Works (3)

Updated: July 5th, 2023 14:48

2020 journal article

Equiprobable discrete models of site-specific substitution rates underestimate the extent of rate variability

PLOS ONE, 15(3).

By: F. Mannino n, S. Wisotsky n, S. Pond* & S. Muse n

MeSH headings : Algorithms; Amino Acid Substitution; Evolution, Molecular; Likelihood Functions; Models, Genetic; Mutation Rate; Phylogeny; Sequence Alignment; Sequence Analysis, DNA / methods
TL;DR: It is demonstrated that the variance of this discretized distribution has an upper bound determined solely by the choice of K and the mean of the distribution, which can introduce biases into statistical inference when estimating parameters governing site-to-site variability of substitution rates. (via Semantic Scholar)
Source: Web Of Science
Added: June 15, 2020

2020 journal article

Synonymous Site-to-Site Substitution Rate Variation Dramatically Inflates False Positive Rates of Selection Analyses: Ignore at Your Own Peril

MOLECULAR BIOLOGY AND EVOLUTION, 37(8), 2430–2439.

By: S. Wisotsky n, S. Pond*, S. Shank* & S. Muse n

author keywords: evolutionary model; synonymous rate variation; codon model; episodic selection
MeSH headings : Animals; Models, Genetic; Phylogeny; Rhodopsin / genetics; Selection, Genetic; Silent Mutation; Vertebrates / genetics
TL;DR: It is found that failing to account for even moderate levels of SRV in selection testing is likely to produce intolerably high false positive rates and add to a growing literature establishing that tests of selection are much more sensitive to certain model assumptions than previously believed. (via Semantic Scholar)
Source: Web Of Science
Added: October 19, 2020

2019 journal article

HyPhy 2.5-A Customizable Platform for Evolutionary Hypothesis Testing Using Phylogenies

MOLECULAR BIOLOGY AND EVOLUTION, 37(1), 295–299.

By: S. Pond*, A. Poon*, R. Velazquez*, S. Weaver*, N. Hepler*, B. Murrell*, S. Shank*, B. Magalis* ...

author keywords: evolutionary analysis; natural selection; hypothesis testing; statistical inference; software engineering
MeSH headings : Genetic Techniques; Phylogeny; Software
TL;DR: The 2.5 release of Hyphy includes a completely re-engineered computational core and analysis library that introduces new classes of evolutionary models and statistical tests, delivers substantial performance and stability enhancements, improves usability, streamlines end-to-end analysis workflows, makes it easier to develop custom analyses, and is mostly backwards compatible with previous HyPhy releases. (via Semantic Scholar)
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15. Life on Land (Web of Science)
Source: Web Of Science
Added: March 10, 2020

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