Sharonda LeBlanc

Works (16)

Updated: March 5th, 2026 15:07

2026 article

Film formation of two-dimensional hybrid perovskite using resonant infrared matrix-assisted pulsed laser evaporation

Roy, M., Castaneda, J. F., LeBlanc, S. J., & Stiff-Roberts, A. D. (2026, January 1). AIP Advances.

By: M. Roy *, J. Castaneda n, S. LeBlanc n  & A. Stiff-Roberts*

topics (OpenAlex): Perovskite Materials and Applications; 2D Materials and Applications; Strong Light-Matter Interactions
Source: ORCID
Added: January 28, 2026

2025 article

BPS2025 - Monitoring AAA-ATPase-mediated ribosome assembly in Saccharomyces cerevisiae with PIE-FRET imaging

Kerr, A. N., Borgognoni, K., Hsu, O., Stanley, R., & LeBlanc, S. J. (2025, February 1). Biophysical Journal.

By: A. Kerr n, K. Borgognoni*, O. Hsu n, R. Stanley * & S. LeBlanc n 

topics (OpenAlex): RNA and protein synthesis mechanisms
Source: NC State University Libraries
Added: March 4, 2026

2025 article

BPS2025 - Probing nuclear mechanics across cell division through protein diffusion

Goodbee, N. Z., Elting, M. W., & LeBlanc, S. J. (2025, February 1). Biophysical Journal, Vol. 2.

By: N. Goodbee n, M. Elting n  & S. LeBlanc n 

topics (OpenAlex): Nuclear Structure and Function; Mitochondrial Function and Pathology
Sources: NC State University Libraries, NC State University Libraries
Added: March 4, 2026

2025 article

Design and Characterization of DNA-Driven Condensates: Regulating Topology, Mechanical Properties, and Immunorecognition

Skelly, E., Bayard, C. J., Jarusek, J., Clark, B., Rebolledo, L. P., Radwan, Y., … Afonin, K. A. (2025, April 1). ACS Applied Materials & Interfaces, Vol. 4.

By: E. Skelly *, C. Bayard n, J. Jarusek*, B. Clark n, L. Rebolledo *, Y. Radwan *, P. Nguyen*, M. Andrade-Muñoz* ...

author keywords: nucleic acid condensates; microrheology; dissipativeparticle dynamics; stimuli responsiveness; quantumdots; cGAS-STING
MeSH headings : DNA / chemistry; Humans; Biomolecular Condensates / chemistry; Nanotechnology; Oligonucleotides / chemistry
topics (OpenAlex): RNA Research and Splicing; interferon and immune responses; RNA modifications and cancer
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2025

2025 article

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

Begley, M. A., Mahoney, T., Medina, C. P., Zareiesfandabadi, P., Rapp, M. B., Tirfe, M., … Elting, M. W. (2025, May 10). Cytoskeleton, Vol. 5.

By: M. Begley n, T. Mahoney n, C. Medina  n, P. Zareiesfandabadi n, M. Rapp n, M. Tirfe n, S. LeBlanc n , M. Betterton *, M. Elting n 

author keywords: closed mitosis; cytoskeleton; fission yeast; mitotic spindle; nuclear mechanics
topics (OpenAlex): Microtubule and mitosis dynamics; Nuclear Structure and Function; Photosynthetic Processes and Mechanisms
Sources: Web Of Science, NC State University Libraries
Added: May 19, 2025

2025 article

Quantitative single-molecule FLIM and PIE-FRET imaging of biomolecular systems

Silvernail, I., Morgan, A. N., Gordon, K., Kerr, A. N., Borgognoni, K., Atisa, A. M., … LeBlanc, S. J. (2025, November 2). BMC Methods.

By: I. Silvernail n, A. Morgan n, K. Gordon n, A. Kerr n, K. Borgognoni*, A. Atisa n, B. Clark n, J. Castaneda n, R. Stanley *, S. LeBlanc n 

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Near-Field Optical Microscopy; Force Microscopy Techniques and Applications
Sources: NC State University Libraries, NC State University Libraries
Added: November 22, 2025

2024 article

A practical guide to time-resolved fluorescence microscopy and spectroscopy

Clark, B. S., Silvernail, I., Gordon, K., Castaneda, J. F., Morgan, A. N., Rolband, L. A., & LeBlanc, S. J. (2024, January 30).

By: B. Clark n, I. Silvernail n, K. Gordon n, J. Castaneda n, A. Morgan n, L. Rolband  n, S. LeBlanc n 

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Photochemistry and Electron Transfer Studies; Spectroscopy and Quantum Chemical Studies
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UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: August 14, 2025

2023 article

MitoTracker: A useful tool in need of better alternatives

Neikirk, K., Marshall, A. G., Kula, B., Smith, N., LeBlanc, S., & Hinton, A. (2023, October 31). European Journal of Cell Biology, Vol. 102.

