Seth William Kullman

Early disruptions in vitamin D receptor signaling induces persistent developmental behavior deficits in zebrafish larvae

Barnes, M., Burton, D., Marsden, K., Kullman, S. W., Barnes, M., Burton, D., … Kullman, S. W. (2025, November 14). PLoS ONE.

Embryonic Exposure to TPhP Elicits Osteotoxicity via Metabolic Disruption in Oryzias latipes

Gronske, M., Cochran, J., Foland, J., Jima, D., Buchwalter, D., Stapleton, H., & Kullman, S. (2025, July 31). Toxics, Vol. 13.

Machine Learning Modeling of Zebrafish Toxicity Endpoints After Exposure to PROTACs

Yogodzinski, C., Harris, J. S., Lane, T. R., Barnes, M., Vignaux, P. A., Raman, R., … Ekins, S. (2025, November 18). Toxicological Sciences.

Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish

Hawkey, A. B., Shekey, N., Dean, C., Asrat, H., Koburov, R., Holloway, Z. R., … Levin, E. D. (2024, January 17). Toxicological Sciences.

Quantitative sampling by IR-MALDESI is not susceptible to tissue heterogeneity in a multi-organ model

Joignant, A. N., Hector, E. C., Barnes, M. M., Kullman, S. W., & Muddiman, D. C. (2024, November 13). Analytical and Bioanalytical Chemistry, Vol. 11.

Comparative analysis of sucrose-embedding for whole-body zebrafish MSI by IR-MALDESI

Wang, M. F., Ritter, M. M., Kullman, S. W., & Muddiman, D. C. (2023, August 29). Analytical and Bioanalytical Chemistry, Vol. 8.

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

Phelps, D. W., Palekar, A. I., Conley, H. E., Ferrero, G., Driggers, J. H., Linder, K. E., … Yoder, J. A. (2023, February 14). Journal of Immunotoxicology, Vol. 20.

Maximized Spatial Information and Minimized Acquisition Time of Top-Hat IR-MALDESI-MSI of Zebrafish Using Nested Regions of Interest (nROIs)

Joignant, A. N., Ritter, M. M., Knizner, K. T., Garrard, K. P., Kullman, S. W., & Muddiman, D. C. (2023, August 1). Journal of the American Society for Mass Spectrometry, Vol. 8.

Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays

Hamm, J., Mahapatra, D., Knuth, M. M., Abedini, J., Lingerfelt, M., Ekins, S., & Kullman, S. W. (2022, January 1). Current Research in Toxicology, Vol. 3.

Correction: Kassotis et al. Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish. Toxics 2022, 10, 99

Kassotis, C. D., LeFauve, M. K., Chiang, Y.-T. T., Knuth, M. M., Schkoda, S., & Kullman, S. W. (2022, June 22). Toxics.

Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish

Toxics, 10(2), 99.

TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells

Watson, A. L. T. D., Baez, A. C., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 11). Toxicological Sciences, Vol. 11, pp. 149–162.

Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish

Knuth, M. M., Stutts, W. L., Ritter, M. M., Garrard, K. P., & Kullman, S. W. (2021, January 1). Journal of Lipid Research, Vol. 62, p. 100142.

20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms

Baldwin, W. S., Bain, L. J., Giulio, R. D., Kullman, S., Rice, C. D., Ringwood, A. H., & Hurk, P. (2020, September 6). Aquatic Toxicology.

Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function

Oliveri, A. N., Glazer, L., Mahapatra, D., Kullman, S. W., & Levin, E. D. (2020, May 27). Neurotoxicology and Teratology.

Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish

Journal of the American Society for Mass Spectrometry, 31(4), 768–772.

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

Kassotis, C. D., Herkert, N. J., Hammel, S. C., Hoffman, K., Xia, Q., Kullman, S. W., … Stapleton, H. M. (2020, November 13). Environmental Science & Technology.

Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish

Knuth, M. M., Mahapatra, D., Jima, D., Wan, D., Hammock, B. D., Law, M., & Kullman, S. W. (2020, September 29). Scientific Reports.

