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Works (34)
Updated: October 2nd, 2024 05:01
2024 journal article
Increased Systemic Levels of Centrally Acting B-Type Natriuretic Peptide Are Associated with Chronic Itch of Different Types
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 144(10), 2267–2272.
author keywords: BNP; B-type natriuretic peptide; Chronic pruritus of unknown origin; NT-proBNP; Pruritus
Source: Web Of Science
Added: September 30, 2024
2023 article
A new role of TRPM8 in circadian rhythm and molecular clock
Mishra, S. K., & Gaddameedhi, S. (2023, January 20). ACTA PHYSIOLOGICA, Vol. 1.
MeSH headings : Circadian Rhythm; Circadian Clocks
TL;DR:
Evidence is provided that TRPM8 might regulate Period 2 (Per2) mRNA levels in central clock (SCN) and peripheral clock (liver and white adipose tissue) and the circadian regulation of core body temperature and the most significant advances in the field of circadian regulation using cold sensors are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 21, 2023
2023 journal article
Acute radiotherapy-associated oral pain may promote tumor growth at distant sites
FRONTIERS IN ONCOLOGY, 13.
author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR:
This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2023
2023 personal communication
Brain Natriuretic Peptide Exerts Inflammation and Peripheral Itch in a Mouse Model of Atopic Dermatitis
Wheeler, J. J., Williams, N., Yu, J., & Mishra, S. K. (2024, March).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 22, 2024
2022 journal article
Investigating the Role of Artemin and Its Cognate Receptor, GFR alpha 3, in Osteoarthritis Pain
FRONTIERS IN NEUROSCIENCE, 16.
author keywords: pain; osteoarthritis (OA); artemin; GFR alpha 3; TRPV1; monoiodoacetate (MIA)
TL;DR:
The results provide a molecular basis of arthritis pain linked with artemin/GFRα3 signaling and indicate that further work is warranted to investigate the neuronal plasticity and the pathways that drive pain in OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 28, 2022
2021 journal article
Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels
RADIATION RESEARCH, 196(4), 331–344.
MeSH headings : Animals; Calcium; Female; Mice; Neurons; Transient Receptor Potential Channels; Trigeminal Ganglion; Up-Regulation
TL;DR:
The results intimate that various TRP channels, and TRPV1 in particular, should be explored as analgesic targets for patients experiencing pain after oral irradiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 18, 2021
2021 review
Periostin, an Emerging Player in Itch Sensation
[Review of ]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2338–2343.
MeSH headings : Animals; Cell Adhesion Molecules / physiology; Humans; Integrins / physiology; Natriuretic Peptide, Brain / physiology; Pruritus / etiology; Sensation; TRPA1 Cation Channel / physiology
TL;DR:
The role of periostin in itch induction in human and animal models and its expression in human pruritic conditions are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 21, 2021
2021 review
Role of TRP ion channels in pruritus
[Review of ]. NEUROSCIENCE LETTERS, 768.
author keywords: TRP channels; Pruritus; Dorsal root ganglia; skin
MeSH headings : Animals; Humans; Pruritus / metabolism; Pruritus / physiopathology; Sensory Receptor Cells / metabolism; Transient Receptor Potential Channels / metabolism
TL;DR:
This review will focus on involvement of TRP channels in pruriception that may render these channels as the targets of many antagonistic topical medications, which may help patients' better cope with the pruritus that results from various cutaneous and systemic diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 20, 2021
2021 journal article
Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Arthralgia / diagnosis; Arthralgia / etiology; Dogs; Female; Male; Nerve Tissue Proteins / blood; Osteoarthritis / blood; Osteoarthritis / complications; Pain Threshold; Severity of Illness Index; Symptom Assessment
TL;DR:
Serum ARTN was not associated with the degree of sensitization within dogs with OAP, and across dogs with varying OAP severity, there did not find any association between ARTN, and clinical measures of joint pain and disability, although a relationship between Artemin and joint pain was not ruled out.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 19, 2021
2021 journal article
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch
BIOMOLECULES, 11(8).
