, 2021

2021 journal article

Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery

BULLETIN OF MATHEMATICAL BIOLOGY, 83(12).

co-author countries: United States of America 🇺🇸
author keywords: PBPK model; Latin hypercube sampling; Parameter optimization; Anti-PEG antibodies; PEGylated liposomes
MeSH headings : Animals; Drug Carriers; Mathematical Concepts; Mice; Models, Biological; Polyethylene Glycols / pharmacokinetics; Positron Emission Tomography Computed Tomography; Tissue Distribution
Source: Web Of Science
Added: November 23, 2021

2021 journal article

High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies

JOURNAL OF CONTROLLED RELEASE, 338, 804–812.

By: A. Talkington*, M. McSweeney*, T. Zhang*, Z. Li*, A. Nyborg*, B. LaMoreaux*, E. Livingston*, J. Frank*, H. Yuan*, S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: Pegloticase; PEG; Anti-PEG antibodies
MeSH headings : Animals; Gout; Humans; Mice; Polyethylene Glycols; Tissue Distribution; Urate Oxidase; Uric Acid
Source: Web Of Science
Added: October 26, 2021

2021 journal article

Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19

JOURNAL OF CONTROLLED RELEASE, 329, 87–95.

By: S. Lai n, M. McSweeney* & R. Pickles*

co-author countries: United States of America 🇺🇸
MeSH headings : Administration, Inhalation; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / therapeutic use; Antibodies, Neutralizing / immunology; Antibodies, Viral / immunology; Antiviral Agents / administration & dosage; Antiviral Agents / therapeutic use; Humans; Immunotherapy / methods; Injections, Intravenous; Nebulizers and Vaporizers; SARS-CoV-2 / drug effects; Secondary Prevention; Treatment Outcome; COVID-19 Drug Treatment
Source: Web Of Science
Added: June 10, 2021

2021 journal article

Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice

JOURNAL OF CONTROLLED RELEASE, 329, 774–781.

By: M. McSweeney*, L. Shen*, A. DeWalle*, J. Joiner*, E. Ciociola*, D. Raghuwanshi, M. Macauley, S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: Polyethylene glycol antibodies; Anti-PEG antibodies; PEGylation; Polyethylene glycol; Anti-drug antibodies; Drug delivery; Accelerated blood clearance; Nanoparticles; Tolerogenesis
MeSH headings : Animals; Humans; Liposomes; Mice; Polyethylene Glycols
Source: Web Of Science
Added: June 10, 2021

2021 article

The biophysical principles underpinning muco-trapping functions of antibodies

Schaefer, A., & Lai, S. K. (2021, June 26). HUMAN VACCINES & IMMUNOTHERAPEUTICS.

By: A. Schaefer n & S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: Passive immunization; antibodies; mucus
MeSH headings : Antibody-Dependent Cell Cytotoxicity; Immunoglobulin G; Mucins; Mucus / metabolism
Source: Web Of Science
Added: August 2, 2021

2020 journal article

Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds

ACTA BIOMATERIALIA, 107, 91–101.

By: J. Schiller*, M. Fogle*, O. Bussey*, W. Kissner*, D. Hill* & S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: Biological hydrogels; Glycosylation; Antibodies; Hydrogen bonds
MeSH headings : Alginates / chemistry; Chitosan / chemistry; Hydrogels / chemistry; Hydrogen Bonding; Immunoglobulin G / immunology; Immunoglobulin G / metabolism; Immunoglobulin M / immunology; Immunoglobulin M / metabolism; Nanoparticles / chemistry; Polyethylene Glycols / chemistry; Polyethylene Glycols / metabolism; Polystyrenes / chemistry; Protein Binding; Sepharose / chemistry
Source: Web Of Science
Added: May 8, 2020

2020 review

Challenges & opportunities for phage-based in situ microbiome engineering in the gut

[Review of Challenges & opportunities for phage-based in situ microbiome engineering in the gut]. JOURNAL OF CONTROLLED RELEASE, 326, 106–119.

By: P. Voorhees*, C. Cruz-Teran*, J. Edelstein n & S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: Bacteriophage; Phage; Microbiome; Microbiome engineering; in situ engineering; Microbiome gene therapy
MeSH headings : Bacteria; Bacteriophages; Gastrointestinal Microbiome; Humans; Microbiota
Source: Web Of Science
Added: October 12, 2020

2020 journal article

Engineering tetravalent IgGs with enhanced agglutination potencies for trapping vigorously motile sperm in mucin matrix

ACTA BIOMATERIALIA, 117, 226–234.

By: B. Shrestha*, A. Schaefer n, E. Chavez*, A. Kopp*, T. Jacobs*, T. Moench, S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: Agglutination; Antibodies; Antibody engineering; Contraception; Sperm; Tetravalent IgG
MeSH headings : Agglutination; Antibodies; Female; Humans; Male; Mucins; Sperm Agglutination; Spermatozoa
Source: Web Of Science
Added: November 30, 2020

2020 journal article

LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus

MUCOSAL IMMUNOLOGY, 13(5), 814–823.

