Works (93)

Updated: April 3rd, 2024 18:07

2024 article

Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish

Hawkey, A. B., Shekey, N., Dean, C., Asrat, H., Koburov, R., Holloway, Z. R., … Levin, E. D. (2024, January 17). TOXICOLOGICAL SCIENCES, Vol. 1.

By: A. Hawkey*, N. Shekey n, C. Dean*, H. Asrat*, R. Koburov*, Z. Holloway*, S. Kullman n, E. Levin*

author keywords: zebrafish; development; neurobehavioral toxicology; retinoic acid receptors
TL;DR: It is demonstrated that early developmental exposure to environmental toxicants that interfere with RA signaling cause short as well as long-term behavioral disruption in a well-established zebrafish behavioral model and the meaning of the RA adverse outcome pathway is expanded, indicating that observed effects likely correspond with the nature of underlying homeostatic effects. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 29, 2024

2023 article

Comparative analysis of sucrose-embedding for whole-body zebrafish MSI by IR-MALDESI

Wang, M. F., Ritter, M. M., Kullman, S. W., & Muddiman, D. C. (2023, August 29). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 8.

By: M. Wang n, M. Ritter n, S. Kullman n & D. Muddiman n

author keywords: IR-MALDESI; Mass spectrometry imaging; Sucrose; PFA; Zebrafish
TL;DR: Danio rerio, or zebrafish, are model organisms for various disease states and can be imaged as a multi-organ sample to analyze morphological and metabolomic preservation as a result of sample preparation to compare sucrose-embedding with paraformaldehyde fixation against conventional fresh-frozen sample preparation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: September 25, 2023

2023 journal article

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

JOURNAL OF IMMUNOTOXICOLOGY, 20(1).

By: D. Phelps*, A. Palekar, H. Conley*, G. Ferrero, J. Driggers*, K. Linder*, S. Kullman n, D. Reif n ...

author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
TL;DR: This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: February 15, 2023

2023 article

Maximized Spatial Information and Minimized Acquisition Time of Top-Hat IR-MALDESI-MSI of Zebrafish Using Nested Regions of Interest (nROIs)

Joignant, A. N., Ritter, M. M., Knizner, K. T., Garrard, K. P., Kullman, S. W., & Muddiman, D. C. (2023, August 1). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 8.

By: A. Joignant n, M. Ritter n, K. Knizner n, K. Garrard n, S. Kullman n & D. Muddiman n

author keywords: IR-MALDESI; mass spectrometry imaging; spatialresolution; nested region of interest; zebrafish
TL;DR: The nROI method was characterized on mouse liver and applied to top-hat MSI of zebrafish using a novel optical train, which resulted in a significant improvement in both acquisition time and spatial detail of the zebra fish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 21, 2023

2022 journal article

Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays

CURRENT RESEARCH IN TOXICOLOGY, 3.

By: J. Hamm*, D. Mahapatra n, M. Knuth n, J. Abedini*, M. Lingerfelt*, S. Ekins*, S. Kullman n

author keywords: ToxCast; Farnesoid X receptor; High -throughput screening; Teleost models; Medaka
Sources: Web Of Science, ORCID
Added: January 23, 2023

2022 journal article

Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish

Toxics, 10(2), 99.

author keywords: endocrine disrupting chemicals; adipogenesis; alkylphenol ethoxylates; ethoxylated surfactants; mixtures; obesogen
TL;DR: Consistent adipogenic effects are demonstrated in two separate human bone-marrow-derived mesenchymal stem cell models and that nonylphenol and its ethoxylates promoted weight gain and increased adipose deposition in developmentally exposed zebrafish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 14, 2022

2022 article

Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish (vol 10, 99, 2022)

Kassotis, C. D., LeFauve, M. K., Chiang, Y.-T. T., Knuth, M. M., Schkoda, S., & Kullman, S. W. (2022, July). TOXICS, Vol. 10.

Sources: Web Of Science, ORCID
Added: August 8, 2022

2022 article

TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells

Watson, A. L. T. D., Carmona Baez, A., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.

By: A. Watson n, A. Carmona Baez n, D. Jima n, D. Reif n, J. Ding*, R. Roberts n, S. Kullman n

author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
TL;DR: A global transcriptomic landscape during early, intermediate, and apical stages of osteogenic differentiation in vitro in response to TCDD is established to identify novel pathways and transcription factors that may facilitate a better understanding of the osteoblast differentiation process, perturbation by exogenous agents, and potential intervention strategies targeting those specific pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: November 12, 2022

2021 journal article

Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish

JOURNAL OF LIPID RESEARCH, 62.

By: M. Knuth n, W. Stutts n, M. Ritter n, K. Garrard n & S. Kullman n

author keywords: MS; metabolomics; lipidomics; lipids; nutrition; endocannabinoid biosynthesis; MSI; IR-MALDESI; anandamide
MeSH headings : Animals; Endocannabinoids / metabolism; Lipid Metabolism; Lipids / chemistry; Vitamin D Deficiency / metabolism; Zebrafish
TL;DR: Investigation of putative linkages between vitamin D deficiency and metabolic disruption of bioactive lipids by MS imaging and expression of genes involved in EC biosynthesis, metabolism, and receptor signaling in adipose tissue and liver suggest that VDD may promote accumulation of bio active lipids and increased EC tone in zebrafish. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 19, 2021

2020 article

20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms

Baldwin, W. S., Bain, L. J., Di Giulio, R., Kullman, S., Rice, C. D., Ringwood, A. H., & Hurk, P. (2020, October). AQUATIC TOXICOLOGY, Vol. 227.

By: W. Baldwin*, L. Bain*, R. Di Giulio*, S. Kullman n, C. Rice*, A. Ringwood*, P. Hurk*

MeSH headings : Animals; Aquatic Organisms / drug effects; Aquatic Organisms / physiology; Ecosystem; Endocrine Disruptors; Environmental Monitoring; Environmental Pollutants / pharmacology; Fishes; Fresh Water; Humans; Plastics; Water Pollutants, Chemical / toxicity
TL;DR: This issue of Aquatic Toxicology describes the appropriateness of using aquatic organisms as models for human health, while the keynote speakers presented research that highlighted bioaccumulation of contaminants such as PFOS and mercury from fish to marine mammals and coastal human populations such as the Gullah/GeeChee near Charleston, South Carolina, USA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: October 19, 2020

2020 journal article

Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function

NEUROTOXICOLOGY AND TERATOLOGY, 81.