author keywords: histamine; histamine H1 receptor; histamine H4 receptor; itch; signal transduction; TRPV1; TRPA1; dorsal root ganglion neurons (DRG); Ca2+-imaging
MeSH headings : Acetanilides / pharmacology; Animals; Calcium / metabolism; Capsaicin / analogs & derivatives; Capsaicin / pharmacology; Female; Ganglia, Spinal / drug effects; Ganglia, Spinal / metabolism; Gene Expression; Histamine / administration & dosage; Male; Methylhistamines / administration & dosage; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Molecular Imaging; Primary Cell Culture; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / genetics; Pruritus / metabolism; Purines / pharmacology; Ruthenium Red / pharmacology; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Signal Transduction; TRPA1 Cation Channel / antagonists & inhibitors; TRPA1 Cation Channel / genetics; TRPA1 Cation Channel / metabolism; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism
TL;DR:
Results indicate that both channels, TRPV1 and TRPA1, are involved in the transmission of histamine-induced pruritus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 7, 2021
2021 journal article
The Role of CNTNAP2 in Itch Sensation
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 142(1), 251–253.
MeSH headings : Animals; Dermatitis, Atopic / genetics; Dermatitis, Atopic / metabolism; Ganglia, Spinal / metabolism; Glutamic Acid / metabolism; Humans; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mice; Mice, Knockout; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Pruritus / genetics; Pruritus / metabolism; Sensation; Sensation Disorders / genetics; Sensation Disorders / metabolism; Signal Transduction; TOR Serine-Threonine Kinases / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 21, 2022
2021 review
The emerging role of neuroimmune interactions in atopic dermatitis and itch
[Review of ]. FEBS JOURNAL, 289(10), 2723–2735.
author keywords: atopic dermatitis; cytokines; dorsal root ganglia; integrin receptors; itch; keratinocytes; mast cells; periostin; TRP channels; TSLP
MeSH headings : Dermatitis, Atopic; Humans; Hypersensitivity / complications; Neuroimmunomodulation; Pruritus / complications; Quality of Life; Skin
TL;DR:
The endogenous mediators released from immune/nonimmune skin cells (that are indirectly involved in the propagation of itch) and the sensory neurons that express receptors for these itch mediators that are associated with direct transmission of itch in cutaneous allergic diseases are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 3, 2021
2020 journal article
B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension
JCI INSIGHT, 5(8).
MeSH headings : Animals; Cell Line; Humans; Hypotension / etiology; Hypotension / metabolism; JNK Mitogen-Activated Protein Kinases / metabolism; Mice; Natriuretic Peptide, Brain / metabolism; Sepsis / complications; Sepsis / metabolism; Up-Regulation
TL;DR:
In conclusion, genetic ablation of BNP, as well as treatment with a potentially novel neutralizing anti-BNP monoclonal antibody (19B3) or suppression of its expression via administration of JNK inhibitor SP600125 improved cardiac output, stabilized blood pressure, and improved survival in mice with polymicrobial sepsis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 18, 2020
2020 journal article
Differential contribution of sensory transient receptor potential channels in response to the bioactive lipid sphingosine-1-phosphate
MOLECULAR PAIN, 16.
author keywords: Itch; pain; sphingosine 1-phosphate; TRPA1; TRPV1
MeSH headings : Animals; Behavior, Animal; Calcium / metabolism; Cells, Cultured; Female; Gene Expression Regulation; Lysophospholipids / chemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pruritus / drug therapy; Sensory Receptor Cells / metabolism; Sphingosine / analogs & derivatives; Sphingosine / chemistry; TRPA1 Cation Channel / metabolism; TRPV Cation Channels / metabolism
TL;DR:
It is revealed that S1P induces both pain and itch in vivo and that these responses are partially dependent upon the TRPV1, but not TRPA1 channels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 16, 2020
2020 journal article
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
CELL REPORTS, 31(1).
