Works (100)
Updated: November 1st, 2024 04:42
2024 article
An in vitro and machine learning framework for quantifying serum albumin binding of per- and polyfluoroalkyl substances
Starnes, H. M., Green, A. J., Reif, D. M., & Belcher, S. M. (2024, October 3). TOXICOLOGICAL SCIENCES, Vol. 10.
author keywords: binding affinity; bioaccumulation; computational toxicology; PFAS; protein binding
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 22, 2024
2024 journal article
Assessing Per- and Polyfluoroalkyl Substances in Fish Fillet Using Non-Targeted Analyses
Environmental Science & Technology.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Source: ORCID
Added: August 1, 2024
2024 journal article
Combined screening and retroactive data mining for emerging perfluoroethers in wildlife and pets in the Cape Fear region of North Carolina
Chemosphere.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: July 22, 2024
2024 article
Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes
Starnes, H. M., Jackson, T. W., Rock, K. D., & Belcher, S. M. (2024, March 22). TOXICOLOGICAL SCIENCES, Vol. 3.
author keywords: binding affinity; differential scanning fluorimetry; in vitro; PFAS; species extrapolation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 22, 2024
2024 review
Temperature-Dependent Sex Determination in Crocodilians and Climate Challenges
[Review of ]. ANIMALS, 14(13).
author keywords: crocodile sex determination; aromatase; anti-M & uuml;llerian hormone; SOX-9; SF-1; TRPV; miRNA; DNA methylation; climate change
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 22, 2024
2024 journal article
The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA)
ENVIRONMENTAL HEALTH PERSPECTIVES, 132(4).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2024
2023 journal article
A vision for safer food contact materials: Public health concerns as drivers for improved testing
ENVIRONMENT INTERNATIONAL, 180.
author keywords: Food packaging; Hazard assessment; Chronic disease; Chemical safety
TL;DR:
The safety of FCMs may be improved by testing the overall migrate, including non-intentionally added substances (NIAS), of finished food contact articles, and expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 26, 2023
2023 article
Assessing Per- and Polyfluoroalkyl Substances (PFAS) in Fish Fillet Using Non-Targeted Analyses
Boatman, A. K., Chappel, J. R., Polera, M. E., Dodds, J. N., Belcher, S. M., & Baker, E. S. (2023, September 5).
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: September 6, 2023
2023 journal article
Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray's Creek North Carolina
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57(26), 9567–9579.
author keywords: canine; drinking water; equine; fluoroether; One Health; nafion by-product 2; GenX chemicals; PFOA; PFOS
TL;DR:
The utility of companion animal and livestock species as sentinels of PFAS exposure differences inside and outside of the home is supported, as in humans, renal and hepatic health in domestic animals may be sensitive to long-term PFAS exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 21, 2023
2023 article
Quantitative Cross-Species Comparison of Serum Albumin Binding of Per- and Polyfluoroalkyl Substances from Five Structural Classes
Starnes, H. M., Jackson, T. W., Rock, K. D., & Belcher, S. M. (2023, November 14).
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: January 29, 2024
2022 journal article
A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior
Frontiers in Toxicology, 4.
TL;DR:
Evaluation of the available human epidemiological, experimental, and wildlife data indicates heightened accumulation of perfluoroalkyl acids in the brain after environmental exposure, in comparison to the experimental studies, and highlights the need for additional experimental analysis of neurodevelopmental impacts of environmentally relevant concentrations and complex mixtures of PFAS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
15. Life on Land
(OpenAlex)
Source: ORCID
Added: January 6, 2023
2022 journal article
Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina
FRONTIERS IN TOXICOLOGY, 4.
author keywords: autoantibodies; autoimmune; crocodilian; immune toxicity; lupus; one health; PFAS
TL;DR:
The association of increased PFAS exposure with disrupted immune functions is interpreted to suggest that PFAS broadly alters immune activities resulting in autoimmune-like pathology in American alligators.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 6, 2023
2022 article
Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida
Belcher, S. M., Guillette, M. P., Robb, F., & Rock, K. D. (2022, August 3). ECOTOXICOLOGY, Vol. 8.
author keywords: Bioaccumulation; Biomonitoring; Ecotoxicology; Mercury; Metals; Reptile
MeSH headings : Alligators and Crocodiles; Animals; Ecosystem; Environmental Monitoring; Florida; Humans; Mercury / analysis; North Carolina
TL;DR:
It is revealed that local environmental factors greatly impact Hg bioaccumulation in alligators, and findings that reaffirm local contaminant biomonitoring in alligator populations will be critical for affective management and determination of guidelines for safe consumption of harvested alligators.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 3, 2022
2022 article
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis
Jackson, T. W., Baars, O., & Belcher, S. M. (2022, February 25). TOXICOLOGICAL SCIENCES, Vol. 2.
author keywords: gestation; epigenetic; essential metals; metallothionein; placenta
MeSH headings : Animals; Cadmium / toxicity; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Female; Homeostasis; Iron / metabolism; Liver / metabolism; Male; Manganese / metabolism; Manganese / toxicity; Metallothionein / genetics; Metallothionein / metabolism; Mice; Placenta / metabolism; Pregnancy; Zinc / toxicity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 26, 2022
2022 article
The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease
Riegl, S. D., Starnes, C., Jima, D. D., Baptissart, M., Diehl, A. M., Belcher, S. M., & Cowley, M. (2022, October 6). TOXICOLOGICAL SCIENCES, Vol. 10.
author keywords: nonalcoholic fatty liver disease; developmental toxicology; epigenetics; cadmium; genomic imprinting; developmental programming
MeSH headings : Mice; Animals; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Cadmium; Cadmium Chloride / toxicity; PPAR gamma; Liver / metabolism; Fibrosis
TL;DR:
It is demonstrated that developmental Cd exposure is sufficient to program NAFLD in later life, and Zac1 and the IGN are established as key regulators of prosteatotic and profibrotic pathways, two of the major pathological hallmarks ofNAFLD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 29, 2022
2022 journal article
Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS)
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(6), 3441–3451.
author keywords: Biomonitoring; contamination; per- and polyfluoroalkyl substances; fluoroethers; ion mobility; mass spectrometry; PFAS
MeSH headings : Alkanesulfonic Acids / analysis; Chromatography, Liquid; Fluorocarbons / analysis; United States; United States Environmental Protection Agency
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 18, 2022
2021 article
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis
Jackson, T. W., Baars, O., & Belcher, S. M. (2021, November 7). (Vol. 11). Vol. 11.
TL;DR:
It is demonstrated that Cd can preferentially cross the female placenta, accumulate in the liver, and cause lifelong dysregulation of metal ion concentrations associated with metabolic disruption.
(via Semantic Scholar)
Source: ORCID
Added: November 8, 2021
2021 journal article
Key Characteristics of Cardiovascular Toxicants
ENVIRONMENTAL HEALTH PERSPECTIVES, 129(9).
MeSH headings : Air Pollutants / analysis; Air Pollution / analysis; Carcinogens; Environmental Pollutants / toxicity; Hazardous Substances / toxicity; Particulate Matter / analysis
TL;DR:
The KCs could be used to identify potential CV toxicants and to define a set of test methods to evaluate CV toxicity in a more comprehensive and standardized manner than current approaches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021
2021 journal article
Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 55(18), 12291–12301.
author keywords: alcohols; carboxylic acids; fluorocarbons; perfluorocarbons; protein; sulfonic acids; telomer; thermal stability; toxicokinetic
MeSH headings : Alkanesulfonic Acids; Carboxylic Acids; Fluorocarbons; Fluorometry; Humans; Serum Albumin, Human; Sulfonic Acids
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 9, 2021
2021 article
Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances
Kirkwood, K. I., Fleming, J., Nguyen, H., Reif, D. M., Baker, E. S., & Belcher, S. M. (2021, August 26). (Vol. 8). Vol. 8.
TL;DR:
Over 70 PFAS were detected in the pine needles from this study, providing information from the last six decades related to PFAS exposure, contamination, and reduction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: August 27, 2021
2020 journal article
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
REPRODUCTIVE TOXICOLOGY, 98, 29–60.
Contributors: J. Heindel*, n , J. Flaws *, G. Prins *, S. Ho*, J. Mao *, H. Patisaul n , W. Ricke *
author keywords: CLARITY-BPA; Guideline study; Bisphenol A; EDC; Endocrine disruptor; GLP; Systemic effects
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; DNA Methylation; Endocrine Disruptors / toxicity; Female; Gene Expression Regulation, Developmental / drug effects; Heart / drug effects; Heart / growth & development; Male; Mammary Glands, Animal / drug effects; Mammary Glands, Animal / growth & development; Maternal-Fetal Exchange; Ovary / drug effects; Ovary / growth & development; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Prostate / drug effects; Prostate / growth & development; Rats, Sprague-Dawley; Reproducibility of Results; Thyroid Gland / drug effects; Thyroid Gland / growth & development; Urethra / drug effects; Urethra / growth & development
TL;DR:
The goal of this collaboration was to provide a more comprehensive dataset upon which to base safety standards and to determine whether industry-standard tests are as sensitive and predictive as molecular and disease-associated endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021
2020 journal article
Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function
ENVIRONMENT INTERNATIONAL, 136.