Zebrafish show long-term behavioral impairments resulting from developmental vitamin D deficiency

Oliveri, A. N., Knuth, M., Glazer, L., Bailey, J., Kullman, S. W., & Levin, E. D. (2020, June 17). Physiology & Behavior.

Alterations in skeletogenesis during medaka embryonic development

In K. Murata, M. Kinoshita, K. Naruse, M. Tanaka, & Y. Kamei (Eds.), Medaka: Biology, Management, and Experimental Protocols (2nd ed.). Hoboken, NJ: Wiley.

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Ideraabdullah, F. Y., Belenchia, A. M., Rosenfeld, C. S., Kullman, S. W., Knuth, M., Mahapatra, D., … Peterson, C. A. (2019, March 25). Journal of Endocrinology.

An object-oriented Bayesian network approach for establishing swine manure-borne natural estrogenic compounds budget

Lee, B., Kullman, S. W., Yost, E. E., Worley-Davis, L., & Reckhow, K. H. (2018, May 25). The Science of The Total Environment.

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

Scientific Reports, 8(1).

Corrigendum to “Predicting characteristics of rainfall driven estrogen runoff and transport from swine AFO spray fields” [Sci. Total Environ. 532 (2015) 571–580]

Lee, B., Kullman, S. W., Yost, E. E., Meyer, M. T., Worley-Davis, L., Williams, C. M., & Reckhow, K. H. (2018, February 28). The Science of The Total Environment.

Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells

Watson, A. L. T. D., Nordberg, R. C., Loboa, E. G., & Kullman, S. W. (2018, September 5). Toxicological Sciences.

Nuclear receptors

In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed., pp. 293–326). Hoboken, NJ: John Wiley & Sons.

Relation of contaminants to fish intersex in riverine sport fishes

Science of The Total Environment, 643, 73–89.

Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years

Neelon, S. E. B., White, A. J., Vidal, A. C., Schildkraut, J. M., Murtha, A. P., Murphy, S. K., … Hoyo, C. (2017, July 5). International Journal of Obesity, Vol. 42, pp. 587–593.

Windows of Susceptibility and Consequences of Early Life Exposures to 17β–estradiol on Medaka (Oryzias latipes) Reproductive Success

Environmental Science & Technology, 51(9), 5296–5305.

Advancing toxicology research using in vivo high throughput toxicology with small fish models

ALTEX, 33(4), 435–452.

Endocrine active contaminants in aquatic systems and intersex in common sport fishes

Environmental Toxicology and Chemistry, 36(4), 959–968.

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership

Kollitz, E. M., Zhang, G., Hawkins, M. B., Whitfield, G. K., Reif, D. M., & Kullman, S. W. (2016, December 12). (C. Zhang, Ed.). PLoS ONE, Vol. 11, p. e0168278.

Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development

Macaulay, L. J., Chernick, M., Chen, A., Hinton, D. E., Bailey, J. M., Kullman, S. W., … Stapleton, H. M. (2016, June 22). Environmental Toxicology and Chemistry.

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

Sharing the Roles: An Assessment of Japanese Medaka Estrogen Receptors in Vitellogenin Induction

Pow, C. S. D. L., Yost, E. E., Aday, D. D., & Kullman, S. W. (2016, July 8). Environmental Science & Technology.

Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

In Response : Conservation versus functional diversification of nuclear receptors: An academic perspective

Environmental Toxicology and Chemistry, 34(3), 463–465.

Molecular Cloning, Functional Characterization, and Evolutionary Analysis of Vitamin D Receptors Isolated from Basal Vertebrates

Kollitz, E. M., Zhang, G., Hawkins, M. B., Whitfield, G. K., Reif, D. M., & Kullman, S. W. (2015, April 9). PLoS ONE, Vol. 10.

Predicting characteristics of rainfall driven estrogen runoff and transport from swine AFO spray fields

Lee, B., Kullman, S. W., Yost, E. E., Meyer, M. T., Worley-Davis, L., Williams, C. M., & Reckhow, K. H. (2015, June 22). The Science of The Total Environment.