Contributors: n, J. Wheeler n, S. Pitake n, H. Ding *, C. Jiang *, T. Fukuyama n, J. Paps n, P. Ralph n
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
TL;DR:
A TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons is identified and the non-canonical functional role of an integrin in itch is characterized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020
2019 journal article
Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients
CANCER MEDICINE, 8(3), 1110–1123.
author keywords: biomarker; exosomes; health disparity; inflammation; prostate cancer
MeSH headings : Black or African American; Biomarkers, Tumor; Biopsy; Calcium / metabolism; Cell Line, Tumor; Chromatography, Liquid; Exosomes / metabolism; Exosomes / ultrastructure; Filamins / metabolism; Healthcare Disparities; Humans; Immunohistochemistry; Inflammation Mediators; Macrophages / metabolism; Male; Molecular Imaging; Neurons / metabolism; Phenotype; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / metabolism; Proteome; Proteomics / methods; Tandem Mass Spectrometry; White People
TL;DR:
Results support the usefulness of serum exosomes to noninvasively detect inflammatory phenotype and to discover novel biomarkers associated with PCa in African American men.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 9, 2019
2019 journal article
Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2
FRONTIERS IN NEUROSCIENCE, 13.
author keywords: Cav2.2; inflammation; pain; nerve growth; hyperalgesia
TL;DR:
A role is uncovered for Cav2.2 during inflammation, demonstrating that VGCC activity can promote thermal hyperalgesia through both changes in firing rates of sensory neurons as well as promotion of new neurite outgrowth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Itch-associated Neuropeptides and Their Receptor Expression in Dog Dorsal Root Ganglia and Spinal Cord
ACTA DERMATO-VENEREOLOGICA, 99(12), 1131–1135.
Contributors: J. Wheeler*, B. Lascelles n, T. Olivry n & *
author keywords: dog; canine atopic dermatitis; somatostatin; NPPB; NMB; GRP
MeSH headings : Animals; Calcium Signaling; Cells, Cultured; Dogs; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression Regulation; Male; Neuropeptides / genetics; Neuropeptides / metabolism; Pruritus / genetics; Pruritus / metabolism; Pruritus / physiopathology; Receptors, Neuropeptide / genetics; Receptors, Neuropeptide / metabolism; Spinal Cord / metabolism; Spinal Cord / physiopathology
TL;DR:
The results provide the first evidence that dogs use similar pruritogenic pathways to those characterized in mice and thus identify multiple targets for the future treatment of itch in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2019
2018 journal article
Author Correction: Circuit dissection of the role of somatostatin in itch and pain
Nature Neuroscience, 21(6), 894–894.
TL;DR:
In the version of this article initially published online, the labels were switched for the right-hand pair of bars in Fig. 4e, the left one of the two should be Chloroquine + veh, the right one Chlorquine + CNO.
(via Semantic Scholar)
Source: Crossref
Added: February 21, 2020
2018 journal article
Circuit dissection of the role of somatostatin in itch and pain
NATURE NEUROSCIENCE, 21(5), 707-+.
MeSH headings : Animals; Dynorphins / metabolism; Female; Ganglia, Spinal / metabolism; Male; Mice; Mice, Inbred C57BL; Neural Pathways / physiopathology; Optogenetics; Pain / metabolism; Pain / physiopathology; Pruritus / metabolism; Pruritus / physiopathology; Receptors, Atrial Natriuretic Factor / biosynthesis; Receptors, Atrial Natriuretic Factor / metabolism; Receptors, Purinergic / metabolism; Receptors, Somatostatin / antagonists & inhibitors; Receptors, Somatostatin / genetics; Sensory Receptor Cells; Somatostatin / biosynthesis; Somatostatin / metabolism; Spinal Cord / cytology; Spinal Cord / physiopathology
TL;DR:
The neural circuit underlying somatostatin-induced itch is defined and a contrasting antinociceptive role for the peptide is characterized, and it is demonstrated that somatstatin (Sst)-expressing primary afferents are pruriceptors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Histamine H4 receptor mediates itch through TRPV1 and TRPA1 ion channels
Journal of Veterinary Pharmacology and Therapeutics, 41, 48–48.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
A central role for R7bp in the regulation of itch sensation
PAIN, 158(5), 931–944.
