Sara Marie Smith

Works (4)

Updated: July 5th, 2023 15:35

2022 journal article

Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy

PLOS ONE, 17(8).

By: E. Crabtree  n, K. Uribe n, S. Smith n, D. Roberts n , J. Salmon  n, J. Bower *, L. Song *, P. Bastola *, M. Hirsch*, B. Gilger n 

Ed(s): A. Taylor

MeSH headings : Animals; Autoimmune Diseases; Dependovirus / genetics; Genetic Therapy; Horses / genetics; Humans; Interleukin-10 / genetics; Interleukin-10 / therapeutic use; Rats; Uveitis
TL;DR: Safety and efficacy of AAV8-Equine-IL10 to prevent EAU are demonstrated and support continued exploration of A AV gene therapy for the treatment of equine and perhaps human recurrent uveitis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 19, 2022

2020 journal article

Tolerability, pharmacokinetics, and pharmacodynamics of a brinzolamide episcleral sustained release implant in normotensive New Zealand white rabbits

Journal of Drug Delivery Science and Technology, 61, 102123.

By: S. Smith n, J. Salmon  n, S. Abbaraju, R. Amin & B. Gilger n 

author keywords: Glaucoma; Sustained-release; Episcleral; Brinzolamide; Rabbit; Tolerability
TL;DR: Episcleral brinzolamide-loaded silicone-matrix implants were extremely well tolerated and delivered sustained drug levels and therapeutic effect for up to 28 days in a rabbit model with an estimated duration of delivery of greater than 12 months. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 29, 2020

2017 journal article

AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis

Scientific Reports, 7(1).

By: M. Hirsch*, L. Conatser*, S. Smith n, J. Salmon n, J. Wu*, N. Buglak *, R. Davis*, B. Gilger n 

MeSH headings : Animals; Corneal Injuries / genetics; Corneal Injuries / metabolism; Corneal Injuries / pathology; Corneal Injuries / therapy; Corneal Neovascularization / genetics; Corneal Neovascularization / metabolism; Corneal Neovascularization / pathology; Corneal Neovascularization / therapy; Dependovirus; Gene Expression; Genetic Therapy; HEK293 Cells; HLA-G Antigens / biosynthesis; HLA-G Antigens / genetics; Humans; Rabbits
TL;DR: The collective data demonstrate the clinical potential of scAAV8G9-optHLA-G to safely and effectively treat corneal vascularization and inhibit fibrosis while alluding to broader roles in ocular surface immunity and allogenic organ transplantation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Optic neuritis in dogs: 96 cases (1983-2016)

Veterinary Ophthalmology, 21(5), 442–451.

By: S. Smith n, H. Westermeyer n , C. Mariani n , B. Gilger n  & M. Davidson n

author keywords: causes of canine optic neuritis; dogs; granulomatous meningoencephalitis; meningoencephalitis of unknown etiology; ocular GME; optic neuritis
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / therapy; Dogs; Female; Magnetic Resonance Imaging; Male; Medical Records; Meningoencephalitis / complications; Meningoencephalitis / veterinary; North Carolina / epidemiology; Optic Neuritis / epidemiology; Optic Neuritis / veterinary
TL;DR: Optic neuritis was most commonly associated with multifocal MUE or was isolated as the sole neurologic finding, with a similar incidence between the two groups. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: November 12, 2018

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