Works (81)

Updated: June 5th, 2023 08:43

2023 article

Characterization and implications of host-cell protein aggregates in biopharmaceutical processing

Oh, Y. H., Becker, M. L., Mendola, K. M., Choe, L. H., Min, L., Lee, K. H. H., … Lenhoff, A. M. (2023, January 12). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 1.

By: Y. Oh*, M. Becker*, K. Mendola*, L. Choe*, L. Min*, K. Lee*, Y. Yigzaw*, A. Seay* ...

author keywords: host-cell proteins; monoclonal antibody; protein aggregation; protein purification; size-exclusion chromatography; unfolded protein response
Sources: Web Of Science, ORCID
Added: February 6, 2023

2023 journal article

Development of peptide affinity ligands for the purification of polyclonal and monoclonal Fabs from recombinant fluids

JOURNAL OF CHROMATOGRAPHY A, 1687.

By: R. Kilgore, W. Chu, D. Bhandari*, D. Fischler*, R. Carbonell, M. Crapanzano*, S. Menegatti

author keywords: Peptide ligands; Affinity chromatography; Fragment antigen binding; Monoclonal antibodies; Cell culture harvests
Sources: Web Of Science, ORCID
Added: January 17, 2023

2023 journal article

Integrated in silico and experimental discovery of trimeric peptide ligands targeting Butyrylcholinesterase

COMPUTATIONAL BIOLOGY AND CHEMISTRY, 102.

By: R. Mukherjee, G. Yow, S. Sarakbi, S. Menegatti, P. V. Gurgel, R. Carbonell, B. Bobay

author keywords: Acetylcholinesterase; Butyrylcholinesterase; Purification; Molecular docking; Affinity ligands
Sources: Web Of Science, ORCID
Added: January 17, 2023

2023 article

Molecular Engineering of Cyclic Azobenzene-Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo-Affinity Chromatography

Prodromou, R., Moore, B. D., Chu, W., Deal, H., San Miguel, A., Brown, A. C., … Menegatti, S. (2023, January 25). ADVANCED FUNCTIONAL MATERIALS, Vol. 1.

author keywords: affinity ligands; azobenzene-peptide hybrids; biomolecular recognition; factor VIII; photo-affinity chromatography
Sources: Web Of Science, ORCID
Added: February 20, 2023

2023 article

Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates

WENNING, C. H. U., Shastry, S., Barbieri, E., Prodromou, R., Greback-Clarke, P., Smith, W., … Menegatti, S. (2023, February 21). (Vol. 2). Vol. 2.

By: C. Wenning n, S. Shastry, E. Barbieri n, R. Prodromou n, P. Greback-Clarke n, W. Smith n, B. Moore n, R. Kilgore n ...

Source: ORCID
Added: February 22, 2023

2022 journal article

De novo discovery of peptide-based affinity ligands for the fab fragment of human immunoglobulin G

JOURNAL OF CHROMATOGRAPHY A, 1669.

By: X. Xiao, R. Kilgore, S. Sarma, W. Chu, S. Menegatti & C. Hall

author keywords: Affinity ligands; Ligand design; Biorecognition; Protein chromatography; Fragment antigen binding
Sources: Web Of Science, ORCID
Added: May 2, 2022

2022 journal article

An accelerated antibody aggregation test based on time sequenced dynamic light scattering

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 653.

By: C. Conner, J. McAndrew, S. Menegatti & O. Velev

author keywords: Protein colloidal stability; Protein aggregation; Dynamic light scattering; Antibodies
Sources: Web Of Science, ORCID
Added: November 21, 2022

2022 journal article

Development of peptide ligands for the purification of a-1 antitrypsin from cell culture fluids

JOURNAL OF CHROMATOGRAPHY A, 1679.

author keywords: a-1 antitrypsin; Peptide ligands; Affinity chromatography; Protein purification; CHO cell culture harvest
Sources: Web Of Science, ORCID
Added: October 11, 2022

2022 article

Nonwoven Membranes with Infrared Light-Controlled Permeability

Ramesh, S., Davis, J., Roros, A., Zhou, C., He, N., Gao, W., … Genzer, J. (2022, September 9). ACS APPLIED MATERIALS & INTERFACES, Vol. 9.

By: S. Ramesh, J. Davis n, A. Roros n, C. Zhou, N. He, W. Gao, S. Menegatti, S. Khan, J. Genzer

author keywords: smart-gated membranes; photothermal effect; stimuli-responsive hydrogels; nonwovens; graphene oxide
Sources: Web Of Science, ORCID
Added: November 7, 2022

2022 article

Potent Antibacterial Composite Nonwovens Functionalized with Bioactive Peptides and Polymers

Barbieri, E., Cutright, C. C., Ramesh, S., Khan, S. A., Efimenko, K., Genzer, J., & Menegatti, S. (2022, August 23). ADVANCED MATERIALS INTERFACES, Vol. 8.