MeSH headings : Animals; Camphor / analogs & derivatives; Camphor / toxicity; Cells, Cultured; Chromones / toxicity; Endothelin-1 / toxicity; Female; GTP-Binding Protein alpha Subunits, Gi-Go / genetics; GTP-Binding Protein alpha Subunits, Gi-Go / metabolism; Ganglia, Spinal / pathology; Gastrin-Releasing Peptide / toxicity; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation / genetics; Natriuretic Peptide, Brain / toxicity; Nociception / physiology; Pain Threshold / physiology; Pruritus / chemically induced; Pruritus / genetics; Pruritus / metabolism; Psychomotor Performance / physiology; RGS Proteins / genetics; RGS Proteins / metabolism; Receptors, Opioid, kappa / genetics; Receptors, Opioid, kappa / metabolism; Sensation / genetics; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / physiology
TL;DR:
Results indicate that R7BP is a key regulator of itch sensation and suggest the potential targeting of R7bp-dependent GTPase activating protein activity as a novel therapeutic strategy for pathological itch.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 personal communication
Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor
Fukuyama, T., Ganchingco, J. R., Mishra, S. K., Olivry, T., Rzagalinski, I., Volmer, D. A., & Baeumer, W. (2017, July).
Contributors: T. Fukuyama n, J. Ganchingco n, n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Bäumer n
MeSH headings : Animals; Antipruritics / chemistry; Antipruritics / pharmacology; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Female; Humans; Janus Kinase Inhibitors / chemistry; Janus Kinase Inhibitors / pharmacology; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging / methods; Protein Binding; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Structure-Activity Relationship; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / chemistry; TRPV Cation Channels / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Molecular Signatures of Mouse TRPV1-Lineage Neurons Revealed by RNA-Seq Transcriptome Analysis
The Journal of Pain, 15(12), 1338–1359.
author keywords: Pain; nociception; dorsal root ganglion; capsaicin; resiniferatoxin
MeSH headings : Animals; Cell Lineage; Ganglia, Spinal / metabolism; Gene Expression; Gene Expression Profiling; Immunohistochemistry; In Situ Hybridization; Mice, Transgenic; Neuroglia / metabolism; Neurons, Afferent / metabolism; Pain / metabolism; Rats; Species Specificity; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Transcriptome; Trigeminal Nerve / metabolism
TL;DR:
The transcriptome highlights previously unrecognized protein families, identifies multiple molecular circuits for excitatory or inhibitory autocrine and paracrine signaling, and suggests new combinatorial approaches to pain control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2013 journal article
The Cells and Circuitry for Itch Responses in Mice
Science, 340(6135), 968–971.
MeSH headings : Animals; Chloroquine / pharmacology; Endothelin-1 / pharmacology; Gastrin-Releasing Peptide / metabolism; Gastrin-Releasing Peptide / pharmacology; Histamine / pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Natriuretic Peptide, Brain / genetics; Natriuretic Peptide, Brain / metabolism; Natriuretic Peptide, Brain / pharmacology; Nociception; Phospholipase C beta; Pruritus / chemically induced; Pruritus / metabolism; Pruritus / physiopathology; Receptors, Atrial Natriuretic Factor / metabolism; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Spinal Cord / drug effects; Spinal Cord / pathology; Spinal Cord / physiopathology; TRPV Cation Channels / metabolism
TL;DR:
The results define the primary pruriceptive neurons, characterize Nppb as an itch-selective neuropeptide, and reveal the next two stages of this dedicated neuronal pathway.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2013 journal article
The Cellular Code for Mammalian Thermosensation
Journal of Neuroscience, 33(13), 5533–5541.
