Works (4)
Updated: July 5th, 2023 15:35
2022 journal article
Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy
PLOS ONE, 17(8).
Ed(s): A. Taylor
MeSH headings : Animals; Autoimmune Diseases; Dependovirus / genetics; Genetic Therapy; Horses / genetics; Humans; Interleukin-10 / genetics; Interleukin-10 / therapeutic use; Rats; Uveitis
TL;DR:
Safety and efficacy of AAV8-Equine-IL10 to prevent EAU are demonstrated and support continued exploration of A AV gene therapy for the treatment of equine and perhaps human recurrent uveitis.
(via Semantic Scholar)
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 19, 2022
2020 journal article
Tolerability, pharmacokinetics, and pharmacodynamics of a brinzolamide episcleral sustained release implant in normotensive New Zealand white rabbits
Journal of Drug Delivery Science and Technology, 61, 102123.
author keywords: Glaucoma; Sustained-release; Episcleral; Brinzolamide; Rabbit; Tolerability
TL;DR:
Episcleral brinzolamide-loaded silicone-matrix implants were extremely well tolerated and delivered sustained drug levels and therapeutic effect for up to 28 days in a rabbit model with an estimated duration of delivery of greater than 12 months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 29, 2020
2017 journal article
AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis
Scientific Reports, 7(1).
MeSH headings : Animals; Corneal Injuries / genetics; Corneal Injuries / metabolism; Corneal Injuries / pathology; Corneal Injuries / therapy; Corneal Neovascularization / genetics; Corneal Neovascularization / metabolism; Corneal Neovascularization / pathology; Corneal Neovascularization / therapy; Dependovirus; Gene Expression; Genetic Therapy; HEK293 Cells; HLA-G Antigens / biosynthesis; HLA-G Antigens / genetics; Humans; Rabbits
TL;DR:
The collective data demonstrate the clinical potential of scAAV8G9-optHLA-G to safely and effectively treat corneal vascularization and inhibit fibrosis while alluding to broader roles in ocular surface immunity and allogenic organ transplantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Optic neuritis in dogs: 96 cases (1983-2016)
Veterinary Ophthalmology, 21(5), 442–451.
author keywords: causes of canine optic neuritis; dogs; granulomatous meningoencephalitis; meningoencephalitis of unknown etiology; ocular GME; optic neuritis
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / therapy; Dogs; Female; Magnetic Resonance Imaging; Male; Medical Records; Meningoencephalitis / complications; Meningoencephalitis / veterinary; North Carolina / epidemiology; Optic Neuritis / epidemiology; Optic Neuritis / veterinary
TL;DR:
Optic neuritis was most commonly associated with multifocal MUE or was isolated as the sole neurologic finding, with a similar incidence between the two groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: November 12, 2018
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