By: E. Barbieri, C. Cutright, S. Ramesh, S. Khan, K. Efimenko, J. Genzer, S. Menegatti

author keywords: antimicrobial coating; bacitracin; controlled release; E; coli; polymyxin B; S; aureus; surface functionalization
Sources: Web Of Science, ORCID
Added: August 24, 2022

2022 journal article

Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

MEMBRANES, 12(10).

By: J. Fan, E. Barbieri, S. Shastry, S. Menegatti, C. Boi & R. Carbonell

author keywords: adeno-associated virus (AAV); viral vector purification; nonwovens; membrane adsorber; anion exchange; cation exchange; membrane chromatography
Sources: Web Of Science, ORCID
Added: November 14, 2022

2022 review

Self-healing and repair of fabrics: A comprehensive review of the application toolkit

[Review of ]. MATERIALS TODAY, 54, 90–109.

By: S. Ramesh, S. Khan, Y. Park, E. Ford, S. Menegatti & J. Genzer

author keywords: Self-repair; Self-healing; Fabrics; Nonwovens; Property recovery; Repair
Sources: Web Of Science, ORCID
Added: August 15, 2022

2022 article

Toward an Aptasensor for Monitoring of Tacrolimus

2022 IEEE SENSORS.

By: B. Lee n, A. Aroche n, S. Menegatti & M. Daniele

author keywords: aptamer; tacrolimus; surface plasmon resonance; square wave voltammetry
Sources: Web Of Science, ORCID
Added: February 27, 2023

2022 article

Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents

Sripada, S. A., Chu, W., Williams, T. I., Teten, M. A., Mosley, B. J., Carbonell, R. G., … Menegatti, S. (2022, April 22). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 4.

By: S. Sripada, W. Chu, T. Williams, M. Teten n, B. Mosley n, R. Carbonell, A. Lenhoff*, S. Cramer* ...

author keywords: CHO; flow-through chromatography; host cell proteins; monoclonal antibodies; peptide-based adsorbents
Sources: Web Of Science, ORCID
Added: April 10, 2022

2021 journal article

Design and in situ biosynthesis of precision therapies against gastrointestinal pathogens

CURRENT OPINION IN PHYSIOLOGY, 23.

By: D. Durmusoglu, C. Catella, E. Purnell, S. Menegatti & N. Crook

Sources: Web Of Science, ORCID
Added: October 26, 2021

2021 article

Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests

PROTEOMIC PROFILING, 2 EDITION, Vol. 2261, pp. 489–506.

By: R. Lavoie n, T. Islam n, W. Blackburn*, R. Carbonell & S. Menegatti

author keywords: Proteomics; Mass spectrometry; Host cell proteins; Monoclonal antibodies; Peptide ligands; Flow-through chromatography
Sources: Web Of Science, ORCID
Added: April 8, 2021

2021 journal article

Dual-Responsive Microgels for Structural Repair and Recovery of Nonwoven Membranes for Liquid Filtration

ACS APPLIED POLYMER MATERIALS, 3(3), 1508–1517.

By: S. Ramesh, J. Davis, A. Roros n, J. Eiben, T. Fabiani, R. Smith, L. Reynolds, B. Pourdeyhimi ...

author keywords: stimuli-responsive; microgels; nonwovens; permeability; healing; fabric repair
Sources: Web Of Science, ORCID
Added: February 13, 2021

2021 journal article

Engineering Next Generation Cyclized Peptide Ligands for Light-Controlled Capture and Release of Therapeutic Proteins

ADVANCED FUNCTIONAL MATERIALS, 31(27).

By: R. Prodromou, K. Day, S. Saberi-Bosari n, J. Schneible, M. Mabe n, A. San Miguel, M. Daniele, V. Pozdin, S. Menegatti

author keywords: azobenzene; cyclized peptide; light‐ controlled biorecognition; microfluidic devices; photochromic switch; photo‐ isomerization kinetics
Sources: Web Of Science, ORCID
Added: May 24, 2021

2021 article

In Silico Identification and Experimental Validation of Peptide-Based Inhibitors Targeting Clostridium difficile Toxin A

Xiao, X., Sarma, S., Menegatti, S., Crook, N., Magness, S. T., & Hall, C. K. (2021, December 29). ACS CHEMICAL BIOLOGY, Vol. 12.