By: A. Oliveri*, L. Glazer*, D. Mahapatra n, S. Kullman n & E. Levin*

author keywords: Vitamin D receptor; Agonists; Antagonists; Zebrafish, larvae; Neurodevelopment; Behavioral toxicology
MeSH headings : Animals; Behavior, Animal / drug effects; Habituation, Psychophysiologic / drug effects; Hazardous Substances / pharmacology; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Pharmaceutical Preparations; Receptors, Calcitriol / metabolism; Reflex, Startle / drug effects; Zebrafish / physiology
TL;DR: Zebrafish can be useful for screening compounds identified in high throughput in vitro assays to provide an initial test for how those compounds would affect construction and behavioral function of a complex nervous system, helping to bridge the gap between in vitro neurotoxicity assays and mammalian models for risk assessment in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: October 12, 2020

2020 journal article

Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish

Journal of the American Society for Mass Spectrometry, 31(4), 768–772.

By: W. Stutts n, M. Knuth n, M. Ekelöf n, D. Mahapatra n, S. Kullman n & D. Muddiman n

author keywords: zebrafish; mass spectrometry imaging; cryosectioning; IR-MALDESI; lipids
MeSH headings : Animals; Cryoultramicrotomy / methods; Lipids / analysis; Male; Molecular Imaging; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Zebrafish / metabolism
TL;DR: The zebrafish (Danio rerio) is an ideal model for whole animal studies of lipid metabolism and lipid-related disease, and infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) was applied for direct visualization of lipid and metabolite distributions across various organs in whole-body zebra fish tissue sections. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 6, 2021

2020 journal article

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(23), 15296–15312.

MeSH headings : Adult; Antithyroid Agents; Case-Control Studies; Environmental Monitoring; Flame Retardants / analysis; HEK293 Cells; Halogenated Diphenyl Ethers / analysis; Humans; North Carolina; Pilot Projects; Prospective Studies; Silicones; Thyroid Cancer, Papillary; Thyroid Neoplasms
TL;DR: The results suggest that personal passive samplers may be useful in evaluating the bioactivities of mixtures that people contact on a daily basis and tentative associations between thyroid receptor antagonism, chemical concentrations, and papillary thyroid cancer case status are reported. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 19, 2021

2020 journal article

Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish

SCIENTIFIC REPORTS, 10(1).

By: M. Knuth n, D. Mahapatra n, D. Jima n, D. Wan*, B. Hammock*, M. Law n, S. Kullman n

MeSH headings : Adipose Tissue / metabolism; Adiposity / physiology; Animals; Diet; Growth Disorders / metabolism; Hyperplasia / etiology; Hyperplasia / physiopathology; Liver / metabolism; Obesity / metabolism; Obesity, Abdominal / complications; Vitamin D / metabolism; Vitamin D Deficiency / metabolism; Vitamin D Deficiency / physiopathology; Zebrafish / growth & development; Zebrafish / metabolism; Zebrafish Proteins / metabolism
TL;DR: Findings indicate that early developmental VDD impacts metabolic health by disrupting the balance between somatic growth and adipose accumulation, which is associated with hallmarks of dyslipidemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: October 26, 2020

2020 journal article

Zebrafish show long-term behavioral impairments resulting from developmental vitamin D deficiency

PHYSIOLOGY & BEHAVIOR, 224.

By: A. Oliveri*, M. Knuth n, L. Glazer*, J. Bailey*, S. Kullman n & E. Levin*

author keywords: Vitamin D deficiency; Zebrafish; Anxiety; Neurodevelopment; Behavioral toxicology
MeSH headings : Animals; Behavior, Animal; Reflex, Startle; Swimming; Vitamin D Deficiency / complications; Zebrafish
TL;DR: Results indicate a phenotype of vitamin D deficiency characterized by more anxiety-like behavior, which was relatively specific inasmuch as few or no behavioral effects were seen in other behavioral tests. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 24, 2020

2019 chapter

Alterations in skeletogenesis during medaka embryonic development

In K. Murata, M. Kinoshita, K. Naruse, M. Tanaka, & Y. Kamei (Eds.), Medaka: Biology, Management, and Experimental Protocols (2nd ed.). Hoboken, NJ: Wiley.

By: S. Kullman & A. Watson

Ed(s): K. Murata, M. Kinoshita, K. Naruse, M. Tanaka & Y. Kamei

Source: NC State University Libraries
Added: September 15, 2022

2019 journal article

Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells

TOXICOLOGICAL SCIENCES, 167(1), 145–156.

By: A. Watson n, R. Nordberg n, E. Loboa n & S. Kullman n

author keywords: aryl hydrocarbon receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD; mesenchymal stem cell; osteoblast differentiation; skeletal toxicity; bone toxicity
MeSH headings : Basic Helix-Loop-Helix Transcription Factors / agonists; Cell Differentiation / drug effects; Fibroblast Growth Factor 9 / genetics; Fibroblast Growth Factors / genetics; Humans; Ligands; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / agonists; Up-Regulation
TL;DR: Experimental evidence from this study suggests that AhR transactivation likely attenuates osteoblast differentiation in multipotent hBMSCs, and underscores the use of primary human MSCs to evaluate osteoinductive or osteotoxic potential of chemical and pharmacologic agents in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: April 15, 2019

2019 review

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

[Review of ]. JOURNAL OF ENDOCRINOLOGY, 241(2), R65–R80.

By: F. Ideraabdullah*, A. Belenchia*, C. Rosenfeld*, S. Kullman n, M. Knuth n, D. Mahapatra n, M. Bereman n, E. Levinlo, C. Peterson*

author keywords: vitamin D deficiency; DOHAD; metabolic disorders; autism; neurobehavioral disorders; animal models
TL;DR: A detailed review and perspective of evidence for the role of maternal VDD in offspring long term health, particularly as it relates to Developmental Origins of Health and Disease (DOHaD), and evidence implicating epigenetic mechanisms as a mediator of this link is explored. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: June 17, 2019

2018 journal article

An object-oriented Bayesian network approach for establishing swine manure-borne natural estrogenic compounds budget

SCIENCE OF THE TOTAL ENVIRONMENT, 639, 815–825.

By: B. Lee*, S. Kullman n, E. Yost n, L. Worley-Davis n & K. Reckhow*

author keywords: Natural estrogens; Swine CAFO; Total facility estrogen budget; OOBN
MeSH headings : Animals; Bayes Theorem; Estradiol; Estrogens / analysis; Estrogens / metabolism; Estrone; Female; Lactation; Manure / analysis; North Carolina; Swine; Waste Disposal, Fluid / methods; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / metabolism
TL;DR: Results from the OOBN model indicate a rank order of lactating sows in terms of contribution of estrogen loads to the total natural estrogen budget, and E1 was found as the major estrogen metabolite with the summed concentrations of urine, feces, and flushing slurry wastes exceeding 3000 ng/l > 90% of the time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

Scientific Reports, 8(1).