Contributors: T. Guillette n, J. McCord*, M. Guillette n, M. Polera n, K. Rachels*, C. Morgeson*, N. Kotlarz n , D. Knappe n
MeSH headings : Animals; Bass; Biomarkers; Fluorocarbons / toxicity; Liver; Rivers; Water Pollutants, Chemical / toxicity
TL;DR:
The elevated PFAS concentrations found in the Cape Fear River Striped Bass were associated with biomarkers of alterations in the liver and immune system, and correlations betweenPFAS concentrations and health-related serum biomarkers were evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 2, 2020
2020 journal article
Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring
TOXICOLOGICAL SCIENCES, 178(2), 264–280.
Contributors: T. Jackson n, G. Ryherd n, C. Scheibly n, A. Sasser n, T. Guillette n & n
author keywords: cadmium; diabetes mellitus type 2; endocrine disruption; insulin resistance; metabolic; nonalcoholic fatty liver disease; retinoic acid
MeSH headings : Animals; Cadmium / toxicity; Cadmium Chloride / toxicity; Diabetes Mellitus, Type 2 / chemically induced; Female; Insulin Resistance; Liver / physiopathology; Male; Metabolic Syndrome / chemically induced; Mice; Obesity / chemically induced; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors
TL;DR:
The observed steatosis and metabolic syndrome-like phenotypes resulting from exposure to 500 ppb CdCl2 during the pre- and perinatal period of development equivalent to human gestation indicate that Cd acts developmentally as a sex-specific delayed obesogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2021
2020 article
Heterozygous mutation of Sonic Hedgehog receptor (Ptch) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice
Jackson, T. W., Bendfeldt, G. A., Beam, K. A., Rock, K. D., & Belcher, S. M. (2020, January 25).
TL;DR:
Neuroanatomical changes related to deficient SHH signaling may alter social behavior and activity in Ptch1+/- females was explored, suggesting some behavioral abnormalities could be inherent to the medulloblastoma sequalae rather than treatment.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2020 journal article
Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice
NEUROTOXICOLOGY AND TERATOLOGY, 78.
Contributors: T. Jackson n, G. Bendfeldt n, K. Beam n, K. Rock n & n
author keywords: Cerebellum; Cortex; Holoprosencephaly; Hyperactivity; Medial prefrontal cortex; Medulloblastoma; Sex differences
MeSH headings : Animals; Cerebellum / anatomy & histology; Cerebellum / physiology; Cerebral Cortex / anatomy & histology; Cerebral Cortex / physiology; Female; Heterozygote; Hippocampus / anatomy & histology; Hippocampus / physiology; Mice, Knockout; Mutation; Patched-1 Receptor / genetics; Patched-1 Receptor / physiology; Sex Characteristics; Signal Transduction; Social Behavior
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2020
2019 journal article
Endocrine Disruption and Reproductive Pathology
TOXICOLOGIC PATHOLOGY, 47(8), 1049–1071.
Contributors: n , J. Cline *, J. Conley *, S. Groeters*, W. Jefferson *, M. Law n, E. Mackey*, A. Suen *
author keywords: endocrine disrupters; environmental toxicology; fish pathology; hormonal carcinogenesis; reproductive system; nonhuman primate; rodent pathology
MeSH headings : Animals; Congresses as Topic; Endocrine Disruptors / toxicity; Female; Fetal Development / drug effects; Heart / drug effects; Heart / embryology; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Prenatal Exposure Delayed Effects / pathology; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Reproduction / drug effects; Species Specificity; Testis / drug effects; Testis / embryology; Testis / pathology; Uterus / drug effects; Uterus / embryology; Uterus / pathology
TL;DR:
Investigations involving endocrine active substances and reproductive toxicity have dominated the landscape of ecotoxicological research, and it is now recognized that anthropomorphic substances may also adversely affect the nervous and immune systems via hormonal mechanisms and play substantial roles in metabolic diseases, such as type 2 diabetes and obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 30, 2019
2019 journal article
Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood
SCIENTIFIC REPORTS, 9(1).
MeSH headings : Animals; Animals, Newborn; Body Weight / drug effects; Cadmium / adverse effects; Disease Models, Animal; Female; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks / drug effects; Heart / anatomy & histology; Heart / drug effects; Hypotension / chemically induced; Hypotension / genetics; Maternal Exposure / adverse effects; Metabolic Networks and Pathways / drug effects; Mice; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Sequence Analysis, RNA
TL;DR:
It is proposed that a maternal Cd exposure-induced iron deficiency leads to altered cellular metabolic pathways and hypoxic conditions during fetal development; this stress may contribute to increased heart weight at birth and the programming of susceptibility to hypertension in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 7, 2019
2018 journal article
CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems
Basic & Clinical Pharmacology & Toxicology, 125(S3), 14–31.
Contributors: G. Prins *, H. Patisaul n , n & L. Vandenberg *
author keywords: Bisphenol A; CLARITY-BPA; endocrine disruptor; endocrine-disrupting chemical; oestrogen
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Congresses as Topic; Disease Models, Animal; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Female; Fetal Development / drug effects; Guidelines as Topic; Humans; National Institute of Environmental Health Sciences (U.S.) / standards; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / prevention & control; Rats, Sprague-Dawley; Risk Assessment / methods; Risk Assessment / standards; Toxicity Tests / methods; Toxicity Tests / standards; United States; United States Food and Drug Administration / standards
TL;DR:
The findings highlighted herein corroborate a significant body of evidence that documents adverse effects of BPA at doses relevant to human exposures and emphasizes the need for updated risk assessment analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 17, 2019
2018 article
CLARITY-BPA: Heart (Belcher)
Belcher, S. (2018, August). Chemical Effects in Biological Systems (CEBS).
Source: ORCID
Added: March 5, 2021
2018 journal article
Duality of estrogen receptor beta action in cancer progression
CURRENT OPINION IN PHARMACOLOGY, 41, 66–73.
Contributors: T. Guillette n, T. Jackson n & n
MeSH headings : Animals; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cerebellar Neoplasms / metabolism; Cerebellar Neoplasms / pathology; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / metabolism; Female; Humans; Male; Medulloblastoma / metabolism; Medulloblastoma / pathology; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 journal article
Elevated metabolites of acetaminophen in cord blood of children with obesity
PEDIATRIC OBESITY, 14(1).
Contributors: P. Sorrow n, R. Maguire n, S. Murphy *, n & C. Hoyo n
author keywords: Acetaminophen; children; metabolomics; obesity
MeSH headings : Acetaminophen / blood; Acetaminophen / metabolism; Case-Control Studies; Child, Preschool; Fatty Acids / blood; Female; Fetal Blood / metabolism; Humans; Male; Metabolomics / methods; Pediatric Obesity / blood; Pregnancy
TL;DR:
High‐throughput metabolomics has been used cross‐sectionally to evaluate differential metabolic profiles associated with human obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 7, 2019
2017 journal article
Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study
Toxicology Letters, 275, 123–135.
Contributors: R. Gear*, J. Kendziorski * & n
MeSH headings : Age Factors; Animals; Benzhydryl Compounds / toxicity; Body Weight / drug effects; Cardiomyopathies / chemically induced; Cardiomyopathies / pathology; Cardiotoxicity; Environmental Pollutants / toxicity; Female; Fibrosis; Male; Myocardium / pathology; Organ Size / drug effects; Phenols / toxicity; Rats, Sprague-Dawley; Severity of Illness Index; Sex Factors
TL;DR:
Across all exposure groups including vehicle controls, body weight of continuously dosed males was reduced compared to males dosed only until PND21, and heart weight was increased only in females exposed to EE, and consistent alterations in LV wall thickness were not observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2017 book
Endocrine Disruptors, Brain, and Behavior
In Oxford Scholarship Online.
Source: ORCID
Added: March 5, 2021
2017 journal article
Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity
BMC PHARMACOLOGY & TOXICOLOGY, 18(1).
author keywords: Chemotherapy; Cytoprotection; Concentration-response; Estrogen; In vitro; Isoflavones; Medulloblastoma; Phytoestrogen
TL;DR:
It is demonstrated that E2 and environmental estrogens decrease sensitivity of MB to cytotoxic chemotherapeutic drugs, and that ERβ selective and non-selective inhibition of estrogen receptor activity blocks these cytoprotective actions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk
Endocrine-Related Cancer, 24(7), 365–378.