By: X. Xiao, S. Sarma, S. Menegatti, N. Crook, S. Magness & C. Hall

Sources: Web Of Science, ORCID
Added: December 30, 2021

2021 journal article

Peptides and pseudopeptide ligands: a powerful toolbox for the affinity purification of current and next-generation biotherapeutics

JOURNAL OF CHROMATOGRAPHY A, 1635.

By: W. Chu, R. Prodromou, K. Day, J. Schneible, K. Bacon, J. Bowen n, R. Kilgore, C. Catella ...

author keywords: Affinity ligands; peptides; peptoids; pseudopeptides; biotherapeutics
Sources: Web Of Science, ORCID
Added: January 25, 2021

2021 article

Purification of polyclonal immunoglobulin G from human serum using peptide-based adsorbents

Chu, W., Sripada, S. A., Reese, H. R., Bhandari, D., Adams, A., Sly, J., … Menegatti, S. (2021, October 20). AICHE JOURNAL, Vol. 10.

By: W. Chu, S. Sripada, H. Reese, D. Bhandari*, A. Adams n, J. Sly*, M. Crapanzano*, S. Menegatti

author keywords: affinity ligands; LigaGuard (TM); LigaTrap (TM); polyclonal antibodies; protein chromatography
Sources: Web Of Science, ORCID
Added: November 1, 2021

2021 journal article

Quantitative Yeast-Yeast Two Hybrid for the Discovery and Binding Affinity Estimation of Protein-Protein Interactions

ACS SYNTHETIC BIOLOGY, 10(3), 505–514.

By: K. Bacon, A. Blain n, J. Bowen n, M. Burroughs n, N. McArthur n, S. Menegatti, B. Rao

author keywords: yeast two-hybrid; protein-protein interactions; protein engineering; yeast surface display; post-translational modification; cDNA library
Sources: Web Of Science, ORCID
Added: March 29, 2021

2021 journal article

Removal of host cell proteins from cell culture fluids by weak partitioning chromatography using peptide-based adsorbents

SEPARATION AND PURIFICATION TECHNOLOGY, 257.

By: R. Lavoie n, W. Chu, J. Lavoie, Z. Hetzler n, T. Williams, R. Carbonell, S. Menegatti

author keywords: Host cell proteins; Monoclonal antibodies; Flow-through chromatography; Weak partitioning mode; Polishing; Proteomics; Peptide ligands
Sources: Web Of Science, ORCID
Added: January 11, 2021

2021 article

Resorbable elastomers for implantable medical devices: highlights and applications

Turner, B., Ramesh, S., Menegatti, S., & Daniele, M. (2021, December 29). POLYMER INTERNATIONAL, Vol. 12.

By: B. Turner, S. Ramesh, S. Menegatti & M. Daniele

author keywords: elastomers; implantable medical devices; resorbable; bioelectronics
Sources: Web Of Science, ORCID
Added: January 10, 2022

2021 journal article

Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4).

By: J. Bowen n, J. Schneible, K. Bacon, C. Labar n, S. Menegatti & B. Rao

author keywords: yeast display library; cyclic peptide; Yes Associated Protein (YAP) 65; WW domain; transglutaminase
Sources: Web Of Science, ORCID
Added: March 22, 2021

2021 article

Surface-Bound Microgels for Separation, Sensing, and Biomedical Applications

Cutright, C. C., Harris, J. L., Ramesh, S., Khan, S. A., Genzer, J., & Menegatti, S. (2021, August 16). ADVANCED FUNCTIONAL MATERIALS, Vol. 8.

By: C. Cutright, J. Harris n, S. Ramesh, S. Khan, J. Genzer & S. Menegatti

author keywords: deposition techniques; hydrogel microparticles; stimuli-responsive polymers; surface coating; surface morphology
Sources: Web Of Science, ORCID
Added: August 17, 2021

2021 journal article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

ADVANCED THERAPEUTICS, 4(5).

By: S. Nandi, E. Mihalko, K. Nellenbach, M. Castaneda n, J. Schneible, M. Harp*, H. Deal, M. Daniele ...

author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
Sources: Web Of Science, ORCID
Added: April 5, 2021

2021 article

Ultrasound-Powered Implants: A Critical Review of Piezoelectric Material Selection and Applications

Turner, B. L., Senevirathne, S., Kilgour, K., McArt, D., Biggs, M., Menegatti, S., & Daniele, M. A. (2021, July 8). ADVANCED HEALTHCARE MATERIALS, Vol. 7.