By: D. Mahapatra n, J. Franzosa*, K. Roell n, M. Kuenemann n, K. Houck*, D. Reif n, D. Fourches n, S. Kullman n

Contributors: D. Mahapatra n, J. Franzosa*, K. Roell n, M. Kuenemann n, K. Houck*, D. Reif n, D. Fourches n, S. Kullman n

MeSH headings : Drug Evaluation, Preclinical; Genes, Reporter; High-Throughput Screening Assays; Humans; Luciferases / analysis; Luciferases / genetics; Protein Binding; Receptors, Calcitriol / agonists; Receptors, Calcitriol / antagonists & inhibitors; Two-Hybrid System Techniques; Xenobiotics / metabolism
TL;DR: Data emphasizes the molecular complexity of ligand-mediated interactions with VDR and suggest that VDR transactivation may be a target site of action for diverse xenobiotics. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years

INTERNATIONAL JOURNAL OF OBESITY, 42(4), 587–593.

By: S. Neelon*, A. White*, A. Vidal*, J. Schildkraut*, A. Murtha*, S. Murphy*, S. Kullman n, C. Hoyo n

MeSH headings : Adult; Birth Weight / physiology; Child, Preschool; DNA Methylation / genetics; Female; Genomic Imprinting / genetics; Humans; Infant; Infant, Newborn; Mothers; Pregnancy; Prospective Studies; Socioeconomic Factors; Vitamin D / blood; Young Adult
TL;DR: Reduced maternal 25(OH)D was associated with lower birth weight for gestational age z-scores but higher 1-year weight-for-length and 3-year BMI z-Scores in offspring, however, 25( OH)D does not appear to be operating through the regulatory sequences of the genomically imprinted genes the authors examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 chapter

Nuclear receptors

In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed., pp. 293–326). Hoboken, NJ: John Wiley & Sons.

By: S. Kullman, W. Baldwin & G. LeBlanc

Ed(s): R. Smart & E. Hodgson

Source: NC State University Libraries
Added: September 15, 2022

2018 article

Predicting characteristics of rainfall driven estrogen runoff and transport from swine AFO spray fields (vol 532, pg 571, 2015)

Lee, B., Kullman, S. W., Yost, E. E., Meyer, M. T., Worley-Davis, L., Williams, C. M., & Reckhow, K. H. (2018, July 1). SCIENCE OF THE TOTAL ENVIRONMENT, Vol. 628-629, pp. 1460–1460.

By: B. Lee*, S. Kullman n, E. Yost n, M. Meyer*, L. Worley-Davis n, C. Williams n, K. Reckhow*

UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Relation of contaminants to fish intersex in riverine sport fishes

Science of The Total Environment, 643, 73–89.

By: C. Grieshaber n, T. Penland n, T. Kwak n, W. Cope n, R. Heise*, J. Law n, D. Shea n, D. Aday n ...

Contributors: C. Grieshaber n, T. Penland n, T. Kwak n, W. Cope n, R. Heise*, J. Law n, D. Shea n, D. Aday n, J. Rice n, S. Kullman n

author keywords: Endocrine active compounds; Endocrine disruption; Bass; Polycyclic aromatic hydrocarbons; Ethinylestradiol; Mercury
MeSH headings : Animals; Disorders of Sex Development / epidemiology; Disorders of Sex Development / veterinary; Environmental Monitoring; Female; Fish Diseases / epidemiology; Fishes / physiology; Male; North Carolina; Rivers / chemistry; South Carolina; Sports; Water Pollutants, Chemical / analysis; Water Pollution, Chemical / statistics & numerical data
TL;DR: Polycyclic aromatic hydrocarbons, ethinylestradiol, and heavy metals were the most prevalent contaminants that exceeded effect levels for the protection of aquatic organisms and principal component analysis identified waterborne PAHs as the most correlated environmental contaminant with intersex occurrence and severity in black bass and sunfish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: October 16, 2018

2017 journal article

Endocrine active contaminants in aquatic systems and intersex in common sport fishes

Environmental Toxicology and Chemistry, 36(4), 959–968.

By: C. Lee Pow n, J. Law n, T. Kwak n, W. Cope n, J. Rice n, S. Kullman n, D. Aday n

author keywords: Intersex; Estrogens; Endocrine disruption; Black bass; Sunfish
MeSH headings : Animals; Bass / growth & development; Bass / metabolism; Disorders of Sex Development / chemically induced; Endocrine Disruptors / analysis; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Environmental Monitoring; Female; Male; North Carolina; Oocytes / drug effects; Oocytes / growth & development; Rivers / chemistry; Seasons; Species Specificity; Sports; Testis / drug effects; Testis / growth & development; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR: The authors’ results associate genus‐specific prevalence of intersex with specific EAC classes in common sport fishes having biological, ecological, and conservation implications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 36(1), 36–48.

By: L. Macaulay*, M. Chernick*, A. Chen*, D. Hinton*, J. Bailey*, S. Kullman n, E. Levin*, H. Stapleton*

author keywords: Polybrominated diphenyl ether (PBDE); Mixture; Development; Juvenile; Zebrafish
MeSH headings : Adult; Animals; Dose-Response Relationship, Drug; Gene Expression / drug effects; Halogenated Diphenyl Ethers / metabolism; Halogenated Diphenyl Ethers / toxicity; Humans; Osteogenesis / drug effects; Osteogenesis / genetics; Polybrominated Biphenyls / metabolism; Polybrominated Biphenyls / toxicity; Thyroid Gland / drug effects; Thyroid Gland / metabolism; Thyroid Hormones / genetics; Thyroid Hormones / metabolism; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish / metabolism
TL;DR: Exposure to PBDE/OH‐BDE mixtures adversely impact zebrafish maturation during metamorphosis, and assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Windows of Susceptibility and Consequences of Early Life Exposures to 17β–estradiol on Medaka (<i>Oryzias latipes</i>) Reproductive Success

Environmental Science & Technology, 51(9), 5296–5305.

By: C. Lee Pow n, K. Tilahun n, K. Creech n, J. Law n, W. Cope n, T. Kwak n, J. Rice n, D. Aday n, S. Kullman n

MeSH headings : Animals; Estradiol / pharmacology; Gonads / drug effects; Oryzias; Reproduction / drug effects; Sex Differentiation / drug effects
TL;DR: Insight is provided into factors (window of exposure, exposure concentration and duration of exposure period) contributing to reproductive disruption in fish and differential effects among four critical stages of development are documents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Advancing toxicology research using in vivo high throughput toxicology with small fish models

ALTEX - Alternatives to Animal Experimentation, 33(4), 435–452.

By: A. Planchart n, C. Mattingly n, D. Allen*, P. Ceger*, W. Casey*, D. Hinton*, J. Kanungo*, S. Kullman n ...

Contributors: A. Planchart n, C. Mattingly n, D. Allen*, P. Ceger*, W. Casey*, D. Hinton*, J. Kanungo*, S. Kullman n ...

author keywords: aquatic models; 21st century toxicology; alternatives
TL;DR: The recommendations formulated by workshop participants to enhance the utility of small fish species in toxicology studies are summarized, as well as many of the advances in the field of toxicology that resulted from usingSmall freshwater fish species, including advances in developmental toxicology, cardiovascular toxicologists, neurotoxicology, and immunotoxicology are reviewed. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership

PLOS ONE, 11(12).