Contributors: Y. Leung *, V. Govindarajah*, A. Cheong *, J. Veevers *, D. Song *, R. Gear*, X. Zhu*, J. Ying *
author keywords: breast cancer; developmental origin of health and disease (DOHaD); RNA-seq; transcriptomics; DNA methylation; patient survival; TCGA; windows of susceptibility; in utero exposure; bisphenol A; high-butter fat diet; non-monotonic response
MeSH headings : Animals; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / toxicity; Diet, High-Fat; Female; Mammary Glands, Animal / drug effects; Mammary Neoplasms, Experimental / chemically induced; Mammary Neoplasms, Experimental / etiology; Mammary Neoplasms, Experimental / pathology; Phenols / administration & dosage; Phenols / toxicity; Random Allocation; Rats; Risk
TL;DR:
Concurrent HBF dietary and a low-dose BPA exposure during pregnancy increases mammary tumor incidence in offspring, accompanied by alterations in mammary gland development and gene expression, and possibly through epigenetic reprogramming.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2017 journal article
Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen
SCIENTIFIC REPORTS, 7(1).
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Endocrine Disruptors / toxicity; Estrogens / toxicity; Ethinyl Estradiol / toxicity; Female; Male; Mice; Phenols / toxicity; Sex Factors; Spleen / drug effects; Spleen / ultrastructure
TL;DR:
Results indicate that both BPA and EE have dose- and sex-specific impacts on the cellular and microanatomical structures of the spleens that reveal minor alterations in immunomodulatory and hematopoietic functions, and support previous studies demonstrating the murine immune system as a sensitive target for estrogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study
Endocrinology, 157(10), 3856–3872.
Contributors: S. Arambula n, n , A. Planchart n , S. Turner * & H. Patisaul n
MeSH headings : Administration, Oral; Animals; Animals, Newborn; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / toxicity; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Female; Gene Expression / drug effects; Hippocampus / drug effects; Hippocampus / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Phenols / administration & dosage; Phenols / toxicity; Random Allocation; Rats; Rats, Sprague-Dawley; Sex Characteristics; Transcriptome / drug effects
TL;DR:
Preliminary data demonstrate prenatal BPA exposure, even at doses below the current no-observed-adverse-effect level, can alter gene expression in the developing brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Bisphenol a alters autonomic tone and extracellular matrix structure and induces sex-specific effects on cardiovascular function in male and female CD-1 mice
Endocrinology, 156(3), 882–895.
MeSH headings : Animals; Baroreflex / drug effects; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / pharmacology; Blood Pressure / drug effects; Cardiomegaly / chemically induced; Dose-Response Relationship, Drug; Electrocardiography; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / pharmacology; Ethinyl Estradiol / pharmacology; Extracellular Matrix; Female; Male; Mice; Mice, Inbred Strains; Myocardium / pathology; Phenols / administration & dosage; Phenols / pharmacology; Receptors, Adrenergic, beta; Sex Factors; Sympathetic Nervous System / drug effects
TL;DR:
Results of RNA sequence analysis identified significant sex-specific changes in gene expression in response to BPA that were consistent with the observed exposure-related phenotypic changes in the collagenous and noncollagenous extracellular matrix, cardiac remodeling, altered autonomic responses, changes in ion channel and transporter functions, and altered glycolytic and lipid metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2015 journal article
Effects of whole life exposure to Bisphenol A or 17α-ethinyl estradiol in uterus of nulligravida CD1 mice
Data in Brief, 5, 948–953.
Contributors: J. Kendziorski * & *
author keywords: BPA; Estrogen; EDC; endocrine disruption; Collagen; Fibrosis; Immune; Macrophage
TL;DR:
Uterine histopathology findings from CD1 mice exposed to BPA or 17α-ethinyl estradiol at multiple doses from conception through postnatal day 90 are reported, along with uterine pathology, impacts of exposure on collagen accumulation and F4/80 positive macrophage numbers, as an indicator of immune response in the endometrium and myometrium are presented.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2015 journal article
Estrogen receptor-β up-regulates IGF1R expression and activity to inhibit apoptosis and increase growth of medulloblastoma
Endocrinology, 156(7), 2395–2408.
MeSH headings : Animals; Apoptosis / drug effects; Apoptosis / genetics; Caspase 3 / metabolism; Cell Line, Tumor; Estradiol / pharmacology; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation, Neoplastic / drug effects; Gene Expression Regulation, Neoplastic / genetics; Humans; Insulin-Like Growth Factor I / drug effects; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Insulin-Like Growth Factor II / drug effects; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Male; Medulloblastoma / genetics; Medulloblastoma / metabolism; Mice; Mice, Knockout; Patched Receptors; Patched-1 Receptor; Proto-Oncogene Proteins c-bcl-2 / drug effects; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Receptor, IGF Type 1 / drug effects; Receptor, IGF Type 1 / genetics; Receptor, IGF Type 1 / metabolism; Receptors, Cell Surface / genetics; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 / genetics; Up-Regulation / drug effects; Up-Regulation / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2015 journal article
New Master of Science program emphasizing Safety Pharmacology—Results to date
Journal of Pharmacological and Toxicological Methods, 75, 191–192.
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2015 journal article
Non-monotonic dose-response relationships and endocrine disruptors: A qualitative method of assessment -No section-
Environmental Health: A Global Access Science Source, 14(1).
Contributors: F. Lagarde*, C. Beausoleil *, * , L. Belzunces *, C. Emond *, M. Guerbet*, C. Rousselle *
author keywords: Endocrine disruptors; NMDR; Non-monotonic; Dose-response; Risk assessment; Bisphenol A
MeSH headings : Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Environmental Exposure; Environmental Monitoring / methods; Environmental Pollutants / toxicity; Risk Assessment
TL;DR:
A stepwise decision tree was developed as a tool to standardize the analysis of NMDR relationships observed in the literature with the final aim to use these results in a Risk Assessment purpose.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2015 journal article
MeSH headings : Animals; Apoptosis / genetics; Estrogen Receptor beta / genetics; Female; Gene Expression Regulation, Neoplastic / genetics; Humans; Male; Medulloblastoma / genetics; RNA, Messenger / metabolism; Receptor, IGF Type 1 / genetics
Source: ORCID
Added: March 5, 2021
2015 journal article
Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A
Reproductive Toxicology, 58, 119–130.
Contributors: J. Kendziorski * & *
author keywords: BPA; Endocrine disruptor; Uterus; Mouse; Collagen; Dose response; Endometrial periglandular fibrosis; Equine endometrosis; Matrix metalloproteinase; Non-monotonic
MeSH headings : Age Factors; Animals; Benzhydryl Compounds / toxicity; Collagen Type I / metabolism; Collagen Type III / metabolism; Endocrine Disruptors / toxicity; Endometriosis / chemically induced; Endometriosis / genetics; Endometriosis / metabolism; Endometriosis / pathology; Endometrium / drug effects; Endometrium / metabolism; Endometrium / pathology; Female; Fibrosis; Matrix Metalloproteinase 14 / genetics; Matrix Metalloproteinase 14 / metabolism; Matrix Metalloproteinase 2 / genetics; Matrix Metalloproteinase 2 / metabolism; Mice, Inbred C57BL; Phenols / toxicity; Phenotype; Species Specificity
TL;DR:
The association between the pro-collagen shift in increased collagen expression and decreased MMP2 expression and activity implies that strain differences and BPA exposure alter regulation of endometrial remodeling and contribute to increased fibrosis, a component of several human uterine diseases.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2014 journal article
Classical nuclear hormone receptor activity as a mediator of complex concentration response relationships for endocrine active compounds
Current Opinion in Pharmacology, 19, 112–119.
MeSH headings : Animals; Cell Survival / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Humans; Receptors, Cytoplasmic and Nuclear / metabolism
TL;DR:
Evidence suggests that ligand selectivity, activation of multiple molecular targets, concerted regulation of multiple opposing endpoints, and multiple ligand binding sites within nuclear receptors also contribute to nonmonotonic concentration response relationships of endocrine active ligands.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2014 journal article
Editorial overview: Endocrine and metabolic diseases: Conversations on endocrine disruptors — rising above the din
Current Opinion in Pharmacology, 19, vi-vii.
MeSH headings : Endocrine Disruptors / toxicity; Endocrine System Diseases; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Humans; Metabolic Diseases; Risk Assessment
TL;DR:
Professorott Belcher is professor of Pharmacology d Cell Biophysics in the College of edicine at the University of Cincinnati and his search interests center on mechanisms involving estrogen ceptor beta action that influence cardiac thology and estrogen-responsive growth childhood brain tumors.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 21, 2020
2014 journal article
In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components
Toxicology Letters, 228(2), 93–102.