By: B. Turner, S. Senevirathne*, K. Kilgour, D. McArt*, M. Biggs*, S. Menegatti, M. Daniele

author keywords: energy harvesting; implantable medical devices; piezoelectric devices; ultrasound; wireless power transfer
Sources: Web Of Science, ORCID
Added: July 19, 2021

2020 journal article

A multiscale coarse-grained model to predict the molecular architecture and drug transport properties of modified chitosan hydrogels

SOFT MATTER, 16(47).

By: A. Singhal*, J. Schneible, R. Lilova n, C. Hall, S. Menegatti & A. Grafmueller

Sources: Web Of Science, ORCID
Added: January 4, 2021

2020 journal article

Affibody-Binding Ligands

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11).

By: A. Barozzi n, R. Lavoie n, K. Day, R. Prodromou & S. Menegatti

author keywords: affibody; peptide ligands; affinity chromatography; biomanufacturing; protein purification
Sources: Web Of Science, ORCID
Added: July 20, 2020

2020 journal article

Chitosan Hydrogels for Synergistic Delivery of Chemotherapeutics to Triple Negative Breast Cancer Cells and Spheroids

PHARMACEUTICAL RESEARCH, 37(7).

By: J. Schneible, A. Young, M. Daniele & S. Menegatti

Sources: Web Of Science, ORCID
Added: August 10, 2020

2020 journal article

Chromatographic assay to probe the binding energy and mechanisms of homologous proteins to surface-bound ligands

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1136.

By: H. Reese n, C. Shanahan n, J. Lembo n, L. Tsonev*, A. Hirsh* & S. Menegatti

author keywords: Peptide ligands; IgG subclasses; pISep dual pH and salt LC gradients; Isothermal titration calorimetry; In silico docking, IgG peptide interaction forces
Sources: Web Of Science, ORCID
Added: February 17, 2020

2020 journal article

Discovery of Membrane-Permeating Cyclic Peptides via mRNA Display

BIOCONJUGATE CHEMISTRY, 31(10), 2325–2338.

By: J. Bowen n, A. Schloop, G. Reeves, S. Menegatti & B. Rao

Sources: Web Of Science, ORCID
Added: December 21, 2020

2020 journal article

Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids

ANALYTICAL CHEMISTRY, 92(24), 16274–16283.

By: B. Turner, K. Kilgour, S. Stine, M. Daniele & S. Menegatti

Sources: Web Of Science, ORCID
Added: January 11, 2021

2020 journal article

Exploring the physicochemical and morphological properties of peptide‐hybridized dendrimers ( DendriPeps ) and their aggregates

Journal of Polymer Science, 58(16), 2234–2247.

By: R. Smith, T. Fabiani, S. Wang, S. Ramesh, S. Khan, E. Santiso, F. Silva*, C. Gorman, S. Menegatti

author keywords: dendrimets; DendriPeps; molecular dynamics; PAMAM; reversible aggregation
Sources: Web Of Science, ORCID, Crossref
Added: July 27, 2020

2020 journal article

Highly Efficient 1-Octene Hydroformylation at Low Syngas Pressure: From Single-Droplet Screening to Continuous Flow Synthesis

ACS CATALYSIS, 10(14), 7535–7542.

By: K. Raghuvanshi, C. Zhu, M. Ramezani n, S. Menegatti, E. Santiso, D. Mason*, J. Rodgers*, M. Janka*, M. Abolhasani

author keywords: hydroformylation; flow chemistry; BISBI; continuous organic synthesis; membrane flow reactor
Sources: Web Of Science, ORCID
Added: August 17, 2020

2020 journal article

Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface Display

ACS COMBINATORIAL SCIENCE, 22(10), 519–532.

By: K. Bacon, A. Blain n, M. Burroughs n, N. McArthrur n, B. Rao & S. Menegatti

author keywords: cyclic peptides; interleukin-17 (IL-17); library screening; yeast-display libraries; affinity ligands
Sources: Web Of Science, ORCID
Added: November 9, 2020

2020 journal article

Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics

JOURNAL OF MATERIALS CHEMISTRY B, 8(17), 3852–3868.

By: J. Schneible, K. Shi, A. Young, S. Ramesh, N. He, C. Dowdey n, J. Dubnansky n, R. Libya ...

Sources: Web Of Science, ORCID
Added: June 1, 2020

2020 journal article

Nonwoven fiber mats with thermo-responsive permeability to inorganic and organic electrolytes

JOURNAL OF MEMBRANE SCIENCE, 616.

