Malay K Shah

Works (2)

Updated: July 5th, 2023 15:34

2019 journal article

Genome Editing with CRISPR-Cas9 in Lactobacillus plantarum Revealed That Editing Outcomes Can Vary Across Strains and Between Methods

BIOTECHNOLOGY JOURNAL, 14(3).

By: R. Leenay*, J. Vento*, M. Shah*, M. Martino *, F. Leulier * & C. Beisel*

author keywords: genome editing; lactobacilli; recombineering; shuttle plasmids
MeSH headings : CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Gene Editing / methods; Lactobacillus plantarum / genetics; Plasmids / genetics; Recombinases / genetics; Recombination, Genetic / genetics
TL;DR: Surprising differences for Cas9-mediated genome editing between methods and related strains are highlighted, arguing for the need for multiple, distinct methods when performing CRISPR-based editing in bacteria. (via Semantic Scholar)
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Added: March 18, 2019

2018 journal article

Bacterial Adaptation to the Host's Diet Is a Key Evolutionary Force Shaping Drosophila-Lactobacillus LESymbiosis

CELL HOST & MICROBE, 24(1), 109-+.

By: M. Martino *, P. Joncour *, R. Leenay n, H. Gervais*, M. Shah n, S. Hughes *, B. Gillet *, C. Beisel n, F. Leulier *

MeSH headings : Acetate Kinase / genetics; Acetate Kinase / metabolism; Adaptation, Physiological; Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drosophila melanogaster / microbiology; Evolution, Molecular; Glutamine / analogs & derivatives; Glutamine / metabolism; Host Microbial Interactions; Lactobacillus plantarum / genetics; Lactobacillus plantarum / growth & development; Larva / microbiology; Microbiota; Mutation; Symbiosis
TL;DR: It is found that the diet of the host, rather than the host itself, is a predominant driving force in the evolution of this symbiosis, and a mechanism resulting from the bacterium's adaptation to the diet, which confers growth benefits to the colonized host is identified. (via Semantic Scholar)
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Added: August 6, 2018

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