Contributors: * , C. Cookman*, H. Patisaul n & H. Stapleton *
author keywords: Apoptosis Endocrine disruptor; Flame retardant; Nuclear receptors; Obesity; Peroxisome proliferator-activated receptor
MeSH headings : Adipocytes / drug effects; Animals; CHO Cells; Caspase 3 / metabolism; Cell Survival / drug effects; Cricetinae; Cricetulus; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Humans; Ligands; Organophosphates / chemistry; Organophosphates / toxicity; Organotin Compounds / toxicity; PPAR gamma / drug effects; PPAR gamma / metabolism; Receptors, Cytoplasmic and Nuclear / drug effects; Transcriptional Activation / drug effects
TL;DR:
The resulting data indicated that the primary metabolic disruptive effects of FM 550 were likely mediated by the activity of the triarylphosphates at PPARγ, and have identified TPP as a candidate metabolic disruptor that also acts as a cytotoxicant.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018
2013 journal article
Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease
Endocrine-Related Cancer, 21(2).
Contributors: E. Kopras *, V. Potluri*, M. Bermudez*, K. Williams *, * & S. Kasper *
author keywords: endocrine disruptors; stem cell/progenitor cell; cancer stem cell; organ development; steroid hormone receptors
MeSH headings : Adipogenesis / drug effects; Animals; Bone Development / drug effects; Disease; Endocrine Disruptors / toxicity; Environmental Pollutants / toxicity; Germ Cells / drug effects; Heart / drug effects; Humans; Immune System / drug effects; Male; Mammary Glands, Human / drug effects; Neurogenesis / drug effects; Prostate / drug effects; Stem Cells / drug effects
TL;DR:
The current status of the understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis is reviewed.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2013 journal article
Bisphenol A and cardiometabolic risk factors in obese children
Science of The Total Environment, 470-471, 726–732.
Contributors: N. Khalil *, J. Ebert *, L. Wang *, * , M. Lee *, S. Czerwinski*, K. Kannan *
author keywords: Bisphenol A; Endocrine disruptor; Non-monotonic dose response; Childhood obesity; Nonalcoholic fatty liver disease; Spline analysis
MeSH headings : Anthropometry; Aspartate Aminotransferases / blood; Benzhydryl Compounds / blood; Body Mass Index; Child; Endocrine Disruptors / blood; Fatty Liver / blood; Fatty Liver / epidemiology; Female; Humans; Insulin Resistance; Male; Non-alcoholic Fatty Liver Disease; Obesity / blood; Obesity / epidemiology; Ohio / epidemiology; Phenols / blood; Risk Factors
TL;DR:
Urinary BPA in obese children, at least in males is associated with adverse liver and metabolic effects, and high diastolic blood pressure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2013 journal article
The estrogenic content of rodent diets, bedding, cages, and water bottles and its effect on bisphenol a studies
Journal of the American Association for Laboratory Animal Science, 52(2), 130–141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875526300&partnerID=MN8TOARS
Source: ORCID
Added: March 5, 2021
2012 journal article
Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment
Journal of Biochemical and Molecular Toxicology, 27(2), 124–136.
Contributors: H. Patisaul n , S. Roberts*, N. Mabrey n, K. Mccaffrey n, R. Gear*, J. Braun *, * , H. Stapleton *
author keywords: Anxiety; Cardiac Hypertrophy; Endocrine Disruptor; Flame Retardants; Metabolic Syndrome; Metabolism; Obesity; Obesogen; Polybrominated Diphenyl Ethers; Rodents
MeSH headings : Animals; Cardiomegaly / blood; Cardiomegaly / chemically induced; Cardiomegaly / pathology; Endocrine System / metabolism; Endocrine System / pathology; Endocrine System / physiology; Female; Flame Retardants / adverse effects; Male; Maternal Exposure / adverse effects; Obesity / blood; Obesity / chemically induced; Obesity / pathology; Pregnancy; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / pathology; Rats; Rats, Wistar; Thyroxine / blood
TL;DR:
Results are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels and induced phenotypic hallmarks associated with metabolic syndrome in the offspring.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018
2012 journal article
Estrogen-like disruptive effects of dietary exposure to bisphenol A or 17α-ethinyl estradiol in CD1 mice
International Journal of Toxicology, 31(6), 537–550.
Contributors: E. Kendig*, D. Buesing*, S. Christie*, C. Cookman*, R. Gear*, E. Hugo *, S. Kasper*, J. Kendziorski *
author keywords: Bisphenol A; diabetes; endocrine disruptor; estrogen; metabolic effects; obesity; prolactin
MeSH headings : Animal Feed; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Environmental Pollutants / toxicity; Estrogens / toxicity; Ethinyl Estradiol / toxicity; Female; Glucose Tolerance Test; Male; Maternal Exposure; Mice; Mice, Inbred Strains; No-Observed-Adverse-Effect Level; Obesity / chemically induced; Organ Size / drug effects; Paternal Exposure; Phenols / toxicity; Reproduction / drug effects; Sex Factors; Sexual Maturation / drug effects; Sperm Count; Spermatozoa / drug effects; Uterus / drug effects
TL;DR:
Overall, BPA was found to have modest, sex specific endocrine disruptive effects on a variety of end points below the established no observed adverse effect level, and the dose response characteristics for many of the effects were nonmonotonic and not predictable from high-dose extrapolations.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2012 journal article
Inhibition of stathmin1 accelerates the metastatic process
Cancer Research, 72(20), 5407–5417.
Contributors: K. Williams *, R. Ghosh *, P. Giridhar *, G. Gu *, T. Case *, * , S. Kasper *
MeSH headings : Base Sequence; Cells, Cultured; DNA Primers; Down-Regulation; Humans; Male; Neoplasm Metastasis; Signal Transduction; Stathmin / antagonists & inhibitors
TL;DR:
It is reported for the first time that STMN1 strongly inhibits metastatic behavior in both normal epithelial and cancerous epithelial cells, suggesting that there may be a tumor stage-specific window-of-opportunity in which conserving ST MN1 expression is required to inhibit emergence of metastatic disease.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2012 journal article
Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17α-ethinyl estradiol or the endocrine disrupting chemical bisphenol A
Reproductive Toxicology, 34(1), 22–30.
Contributors: J. Kendziorski *, E. Kendig*, R. Gear* & *
author keywords: Bisphenol A; Macrophage; Pyometra; Uterus; Mouse; Estrogen; Endocrine disruptor; Immune response
MeSH headings : Animals; Benzhydryl Compounds; Cell Count; Endocrine Disruptors / toxicity; Estrogens, Non-Steroidal / toxicity; Ethinyl Estradiol / toxicity; Female; Fertility / drug effects; Macrophages / cytology; Macrophages / drug effects; Macrophages / immunology; Male; Mice; Mice, Inbred C57BL; Phenols / toxicity; Pyometra / chemically induced; Pyometra / immunology; Pyometra / pathology; Species Specificity; Uterus / drug effects; Uterus / immunology; Uterus / pathology
TL;DR:
It is suggested that BPA enhances immune responsiveness of the uterus and that heightened responsiveness in C57BL/6 females is related to increased susceptibility to pyometra.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2011 journal article
Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles
Chemosphere, 85(6), 943–947.
author keywords: Bisphenol A; Copolyester; Epoxy resins; Endocrine disrupting chemicals; Polycarbonate; Water bottles
MeSH headings : Aluminum / chemistry; Benzhydryl Compounds; Endocrine Disruptors / analysis; Endocrine Disruptors / chemistry; Food Packaging / methods; Phenols / analysis; Phenols / chemistry; Plastics / chemistry; Recycling; Stainless Steel / chemistry; Water / chemistry
TL;DR:
The results from this study demonstrate that when used according to manufacturers' recommendations reusable water bottles constructed from "BPA-free" alternative materials are suitable for consumption of beverages free of BPA contamination.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2011 journal article
Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling
PLoS ONE, 6(9).
MeSH headings : Animals; Arrhythmias, Cardiac / chemically induced; Arrhythmias, Cardiac / metabolism; Arrhythmias, Cardiac / pathology; Benzhydryl Compounds; Calcium Signaling / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / pharmacology; Estradiol / pharmacology; Estrogen Receptor beta / deficiency; Estrogen Receptor beta / genetics; Estrogens / pharmacology; Female; Gene Knockout Techniques; Heart / drug effects; Heart Ventricles / drug effects; Heart Ventricles / pathology; Male; Mice; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Phenols / pharmacology; Rats; Sarcoplasmic Reticulum / drug effects; Sarcoplasmic Reticulum / metabolism; Sex Characteristics; Time Factors
TL;DR:
Physiologically-relevant concentrations of BPA and E2 promote arrhythmias in a female-specific manner in rat hearts; the pro-arrhythmic actions of estrogens are mediated by ERβ-signaling through alterations of myocyte Ca2- handling, particularly increases in SR Ca2+ leak.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2011 journal article
Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17β-estradiol and the environmental endocrine disruptor bispheno A
Endocrinology, 153(2), 712–720.