By: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

Contributors: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

Ed(s): C. Zhang n

MeSH headings : Animals; Biological Evolution; Hep G2 Cells; Humans; Lithocholic Acid / metabolism; Receptors, Calcitriol / metabolism; Vertebrates
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

By: A. Watson*, A. Planchart n, C. Mattingly n, C. Winkler*, D. Reif n & S. Kullman n

Contributors: A. Watson, A. Planchart n, C. Mattingly n, C. Winkler*, D. Reif n & S. Kullman n

author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
TL;DR: It is suggested that TCDD exposure inhibits axial bone formation through dysregulation of osteoblast differentiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Sharing the Roles: An Assessment of Japanese Medaka Estrogen Receptors in Vitellogenin Induction

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 50(16), 8886–8895.

By: C. Pow n, E. Yost n, D. Aday n & S. Kullman n

MeSH headings : Animals; Biological Assay; Estradiol / metabolism; Estrogens / metabolism; Gene Expression / drug effects; Oryzias / metabolism; Receptors, Estrogen / metabolism; Up-Regulation / drug effects; Vitellogenins / metabolism
TL;DR: Investigation of putative roles of three ER subtypes in Japanese medaka shows that all three medaka ERs are capable of initiating transactivation of both VTG I and II, and suggests that preferential ligand/receptor/promoter interactions may have direct implications for VTG gene expression and other ER-mediated regulatory functions that are relevant to the risk assessment of estrogenic compounds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 content posted

Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

By: V. Wilson*, G. LeBlanc n, S. Kullman n, K. Crofton*, P. Schmieder* & M. Jacobs*

TL;DR: Challenges and the future of endocrine disrupting compound screening and testing and running head: Future challenges for EDC screenings and testing. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 11, 2019

2015 journal article

In Response : Conservation versus functional diversification of nuclear receptors: An academic perspective

Environmental Toxicology and Chemistry, 34(3), 463–465.

By: S. Kullman n

MeSH headings : Animals
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, ORCID
Added: December 31, 2020

2015 journal article

Molecular Cloning, Functional Characterization, and Evolutionary Analysis of Vitamin D Receptors Isolated from Basal Vertebrates

PLOS ONE, 10(4).

By: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

Contributors: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

MeSH headings : Animals; Base Sequence; Cloning, Molecular; Computational Biology; Electrophoretic Mobility Shift Assay; Evolution, Molecular; Fishes / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Petromyzon / genetics; Phylogeny; Protein Binding; Protein Interaction Mapping; Receptors, Calcitriol / genetics; Sequence Analysis, DNA; Skates, Fish / genetics; Species Specificity; Two-Hybrid System Techniques
TL;DR: This study compares molecular activities of vitamin D receptors (VDR) from basal species that diverged at key points in vertebrate evolution in order to infer derived and ancestral VDR functions of teleost paralogs and suggests that 1, 25D3 acts as a partial agonist in basal species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Predicting characteristics of rainfall driven estrogen runoff and transport from swine AFO spray fields

SCIENCE OF THE TOTAL ENVIRONMENT, 532, 571–580.

By: B. Lee*, S. Kullman n, E. Yost n, M. Meyer*, L. Worley-Davis n, C. Williams n, K. Reckhow*

author keywords: Estrogen runoff and transport; Bayesian network model; Swine animal feeding operation; Spray fields
MeSH headings : Agriculture / methods; Animal Feed; Animals; Bayes Theorem; Environmental Monitoring / methods; Estrogens / analysis; Geologic Sediments; Manure; Models, Chemical; Rain; Soil / chemistry; Swine; Water Movements; Water Pollutants, Chemical / analysis; Water Pollution, Chemical / statistics & numerical data
TL;DR: What-if scenario analyses suggest that planting Bermuda grass in the spray fields is likely to reduce runoff losses of natural estrogens near the water bodies and ecosystems, as compared to planting of soybeans. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Sources of endocrine-disrupting compounds in North Carolina waterways: A geographic information systems approach

Environmental Toxicology and Chemistry, 34(2), 437–445.

By: D. Sackett n, C. Pow n, M. Rubino n, D. Aday n, W. Cope n, S. Kullman n, J. Rice n, T. Kwak n, M. Law n

author keywords: Ecotoxicology; Endocrine disrupting compound; Estrogenicity; Geographic information system prediction; Surface water
MeSH headings : Endocrine Disruptors / analysis; Estradiol / analysis; Estrogens / analysis; Geographic Information Systems; Geography; Least-Squares Analysis; Models, Theoretical; North Carolina; Water Pollutants, Chemical / analysis
TL;DR: The results suggested that water 17β-estradiol was reflective of GIS predictions, confirming the relevance of landscape-level influences on water quality and validating the GIS approach to characterize such relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

A Bayesian Network Model for Assessing Natural Estrogen Fate and Transport in a Swine Waste Lagoon

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, 10(4), 511–521.

By: B. Lee*, S. Kullman n, E. Yost n, M. Meyer*, L. Worley-Davis n, C. Williams n, K. Reckhow*

MeSH headings : Animals; Bayes Theorem; Estrogens / chemistry; Models, Theoretical; Sewage / chemistry; Swine; Waste Disposal, Fluid; Water Pollutants, Chemical / chemistry
TL;DR: Management scenario evaluations demonstrated that the best possible management options to reduce estrogen levels in the lagoon are either to adjust the estrogen input loading from swine barn facilities or to effectively enhance estrogen bonding with suspended solids through the use of organic polymers or inorganic coagulants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Bridging the Gap From Screening Assays to Estrogenic Effects in Fish: Potential Roles of Multiple Estrogen Receptor Subtypes

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 48(9), 5211–5219.

By: E. Yost n, C. Pow n, M. Hawkins n & S. Kullman n

MeSH headings : Animals; Estrogen Receptor alpha / physiology; Estrogen Receptor beta / physiology; Estrogens / pharmacology; Humans; Liver / metabolism; Male; Oryzias; Polymerase Chain Reaction; Vitellogenins / metabolism; Water Pollutants, Chemical / pharmacology
TL;DR: Results support emerging evidence that ERβ subtypes are critically involved in the teleost estrogenic response, with the ERα:ERβ ratio being of particular importance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Functional diversification of vitamin D receptor paralogs in teleost fish after a whole genome duplication event

Endocrinology, 155(12), 4641–4654.