MeSH headings : Animals; Avoidance Learning / drug effects; Avoidance Learning / physiology; Body Temperature / drug effects; Body Temperature / genetics; Cell Count; Choice Behavior / drug effects; Choice Behavior / physiology; Cold Temperature; Diphtheria Toxin / toxicity; Escape Reaction / drug effects; Escape Reaction / physiology; Ganglia, Spinal / cytology; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Gene Expression Regulation / physiology; Green Fluorescent Proteins / genetics; Heparin-binding EGF-like Growth Factor; Hot Temperature / adverse effects; Intercellular Signaling Peptides and Proteins / genetics; Mice; Mice, Transgenic; Mutation / genetics; Poisons / toxicity; Reaction Time / drug effects; Reaction Time / genetics; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / physiology; TRPM Cation Channels / genetics; TRPV Cation Channels / genetics; Thermosensing / drug effects; Thermosensing / genetics; Thermosensing / physiology
TL;DR:
The results provide a simple cellular basis for mammalian thermosensation whereby two molecularly defined classes of sensory neurons detect and encode both attractive and aversive cues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2012 journal article
A Nociceptive Signaling Role for Neuromedin B
Journal of Neuroscience, 32(25), 8686–8695.
MeSH headings : Animals; Behavior, Animal / physiology; Calcitonin Gene-Related Peptide / metabolism; Ganglia, Spinal / metabolism; Hot Temperature; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Microarray Analysis; Neuritis / pathology; Neurokinin B / analogs & derivatives; Neurokinin B / antagonists & inhibitors; Neurokinin B / pharmacology; Neurokinin B / physiology; Neuropeptides / biosynthesis; Nociception / physiology; Pain Measurement / drug effects; Posterior Horn Cells / physiology; Receptors, Bombesin / biosynthesis; Receptors, Bombesin / genetics; Sensory Receptor Cells / metabolism; Signal Transduction / physiology; Spinal Cord / physiology; Substance P / metabolism
TL;DR:
An array-based differential screen to uncover the expression of the neuropeptide neuromedin B (NMB) in the trigeminal ganglia of mice reveals a subset of sensory neurons that colabel with calcitonin gene-related peptide and TRPV1 suggestive of a role for NMB in nociception.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2012 journal article
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice
The FASEB Journal, 27(1), 174–186.
author keywords: Cdk5 hyperphosphorylation; neurodegeneration; therapeutics
MeSH headings : Alzheimer Disease / prevention & control; Amino Acid Sequence; Animals; Apoptosis; Enzyme Activators / pharmacology; Mice; Mice, Transgenic; Molecular Sequence Data; Nerve Tissue Proteins / chemistry; Nerve Tissue Proteins / pharmacology; Phosphorylation
TL;DR:
It is shown that a modified truncated 24‐aa peptide (TFP5), derived from the Cdk5 activator p35, penetrates the blood‐brain barrier after intraperitoneal injections, inhibits abnormal Cdk 5 hyperactivity, and significantly rescues AD pathology in 5XFAD AD model mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2011 journal article
Oxidative stress in neurodegeneration
Advances in Pharmacological Sciences, 2011, 1–13.
TL;DR:
The role of oxidative stress in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis is highlighted, and the role of oxidants and antioxidants causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with Neurodegeneration is described.
(via Semantic Scholar)
Source: Web Of Science
Added: December 28, 2020
2011 journal article
Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH
Journal of Pharmacology and Experimental Therapeutics, 340(1), 152–160.