By: H. Schroeder*, J. Newby*, A. Schaefer*, B. Subramani*, A. Tubbs*, M. Gregory Forest*, E. Miao*, S. Lai n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Antibodies, Bacterial / immunology; Disease Models, Animal; Immunoglobulin Fab Fragments / immunology; Immunoglobulin Fc Fragments / immunology; Immunoglobulin G / immunology; Intestinal Mucosa; Lipopolysaccharides / immunology; Mice; Mucus / immunology; Mucus / microbiology; Polysaccharides / immunology; Protein Binding / immunology; Salmonella Infections / immunology; Salmonella Infections / microbiology; Salmonella typhimurium / immunology
Source: Web Of Science
Added: March 23, 2020

2020 journal article

Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers

COMMUNICATIONS CHEMISTRY, 3(1).

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: September 28, 2020

2020 journal article

The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis

PLOS PATHOGENS, 16(1).

By: T. Hoang*, E. Toler*, K. DeLong*, N. Mafunda*, S. Bloom*, H. Zierden*, T. Moench*, J. Coleman* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Adult; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Cervix Uteri / microbiology; Cervix Uteri / virology; Coinfection / microbiology; Coinfection / virology; Female; HIV Infections / virology; HIV-1 / physiology; Humans; Microbiota; Middle Aged; Mucus / microbiology; Mucus / virology; Vagina / microbiology; Vagina / virology; Vaginosis, Bacterial / microbiology; Young Adult
Source: Web Of Science
Added: February 17, 2020

2020 review

Tuning Barrier Properties of Biological Hydrogels

[Review of ]. ACS APPLIED BIO MATERIALS, 3(5), 2875–2890.

By: J. Schiller* & S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: biological hydrogels; barriers; steric hindrance; adhesion; antibodies; agglutination; cross-linking; third-party modulators
Source: Web Of Science
Added: February 1, 2021

2019 journal article

Engineering Polymer-Binding Bispecific Antibodies for Enhanced Pretargeted Delivery of Nanoparticles to Mucus-Covered Epithelium

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(17), 5604–5608.

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: antibodies; drug delivery; mucus; nanoparticles; PEGylation
MeSH headings : Antibodies, Bispecific / metabolism; Humans; Nanoparticles / metabolism; Polymers / metabolism
Source: Web Of Science
Added: June 4, 2019

2019 journal article

Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes

PHYSICAL REVIEW E, 100(2).

By: K. Patel n, S. Mao*, M. Forest n, S. Lai n & J. Newby*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
MeSH headings : Biological Transport; Kinetics; Models, Biological; Molecular Motor Proteins / metabolism; Monte Carlo Method; Protein Binding
Source: Web Of Science
Added: August 26, 2019

2019 journal article

Modeling Barrier Properties of Intestinal Mucus Reinforced with IgG and Secretory IgA against Motile Bacteria

ACS INFECTIOUS DISEASES, 5(9), 1570–1580.

co-author countries: United States of America 🇺🇸
author keywords: mucin; immunoglobulins; mucosal immunity; pathogen
MeSH headings : Agglutination; Animals; Bacteria / immunology; Bacteria / pathogenicity; Binding Sites; Humans; Immunoglobulin A, Secretory / chemistry; Immunoglobulin A, Secretory / metabolism; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Intestinal Mucosa / immunology; Models, Theoretical; Mucins / chemistry; Mucins / immunology; Protein Binding
Source: Web Of Science
Added: October 7, 2019

2019 journal article

Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

JOURNAL OF CONTROLLED RELEASE, 311, 138–146.

By: M. McSweeney*, L. Price*, T. Wessler*, E. Ciociola*, L. Herity*, J. Piscitelli*, A. DeWalle*, T. Harris* ...

co-author countries: United States of America 🇺🇸
author keywords: Polyethylene glycol antibodies; Anti-PEG antibodies; PEGylation; Polyethylene glycol; Anti-drug antibodies; Drug delivery; Accelerated blood clearance; Nanoparticles
MeSH headings : Administration, Intravenous; Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / pharmacokinetics; Antibodies / immunology; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Female; Liposomes; Liver / metabolism; Mice, Inbred BALB C; Molecular Weight; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics
Source: Web Of Science
Added: December 9, 2019

2019 journal article

Robust antigen-specific tuning of the nanoscale barrier properties of biogels using matrix-associating IgG and IgM antibodies

ACTA BIOMATERIALIA, 89, 95–103.

By: J. Schiller*, A. Marvin*, J. McCallen* & S. Lai n

co-author countries: United States of America 🇺🇸
author keywords: Basement membrane; Extracellular matrix; Antibodies; Laminin; Particle tracking; PEG
MeSH headings : Animals; Antigens / chemistry; Collagen / chemistry; Drug Combinations; Hydrogels / chemistry; Immunoglobulin G / chemistry; Immunoglobulin M / chemistry; Laminin / chemistry; Membranes, Artificial; Nanoparticles / chemistry; Proteoglycans / chemistry
Source: Web Of Science
Added: May 20, 2019

2014 journal article

Transient Antibody-Mucin Interactions Produce a Dynamic Molecular Shield against Viral Invasion

BIOPHYSICAL JOURNAL, 106(9), 2028–2036.

co-author countries: United States of America 🇺🇸
MeSH headings : Antibodies, Neutralizing / immunology; Antibodies, Neutralizing / metabolism; Antibodies, Viral / metabolism; Antibody Specificity; Cervix Uteri / virology; Female; HIV-1 / physiology; Humans; Immunoglobulin G / immunology; Kinetics; Mucins / metabolism; Mucus / virology; Protein Binding; Vagina / virology
Source: Web Of Science
Added: August 6, 2018

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