By: E. Kollitz n, M. Hawkins n, G. Whitfield* & S. Kullmam

MeSH headings : Animals; Calcitriol / metabolism; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Duplication; Genome; Nuclear Receptor Coactivators / metabolism; Oryzias; Receptors, Calcitriol / genetics; Receptors, Calcitriol / metabolism; Retinoid X Receptors / metabolism; Zebrafish
TL;DR: The results imply that functional differences between VDRα and VDRβ occurred early in teleost evolution because they are conserved between distantly related species, and suggest that the observed differences may be associated with differential protein-protein interactions between the VDR paralogs and coactivators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Transport of Steroid Hormones, Phytoestrogens, and Estrogenic Activity across a Swine Lagoon/Sprayfield System

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 48(19), 11600–11609.

By: E. Yost n, M. Meyer*, J. Dietze*, C. Williams n, L. Worley-Davis n, B. Lee*, S. Kullman n

MeSH headings : Agriculture / methods; Androgens / chemistry; Androstenedione / chemistry; Animals; Diet / veterinary; Environmental Monitoring / methods; Equol / chemistry; Estrogens / chemistry; Estrone / chemistry; Feces / chemistry; Genistein / chemistry; Hormones / chemistry; Isoflavones / chemistry; Phytoestrogens / chemistry; Progesterone / chemistry; Steroids / chemistry; Swine; Urine / chemistry
TL;DR: This investigation encompasses the most comprehensive suite of natural hormone and phytoestrogen analytes examined to date across a livestock lagoon/sprayfield and provides global insight into the fate of these analytes in this widely used waste management system. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 report

A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: Proposed Endocrine Disruptor Screening Program (EDSP) Tier 2 Ecotoxicity Tests

(SAP Minutes No. 2013-04). Environmental Protection Agency.

By: S. Kullman

Source: NC State University Libraries
Added: September 16, 2022

2013 journal article

Comprehensive Assessment of Hormones, Phytoestrogens, and Estrogenic Activity in an Anaerobic Swine Waste Lagoon

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 47(23), 13781–13790.

By: E. Yost n, M. Meyer*, J. Dietze*, B. Meissner*, L. Worley-Davis n, C. Williams n, B. Lee*, S. Kullman n

MeSH headings : Anaerobiosis; Animals; Chromatography, Liquid; Estrogens / analysis; Mass Spectrometry; Phytoestrogens / analysis; Sewage / chemistry; Swine; Wastewater / chemistry; Water Pollutants, Chemical / analysis
TL;DR: Findings emphasize the importance of adsorption and transformation processes in governing the fate of these compounds in lagoon waste, which is ultimately used for broadcast application as a fertilizer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (oryzias latipes) following hepatic injury

Journal of Comparative Pathology, 149(4), 434–445.

By: A. Wettere n, S. Kullmam, D. Hinton* & J. Law n

MeSH headings : Animals; Animals, Genetically Modified; Cell Differentiation / physiology; Disease Models, Animal; Female; Hepatocytes / cytology; Hepatocytes / ultrastructure; Immunohistochemistry; Liver / injuries; Liver Regeneration / physiology; Male; Microscopy, Electron, Transmission; Oryzias; Stem Cells / cytology; Stem Cells / ultrastructure
TL;DR: The present study defines the process of OC differentiation in fish liver using histopathology, immunohistochemistry and transmission electron microscopy and confirms the presence of, and support the putative bipotential lineage capabilities of, the fish OC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Phenotypic Characterization of Transgenic Japanese Medaka (Oryzias latipes) That Express a Red Fluorescent Protein in Hepatocytes

Toxicologic Pathology, 42(3), 616–621.

By: A. Van Wettere n, J. Law n, D. Hinton* & S. Kullman n

author keywords: transgenic medaka; Oryzias latipes; liver fatty acid binding protein; inclusion; red fluorescent protein
MeSH headings : Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Cloning, Molecular; Embryo, Nonmammalian; Fatty Acid-Binding Proteins / genetics; Female; Hepatocytes / chemistry; Hepatocytes / metabolism; Liver / chemistry; Liver / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Oryzias / genetics; Oryzias / metabolism; Phenotype
TL;DR: The phenotype of a transgenic medaka strain that expresses a red fluorescent protein (RFP) in hepatocytes was characterized using light and fluorescence microscopy, immunohistochemistry, and transmission electron microscopy (TEM). (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Anchoring Ethinylestradiol Induced Gene Expression Changes with Testicular Morphology and Reproductive Function in the Medaka

PLOS ONE, 7(12).

By: H. Miller*, B. Clark*, D. Hinton*, A. Whitehead*, S. Martin n, K. Kwok*, S. Kullman n

MeSH headings : Animals; Breeding; Estrogens / toxicity; Ethinyl Estradiol / toxicity; Male; Oligonucleotide Array Sequence Analysis; Oryzias / anatomy & histology; Oryzias / genetics; Oryzias / physiology; Reproduction / drug effects; Reproduction / genetics; Species Specificity; Testis / anatomy & histology; Testis / drug effects; Testis / metabolism; Testis / physiology; Time Factors; Transcriptome / drug effects
TL;DR: It is demonstrated that a 14 day exposure to EE2 induced impaired male reproductive capacity and time- and dose-dependent alterations in testicular morphology and gene expression, highlighting the importance of anchoring global gonadal gene expression changes with morphology and ultimately with tissue/organ function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury

Toxicologic Pathology, 41(5), 1–17.

By: A. Van Wettere n, J. Law n, D. Hinton* & S. Kullman n

author keywords: dimethylnitrosamine; liver; fibrosis; neoplasia; medaka; Oryzias latipes; gene expression
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Dimethylnitrosamine / toxicity; Disease Models, Animal; Female; Fish Proteins / chemistry; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Expression; Immunohistochemistry; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Cirrhosis / chemically induced; Liver Cirrhosis / genetics; Liver Cirrhosis / metabolism; Liver Cirrhosis / pathology; Male; Microscopy, Electron, Transmission; Oryzias; Phenotype
TL;DR: This study identified a group of candidate genes likely to be involved in the development of hepatic fibrosis and demonstrated that the TGF-β pathway likely plays a major role in the pathogenesis. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Comparative Genomics of Duplicate gamma-Glutamyl Transferase Genes in Teleosts: Medaka (Oryzias latipes), Stickleback (Gasterosteus aculeatus), Green Spotted Pufferfish (Tetraodon nigroviridis), Fugu (Takifugu rubripes), and Zebrafish (Danio rerio)

JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, 318B(1), 35–49.

By: S. Law n, B. Redelings n & S. Kullman n

MeSH headings : Amino Acid Sequence; Animals; Female; Fishes / classification; Fishes / genetics; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Duplicate / genetics; Genomics; Larva; Male; Molecular Sequence Data; Phylogeny; Sequence Alignment; Synteny; gamma-Glutamyltransferase / chemistry; gamma-Glutamyltransferase / genetics
TL;DR: Examination of multiple paralogous genes of γ-glutamyl transferase (GGT) in several distantly related teleost species including medaka, stickleback, green spotted pufferfish, fugu, and zebrafish demonstrates that multiple GGT genes have been retained within teleost genomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 book

Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors

In OECD Series on Testing and Assessment.