By: C. Cutright, R. Finkelstein n, E. Orlowski n, E. McIntosh n, Z. Brotherton n, T. Fabiani, S. Khan, J. Genzer, S. Menegatti

author keywords: Stimuli-responsive hydrogels; "Smart gating" membranes; Stimuli-controlled permeability; Fiber coating; Controlled transport
Sources: Web Of Science, ORCID
Added: October 12, 2020

2020 journal article

Novel peptide ligands for antibody purification provide superior clearance of host cell protein impurities

JOURNAL OF CHROMATOGRAPHY A, 1625.

By: H. Reese n, X. Xiao, C. Shanahan n, G. Driessche n, D. Fourches, R. Carbonell, C. Hall, S. Menegatti

author keywords: Peptide affinity ligands; Protein A; mAb purification; Affinity chromatography; Peptide design
Sources: Web Of Science, ORCID
Added: August 10, 2020

2020 journal article

Novel peptoid-based adsorbents for purifying IgM and IgG from polyclonal and recombinant sources

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1137.

By: H. Reese n, T. Bordelon*, C. Shanahan n, M. Crapanzano*, J. Sly* & S. Menegatti

author keywords: Peptoid ligand; Affinity purification; Protein chromatography; IgG and IgM; Antibody therapeutics
Sources: Web Of Science, ORCID
Added: February 10, 2020

2020 journal article

Packing density, homogeneity, and regularity: Quantitative correlations between topology and thermoresponsive morphology of PNIPAM-co-PAA microgel coatings

APPLIED SURFACE SCIENCE, 508.

By: C. Cutright, Z. Brotherton, L. Alexander, J. Harris, K. Shi, S. Khan, J. Genzer, S. Menegatti

author keywords: Stimuli-responsive microgels; Self-assembled monolayers; Spin coating; Particle interactions; Particle packing
Sources: Web Of Science, ORCID
Added: April 14, 2020

2020 review

Past, Present, and Future of Affinity-based Cell Separation Technologies

[Review of ]. ACTA BIOMATERIALIA, 112, 29–51.

By: K. Bacon, A. Lavoie, B. Rao, M. Daniele & S. Menegatti

author keywords: Cell purification; Immunoaffinity; MACS; FACS; Microfluidics
Sources: Web Of Science, ORCID
Added: August 3, 2020

2020 review

Peptide science: A "rule model" for new generations of peptidomimetics

[Review of ]. ACTA BIOMATERIALIA, 102, 35–74.

By: H. Reese n, C. Shanahan n, C. Proulx & S. Menegatti

author keywords: Peptides; Peptoids; Simulation; Peptidomimetics; Biomaterials
Sources: Web Of Science, ORCID
Added: February 27, 2020

2020 journal article

Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides

JOURNAL OF MATERIALS CHEMISTRY B, 8(33), 7413–7427.

By: K. Day, J. Schneible, A. Young, V. Pozdin, G. Driessche n, L. Gaffney, R. Prodromou, D. Freytes ...

Sources: Web Of Science, ORCID
Added: September 14, 2020

2020 journal article

Platelet-rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro

JOURNAL OF ORTHOPAEDIC RESEARCH, 38(6), 1365–1374.

By: J. Gilbertie, T. Schaer*, A. Schubert, M. Jacob, S. Menegatti, R. Lavoie n, L. Schnabel

author keywords: biofilms; equine model; infectious arthritis; platelet-rich plasma; Staphylococcus aureus
Sources: Web Of Science, ORCID
Added: January 27, 2020

2020 article

Purification of animal immunoglobulin G (IgG) using peptoid affinity ligands

BIOTECHNOLOGY PROGRESS.

By: H. Reese, T. Bordelon*, F. Odeh*, A. Broussard*, C. Kormos*, A. Murphy*, C. Shanahan n, S. Menegatti

Sources: Web Of Science, ORCID
Added: August 31, 2020

2020 journal article

Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis

BIOTECHNOLOGY AND BIOENGINEERING, 117(2), 438–452.

By: R. Lavoie n, A. Fazio n, T. Williams, R. Carbonell & S. Menegatti

author keywords: host cell proteins; monoclonal antibodies; polishing; peptide ligands; protein purification
Sources: Web Of Science, ORCID
Added: December 2, 2019

2020 journal article

Use of Target-Displaying Magnetized Yeast in Screening mRNA-Display Peptide Libraries to Identify Ligands

ACS COMBINATORIAL SCIENCE, 22(12), 738–744.