By: K. Neikirk *, A. Marshall *, B. Kula *, N. Smith *, S. LeBlanc n  & A. Hinton *

author keywords: MitoTracker; Mitochondria; Fluorescent probes; Membrane potential
MeSH headings : Fluorescent Dyes; Mitochondria
topics (OpenAlex): Mitochondrial Function and Pathology; Molecular Sensors and Ion Detection; Advanced biosensing and bioanalysis techniques
TL;DR: The aim is to offer alternative dyes and discuss their advantages and disadvantages, and offer options for software with alternatives to MitoTracker to expedite future experimental design. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2020 article

Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby

Hao, P., LeBlanc, S. J., Case, B. C., Elston, T. C., Hingorani, M. M., Erie, D. A., & Weninger, K. R. (2020, July 15). Proceedings of the National Academy of Sciences, Vol. 117, pp. 17775–17784.

By: P. Hao n, S. LeBlanc n , B. Case *, T. Elston *, M. Hingorani *, D. Erie *, K. Weninger n 

author keywords: smFRET; MMR; mismatch repair; MutS
MeSH headings : Adenosine Triphosphatases / metabolism; Adenosine Triphosphate / metabolism; Base Pair Mismatch; DNA / chemistry; DNA / genetics; DNA / metabolism; DNA Mismatch Repair; Hydrolysis; Models, Molecular; Multiprotein Complexes / metabolism; MutL Proteins / chemistry; MutL Proteins / metabolism; MutS DNA Mismatch-Binding Protein / chemistry; MutS DNA Mismatch-Binding Protein / metabolism; Structure-Activity Relationship
topics (OpenAlex): Genetic factors in colorectal cancer; DNA Repair Mechanisms; RNA and protein synthesis mechanisms
TL;DR: It is revealed that after the initial mobile clamp formation event, MutS undergoes frequent cycles of mismatch rebinding and mobile clamp reformation without releasing DNA, and mechanisms that localize repair complexes to the vicinity of the mismatch are supported. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 17, 2020

2018 article

Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS

LeBlanc, S. J., Gauer, J. W., Hao, P., Case, B. C., Hingorani, M. M., Weninger, K. R., & Erie, D. A. (2018, September 27). Nucleic Acids Research, Vol. 46, pp. 10782–10795.

By: S. LeBlanc n , J. Gauer*, P. Hao n, B. Case *, M. Hingorani *, K. Weninger n , D. Erie *

MeSH headings : Base Pair Mismatch / genetics; Base Pairing / physiology; DNA / chemistry; DNA Mismatch Repair / genetics; Escherichia coli; Fluorescence Resonance Energy Transfer; Genomic Instability / genetics; Models, Molecular; MutS DNA Mismatch-Binding Protein / chemistry; MutS DNA Mismatch-Binding Protein / genetics; MutS DNA Mismatch-Binding Protein / metabolism; Mutant Proteins / chemistry; Mutant Proteins / metabolism; Nucleic Acid Conformation; Protein Binding / physiology; Protein Conformation; Protein Domains / genetics; Protein Isoforms / chemistry; Protein Isoforms / genetics; Protein Isoforms / metabolism
topics (OpenAlex): Genetic factors in colorectal cancer; DNA Repair Mechanisms; Genomics and Chromatin Dynamics
TL;DR: A unified model of coordinated MutS and DNA conformational changes wherein initiation of mismatch repair is governed by a balance of DNA bending/unbending energetics and MutS conformationalChanges coupled to its nucleotide binding properties is proposed. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 11, 2019

2018 article

Single Molecule FRET: A Powerful Tool to Study Intrinsically Disordered Proteins

LeBlanc, S., Kulkarni, P., & Weninger, K. (2018, November 8). Biomolecules, Vol. 8, p. 140.

By: S. LeBlanc n , P. Kulkarni * & K. Weninger n 

author keywords: single molecule biophysics; FRET; intrinsically disordered protein; IDP
MeSH headings : Fluorescence Resonance Energy Transfer; Intrinsically Disordered Proteins / chemistry; Intrinsically Disordered Proteins / metabolism; Phosphorylation; Single Molecule Imaging
topics (OpenAlex): Protein Structure and Dynamics; Advanced Fluorescence Microscopy Techniques; DNA and Nucleic Acid Chemistry
TL;DR: The power of applyingsmFRET to IDPs is illustrated by discussing two cases in the literature of protein systems for which smFRET has successfully reported phosphorylation-induced modification (but not elimination) of the disordered properties that have been connected to impacts on the related biological function. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 14, 2019

2017 journal article

Dynamic Studies of MutS-MutL-DNA Complexes in Mismatch Repair

Biophysical Journal, 112(3), 516a–517a.

By: S. LeBlanc* , J. Gauer*, P. Hao  n, T. Walser n, K. Weninger n  & D. Erie *

Contributors: S. LeBlanc* , J. Gauer*, P. Hao  n, T. Walser n, K. Weninger n  & D. Erie *

topics (OpenAlex): Genetic factors in colorectal cancer; RNA and protein synthesis mechanisms
Sources: ORCID, Crossref, NC State University Libraries
Added: February 5, 2020

2017 article

Using Atomic Force Microscopy to Characterize the Conformational Properties of Proteins and Protein–DNA Complexes That Carry Out DNA Repair

LeBlanc, S., Wilkins, H., Li, Z., Kaur, P., Wang, H., & Erie, D. A. (2017, January 1). Methods in Enzymology on CD-ROM/Methods in Enzymology, Vol. 592, pp. 187–212.