Seth Kullman

Sources: Crossref, ORCID
Added: September 15, 2022

2012 journal article

TCDD Disrupts Hypural Skeletogenesis during Medaka Embryonic Development

TOXICOLOGICAL SCIENCES, 125(1), 91–104.

By: W. Dong n, D. Hinton* & S. Kullman n

author keywords: medaka; dioxin; cartilage; skeletogenesis; aquatic toxicology
MeSH headings : Animals; Cartilage / abnormalities; Cartilage / drug effects; Cartilage / embryology; Cartilage / ultrastructure; Cell Differentiation / drug effects; Cell Proliferation / drug effects; Chondrocytes / drug effects; Chondrocytes / ultrastructure; Collagen Type II / genetics; Dose-Response Relationship, Drug; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / pathology; Gene Expression / drug effects; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / ultrastructure; Microscopy, Electron, Transmission; Musculoskeletal Abnormalities / chemically induced; Musculoskeletal Abnormalities / embryology; Musculoskeletal Abnormalities / pathology; Oryzias / abnormalities; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction
TL;DR: It is illustrated that TCDD impacts terminal differentiation and growth of cartilage and bone in axial structures not likely derived from neural crest progenitors in medaka hypurals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

BMC BIOCHEMISTRY, 12.

By: M. Krasowski*, N. Ai, L. Hagey*, E. Kollitz n, S. Kullman n, E. Reschly*, S. Ekins*

MeSH headings : Animals; Bile Acids and Salts / metabolism; Evolution, Molecular; Humans; Ligands; Mice; Models, Molecular; Pregnane X Receptor; Protein Interaction Domains and Motifs; Rats; Receptors, Calcitriol / genetics; Receptors, Calcitriol / metabolism; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Species Specificity; Structure-Activity Relationship; Tetraodontiformes; Zebrafish
TL;DR: These studies provide further evidence of the relationship between both FXR, PXR, and VDR ligand selectivity and cross-species variation in bile salt profiles and suggest a ligand-binding pocket architecture more similar to human and rat FXRs than to lamprey or zebrafish FXRs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)

TOXICOLOGY AND APPLIED PHARMACOLOGY, 243(1), 111–121.

By: D. Howarth*, S. Law n, J. Law n, J. Mondon*, S. Kullman n & D. Hinton*

author keywords: Farnesoid X receptor; Liver; Medaka; Toxicity; Eleutheroembryo
MeSH headings : Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiology; Female; Gene Expression Regulation, Developmental / drug effects; Isoxazoles / pharmacology; Liver / drug effects; Liver / pathology; Liver / ultrastructure; Male; Oryzias / embryology; Protein Isoforms; Receptors, Cytoplasmic and Nuclear / agonists; Yolk Sac
TL;DR: This report of hepatobiliary injury following GW4064 exposure extends previous investigations of the intrahepatic biliary system in medaka, reveals sensitivity to toxicant exposure, and illustrates the need for added resolution in detection and interpretation of toxic responses in this vertebrate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 chapter

Perspectives on Informatics in Toxicology, in A Textbook of Modern Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 593–605). Hoboken NJ: John Wiley and Sons.

By: S. Kullman, C. Mattingly, J. Meyer & A. Whitehead

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: September 16, 2022

2010 journal article

TCDD Induced Pericardial Edema and Relative COX-2 Expression in Medaka (Oryzias Latipes) Embryos

TOXICOLOGICAL SCIENCES, 118(1), 213–223.

By: W. Dong n, F. Matsumura n & S. Kullman n

author keywords: COX-2; TCDD; medaka; pericardial edema
MeSH headings : Animals; Arachidonic Acid / pharmacology; Cyclooxygenase 2 / biosynthesis; Cyclooxygenase 2 / genetics; Cyclooxygenase Inhibitors / pharmacology; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / enzymology; Gene Expression Regulation, Developmental / drug effects; Gene Silencing; Nitrobenzenes / pharmacology; Oryzias / physiology; Pericardial Effusion / chemically induced; Pericardial Effusion / genetics; Pericardial Effusion / pathology; Polychlorinated Dibenzodioxins / toxicity; RNA, Messenger / metabolism; Sulfonamides / pharmacology; Teratogens / toxicity
TL;DR: It is suggested that AhR activation results in stimulation of inflammation and "eicosanoid" pathways, which contribute to the observed developmental, cardiovascular phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro

Aquatic Toxicology (Amsterdam, Netherlands), 98(3), 245–255.

By: D. Howarth*, L. Hagey*, S. Law n, N. Ai, M. Krasowski*, S. Ekins*, J. Moore*, E. Kollitz n, D. Hinton*, S. Kullmam

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Bile Acids and Salts / pharmacology; Binding Sites; Fresh Water; Genes, Reporter / genetics; Humans; Molecular Sequence Data; Oryzias / genetics; Protein Isoforms / genetics; Protein Isoforms / metabolism; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Titrimetry; Transcriptional Activation / drug effects; Transcriptional Activation / genetics; Transfection
TL;DR: M mammalian two-hybrid studies demonstrated the ability of Fxralpha2, but not FxRALpha1, to interact with PGC-1alpha and SRC-1, and supported the results from the transient transfection reporter gene activation assays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

Aquatic animal models of human disease: Selected papers and recommendations from the 4th Conference

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 121–128.

By: D. Hinton*, R. Hardman*, S. Kullman n, J. Law n, M. Schmale*, R. Walter*, R. Winn*, J. Yoder n

MeSH headings : Animals; Disease Models, Animal; Fishes; Humans; Mollusca
TL;DR: Of increasing importance are contributions of aquatic invertebrates and fishes to the detection of toxic responses from: metal mining and smelting impacts, polycyclic aromatichydrocarbons and persistent organic pollutants and their adverse effects in harbors and coastal estuaries, including the verification of remediation processes. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2009 journal article

Use of Medaka in Toxicity Testing

Current Protocols in Toxicology, 39(1).

By: S. Padilla*, J. Cowden*, D. Hinton*, B. Yuen*, S. Law*, S. Kullman n, R. Johnson*, R. Hardman*, K. Flynn*, D. Au*

MeSH headings : Animals; Biliary Tract / drug effects; Biliary Tract / pathology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / pathology; Female; Liver / drug effects; Liver / pathology; Male; Models, Animal; Nervous System / drug effects; Oryzias / embryology; Oryzias / growth & development; Oryzias / physiology; Toxicity Tests / methods
TL;DR: To illustrate the utility and breadth of toxicity testing possible using medaka fish, protocols for assessing neurotoxicity in developing embryos, evaluating toxicant effects on sexual phenotype after treatment with endocrine‐disrupting chemicals by sexual genotyping, and measuring hepatotoxicity in adult fish aftertreatment with a model hepatotoxicant are presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: September 13, 2022

2008 chapter

Biotransformation in Fishes

In The Toxicology of Fishes (pp. 153–234).