By: K. Bacon, J. Bowen n, H. Reese, B. Rao & S. Menegatti

author keywords: yeast surface display; yeast magnetization; peptide ligands; mRNA-display library; ligand discovery
Sources: Web Of Science, ORCID
Added: January 11, 2021

2019 journal article

Affordable Microfluidic Bead-Sorting Platform for Automated Selection of Porous Particles Functionalized with Bioactive Compounds

SCIENTIFIC REPORTS, 9(1).

By: S. Saberi-Bosari n, M. Omary n, A. Lavoie, R. Prodromou, K. Day, S. Menegatti, A. San-Miguel n

Sources: Web Of Science, ORCID
Added: May 28, 2019

2019 journal article

DendriPeps: Expanding Dendrimer Functionality by Hybridizing Poly(amidoamine) (PAMAM) Scaffolds with Peptide Segments

MACROMOLECULAR RAPID COMMUNICATIONS, 40(22).

By: R. Smith, C. Gorman & S. Menegatti

author keywords: internally functionalized dendrimers; orthogonal protection strategies; poly(amidoamine); polymer-peptide chemistry
Sources: Web Of Science, ORCID
Added: October 14, 2019

2019 journal article

Discovery and Evaluation of Peptide Ligands for Selective Adsorption and Release of Cas9 Nuclease on Solid Substrates

BIOCONJUGATE CHEMISTRY, 30(12), 3057–3068.

By: K. Day, R. Prodromou, S. Bosari n, A. Lavoie, M. Omary n, C. Market n, A. San Miguel, S. Menegatti

Sources: Web Of Science, ORCID
Added: January 13, 2020

2019 journal article

Multiplexed Competitive Screening of One-Bead-One-Component Combinatorial Libraries Using a ClonePix 2 Colony Sorter

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(20).

By: R. Lavoie n, A. Fazio n, R. Carbonell & S. Menegatti

author keywords: library screening; bioactive peptides; ligand development; affinity chromatography; affinity ligand; ClonePix 2
Sources: Web Of Science, ORCID
Added: December 16, 2019

2019 journal article

Optimization of Sequence, Display, and Mode of Operation of IgG-Binding Peptide Ligands to Develop Robust, High-Capacity Affinity Adsorbents That Afford High IgG Product Quality

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1).

By: T. Islam, A. Naik, Y. Hashimoto*, S. Menegatti & R. Carbonell

author keywords: affinity chromatography; peptide ligand; antibody purification; binding capacity; process optimization; aggregate removal
Sources: Web Of Science, ORCID
Added: March 11, 2019

2019 journal article

Screening Yeast Display Libraries against Magnetized Yeast Cell Targets Enables Efficient Isolation of Membrane Protein Binders

ACS COMBINATORIAL SCIENCE, 21(12), 817–832.

By: K. Bacon, M. Burroughs, A. Blain, S. Menegatti & B. Rao

author keywords: yeast magnetization; combinatorial library screening; ligand discovery; yeast surface display; membrane protein; Sso7d; nanobody
Sources: Web Of Science, ORCID
Added: December 30, 2019

2019 journal article

Silica resins and peptide ligands to develop disposable affinity adsorbents for antibody purification

BIOCHEMICAL ENGINEERING JOURNAL, 145, 53–61.

By: A. Naika, T. Islam, T. Terasaka, Y. Ohara*, Y. Hashimoto*, S. Menegatti, R. Carbonell

author keywords: Silica resins; Peptide ligands; Monoclonal antibodies; Llama antibodies; Rabbit antibodies
Sources: Web Of Science, ORCID
Added: May 13, 2019

2019 journal article

Tailoring the Chemical Modification of Chitosan Hydrogels to Fine-Tune the Release of a Synergistic Combination of Chemotherapeutics

BIOMACROMOLECULES, 20(8), 3126–3141.

By: J. Schneible, A. Singhal*, R. Lilova n, C. Hall, A. Grafmueller & S. Menegatti

Sources: Web Of Science, ORCID
Added: September 3, 2019

2019 journal article

Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(7).

By: R. Lavoie n, A. Fazio n, R. Blackburn n, M. Goshe, R. Carbonell & S. Menegatti

author keywords: therapeutic antibodies; host cell proteins; protein purification; peptide ligands
Sources: Web Of Science, ORCID
Added: May 6, 2019

2019 journal article

Translating antibody-binding peptides into peptoid ligands with improved affinity and stability

JOURNAL OF CHROMATOGRAPHY A, 1602, 284–299.

By: T. Bordelon*, B. Bobay, A. Murphy*, H. Reese*, C. Shanahan*, F. Odeh*, A. Broussard*, C. Kormos*, S. Menegatti

author keywords: Peptoid ligands; Molecular docking; Affinity chromatography; Antibodies; Protein A mimetic
Sources: Web Of Science, ORCID
Added: September 16, 2019

2019 journal article

Treating Tumors at Low Drug Doses Using an Aptamer-Peptide Synergistic Drug Conjugate

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(5), 1437–1441.

