Sabrina Murray Hess

Works (1)

Updated: July 5th, 2023 15:43

2013 journal article

Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance

Transplant Immunology, 29(1-4), 138–145.

By: S. Hess n, E. Young *, K. Miller*, B. Vincent *, A. Buntzman *, E. Collins *, J. Frelinger *, P. Hess n 

author keywords: Cytotoxic T lymphocytes; Alloreactivity; MHC; Tetramers; Minor histocompatibility antigens; Immunodominance
MeSH headings : Allografts; Animals; Bone Marrow Transplantation; CD8-Positive T-Lymphocytes / immunology; Epitopes, T-Lymphocyte / genetics; Epitopes, T-Lymphocyte / immunology; Female; H-Y Antigen / genetics; H-Y Antigen / immunology; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class I / pharmacology; Immunotoxins / genetics; Immunotoxins / immunology; Immunotoxins / pharmacology; Lymphocyte Depletion / methods; Male; Mice; Mice, Transgenic; Peptides / genetics; Peptides / immunology; Peptides / pharmacology
TL;DR: As hypothesized, toxic tetramer administration prior to immunization increased survival of cognate peptide-pulsed cells in an in vivo CTL assay, and reduced the frequency of corresponding T cells, however, tetramer-mediated decreases in either T-cell population magnified CTL responses against the non-targeted epitope, suggesting that D(b)-Uty(+) and D( b)-Smcy(+) T cells compete for a limited common resource during priming. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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