Scott M Belcher

A vision for safer food contact materials: Public health concerns as drivers for improved testing

ENVIRONMENT INTERNATIONAL, 180.

Assessing Per- and Polyfluoroalkyl Substances (PFAS) in Fish Fillet Using Non-Targeted Analyses

Boatman, A. K., Chappel, J. R., Polera, M. E., Dodds, J. N., Belcher, S. M., & Baker, E. S. (2023, September 5).

Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray's Creek North Carolina

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57(26), 9567–9579.

A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

Frontiers in Toxicology, 4.

Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina

FRONTIERS IN TOXICOLOGY, 4.

Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida

Belcher, S. M., Guillette, M. P., Robb, F., & Rock, K. D. (2022, August 3). ECOTOXICOLOGY, Vol. 8.

Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis

Jackson, T. W., Baars, O., & Belcher, S. M. (2022, February 25). TOXICOLOGICAL SCIENCES, Vol. 2.

The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease

Riegl, S. D., Starnes, C., Jima, D. D., Baptissart, M., Diehl, A. M., Belcher, S. M., & Cowley, M. (2022, October 6). TOXICOLOGICAL SCIENCES, Vol. 10.

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS)

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(6), 3441–3451.

Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis

Jackson, T. W., Baars, O., & Belcher, S. M. (2021, November 7). (Vol. 11). Vol. 11.

Key Characteristics of Cardiovascular Toxicants

ENVIRONMENTAL HEALTH PERSPECTIVES, 129(9).

Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 55(18), 12291–12301.

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances

Kirkwood, K. I., Fleming, J., Nguyen, H., Reif, D. M., Baker, E. S., & Belcher, S. M. (2021, August 26). (Vol. 8). Vol. 8.

Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies

REPRODUCTIVE TOXICOLOGY, 98, 29–60.

Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function

ENVIRONMENT INTERNATIONAL, 136.

Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring

TOXICOLOGICAL SCIENCES, 178(2), 264–280.

Heterozygous mutation of Sonic Hedgehog receptor (Ptch) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice

Jackson, T. W., Bendfeldt, G. A., Beam, K. A., Rock, K. D., & Belcher, S. M. (2020, January 25). (Vol. 1). Vol. 1.

Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice

NEUROTOXICOLOGY AND TERATOLOGY, 78.

Elevated metabolites of acetaminophen in cord blood of children with obesity

PEDIATRIC OBESITY, 14(1).

Endocrine Disruption and Reproductive Pathology

TOXICOLOGIC PATHOLOGY, 47(8), 1049–1071.

Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood

SCIENTIFIC REPORTS, 9(1).

CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems

Basic & Clinical Pharmacology & Toxicology, 125(S3), 14–31.

CLARITY-BPA: Heart (Belcher)

Belcher, S. (2018, August). Chemical Effects in Biological Systems (CEBS).

Duality of estrogen receptor beta action in cancer progression

CURRENT OPINION IN PHARMACOLOGY, 41, 66–73.

Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study

Toxicology Letters, 275, 123–135.

Endocrine Disruptors, Brain, and Behavior

In Oxford Scholarship Online.

Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity

BMC PHARMACOLOGY & TOXICOLOGY, 18(1).

Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk

Endocrine-Related Cancer, 24(7), 365–378.

Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen

SCIENTIFIC REPORTS, 7(1).

Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study

Endocrinology, 157(10), 3856–3872.

Bisphenol a alters autonomic tone and extracellular matrix structure and induces sex-specific effects on cardiovascular function in male and female CD-1 mice

Endocrinology, 156(3), 882–895.

Effects of whole life exposure to Bisphenol A or 17α-ethinyl estradiol in uterus of nulligravida CD1 mice

Data in Brief, 5, 948–953.

Estrogen receptor-β up-regulates IGF1R expression and activity to inhibit apoptosis and increase growth of medulloblastoma

Endocrinology, 156(7), 2395–2408.

New Master of Science program emphasizing Safety Pharmacology—Results to date

Journal of Pharmacological and Toxicological Methods, 75, 191–192.

Non-monotonic dose-response relationships and endocrine disruptors: A qualitative method of assessment -No section-

Environmental Health: A Global Access Science Source, 14(1).

Response to the letter by Gallo D., et al

Endocrinology, 156(8), L8–L9.

Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A

Reproductive Toxicology, 58, 119–130.

Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease

Endocrine-Related Cancer, 21(2).

Bisphenol A and cardiometabolic risk factors in obese children

Science of The Total Environment, 470-471, 726–732.

Classical nuclear hormone receptor activity as a mediator of complex concentration response relationships for endocrine active compounds

Current Opinion in Pharmacology, 19, 112–119.

Editorial overview: Endocrine and metabolic diseases: Conversations on endocrine disruptors — rising above the din

Current Opinion in Pharmacology, 19, vi-vii.

In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components

Toxicology Letters, 228(2), 93–102.

Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment

Journal of Biochemical and Molecular Toxicology, 27(2), 124–136.

The estrogenic content of rodent diets, bedding, cages, and water bottles and its effect on bisphenol a studies

Journal of the American Association for Laboratory Animal Science, 52(2), 130–141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875526300&partnerID=MN8TOARS

Estrogen-like disruptive effects of dietary exposure to bisphenol A or 17α-ethinyl estradiol in CD1 mice

International Journal of Toxicology, 31(6), 537–550.