By: S. LeBlanc* , H. Wilkins*, Z. Li *, P. Kaur  n, H. Wang  n & D. Erie *

Contributors: S. LeBlanc* , H. Wilkins*, Z. Li *, P. Kaur  n, H. Wang  n & D. Erie *

MeSH headings : DNA / chemistry; DNA / metabolism; DNA Mismatch Repair; Equipment Design; Humans; Microscopy, Atomic Force / instrumentation; Microscopy, Atomic Force / methods; MutL Proteins / chemistry; MutL Proteins / metabolism; MutS DNA Mismatch-Binding Protein / chemistry; MutS DNA Mismatch-Binding Protein / metabolism; Protein Binding; Protein Conformation; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / metabolism; Static Electricity; Thermus / chemistry; Thermus / metabolism
topics (OpenAlex): Force Microscopy Techniques and Applications; Integrated Circuits and Semiconductor Failure Analysis; RNA and protein synthesis mechanisms
Source: ORCID
Added: August 14, 2025

2016 article

Single-Molecule FRET to Measure Conformational Dynamics of DNA Mismatch Repair Proteins

Gauer, J. W., LeBlanc, S., Hao, P., Qiu, R., Case, B. C., Sakato, M., … Weninger, K. R. (2016, January 1). Methods in Enzymology on CD-ROM/Methods in Enzymology, Vol. 581, pp. 285–315.

By: J. Gauer*, S. LeBlanc* , P. Hao  n, R. Qiu  n, B. Case *, M. Sakato*, M. Hingorani *, D. Erie *, K. Weninger n

Contributors: J. Gauer*, S. LeBlanc* , P. Hao  n, R. Qiu  n, B. Case *, M. Sakato*, M. Hingorani *, D. Erie *, K. Weninger n

MeSH headings : DNA / chemistry; DNA Mismatch Repair / genetics; Fluorescence Resonance Energy Transfer / methods; Nucleic Acid Conformation; Protein Conformation; Proteins / chemistry; Single Molecule Imaging / methods
topics (OpenAlex): Genetic factors in colorectal cancer; DNA Repair Mechanisms; RNA and protein synthesis mechanisms
Source: ORCID
Added: August 14, 2025

2014 article

Fluorescence modulation in single CdSe quantum dots by moderate applied electric fields

LeBlanc, S. J., McClanahan, M. R., Moyer, T., Jones, M., & Moyer, P. J. (2014, January 17). Journal of Applied Physics, Vol. 115.

By: S. LeBlanc* , M. McClanahan*, T. Moyer*, M. Jones * & P. Moyer*

Contributors: S. LeBlanc* , M. McClanahan*, T. Moyer*, M. Jones * & P. Moyer*

topics (OpenAlex): Quantum Dots Synthesis And Properties; Chalcogenide Semiconductor Thin Films; Molecular Junctions and Nanostructures
Source: ORCID
Added: August 14, 2025

2013 article

Enhancement of Multiphoton Emission from Single CdSe Quantum Dots Coupled to Gold Films

LeBlanc, S. J., McClanahan, M. R., Jones, M., & Moyer, P. J. (2013, March 19). Nano Letters, Vol. 13, pp. 1662–1669.

By: S. LeBlanc* , M. McClanahan*, M. Jones * & P. Moyer*

Contributors: S. LeBlanc* , M. McClanahan*, M. Jones * & P. Moyer*

MeSH headings : Cadmium Compounds / chemistry; Gold / chemistry; Photons; Quantum Dots / chemistry; Selenium Compounds / chemistry; Spectrometry, Fluorescence; Sulfides / chemistry; Surface Plasmon Resonance
topics (OpenAlex): Quantum Dots Synthesis And Properties; Chalcogenide Semiconductor Thin Films; Nanowire Synthesis and Applications
Source: ORCID
Added: August 14, 2025

Employment

Updated: August 15th, 2020 15:45

2020 - present

NC State University Raleigh, North Carolina, US
Assistant Professor Physics

2014 - 2020

University of North Carolina at Chapel Hill Chapel Hill, NC, US
Postdoctoral Fellow Chemistry

Education

Updated: February 5th, 2018 12:57

2007 - 2012

University of North Carolina at Charlotte Charlotte, NC, US
Doctor of Philosophy/Nanoscale Science Physics & Optical Science/ Chemistry

Funding History

Funding history based on the linked ORCID record. Updated: February 5th, 2018 12:55

grant September 1, 2017 - August 31, 2022
Elucidating Molecular Mechanisms of Cancer Development by investigating Key DNA Repair Pathways
National Cancer Institute
grant March 1, 2017 - February 28, 2019
Elucidating molecular interactions of MutL in mismatch repair using single molecule FRET
National Institute of General Medical Sciences

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