MeSH headings : Animals; Benzhydryl Compounds; Calcium / metabolism; Calcium Signaling / physiology; Cells, Cultured; Dose-Response Relationship, Drug; Endocrine Disruptors / pharmacology; Estradiol / administration & dosage; Estradiol / pharmacology; Female; Male; Mice; Mice, Knockout; Myocardial Contraction / drug effects; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenols / administration & dosage; Phenols / pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Sex Characteristics
TL;DR:
The sex-specific sensitivity of myocytes to estrogens and the rapid arrhythmogenic effects of BPA and estradiol in the female heart are regulated by the balance between ERα and ERβ signaling.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2010 journal article
Defining hormesis: Evaluation of a complex concentration response phenomenon
International Journal of Toxicology, 29(3), 235–246.
author keywords: hormesis; dose-response relationship; threshold model; beta-curve; biphasic effects; nonmonotonic; low-dose effects; subthreshold response
MeSH headings : Animals; Dose-Response Relationship, Drug; History, 16th Century; History, 19th Century; History, Ancient; Humans; Models, Biological; Nonlinear Dynamics; Pharmacokinetics; Pharmacology / methods; Terminology as Topic; Toxicology / history; Toxicology / methods
TL;DR:
By examining the history of this dose-response theory, it is clear that both pharmacological and toxicological studies provide evidence for hormetic dose responses, but retrospective examination of studies can be problematic at best.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2010 journal article
Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research
Toxicological Sciences, 115(2), 612–613.
Contributors: F. Saal *, B. Akingbemi *, * , D. Crain*, D. Crews *, L. Guidice*, P. Hunt *, C. Leranth*
MeSH headings : Animals; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Estrogens, Non-Steroidal / toxicity; Ethinyl Estradiol / toxicity; Female; Fertility / drug effects; Genitalia, Female / abnormalities; Genitalia, Female / drug effects; Guidelines as Topic; Male; Maternal Exposure; No-Observed-Adverse-Effect Level; Pregnancy; Rats; Rats, Long-Evans; Research Design / standards; Toxicity Tests / methods; Toxicity Tests / standards
TL;DR:
This dissertation aims to provide a history of tennis in China from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which the sport was introduced to China.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2010 journal article
Rapid signaling actions of environmental estrogens in developing granule cell neurons are mediated by estrogen receptor β
Endocrinology, 151(12), 5689–5699.
MeSH headings : Animals; Cell Death; Endocrine Disruptors / chemistry; Endocrine Disruptors / pharmacology; Environmental Pollutants; Estrogen Receptor beta / metabolism; Estrogens / chemistry; Estrogens / pharmacology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Molecular Structure; Neurons / cytology; Neurons / drug effects; Neurons / physiology; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction
TL;DR:
The utility of estrogen sensitive developing granule cells as an in vitro assay for elucidating rapid estrogen-signaling mechanisms and to detect EDCs that act at ERβ to rapidly regulate intracellular signaling is demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2009 journal article
Blockade of estrogen receptor signaling to improve outlook for medulloblastoma sufferers
Future Oncology, 5(6), 751–754.
MeSH headings : Adolescent; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms / drug therapy; Child; Child, Preschool; Drug Synergism; Estrogen Antagonists / therapeutic use; Humans; Infant; Medulloblastoma / drug therapy; Receptors, Estrogen / antagonists & inhibitors; Signal Transduction / drug effects; Young Adult
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2009 journal article
Good laboratory practices: Myers et al. respond
Environmental Health Perspectives, 117(11).
Contributors: J. Myers, F. Vom Saal*, J. Taylor *, B. Akingbemi *, K. Arizono *, * , T. Colborn*, I. Chahoud*
TL;DR:
The aim in writing the commentary was to show—through an analysis of the application of GLP data on bisphenol A (BPA) in regulatory proceedings—that GLP by itself is insufficient to guarantee valid and reliable science.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2009 journal article
Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: The case of bisphenol A
Environmental Health Perspectives, 117(3), 309–315.
Contributors: J. Myers, F. Saal *, B. Akingbemi *, K. Arizono *, * , T. Colborn*, I. Chahoud*, D. Crain*
author keywords: bisphenol A; endocrine disruptors; FDA; Food and Drug Administration; GLP; good laboratory practices; low-dose; nonmonotonic; positive control
MeSH headings : Benzhydryl Compounds; Clinical Laboratory Techniques / standards; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Phenols / toxicity; Public Health Practice / standards; Risk Assessment / methods; Risk Assessment / standards
TL;DR:
Differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories are reviewed to identify hazards and molecular mechanisms mediating adverse effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: ORCID
Added: March 5, 2021
2008 journal article
Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma
Endocrinology, 150(3), 1112–1121.
MeSH headings : Adolescent; Animals; Cell Movement / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cerebellar Neoplasms / genetics; Cerebellar Neoplasms / metabolism; Cerebellar Neoplasms / pathology; Child; Child, Preschool; Down-Regulation / drug effects; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Female; Fulvestrant; Humans; Infant; Male; Medulloblastoma / genetics; Medulloblastoma / metabolism; Medulloblastoma / pathology; Mice; Mice, Nude; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Xenograft Model Antitumor Assays
TL;DR:
It is demonstrated that the physiological actions of estrogens in MD are mediated by ERbeta, which has defined antiestrogen therapy as a potentially efficacious clinical approach to improve the long-term outcomes for MD patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2008 book
Cardiovascular effects of steroidal agents
In Cardiovascular Toxicology, Fourth Edition (pp. 367–428). http://www.scopus.com/inward/record.url?eid=2-s2.0-85057367081&partnerID=MN8TOARS
Source: ORCID
Added: March 5, 2021
2007 journal article
Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons
Toxicology Letters, 176(2), 149–156.
Contributors: H. Le*, E. Carlson *, J. Chua * & *
author keywords: BPA endocrine disruption; estrogen; neurotoxicity; non-genomic
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Cell Survival / drug effects; Cells, Cultured; Cerebellum / cytology; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endocrine Disruptors / chemistry; Endocrine Disruptors / metabolism; Endocrine Disruptors / toxicity; Enzyme-Linked Immunosorbent Assay; Estradiol / pharmacology; Estrogens / toxicity; Female; Humans; Immunochemistry; L-Lactate Dehydrogenase / metabolism; Neurons / cytology; Neurons / drug effects; Neurons / metabolism; Phenols / chemistry; Phenols / metabolism; Phenols / toxicity; Polycarboxylate Cement / chemistry; Product Packaging; Rats; Rats, Sprague-Dawley; Temperature; Time Factors; Water / analysis; Water / chemistry
TL;DR:
The estrogenic bioactivity of the BPA-like immunoreactivity released into the water samples was confirmed using an in vitro assay of rapid estrogen signaling and neurotoxicity in developing cerebellar neurons and should be considered as a contributing source to the total "EDC-burden" to which some individuals are exposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2007 journal article
Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
Reproductive Toxicology, 24(2), 131–138.
Contributors: F. Saal *, B. Akingbemi *, * , L. Birnbaum *, D. Crain*, M. Eriksen *, F. Farabollini*, L. Guillette Jr.
author keywords: bisphenol A; in vitro; in vivo; rat; mouse; aquatic animal; cancer; low dose; non-monotonic dose-response curves; developmental programming
MeSH headings : Air Pollutants, Occupational / poisoning; Animals; Animals, Wild; Benzhydryl Compounds; Consensus; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal / poisoning; Female; Humans; Male; Models, Animal; National Institutes of Health (U.S.); North Carolina; Phenols / poisoning; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment / methods; Risk Assessment / standards; United States; United States Environmental Protection Agency
TL;DR:
This document is a summary statement of the outcome from he meeting: “Bisphenol A: An Examination of the Relevance of cological, In vitro and Laboratory Animal Studies for Assessng Risks to Human Health” sponsored by both the NIEHS and IDCR at NIH/DHHS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: March 8, 2020
2007 journal article
In vitro molecular mechanisms of bisphenol A action
Reproductive Toxicology, 24(2), 178–198.
Contributors: Y. Wetherill*, B. Akingbemi *, J. Kanno *, J. McLachlan *, A. Nadal *, C. Sonnenschein *, C. Watson*, R. Zoeller *, *
author keywords: bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl) propane; endocrine disruption; endocrine disrupting chemical (EDC); rapid signaling; estrogen receptor; androgen receptor; thyroid receptor; thyroid hormone; GPR30; non-classical membrane estrogen receptor; immune system; allergic resonse; in vitro mechanisms; cell specificity; expert panel review
MeSH headings : Animals; Benzhydryl Compounds; Dose-Response Relationship, Drug; Endocrine Disruptors / pharmacokinetics; Endocrine Disruptors / toxicity; Environmental Exposure / analysis; Female; Fertility / drug effects; Humans; Male; Phenols / chemistry; Phenols / pharmacokinetics; Phenols / toxicity; Reproduction / drug effects
TL;DR:
This review is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2007 journal article
Rapid signaling mechanisms of estrogens in the developing cerebellum
Brain Research Reviews, 57(2), 481–492.
author keywords: cerebellum; development; ERK; estrogen; non-genomic; signal transduction
MeSH headings : Animals; Brain Neoplasms / metabolism; Cerebellum / embryology; Cerebellum / metabolism; Child; Estrogens / metabolism; Humans; Receptors, Estrogen / metabolism; Signal Transduction / physiology
TL;DR:
The goal of this review is to develop a contextual framework to understand the generalized function of estrogen during development of brain regions not known to be sexually specialized by building this framework on the more well-developed foundation of estrogen's gonad-driven sex-specific actions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 21, 2021
2005 journal article
Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: Implications for modulation of multiple homeostatic systems including feeding and sleep–wake behaviors
Neuroscience, 137(4), 1331–1346.