MeSH headings : Animals; Body Temperature / drug effects; Calcium / metabolism; Calcium Radioisotopes; Capsaicin / analogs & derivatives; Capsaicin / pharmacology; Dihydropyridines / pharmacology; Electrophysiological Phenomena; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Phosphorylation; Protons; Rats; Serine / metabolism; TRPV Cation Channels / agonists; TRPV Cation Channels / drug effects
TL;DR:
Positive modulation of TRPV1 sensitivity suggests that it may be possible to produce a selective analgesia through calcium overload restricted to highly active nociceptive nerve endings at sites of tissue damage and inflammation.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2011 journal article
TRPV1 lineage neurons and their functional role in thermal nociception
Neuroscience Research, 71, e80.
TL;DR:
Findings indicate that the suppression of synaptic transmission in the reciprocal synapses in the goldfish olfactory bulb has an important role in the negative regulation of olfaction responsiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: July 30, 2021
2010 journal article
TRPV1-lineage neurons are required for thermal sensation
The EMBO Journal, 30(3), 582–593.
author keywords: itch; pain; thermal; TRPM8; TRPV1
MeSH headings : Animals; Body Temperature; Body Temperature Regulation / genetics; Body Temperature Regulation / physiology; DNA, Complementary / genetics; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; In Situ Hybridization; Mice; Mice, Mutant Strains; Models, Biological; Nociceptors / metabolism; Oligonucleotide Array Sequence Analysis; Pain Measurement; Receptors, G-Protein-Coupled / metabolism; Rotarod Performance Test; TRPM Cation Channels / metabolism; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Thermoreceptors / metabolism
TL;DR:
The results define and delimit the roles of TRPV1‐ and TRPM8‐neurons in thermosensation, thermoregulation and nociception, thus significantly extending the concept of labelled lines in somatosensory coding.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2009 journal article
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation
Molecular and Cellular Neuroscience, 43(1), 157–163.
author keywords: Resiniferotoxin; TrpV1; Nociception; Pain; Thermal sensation
MeSH headings : Analgesics / pharmacology; Animals; Capsaicin / pharmacology; Diterpenes / pharmacology; Male; Mechanoreceptors / drug effects; Mechanoreceptors / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nociceptors / cytology; Nociceptors / drug effects; Nociceptors / metabolism; Pain / physiopathology; Pain Measurement; Plant Oils / pharmacology; Sensory System Agents / pharmacology; Stress, Mechanical; TRPV Cation Channels / agonists; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Thermosensing / drug effects; Thermosensing / physiology; Trigeminal Nerve / drug effects; Trigeminal Nerve / metabolism
TL;DR:
The data demonstrate that TrpV1 neurons are selectively tuned nociceptors that mediate responses to thermal but not mechanical pain and insinuate a labeled line model for somatosensory coding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2019
2006 journal article
Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation
Development, 133(4), 675–684.
author keywords: adult neurogenesis; ATR ecto-nucleotidase; neurosphere; P2 receptor; subventricular zone
MeSH headings : Adenosine / metabolism; Adenosine Diphosphate / analogs & derivatives; Adenosine Diphosphate / pharmacology; Adenosine Triphosphatases / genetics; Adenosine Triphosphatases / metabolism; Adenosine Triphosphate / pharmacology; Alkaline Phosphatase / genetics; Alkaline Phosphatase / metabolism; Animals; Calcium / metabolism; Cell Proliferation; Cells, Cultured; Epidermal Growth Factor / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Isoenzymes / genetics; Isoenzymes / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Multipotent Stem Cells / cytology; Multipotent Stem Cells / metabolism; Neurons / cytology; Neurons / metabolism; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 / metabolism; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Uridine Triphosphate / pharmacology
TL;DR:
Results infer nucleotide receptor-mediated synergism that augments growth factor-mediated cell proliferation that supports the notion that extracellular nucleotides contribute to the control of adult neurogenesis.
(via Semantic Scholar)
Source: Crossref
Added: September 9, 2019
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