By: A. Pusuluri*, V. Krishnan*, V. Lensch*, A. Sarode*, E. Bunyan*, D. Vogus*, S. Menegatti, H. Soh*, S. Mitragotri*

author keywords: aptamer-drug conjugate; cancer; peptide scaffolds; synergy; targeted drug-delivery
Sources: Web Of Science, ORCID
Added: March 4, 2019

2018 journal article

Purification of human erythropoietin by affinity chromatography using cyclic peptide ligands

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1085, 1–12.

By: W. Kish n, M. Roach n, H. Sachi*, A. Naik n, S. Menegatti & R. Carbonell

author keywords: Cyclic peptide ligand; Erythropoietin purification; Affinity chromatography; Chinese hamster ovary; Pichia pastoris
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Quantum dot enabled lateral flow immunoassay for detection of cardiac biomarker NT-proBNP

Sensing and Bio-Sensing Research, 21, 46–53.

By: M. Wilkins n, B. Turner n, K. Rivera n, S. Menegatti & M. Daniele n

author keywords: NT-proBNP; cardiac biomarker; lateral flow; immunoassay; quantum dot
Sources: Crossref, ORCID
Added: February 24, 2020

2017 journal article

A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer

Journal of Controlled Release, 267, 191–202.

By: D. Vogus*, M. Evans*, A. Pusuluri*, A. Barajas*, M. Zhang*, V. Krishnan*, M. Nowak*, S. Menegatti ...

author keywords: Drug combinations; Polymer drug conjugates; Synergy; Breast cancer; Gemcitabine; Doxorubcin
Sources: Crossref, ORCID
Added: February 24, 2020

2017 journal article

Design, selection, and development of cyclic peptide ligands for human erythropoietin

JOURNAL OF CHROMATOGRAPHY A, 1500, 105–120.

By: W. Kish, H. Sachi*, A. Naik, M. Roach, B. Bobay, R. Blackburn n, S. Menegatti, R. Carbonell

author keywords: Erythropoietin; Cyclic peptide ligands; Ligand screening; Affinity chromatography; Affinity maturation; In-silico docking
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

A combined approach for predicting the cytotoxic effect of drug-nanoaggregates

Journal of Materials Chemistry B, 4(40), 6516–6523.

By: M. Wojnilowicz*, M. Tortora*, B. Bobay*, E. Santiso, M. Caruso*, L. Micheli*, M. Venanzi*, S. Menegatti, F. Cavalieri*

Sources: Crossref, ORCID
Added: March 26, 2019

2016 journal article

DAFODIL: A novel liposome-encapsulated synergistic combination of doxorubicin and 5FU for low dose chemotherapy

JOURNAL OF CONTROLLED RELEASE, 229, 154–162.

By: K. Camacho*, S. Menegatti, D. Vogus*, A. Pusuluri*, Z. Fuchs*, M. Jarvis*, M. Zakrewsky*, M. Evans*, R. Chen*, S. Mitragotri*

author keywords: Drug combinations; Synergistic; Chemotherapy; Liposomes; Nanoparticles
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

De Novo Design of Skin-Penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs

ADVANCED HEALTHCARE MATERIALS, 5(5), 602–609.

By: S. Menegatti, M. Zakrewsky*, S. Kumar*, J. De Oliveira*, J. Muraski* & S. Mitragotri*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Design of protease-resistant peptide ligands for the purification of antibodies from human plasma

Journal of Chromatography A, 1445, 93–104.

By: S. Menegatti, B. Bobay n, K. Ward n, T. Islam, W. Kish, A. Naik n, R. Carbonell

author keywords: Peptide affinity ligands; Polyclonal antibodies; Affinity chromatography; Proteolysis; Protease; Molecular docking
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Low-molecular-weight polymer-drug conjugates for synergistic anticancer activity of camptothecin and doxorubicin combinations

Nanomedicine, 11(9), 1139–1151.

By: K. Camacho*, S. Menegatti & S. Mitragotri*

author keywords: combination chemotherapy; drug delivery; linker chemistry; low-molecular-weight conjugates; polymer-drug conjugates
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

ACS Nano, 9(3), 3169–3177.

By: A. Anselmo*, M. Zhang*, S. Kumar*, D. Vogus*, S. Menegatti, M. Helgeson*, S. Mitragotri*

author keywords: elasticity; nanogel; nanoemulsion; biodistribution; circulation; targeting; nanomedicine; nanoparticles
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Peptides as skin penetration enhancers: Mechanisms of action

Journal of Controlled Release, 199, 168–178.

