Shannah K. Witchey

Works (6)

Updated: October 12th, 2024 05:01

2024 journal article

Sex-specific effects on elements of the social brain neural network in Wistar rats from perinatal exposure to FireMaster 550 or its components

NEUROTOXICOLOGY, 105, 111–120.

By: S. Schkoda n, B. Horman n, S. Witchey n, G. Armour n, M. Nelson n, E. Gaeta n, M. Scott  n, H. Patisaul n 

author keywords: Flame retardants; Sex difference; Serotonin; Estrogen receptor alpha; Oxytocin receptor; Neurobehavior; Amygdala; BNST
Sources: Web Of Science, NC State University Libraries
Added: October 8, 2024

2023 journal article

Skeletal effects following developmental flame-retardant exposure are specific to sex and chemical class in the adult Wistar rat

FRONTIERS IN TOXICOLOGY, 5.

By: S. Schkoda n, B. Horman n, S. Witchey*, A. Jansson n, S. Macari * & H. Patisaul n 

author keywords: endocrine disrupting chemicals; flame retardants; sex difference; osteotoxicology; computed tomography; bone
TL;DR: Although sex specificity was expected due to the sexual dimorphic nature of skeletal physiology, the mechanisms accounting for the male- and female-specific phenotypes remain to be determined and future work aims to clarify these unresolved issues. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2022 article

Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters

Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.

By: S. Witchey n, M. Doyle n, J. Fredenburg n, G. St Armour n, B. Horman n, M. Odenkirk n, D. Aylor n, E. Baker n , H. Patisaul n 

TL;DR: This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2022 journal article

Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat

TOXICOLOGICAL SCIENCES, 191(2), 357–373.

By: A. Newell n, V. Kapps n, Y. Cai n, M. Rai, G. St Armour n, B. Horman n, K. Rock n, S. Witchey n, A. Greenbaum n, H. Patisaul n 

author keywords: neurodevelopment; monoamine; OPFR; OPE; flame retardants; neurotransmitters; neurotoxicity; neurotoxicology; prenatal; reproductive and developmental toxicology; mesocortical dopamine system; tissue clearing light sheet microscopy.
TL;DR: Results indicate maternal exposure to OPFRs alters the development trajectory of the embryonic dopaminergic system and adds to growing evidence of OPFR developmental neurotoxicity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2020 journal article

Perinatal exposure to FireMaster (R) 550 (FM550), brominated or organophosphate flame retardants produces sex and compound specific effects on adult Wistar rat socioemotional behavior

HORMONES AND BEHAVIOR, 126.

By: S. Witchey n, L. Al Samara n, B. Horman n, H. Stapleton * & H. Patisaula

author keywords: Behavior; Brain; Neurodevelopment; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Animals, Newborn; Behavior, Animal / drug effects; Emotions / drug effects; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Hydrocarbons, Brominated / toxicity; Male; Maternal Exposure / adverse effects; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / physiopathology; Prenatal Exposure Delayed Effects / psychology; Rats; Rats, Wistar; Sex Characteristics; Social Behavior
TL;DR: Examining adult Wistar rat offspring socioemotional behaviors following perinatal exposure to FM550 helps elucidate how different classes of flame retardants, independently and as a mixture, contribute to sex-specific behavioral effects of exposure. (via Semantic Scholar)
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Source: Web Of Science
Added: February 15, 2021

2019 journal article

Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study

NEUROTOXICOLOGY, 74, 139–148.

By: S. Witchey n, J. Fuchs n & H. Patisaul n 

author keywords: Behavior; Estrogen; Endocrine disruption; Sexual differentiation; Neuroendocrine; Oxytocin
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Brain Chemistry / drug effects; Endocrine Disruptors / toxicity; Ethinyl Estradiol / toxicity; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Oxytocin / biosynthesis; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin / biosynthesis; Septal Nuclei / drug effects; Septal Nuclei / metabolism; Sex Characteristics
TL;DR: Prenatal exposure to BPA can eliminate sex differences in OTR expression in three hypothalamic regions, and that male O TR expression may be more susceptible, and a sexually dimorphic sub-region of the BNST not previously reported in juvenile rats is identified that is also susceptible to B PA. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 21, 2019

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