Inhibition of stathmin1 accelerates the metastatic process

Cancer Research, 72(20), 5407–5417.

Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17β-estradiol and the environmental endocrine disruptor bispheno A

Endocrinology, 153(2), 712–720.

Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17α-ethinyl estradiol or the endocrine disrupting chemical bisphenol A

Reproductive Toxicology, 34(1), 22–30.

Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles

Chemosphere, 85(6), 943–947.

Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling

PLoS ONE, 6(9).

Defining hormesis: Evaluation of a complex concentration response phenomenon

International Journal of Toxicology, 29(3), 235–246.

Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research

Toxicological Sciences, 115(2), 612–613.

Rapid signaling actions of environmental estrogens in developing granule cell neurons are mediated by estrogen receptor β

Endocrinology, 151(12), 5689–5699.

Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma

Endocrinology, 150(3), 1112–1121.

Blockade of estrogen receptor signaling to improve outlook for medulloblastoma sufferers

Future Oncology, 5(6), 751–754.

Good laboratory practices: Myers et al. respond

Environmental Health Perspectives, 117(11).

Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: The case of bisphenol A

Environmental Health Perspectives, 117(3), 309–315.

Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons

Toxicology Letters, 176(2), 149–156.

Cardiovascular effects of steroidal agents

In Cardiovascular Toxicology, Fourth Edition (pp. 367–428). http://www.scopus.com/inward/record.url?eid=2-s2.0-85057367081&partnerID=MN8TOARS

Rapid signaling mechanisms of estrogens in the developing cerebellum

Brain Research Reviews, 57(2), 481–492.

Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

Reproductive Toxicology, 24(2), 131–138.

In vitro molecular mechanisms of bisphenol A action

Reproductive Toxicology, 24(2), 178–198.

Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: Implications for modulation of multiple homeostatic systems including feeding and sleep–wake behaviors

Neuroscience, 137(4), 1331–1346.

Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: Potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A

Endocrinology, 146(12), 5388–5396.

Rapid estrogenic regulation of extracellular signal-regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A

Endocrinology, 146(12), 5397–5406.

Alterations of cerebellar mRNA specific for BDNF, p75NTR, and TrkB receptor isoforms occur within hours of ethanol administration to 4-day-old rat pups

Developmental Brain Research, 151(1-2), 99–109.

Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9

Molecular Brain Research, 129(1-2), 124–134.

Detection of Purkinje cell loss following drug exposures to developing rat pups using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis for calbindin-D28k mRNA expression

Toxicology Letters, 150(3), 325–334.

Estrogen receptor expression in a human primitive neuroectodermal tumor cell line from the cerebral cortex: estrogen stimulates rapid ERK1/2 activation and receptor-dependent cell migration

Biochemical and Biophysical Research Communications, 319(3), 753–758.

Spatial, temporal, and cellular distribution of the activated extracellular signal regulated kinases 1 and 2 in the developing and mature rat cerebellum

Developmental Brain Research, 150(2), 199–209.

Estrogens and ICI182,780 (Faslodex) modulate mitosis and cell death in immature cerebellar neurons via rapid activation of p44/p42 mitogen-activated protein kinase

Journal of Neuroscience, 23(12), 4984–4995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038790428&partnerID=MN8TOARS

Estrogen regulates GFAP-expression in specific subnuclei of the female rat interpeduncular nucleus: A potential role for estrogen receptor β

Brain Research, 958(2), 488–496.

Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum

Brain Research, 924(1), 71–81.

Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat

Neuroscience, 114(2), 327–337.

Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum

Molecular Brain Research, 93(1), 46–55.

Estrogen receptor β immunoreactivity in differentiating cells of the developing rat cerebellum

Journal of Comparative Neurology, 430(3), 396–409.

Estrogenic actions in the brain: Estrogen, phytoestrogens, and rapid intracellular signaling mechanisms

Journal of Pharmacology and Experimental Therapeutics, 299(2), 408–414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034768705&partnerID=MN8TOARS

Identification of a developmental gradient of estrogen receptor expression and cellular localization in the developing and adult female rat primary somatosensory cortex

Developmental Brain Research, 129(1), 39–46.

Simplified serum- and steroid-free culture conditions for high-throughput viability analysis of primary cultures of cerebellar granule neurons

Journal of Neuroscience Methods, 110(1-2), 45–55.

Regulated expression of estrogen receptor α and β mRNA in granule cells during development of the rat cerebellum

Developmental Brain Research, 115(1), 57–69.

High-affinity kainate-type ion channels in rat cerebellar granule cells

Journal of Physiology, 510(2), 401–420.

Localization of the m2 muscarinic acetylcholine receptor protein and mRNA in cortical neurons of the normal and cholinergically deafferented rhesus monkey

Journal of Comparative Neurology, 390(1), 112–132.

Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron

Journal of Molecular Biology, 282(3), 525–541.

Characterization of RNA editing of the glutamate-receptor subunits GluR5 and GluR6 in granule cells during cerebellar development

Molecular Brain Research, 52(1), 130–138.