Contributors: * , A. Zsarnovszky*, P. Crawford*, H. Hemani*, L. Spurling* & T. Kirley *
author keywords: nucleoside triphosphate diphosphohydrolase; NTPDase3; CD39L3; immunohistochemistry; purinergic signaling; orexin/hypocretin co-localization
MeSH headings : Adenosine Triphosphate / metabolism; Amino Acid Sequence; Animals; Brain / enzymology; Brain / physiology; Cloning, Molecular; Feeding Behavior / physiology; Female; Homeostasis; Molecular Sequence Data; Nerve Fibers / enzymology; Ovariectomy; Peptide Fragments / chemistry; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase / metabolism; Pyrophosphatases / genetics; Pyrophosphatases / metabolism; Rats; Sleep / physiology; Wakefulness / physiology
Sources: Crossref, ORCID, NC State University Libraries
Added: January 21, 2021
2005 journal article
Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: Potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A
Endocrinology, 146(12), 5388–5396.
Contributors: A. Zsarnovszky*, H. Le*, H. Wang * & *
MeSH headings : Aging / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds; Cerebellar Cortex / enzymology; Dose-Response Relationship, Drug; Drug Combinations; Endocrine System / drug effects; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / pharmacology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Immunohistochemistry; Male; Phenols / administration & dosage; Phenols / pharmacology; Rats; Rats, Sprague-Dawley; Signal Transduction / drug effects
TL;DR:
It is shown that ERK1/2 signaling in the cerebellum of neonatal and mature rats was rapidly responsive to E(2) and during development to the environmental estrogen bisphenol A (BPA) and the ability of BPA to act as a highly potent E( 2) mimetic and to also disrupt the rapid actions of E(3) at very low concentrations during cerebellar development highlights the potential low-dose impact of xenoestrogens on the developing
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2005 journal article
Rapid estrogenic regulation of extracellular signal-regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A
Endocrinology, 146(12), 5397–5406.
MeSH headings : Animals; Cells, Cultured; Cerebellum / cytology; Cerebellum / metabolism; Cyclic AMP-Dependent Protein Kinases / physiology; Enzyme Activation / physiology; Estradiol / pharmacology; Estrogens / physiology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; GTP-Binding Proteins / physiology; Intracellular Membranes / enzymology; Male; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Neurons / metabolism; Pertussis Toxin / pharmacology; Phosphoprotein Phosphatases / metabolism; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Signal Transduction / drug effects; Signal Transduction / physiology; Time Factors
TL;DR:
The presented evidence indicates that the rapid effects of estrogens on ERK signaling in cerebellar granule cells are induced through a novel G protein-coupled receptor mechanism that requires PKA and Src-kinase activity to link E(2) to the ERK/MAPK signaling module.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2004 journal article
Alterations of cerebellar mRNA specific for BDNF, p75NTR, and TrkB receptor isoforms occur within hours of ethanol administration to 4-day-old rat pups
Developmental Brain Research, 151(1-2), 99–109.
Contributors: Y. Ge *, * & K. Light*
author keywords: Purkinje cell; TrkB isoform; ethanol exposure; RT-PCR; mRNA; neurotrophin; cerebellum; toxicity; apoptosis; BDNF signaling
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Central Nervous System Depressants / pharmacology; Cerebellum / drug effects; Cerebellum / metabolism; Dose-Response Relationship, Drug; Ethanol / pharmacology; Female; Male; Pregnancy; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkB / genetics; Receptor, trkB / metabolism; Receptors, Nerve Growth Factor / genetics; Receptors, Nerve Growth Factor / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Time Factors
TL;DR:
The hypothesis that ethanol induces a disruption of BDNF-TrkB signaling that results in loss of apoptotic suppression in vulnerable Purkinje cells by growth factor withdrawal is supported.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2004 journal article
Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9
Molecular Brain Research, 129(1-2), 124–134.
Contributors: Y. Ge *, * , D. Pierce* & K. Light*
author keywords: apoptosis; Bcl2; Bad; Bax; RT-PCR; Purkinje; cerebellum; ethanol; mRNA
MeSH headings : Actins / metabolism; Animals; Animals, Newborn; Apoptosis / drug effects; Apoptosis / physiology; Calbindins; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cerebellum / cytology; Cerebellum / drug effects; Cerebellum / physiology; Dose-Response Relationship, Drug; Ethanol / administration & dosage; Ethanol / blood; Ethanol / pharmacology; Female; Humans; Male; Pregnancy; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G / metabolism; bcl-2-Associated X Protein; bcl-Associated Death Protein
TL;DR:
The results of this study are in agreement with and provide further support for the hypothesis that ethanol interrupts the active suppression of apoptosis that is a crucial feature of Purkinje cell vulnerability during this time period.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2004 journal article
Detection of Purkinje cell loss following drug exposures to developing rat pups using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis for calbindin-D28k mRNA expression
Toxicology Letters, 150(3), 325–334.
Contributors: Y. Ge *, * , D. Pierce* & K. Light*
MeSH headings : Administration, Oral; Animals; Animals, Newborn; Calbindin 1; Calbindins; Cell Count; Dose-Response Relationship, Drug; Ethanol / toxicity; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Purkinje Cells / cytology; Purkinje Cells / drug effects; Purkinje Cells / metabolism; RNA, Messenger / biosynthesis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; S100 Calcium Binding Protein G / biosynthesis; Valproic Acid / toxicity
TL;DR:
Analysis of mRNA expression specific to calbindin-D28k by comparison to matched controls provides a reliable means of determining whether cell loss has occurred, regardless of whether the cell loss was induced by prenatal valproic acid or postnatal ethanol exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 21, 2021
2004 journal article
Estrogen receptor expression in a human primitive neuroectodermal tumor cell line from the cerebral cortex: estrogen stimulates rapid ERK1/2 activation and receptor-dependent cell migration
Biochemical and Biophysical Research Communications, 319(3), 753–758.
author keywords: ER alpha; ER beta; ERK1/2; estrogen; estrogen receptor; growth; hormone responsive; MAPK; migration; non-genomic; PNET; signal transduction
MeSH headings : Animals; Brain Neoplasms / metabolism; Cell Line, Tumor; Cell Movement / physiology; Cerebral Cortex / metabolism; Cerebral Cortex / pathology; Enzyme Activation; Estrogens / metabolism; Humans; MAP Kinase Signaling System / physiology; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Neuroectodermal Tumors, Primitive / metabolism; Receptors, Estrogen / metabolism; Transcriptional Activation
TL;DR:
Results of immunoblot studies using ER-specific antiserum indicate that both ERalpha and ERbeta are expressed in PFSK1 cells, suggesting that rapid actions of E(2) and ER-mediated processes might contribute to the metastatic phenotype of some PNETs.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 21, 2021
2004 journal article
Spatial, temporal, and cellular distribution of the activated extracellular signal regulated kinases 1 and 2 in the developing and mature rat cerebellum
Developmental Brain Research, 150(2), 199–209.
author keywords: neurotransmitters, modulators, transporters and receptors; second messengers and phosphorylation; Bergmann glia; cerebellum; development; active EPK1/2; glia; granule cell; neuron; immunohistochemistry; kinase; MAPK; Purkinje cell; signal transduction
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Cell Count / methods; Cerebellum / enzymology; Cerebellum / growth & development; Cerebellum / metabolism; Glial Fibrillary Acidic Protein / metabolism; Immunohistochemistry / methods; Indoles / metabolism; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Purkinje Cells / metabolism; Rats; Rats, Sprague-Dawley
TL;DR:
A high degree of developmental plasticity was observed in the spatiotemporal distribution of cerebellar pERK-IR suggesting that the ERK-pathway plays a dynamic role in regulating neuronal and glial migration, proliferation and differentiation in the developing cerebellum.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2003 journal article
Estrogens and ICI182,780 (Faslodex) modulate mitosis and cell death in immature cerebellar neurons via rapid activation of p44/p42 mitogen-activated protein kinase
Journal of Neuroscience, 23(12), 4984–4995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038790428&partnerID=MN8TOARS
Source: ORCID
Added: March 5, 2021
2002 journal article
Estrogen regulates GFAP-expression in specific subnuclei of the female rat interpeduncular nucleus: A potential role for estrogen receptor β
Brain Research, 958(2), 488–496.
author keywords: astrocyte; estrogen; estrogen receptor betas; glia, glial fibrillary acidic protein immunohistochemistry; interpeduncular nucleus
MeSH headings : Animals; Estradiol / pharmacology; Estrogen Receptor beta; Estrogens / pharmacology; Female; Glial Fibrillary Acidic Protein / analysis; Glial Fibrillary Acidic Protein / biosynthesis; Mesencephalon / chemistry; Mesencephalon / drug effects; Mesencephalon / metabolism; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / analysis; Receptors, Estrogen / physiology
TL;DR:
Results indicate that E(2), in the absence of other ovarian hormones, modulates GFAP-expression within select IPN subnuclei and that these affects are dependent on position along the AP axis and suggest that in the IPN, E( 2) may directly modulateGFAP- expression through ERbeta-mediated mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2002 journal article
Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum
Brain Research, 924(1), 71–81.