A Bayesian network model for assessing natural estrogen fate and transport in a swine waste lagoon

Lee, B., Kullman, S. W., Yost, E., Meyer, M. T., Worley-Davis, L., Williams, C. M., & Reckhow, K. H. (2014, May 1). Integrated Environmental Assessment and Management.

Bridging the Gap From Screening Assays to Estrogenic Effects in Fish: Potential Roles of Multiple Estrogen Receptor Subtypes

Yost, E. E., Pow, C. L., Hawkins, M. B., & Kullman, S. W. (2014, January 14). Environmental Science & Technology.

Functional Diversification of Vitamin D Receptor Paralogs in Teleost Fish After a Whole Genome Duplication Event

Kollitz, E. M., Hawkins, M. B., Whitfield, G. K., & Kullman, S. W. (2014, October 3). Endocrinology.

Sources of endocrine-disrupting compounds in North Carolina waterways: A geographic information systems approach

Environmental Toxicology and Chemistry, 34(2), 437–445.

Transport of Steroid Hormones, Phytoestrogens, and Estrogenic Activity across a Swine Lagoon/Sprayfield System

Yost, E. E., Meyer, M. T., Dietze, J. E., Williams, C. M., Worley-Davis, L., Lee, B., & Kullman, S. W. (2014, August 22). Environmental Science & Technology.

A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: Proposed Endocrine Disruptor Screening Program (EDSP) Tier 2 Ecotoxicity Tests

(SAP Minutes No. 2013-04). Environmental Protection Agency.

Comprehensive Assessment of Hormones, Phytoestrogens, and Estrogenic Activity in an Anaerobic Swine Waste Lagoon

Yost, E. E., Meyer, M. T., Dietze, J. E., Meissner, B. M., Worley-Davis, L., Williams, C. M., … Kullman, S. W. (2013, October 21). Environmental Science & Technology.

Immunohistochemical Characterization of the Hepatic Progenitor Cell Compartment in Medaka (Oryzias latipes) following Hepatic Injury

Wettere, A. J. V., Kullman, S. W., Hinton, D. E., & Law, J. M. (2013, May 8). Journal of Comparative Pathology.

Phenotypic Characterization of Transgenic Japanese Medaka (Oryzias latipes) That Express a Red Fluorescent Protein in Hepatocytes

Toxicologic Pathology, 42(3), 616–621.

Anchoring Ethinylestradiol Induced Gene Expression Changes with Testicular Morphology and Reproductive Function in the Medaka

Miller, H. D., Clark, B. W., Hinton, D. E., Whitehead, A., Martin, S., Kwok, K. W., & Kullman, S. W. (2012, December 26). PLoS ONE.

Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury

Toxicologic Pathology, (5), 1–17.

Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors

In OECD Series on Testing and Assessment.

Comparative genomics of duplicate γ‐glutamyl transferase genes in teleosts: medaka (Oryzias latipes), stickleback (Gasterosteus aculeatus), green spotted pufferfish (Tetraodon nigroviridis), fugu (Takifugu rubripes), and zebrafish (Danio rerio)

Law, S. H. W., Redelings, B. D., & Kullman, S. W. (2011, September 6). Journal of Experimental Zoology Part B Molecular and Developmental Evolution.

TCDD Disrupts Hypural Skeletogenesis during Medaka Embryonic Development

Dong, W., Hinton, D. E., & Kullman, S. W. (2011, October 20). Toxicological Sciences.

The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

Krasowski, M. D., Ai, N., Hagey, L. R., Kollitz, E. M., Kullman, S. W., Reschly, E. J., & Ekins, S. (2011, January 1). BMC Biochemistry.

Perspectives on Informatics in Toxicology, in A Textbook of Modern Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 593–605). Hoboken NJ: John Wiley and Sons.

TCDD Induced Pericardial Edema and Relative COX-2 Expression in Medaka (Oryzias Latipes) Embryos

Dong, W., Matsumura, F., & Kullman, S. W. (2010, August 26). Toxicological Sciences.

Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro

Howarth, D. L., Hagey, L. R., Law, S. H. W., Ai, N., Krasowski, M. D., Ekins, S., … Kullman, S. W. (2010, March 2). Aquatic Toxicology.

Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)

Howarth, D. L., Law, S. H. W., Law, J. M. H., Mondon, J. A., Kullman, S. W., & Hinton, D. E. (2009, December 4). Toxicology and Applied Pharmacology.

Use of Medaka in Toxicity Testing

Current Protocols in Toxicology, 39(1).

Aquatic animal models of human disease: Selected papers and recommendations from the 4th Conference

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 121–128.

Biotransformation in Fishes

In The Toxicology of Fishes (pp. 153–234).

Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos

Carney, M. W., Erwin, K., Hardman, R., Yuen, B., Volz, D. C., Hinton, D. E., & Kullman, S. W. (2008, January 1). Marine Pollution Bulletin.

Endocrine Disruptor Screening Program (EDSP) Proposed Tier 1 Screening Battery - Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel

Environmental Protection Agency.

Liver Toxicity

In The Toxicology of Fishes (pp. 327–400).

Non invasive in vivo investigation of hepatobiliary structure and function in STII medaka (Oryzias latipes): methodology and applications

Comparative Hepatology, 7(1).

Paralogous Vitamin D Receptors in Teleosts: Transition of Nuclear Receptor Function

Howarth, D. L., Law, S. H. W., Barnes, B., Hall, J. M., Hinton, D. E., Moore, L., … Kullman, S. W. (2008, February 7). Endocrinology.

Protective Response of the Ah Receptor to ANIT-Induced Biliary Epithelial Cell Toxicity in See-Through Medaka

Volz, D. C., Kullman, S. W., Howarth, D. L., Hardman, R. C., & Hinton, D. E. (2008, January 10). Toxicological Sciences.

An in vivo Look at Vertebrate Liver Architecture: Three-Dimensional Reconstructions from Medaka (Oryzias latipes)

The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 290(7), 770–782.

Application of in vivo methodologies to investigation biological structure, function and xenobiotic response in see-through medaka (Oryzias latipes

The Fish Biology Journal, Medaka, 11, 43–65.

Bioanalytical Analysis Of Natural Estrogens at Concentrated Animal Feed Operations Affecting North Carolina River Waters

(No. 376). Water Resources Research Institute of North Carolina.

Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation

Science of The Total Environment, 376(1-3), 18–26.

Comparisons of polychromatic and monochromatic UV-based treatments of bisphenol-A in water via toxicity assessments

Chemosphere, 68(6), 1041–1049.

Destruction of estrogenic activity in water using UV advanced oxidation

Science of The Total Environment, 377(1), 105–113.

Estrogenic modulation of CYP3A38, CYP3A40, and CYP19 in mature male medaka (Oryzias latipes)

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 145(3), 370–378.

Impact of UV and UV Endocrine Disrupting Compounds in Water

(No. 91175). American Water Works Association Research Foundation.

Non invasive high resolution in vivo imaging of α-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka

Aquatic Toxicology, 86(1), 20–37.

Towards an Innovative DNA Array Technology for Detection of Pharmaceuticals in Reclaimed Water

Water Environment Research Foundation (WERF) and Environmental Protection agency (EPA).

UV/H2O2 degradation of endocrine-disrupting chemicals in water evaluated via toxicity assays

Water Science and Technology, 55(12), 313–319.

Biological assessment of bisphenol A degradation in water following direct photolysis and UV advanced oxidation

Chemosphere, 65(7), 1094–1102.

2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka (Oryzias latipes)

Toxicological Sciences, 85(1), 572–584.

Dynamic Gene Expression Changes Precede Dioxin-Induced Liver Pathogenesis in Medaka Fish

Toxicological Sciences, 89(2), 524–534.

Functional characterization of medaka CYP3A38 and CYP3A40: Kinetics and catalysis by expression in a recombinant baculovirus system

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 141(4), 338–348.

Resolving mechanisms of toxicity while pursuing ecotoxicological relevance?

Marine Pollution Bulletin, 51(8-12), 635–648.

Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity

Marine Environmental Research, 58(2-5), 469–473.