@article{moatti_connard_de britto_dunn_rastogi_rai_schnabel_ligler_hutson_fitzpatrick_et al._2024, title={Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs}, volume={15}, ISSN={["1663-9812"]}, DOI={10.3389/fphar.2024.1348172}, abstractNote={Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear. Although small animal models offer some insights into inner ear pharmacokinetics, their smaller organ size and different barrier (round window membrane) permeabilities compared to humans can complicate study interpretation. Therefore, developing a reliable large animal model for inner ear drug delivery is crucial. The inner and middle ear anatomy of domestic pigs closely resembles that of humans, making them promising candidates for studying inner ear pharmacokinetics. However, unlike humans, the anatomical orientation and tortuosity of the porcine external ear canal frustrates local drug delivery to the inner ear.}, journal={FRONTIERS IN PHARMACOLOGY}, author={Moatti, Adele and Connard, Shannon and De Britto, Novietta and Dunn, William A. and Rastogi, Srishti and Rai, Mani and Schnabel, Lauren V. and Ligler, Frances S. and Hutson, Kendall A. and Fitzpatrick, Douglas C. and et al.}, year={2024}, month={Jan} }