By: D. Schlenk, M. Celander, E. Gallagher, S. George, M. James, S. Kullman*, P. van den Hurk, K. Willett

Sources: Crossref, ORCID
Added: September 15, 2022

2008 article

Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos

MARINE POLLUTION BULLETIN, Vol. 57, pp. 255–266.

By: M. Carney*, K. Erwin*, R. Hardman*, B. Yuen*, D. Volz*, D. Hinton*, S. Kullman n

author keywords: naphthoic acid; PAH metabolites; medaka; embryo toxicity; tube heart; EROD; eleutheroembryos
MeSH headings : Animals; Carboxylic Acids / toxicity; Cell Line; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A1 / metabolism; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / enzymology; Embryonic Development / drug effects; Gene Expression Regulation, Developmental / drug effects; Heart Rate / drug effects; Hydrogen-Ion Concentration; Isomerism; Lethal Dose 50; Linear Models; Mice; Naphthalenes / toxicity; Oryzias / embryology; Receptors, Aryl Hydrocarbon / drug effects; Receptors, Aryl Hydrocarbon / metabolism; Time Factors; Transcriptional Activation / drug effects; Water Pollutants, Chemical / toxicity
TL;DR: The results demonstrate the use of medaka embryos for toxicity analysis thereby achieving REACH objectives for the reduction of adult animal testing in toxicity evaluations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 report

Endocrine Disruptor Screening Program (EDSP) Proposed Tier 1 Screening Battery - Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel

Environmental Protection Agency.

By: S. Kullman

Source: NC State University Libraries
Added: September 16, 2022

2008 chapter

Liver Toxicity

In The Toxicology of Fishes (pp. 327–400).

By: D. Hinton, H. Segner, D. Au, S. Kullman* & R. Hardman

Sources: Crossref, ORCID
Added: September 15, 2022

2008 journal article

Non invasive high resolution in vivo imaging of α-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka

Aquatic Toxicology, 86(1), 20–37.

By: R. Hardman*, S. Kullman*, B. Yuen* & D. Hinton*

author keywords: fish; toxicology; hepatobiliary; liver; toxicity; medaka; ANIT; biliary; biliary toxicity; alpha-naphthylisothiocyanate; hepatotoxicity; piscine liver
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Antibodies / metabolism; Apoptosis; Bile Ducts, Intrahepatic / drug effects; Bile Ducts, Intrahepatic / pathology; Bile Ducts, Intrahepatic / ultrastructure; Blood Vessels / drug effects; Epithelial Cells / cytology; Epithelial Cells / drug effects; Fluorescent Dyes / analysis; Image Processing, Computer-Assisted; Imaging, Three-Dimensional / veterinary; Liver / blood supply; Liver / drug effects; Liver / pathology; Liver / ultrastructure; Microscopy, Confocal / veterinary; Models, Animal; Oryzias / genetics; Oryzias / physiology; Phenotype
TL;DR: The findings presented show for the first time in vivo evaluation of toxicity in the STII medaka hepatobiliary system, and, in conjunction with prior in vivo work characterizing normalcy, advance the comparative understanding of this lower vertebrate hepatOBiliary system and its response to toxic insult. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2008 journal article

Non invasive in vivo investigation of hepatobiliary structure and function in STII medaka (Oryzias latipes): methodology and applications

Comparative Hepatology, 7(1).

By: R. Hardman*, S. Kullman* & D. Hinton*

TL;DR: The development of methodologies for non invasive in vivo investigation in STII medaka and the successful application of these methodologies to in vivo study of hepatobiliary structure, function, and xenobiotic response are described. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 13, 2022

2008 journal article

Paralogous vitamin D receptors in teleosts: Transition of nuclear receptor function

ENDOCRINOLOGY, 149(5), 2411–2422.

By: D. Howarth*, S. Law n, B. Barnes*, J. Hall*, D. Hinton*, L. Moore*, J. Maglich*, J. Moore*, S. Kullman n

MeSH headings : Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Cricetinae; Cricetulus; Evolution, Molecular; Female; Fishes / genetics; Humans; Male; Molecular Sequence Data; Oryzias / genetics; Phylogeny; Receptors, Calcitriol / genetics; Receptors, Calcitriol / metabolism; Receptors, Calcitriol / physiology; Receptors, Cytoplasmic and Nuclear / physiology; Sequence Homology, Amino Acid; Tissue Distribution; Trans-Activators / metabolism
TL;DR: Cl cloning and functional characterization of two novel vitamin D receptor (VDR) paralogs from the freshwater teleost medaka suggest that in mVDRalpha and VDRbeta have undergone a functional divergence through a process of sub- and/or neofunctionalization of VDR nuclear receptor gene pairs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Protective response of the ah receptor to ANIT-Induced biliary epithelial cell toxicity in see-through medaka

TOXICOLOGICAL SCIENCES, 102(2), 262–277.

By: D. Volz, S. Kullman*, D. Howarth, R. Hardman & D. Hinton

author keywords: see-through medaka; AHR; liver; nuclear receptor; bile; ANIT
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Apoptosis / drug effects; Bile Ducts, Intrahepatic / drug effects; Bile Ducts, Intrahepatic / metabolism; Bile Ducts, Intrahepatic / pathology; Bilirubin / pharmacology; Cell Line, Tumor; Cholestasis, Intrahepatic / metabolism; Cholestasis, Intrahepatic / prevention & control; Cloning, Molecular; Cytochrome P-450 CYP1A1 / biosynthesis; Cytochrome P-450 CYP1A1 / genetics; Disease Models, Animal; Drug Antagonism; Enzyme Induction; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / ultrastructure; Gallbladder / drug effects; Gallbladder / pathology; Gene Expression / drug effects; Injections, Intraperitoneal; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Mice; Oryzias / physiology; Pigmentation / genetics; Polychlorinated Dibenzodioxins / pharmacology; RNA, Messenger / metabolism; Receptors, Aryl Hydrocarbon / agonists; Receptors, Aryl Hydrocarbon / drug effects; Receptors, Aryl Hydrocarbon / metabolism
TL;DR: Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment, which suggests that bile-induced AHRactivation may be conserved between teleosts and rodents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

An in vivo Look at Vertebrate Liver Architecture: Three-Dimensional Reconstructions from Medaka (Oryzias latipes)

The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 290(7), 770–782.