Contributors: K. Light*, D. Brown*, B. Newton *, * & C. Kane*
author keywords: cerebellum; truncated TrkB; TrkC; ethanol exposure; immunohistochemical
MeSH headings : Alcohol-Induced Disorders, Nervous System / metabolism; Alcohol-Induced Disorders, Nervous System / physiopathology; Animals; Brain-Derived Neurotrophic Factor / metabolism; Cell Differentiation / drug effects; Cell Differentiation / physiology; Cerebellar Cortex / drug effects; Cerebellar Cortex / growth & development; Cerebellar Cortex / pathology; Ethanol / pharmacology; Female; Fetal Alcohol Spectrum Disorders / metabolism; Fetal Alcohol Spectrum Disorders / physiopathology; Immunohistochemistry; Male; Nerve Degeneration / chemically induced; Nerve Degeneration / metabolism; Nerve Degeneration / physiopathology; Nerve Growth Factors / metabolism; Neurotrophin 3 / metabolism; Pregnancy; Purkinje Cells / drug effects; Purkinje Cells / metabolism; Purkinje Cells / pathology; Rats; Rats, Sprague-Dawley; Receptor, trkB / metabolism; Receptor, trkC / metabolism; Receptors, Nerve Growth Factor / drug effects; Receptors, Nerve Growth Factor / metabolism
TL;DR:
Ethanol selectively decreased Purkinje cell expression of TrkB and TrkC receptors following exposures within the vulnerable period (PN4-6), suggesting that ethanol may induce loss ofPurkinje cells by alteration of neurotrophic regulation at this critical stage.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2002 journal article
Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat
Neuroscience, 114(2), 327–337.
author keywords: cerebellum; neuronal development; apoptosis; caspase-3; cytochrome c
MeSH headings : Alcohol-Induced Disorders, Nervous System / metabolism; Alcohol-Induced Disorders, Nervous System / pathology; Alcohol-Induced Disorders, Nervous System / physiopathology; Animals; Animals, Newborn; Apoptosis / drug effects; Apoptosis / physiology; Calbindin 1; Calbindins; Caspase 3; Caspases / drug effects; Caspases / metabolism; Cerebellar Cortex / drug effects; Cerebellar Cortex / growth & development; Cerebellar Cortex / pathology; Cytochrome c Group / drug effects; Cytochrome c Group / metabolism; Drug Administration Schedule; Ethanol / toxicity; Female; Fetal Alcohol Spectrum Disorders / metabolism; Fetal Alcohol Spectrum Disorders / pathology; Fetal Alcohol Spectrum Disorders / physiopathology; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondria / pathology; Nerve Degeneration / chemically induced; Nerve Degeneration / metabolism; Nerve Degeneration / physiopathology; Pregnancy; Prenatal Exposure Delayed Effects; Purkinje Cells / drug effects; Purkinje Cells / metabolism; Purkinje Cells / pathology; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G / metabolism; Time Factors
TL;DR:
The data demonstrate that a single dose of ethanol results in a significant and extensive, lobular dependent loss of Purkinje cells within 24 h after administration, and support the hypothesis that ethanol-induced loss ofPurkinje Cells involves apoptotic mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2001 journal article
Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum
Molecular Brain Research, 93(1), 46–55.
Contributors: K. Light*, Y. Ge * & *
author keywords: cerebellum; truncated TrkB; TrkC; ethanol-exposure; RT-PCR; mRNA
MeSH headings : Actins / genetics; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor / genetics; Central Nervous System Depressants / pharmacology; Cerebellum / drug effects; Cerebellum / physiology; DNA Primers; Ethanol / pharmacology; Female; Gene Expression Regulation, Developmental / drug effects; Isomerism; Pregnancy; RNA, Messenger / analysis; Rats; Rats, Sprague-Dawley; Receptor, trkB / chemistry; Receptor, trkB / genetics; Receptor, trkC / genetics; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
The current study defines the impact of ethanol exposure at the onset of ethanol vulnerability on the relative concentrations of mRNA encoding the neurotrophic factor receptors TrkB and TrkC and identifies a specific decrease in overall TrkB receptor mRNA expression that is primarily a function of the TrkB-T2 receptor isoform.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2001 journal article
Estrogen receptor β immunoreactivity in differentiating cells of the developing rat cerebellum
Journal of Comparative Neurology, 430(3), 396–409.
author keywords: differentiation; development; glia; granule cells; growth; immunocytochemistry; migration; neurons; Purkinje cells
TL;DR:
The results suggest that ERβ may play a role in growth‐related mechanisms during differentiation of cerebellar neurons and glia during migration.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2001 journal article
Estrogenic actions in the brain: Estrogen, phytoestrogens, and rapid intracellular signaling mechanisms
Journal of Pharmacology and Experimental Therapeutics, 299(2), 408–414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034768705&partnerID=MN8TOARS
Source: ORCID
Added: March 5, 2021
2001 journal article
Identification of a developmental gradient of estrogen receptor expression and cellular localization in the developing and adult female rat primary somatosensory cortex
Developmental Brain Research, 129(1), 39–46.
author keywords: barrel; cortex; development; estrogen; estrogen receptor; immunohistochemistry; posteromedial barrel subfield; somatosensory
MeSH headings : Animals; Antibodies; Estrogens / metabolism; Female; Immunohistochemistry; Neurons / chemistry; Neurons / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / analysis; Receptors, Estrogen / biosynthesis; Receptors, Estrogen / immunology; Somatosensory Cortex / cytology; Somatosensory Cortex / growth & development; Somatosensory Cortex / metabolism
TL;DR:
Observations reveal a developmental transition of ER expression in the PMBS; ER alpha is expressed during early development, ER alpha and ER beta are co-expressed at later developmental times, and only ER beta is expressed in adults.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2001 journal article
Simplified serum- and steroid-free culture conditions for high-throughput viability analysis of primary cultures of cerebellar granule neurons
Journal of Neuroscience Methods, 110(1-2), 45–55.
author keywords: cell culture; cerebellum; excitotoxicity; glutamate; LDH release; MK-801; MTT; neuron; neuroprotection; neurotoxicity; reactive oxygen
MeSH headings : Animals; Animals, Newborn; Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Cell Survival / drug effects; Cell Survival / physiology; Cells, Cultured / cytology; Cells, Cultured / drug effects; Cells, Cultured / enzymology; Cerebellar Cortex / cytology; Cerebellar Cortex / drug effects; Cerebellar Cortex / enzymology; Coloring Agents / metabolism; Culture Media, Serum-Free / pharmacology; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists / pharmacology; Female; Glutamic Acid / toxicity; L-Lactate Dehydrogenase / metabolism; Male; Neurons / cytology; Neurons / drug effects; Neurons / enzymology; Neurophysiology / instrumentation; Neurophysiology / methods; Neuroprotective Agents / pharmacology; Oxidative Stress / drug effects; Oxidative Stress / physiology; Rats; Rats, Sprague-Dawley; Steroids / pharmacology; Tetrazolium Salts / metabolism; Thiazoles / metabolism
TL;DR:
A powerful and flexible primary culture system for cerebellar neurons that is useful for high-throughput analysis of factors that influence neuronal viability and neuroprotective against glutamate-mediated excitotoxicity is defined.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1999 journal article
Regulated expression of estrogen receptor α and β mRNA in granule cells during development of the rat cerebellum
Developmental Brain Research, 115(1), 57–69.
author keywords: alternative splicing; cerebellum; estrogen receptor; granule cell; mRNA expression; RT-PCR
MeSH headings : Alternative Splicing; Animals; Cerebellum / cytology; Cerebellum / growth & development; Cerebellum / metabolism; Estrogen Receptor alpha; Estrogen Receptor beta; Genetic Code; Neurons / metabolism; RNA, Messenger / genetics; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
While transcripts encoding both ERalpha and ERbeta were expressed in granule cells, the relative levels of expression varied significantly during the first two postnatal weeks of cerebellar development.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1998 journal article
High-affinity kainate-type ion channels in rat cerebellar granule cells
Journal of Physiology, 510(2), 401–420.