By: S. Kumar*, M. Zakrewsky*, M. Chen*, S. Menegatti, J. Muraski* & S. Mitragotri*

author keywords: Cell penetrating peptide; Cyclosporine; Keratin; Transporter; Topical; Transcellular
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Synergistic antitumor activity of camptothecin–doxorubicin combinations and their conjugates with hyaluronic acid

Journal of Controlled Release, 210, 198–207.

By: K. Camacho*, S. Kumar*, S. Menegatti, D. Vogus*, A. Anselmo* & S. Mitragotri*

author keywords: Chemotherapy; Drug combinations; Polymer drug conjugate; Synergistic
Sources: Crossref, ORCID
Added: August 28, 2020

2015 journal article

Synthesis and Characterization of a Self-Fluorescent Hyaluronic Acid-Based Gel for Dermal Applications

Advanced Healthcare Materials, 4(15), 2297–2305.

By: S. Menegatti, N. Ruocco*, S. Kumar*, M. Zakrewsky*, J. Sanchez De Oliveira*, M. Helgeson*, G. Leal*, S. Mitragotri*

Sources: Crossref, ORCID
Added: February 24, 2020

2014 journal article

Platelet-like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets To Target Vascular Injuries

ACS Nano, 8(11), 11243–11253.

By: A. Anselmo*, C. Modery-Pawlowski*, S. Menegatti, S. Kumar*, D. Vogus*, L. Tian*, M. Chen*, T. Squires*, A. Sen Gupta*, S. Mitragotri*

author keywords: platelets; synthetic cells; layer-by-layer; nanotechnology; hemostat; vascular targeting
Sources: Crossref, ORCID
Added: August 28, 2020

2013 journal article

Peptide-based affinity adsorbents with high binding capacity for the purification of monoclonal antibodies

Industrial & Engineering Chemistry Research, 52(26), 8800–8811.

By: W. Kish, A. Naik, S. Menegatti & R. Carbonell

Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Reversible cyclic peptide libraries for the discovery of affinity ligands

Analytical Chemistry, 85(19), 9229–9237.

By: S. Menegatti, K. Ward n, A. Naik, W. Kish, R. Blackburn n & R. Carbonell

Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands

Biotechnology and Bioengineering, 110(3), 857–870.

By: S. Menegatti, M. Hussain, A. Naik, R. Carbonell & B. Rao

author keywords: cyclic peptide; mRNA display; Fc binding; affinity ligand; library
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Alkaline-stable peptide ligand affinity adsorbents for the purification of biomolecules

Journal of Chromatography A, 1245, 55–64.

By: S. Menegatti, A. Naik, P. Gurgel & R. Carbonell

author keywords: Peptide ligand; Affinity adsorbent; NaOH stability; Modification of surface chemistry; Solid-phase peptide synthesis; Cleaning-in-place
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Process for purification of monoclonal antibody expressed in transgenic Lemna plant extract using dextran-coated charcoal and hexamer peptide affinity resin

Journal of Chromatography A, 1260, 61–66.

By: A. Naik, S. Menegatti, H. Reese n, P. Gurgel & R. Carbonell

author keywords: Dextran-coated charcoal; Transgenic plants; Hexapeptide ligand; IgG purification; Monoclonal antibody; Phenolics; Lemna minor
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Purification of polyclonal antibodies from Cohn fraction II + III, skim milk, and whey by affinity chromatography using a hexamer peptide ligand

Journal of Separation Science, 35(22), 3139–3148.

By: S. Menegatti, A. Naik, P. Gurgel & R. Carbonell

author keywords: Affinity chromatography; Immunoglobulin G; Milk; Peptide ligands; Plasma
Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media

Journal of Chromatography A, 1218(13), 1691–1700.

By: A. Naik, S. Menegatti, P. Gurgel & R. Carbonell

author keywords: Hexapeptide ligand; IgG purification; Monoclonal antibody; Affinity chromatography; Regeneration
Sources: Web Of Science, ORCID
Added: August 6, 2018

Employment

Updated: November 14th, 2018 12:31

2015 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Chemical and Biomolecular Engineering

Education

Updated: November 14th, 2018 12:33

2009 - 2013

North Carolina State University Raleigh, NC, US
Ph.D. Chemical and Biomolecular Engineering

2006 - 2008

Università degli Studi di Bologna Bologna, Emilia-Romagna, IT
M.Sc. Ingegneria Chimica