By: R. Hardman*, D. Volz*, S. Kullman* & D. Hinton*

author keywords: liver; hepatobiliary; biliary; liver architecture; comparative hepatology; fish; 3-dimensional structure; liver structure and function
MeSH headings : Animals; Biliary Tract / cytology; Biliary Tract / ultrastructure; Computer Simulation; Epithelial Cells / ultrastructure; Fluorescent Dyes; Hepatocytes / ultrastructure; Imaging, Three-Dimensional; Liver / blood supply; Liver / cytology; Liver / ultrastructure; Microscopy, Confocal; Microscopy, Electron, Transmission; Models, Anatomic; Oryzias / anatomy & histology
TL;DR: The investigations show that hepatobiliary architecture in medaka is based on a polyhedral (hexagonal) structural motif, that the intrahepatic biliary system is an interconnected network of canaliculi and bile‐preductules, and that parenchymal architecture in this lower vertebrate is more related to that of the mammalian liver than previously believed. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Application of in vivo methodologies to investigation biological structure, function and xenobiotic response in see-through medaka (Oryzias latipes

The Fish Biology Journal, Medaka, 11, 43–65.

By: R. Hardman, S. Kullman & D. Hinton

Source: NC State University Libraries
Added: September 16, 2022

2007 report

Bioanalytical Analysis Of Natural Estrogens at Concentrated Animal Feed Operations Affecting North Carolina River Waters

(No. 376). Water Resources Research Institute of North Carolina.

By: S. Kullman, K. Linden & D. Hinton

Source: NC State University Libraries
Added: September 16, 2022

2007 journal article

Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation

Science of The Total Environment, 376(1-3), 18–26.

By: P. Chen*, E. Rosenfeldt*, S. Kullman*, D. Hinton* & K. Linden*

author keywords: endocrine disrupting compounds (EDCs); UV/H2O2 oxidation process; yeast estrogen screen (YES); vitellogenin (VTG)
MeSH headings : Animals; Benzhydryl Compounds; Drug Interactions; Endocrine Disruptors / toxicity; Estradiol / toxicity; Estrogens / toxicity; Ethinyl Estradiol / toxicity; Hydrogen Peroxide / chemistry; Male; Oryzias / metabolism; Oxidants / chemistry; Oxidation-Reduction; Phenols / toxicity; Photolysis; Receptors, Estrogen / metabolism; Rivers; Ultraviolet Rays; Vitellogenins / biosynthesis; Water Pollutants, Chemical / toxicity; Water Purification / methods; Yeasts / metabolism
TL;DR: The removal rates of in vitro and in vivo estrogenic activity of the EDC mixtures were lower than those observed for single compounds, and slower in natural waters, likely due to lower steady-state concentrations of hydroxyl radicals in the presence of *OH scavengers from the water matrix and EDC mixture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Comparisons of polychromatic and monochromatic UV-based treatments of bisphenol-A in water via toxicity assessments

Chemosphere, 68(6), 1041–1049.

By: P. Chen*, S. Kullman*, D. Hinton* & K. Linden*

MeSH headings : Animals; Benzhydryl Compounds; Embryo, Nonmammalian / drug effects; Endocrine Disruptors / analysis; Endocrine Disruptors / radiation effects; Endocrine Disruptors / toxicity; Hydrogen Peroxide / chemistry; Oryzias; Oxidation-Reduction / radiation effects; Phenols / analysis; Phenols / radiation effects; Phenols / toxicity; Photolysis / radiation effects; Ultraviolet Rays; Waste Disposal, Fluid / methods
TL;DR: Results demonstrated that MP-UV direct photolysis more effectively removed BPA and associated estrogenic activity compared to LP-UV lamps, and no significant difference was found between the two lamps under UV/H2O2 oxidation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Destruction of estrogenic activity in water using UV advanced oxidation

Science of The Total Environment, 377(1), 105–113.

By: E. Rosenfeldt*, P. Chen*, S. Kullman* & K. Linden*

author keywords: ultraviolet; water treatment; AOP; YES; endocrine disrupter; kinetics; model
MeSH headings : Endocrine Disruptors / analysis; Endocrine Disruptors / radiation effects; Estrogens, Non-Steroidal / analysis; Estrogens, Non-Steroidal / radiation effects; Oxidation-Reduction; Ultraviolet Rays; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / radiation effects; Water Purification / methods
TL;DR: These compounds, when considered at environmentally relevant levels, are significantly degraded at much lower UV fluences than previously thought. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Estrogenic modulation of CYP3A38, CYP3A40, and CYP19 in mature male medaka (Oryzias latipes)

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 145(3), 370–378.

By: S. Kashiwada*, M. Kameshiro*, H. Tatsuta*, Y. Sugaya*, S. Kullman*, D. Hinton*, K. Goka*

author keywords: CYP19; CYP3A; endocrine-disruption; estrogenic modulation; medaka; testosterone
MeSH headings : Animals; Aromatase / biosynthesis; Aromatase / genetics; Cytochrome P-450 CYP3A / biosynthesis; Cytochrome P-450 CYP3A / genetics; Dose-Response Relationship, Drug; Estradiol / pharmacology; Ethinyl Estradiol / pharmacology; Male; Oryzias / metabolism; RNA, Messenger / analysis; Testosterone / metabolism; Vitellogenins / biosynthesis
TL;DR: Estrogenic exposure induced Vtg production, suppressed CYP3A protein production, downregulated TE metabolism, and enhanced CYP19 activity, which could contribute to Vtg induction in male medaka. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2007 report

Impact of UV and UV Endocrine Disrupting Compounds in Water

(No. 91175). American Water Works Association Research Foundation.

By: K. Linden & S. Kullman

Source: NC State University Libraries
Added: September 16, 2022

2007 report

Towards an Innovative DNA Array Technology for Detection of Pharmaceuticals in Reclaimed Water

Water Environment Research Foundation (WERF) and Environmental Protection agency (EPA).

By: S. Kullman, K. Linden & D. Hinton

Source: NC State University Libraries
Added: September 16, 2022

2007 journal article

UV/H2O2 degradation of endocrine-disrupting chemicals in water evaluated via toxicity assays

Water Science and Technology, 55(12), 313–319.

By: K. Linden*, E. Rosenfeldt* & S. Kullman*

author keywords: endocrine disrupting compounds; estrogenic activity; UV photochemistry; UV/H2O2 advanced oxidation processes
MeSH headings : Endocrine Disruptors / chemistry; Endocrine Disruptors / radiation effects; Endocrine Disruptors / toxicity; Estradiol / analogs & derivatives; Estradiol / chemistry; Estradiol / toxicity; Hydrogen Peroxide / chemistry; Hydroxyl Radical / chemistry; Oxidation-Reduction; Saccharomyces cerevisiae / drug effects; Toxicity Tests / methods; Ultraviolet Rays; Water Purification / methods
TL;DR: A steady state model was developed to determine EDC destruction efficiency in waters of differing quality and it was concluded than complete destruction of oestrogenic activity was possible under practical advanced oxidation conditions for a variety of water qualities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: September 13, 2022

2006 journal article

Biological assessment of bisphenol A degradation in water following direct photolysis and UV advanced oxidation

Chemosphere, 65(7), 1094–1102.

By: P. