Sehwon Koh

Works (5)

Updated: July 7th, 2023 21:16

2017 journal article

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

By: J. Lim*, S. Koh*, R. Thomas*, M. Breen* & N. Olby* 

MeSH headings : Adipose Tissue / cytology; Animals; Cells, Cultured; Comparative Genomic Hybridization; Dogs; Female; Gene Dosage / genetics; Gene Expression Profiling; Gene Expression Regulation; Male; Neural Stem Cells / cytology; Neural Stem Cells / pathology; Neurons / cytology; Neurons / pathology; Proteins / genetics; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary; Stromal Cells / cytology; Stromal Cells / physiology
TL;DR: ADSCs can potentially be a safe and clinically relevant autologous source for canine neural progenitor cells and DNA copy number stability was suggested by the methods used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2014 review

From "ES-like" cells to induced pluripotent stem cells: A historical perspective in domestic animals

[Review of ]. THERIOGENOLOGY, 81(1), 103–111.

By: S. Koh n & J. Piedrahita n

author keywords: Pluripotent stem cells; Reprogramming; Large animals; Induced pluripotent stem cells
MeSH headings : Animals; Animals, Domestic / embryology; Animals, Domestic / physiology; Cattle; Dogs; Embryonic Stem Cells; Genomic Instability; Induced Pluripotent Stem Cells; Regenerative Medicine; Swine / physiology
TL;DR: A historical perspective of the isolation of various types of pluripotent stem cells in domesticated animals is provided and the latest progress and limitations in the derivation and application of iPSCs are summarized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

Stem Cells and Development, 22(6), 951–963.

By: S. Koh n, R. Thomas n, S. Tsai n, S. Bischoff n, J. Lim n, M. Breen n, N. Olby n , J. Piedrahita n

MeSH headings : Alkaline Phosphatase / metabolism; Animals; Antigens, Differentiation / genetics; Antigens, Differentiation / metabolism; Cell Differentiation; Cell Shape; Cells, Cultured; Chromosomal Instability; Coculture Techniques; Comparative Genomic Hybridization; Dogs; Fibroblasts / physiology; Gene Expression; In Situ Hybridization, Fluorescence; Induced Pluripotent Stem Cells / enzymology; Induced Pluripotent Stem Cells / pathology; Induced Pluripotent Stem Cells / transplantation; Kruppel-Like Factor 4; Mice; Mice, SCID; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Teratoma / genetics; Teratoma / pathology; Transcription Factors / biosynthesis; Transcription Factors / genetics
TL;DR: The isolated ciPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF2 and LIF are still unknown. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2012 journal article

Isolation and characterization of neural progenitor cells from adult canine brains

American Journal of Veterinary Research, 73(12), 1963–1968.

By: J. Lim n, S. Koh*, N. Olby* , J. Piedrahita* & C. Mariani* 

MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Cell Lineage; Dogs; Female; Hippocampus / cytology; Hippocampus / metabolism; Immunohistochemistry / veterinary; Lateral Ventricles / cytology; Lateral Ventricles / metabolism; Male; Neural Stem Cells / cytology; Neural Stem Cells / physiology; RNA / analysis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: Results suggested the persistence of SOX2- Positive, nestin-positive, GFAP- positive,GFAP-Positive, OCT4-negative, and NANOG-negative neural progenitor cells in the SVZ and SGZ regions of mature canine brains, which are capable of producing multiple cell lineages. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 journal article

STIM1 regulates store-operated Ca2+ entry in oocytes

DEVELOPMENTAL BIOLOGY, 330(2), 368–376.

By: S. Koh n, K. Lee *, C. Wang*, R. Cabot* & Z. Machaty *

author keywords: Ca2+ signaling; STIM1; Store-operated Ca2+ entry; Oocytes; Swine
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Calcium / metabolism; DNA Primers; Humans; Immunohistochemistry; Ion Transport; Membrane Proteins / chemistry; Membrane Proteins / genetics; Membrane Proteins / physiology; Microinjections; Molecular Sequence Data; Oocytes / metabolism; RNA Interference; Sequence Homology, Amino Acid; Swine; Transcription, Genetic
TL;DR: The findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca( 2+) entry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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