Contributors: K. Pemberton*, * , J. Ripellino* & J. Howe *
MeSH headings : Animals; Cell Line; Cerebellum / cytology; Cerebellum / drug effects; Cerebellum / metabolism; Concanavalin A / pharmacology; Electric Stimulation; Electrophysiology; Ion Channels / drug effects; Ion Channels / genetics; Ion Channels / metabolism; Membrane Potentials / physiology; Patch-Clamp Techniques; Precipitin Tests; Rats; Receptors, AMPA / antagonists & inhibitors; Receptors, Kainic Acid / biosynthesis; Receptors, Kainic Acid / drug effects; Receptors, Kainic Acid / genetics; Receptors, Kainic Acid / metabolism; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
The results demonstrate that cerebellar granule cells in culture express functional kainate‐type channels and that in most cells these channels show properties that are similar to those determined for heteromeric channels formed from GluR6(R) and KA2.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1998 journal article
Localization of the m2 muscarinic acetylcholine receptor protein and mRNA in cortical neurons of the normal and cholinergically deafferented rhesus monkey
Journal of Comparative Neurology, 390(1), 112–132.
Contributors: L. Mrzljak *, A. Levey *, * & P. Goldman-Rakic*
TL;DR:
The localization of the m2 receptor in cortical neurons and the sparing of m2 immunoreactivity in lesioned monkeys indicates that the m1 receptor is synthesized largely within the cortex and/or is localized to noncholinergic terminals of either intrinsic or extrinsic origin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
1998 journal article
Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron
Journal of Molecular Biology, 282(3), 525–541.
author keywords: group II introns; yeast mitochondria; splicing; MRS2 gene; dominant negative
MeSH headings : Alleles; Amino Acid Sequence; DNA, Fungal / genetics; DNA, Mitochondrial / genetics; Gene Expression Regulation, Fungal; Genes, Fungal; Genes, Suppressor; Introns / genetics; Ion Channels; Mitochondrial Proteins; Molecular Sequence Data; Mutation; Nuclear Proteins / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / ultrastructure; Saccharomyces cerevisiae Proteins
TL;DR:
The splicing phenotypes of these strains suggest a direct role for Mrs2 protein on group II intron splicing, but an indirect effect is not yet ruled out.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1997 journal article
Characterization of RNA editing of the glutamate-receptor subunits GluR5 and GluR6 in granule cells during cerebellar development
Molecular Brain Research, 52(1), 130–138.
Contributors: * & J. Howe *
author keywords: glutamate receptor; kainate; RNA editing; cerebellum; granule cell; development
MeSH headings : Adenosine Deaminase / biosynthesis; Animals; Cerebellum / cytology; Cerebellum / metabolism; Molecular Sequence Data; Neurons / metabolism; RNA Editing; Rats; Receptors, Kainic Acid / genetics
TL;DR:
Cerebellar granule cells express a previously unreported variant of RED1 which appears to arise from developmentally regulated alternative splicing and the expression of two double-stranded RNA adenosine deaminases implicated in GluR editing increased in granules cells between postnatal days 1 and 15.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1996 journal article
A new sodium channel α-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2
Genomics, 36(1), 202–205.
Contributors: M. Beckers*, E. Ernst*, * , J. Howe *, R. Levenson * & P. Gros *
MeSH headings : Animals; Chromosome Mapping; Crosses, Genetic; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Multigene Family / genetics; Muridae; Polymorphism, Restriction Fragment Length; Rabbits; Rats; Schwann Cells; Sodium Channels / genetics; Species Specificity
TL;DR:
The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel alpha-subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1996 journal article
Cloning of the cDNA encoding the sodium channel β1 subunit from rabbit
Gene, 170(2), 285–286.
Contributors: * & J. Howe *
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary; Humans; Molecular Sequence Data; Rabbits; Rats; Sodium Channels / genetics
TL;DR:
The nucleotide (nt) sequence of the cDNA encoding the sodium channel beta 1 subunit from rabbit (o beta 1) predicts a 218-amino-acid polypeptide which is 96.3 and 97.3% identical to the beta 1 from human and rat, respectively.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1996 book
[24] Transformation of Saccharomyces cerevisiae mitochondria using the biolistic gun
In Methods in Enzymology (Vol. 264, pp. 265–278). http://www.scopus.com/inward/record.url?eid=2-s2.0-0029873586&partnerID=MN8TOARS
Source: ORCID
Added: March 5, 2021
1995 journal article
Cloning of a sodium channel α subunit from rabbit Schwann cells
Proceedings of the National Academy of Sciences of the United States of America, 92(24), 11034–11038.
Contributors: * , C. Zerillo*, R. Levenson *, J. Ritchie* & J. Howe *
MeSH headings : Alternative Splicing; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; DNA Primers / chemistry; DNA, Complementary / genetics; Gene Expression; Genes; Molecular Sequence Data; Muscles / chemistry; Nerve Tissue Proteins / genetics; RNA, Messenger / genetics; Rabbits; Rats; Schwann Cells / chemistry; Sequence Alignment; Sequence Homology, Amino Acid; Sodium Channels / genetics
TL;DR:
The results of reverse transcriptase-polymerase chain reaction experiments suggest that expression of Nas transcripts is restricted to cells in the peripheral and central nervous systems.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1995 journal article
Studies of point mutants define three essential paired nucleotides in the domain 5 substructure of a group II intron
Molecular and Cellular Biology, 15(8), 4479–4488.
Contributors: S. Boulanger*, * , U. Schmidt*, S. Dib-Hajj *, T. Schmidt* & P. Perlman*
MeSH headings : Base Composition; Base Sequence; Conserved Sequence; DNA Mutational Analysis; Electron Transport Complex IV / genetics; Introns / genetics; Molecular Sequence Data; Phenotype; Point Mutation; RNA Splicing; RNA, Catalytic / genetics; Saccharomyces cerevisiae / genetics; Structure-Activity Relationship; Suppression, Genetic
TL;DR:
Intra-D5 second-site suppressors showed that pairing between nucleotides at positions 2 and 33 and 4 and 31 is especially important for D5 function, and the hypothesis of Madhani and Guthrie that helix 1 formed between yeast U2 and U6 small nuclear RNAs may be the spliceosomal cognate of D5 is discussed.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1995 journal article
The responsiveness of a tetracycline-sensitive expression system differs in different cell lines
Journal of Biological Chemistry, 270(23), 14168–14174.
Contributors: J. Howe *, B. Skryabin *, * , C. Zerillo* & C. Schmauss *
MeSH headings : Animals; Cell Line; Gene Expression Regulation / drug effects; Humans; RNA, Messenger / analysis; Rats; Receptors, Dopamine / genetics; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetracycline / pharmacology; Transfection
TL;DR:
HEK 293 cells do not provide a cellular environment in which the expression of a heterologous gene can be tightly controlled in a tetracycline-responsive manner, and in the induced state, its mRNA levels were found to be very low in GH3 cells and very high in HEk 293 cells.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1994 journal article
Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: Initial definition of the maturase domain of the group II intron AI2
Nucleic Acids Research, 22(11), 2057–2064.
Contributors: J. Moran *, K. Mecklenburg*, P. Sass*, * , D. Mahnke*, A. Lewin *, P. Perlman*
MeSH headings : Base Sequence; DNA, Fungal; DNA, Mitochondrial / genetics; Electron Transport Complex IV / genetics; Endoribonucleases / metabolism; Genes, Fungal; Genetic Complementation Test; Introns; Molecular Sequence Data; Mutation; Nucleotidyltransferases / metabolism; Open Reading Frames; RNA Splicing / genetics; RNA, Fungal; Restriction Mapping; Saccharomyces cerevisiae / genetics
TL;DR:
Six mutations blocking the function of a seven intron form of the mitochondrial gene encoding subunit I of cytochrome c oxidase (COXI) and mapping upstream of exon 3 were isolated and characterized and a trans-recessive mutant confirms that the intron 1 reading frame encodes a maturase function.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
1993 journal article
Mutation of the conserved first nucleotide of a group II intron from yeast mitochondrial DNA reduces the rate but allows accurate splicing
Journal of Biological Chemistry, 268(16), 11929–11938. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027156992&partnerID=MN8TOARS
Source: ORCID
Added: March 5, 2021
1992 journal article
A maturase-encoding group MA intron of yeast mitochondria self-splices in vitro
Nucleic Acids Research, 20(7), 1747–1754.
MeSH headings : Base Sequence; DNA, Mitochondrial / genetics; Introns / genetics; Mitochondria / enzymology; Molecular Sequence Data; RNA Splicing / genetics; RNA, Catalytic / metabolism; Yeasts / genetics
TL;DR:
This is the first report of a maturase-encoding intron of either group I or group II that self-splices in vitro, and it requires much higher levels of Mg2+ and added salts for ready detection of splicing activity.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
Employment
Updated: July 20th, 2019 11:01
2016 - present
North Carolina State University Raleigh, NC, US
Professor
Biological Science
Education
Updated: July 20th, 2019 11:05
1990 - 1993
University of Texas Southwestern Department of Biochemistry Dallas, TX, US
PhD
Biochemistry
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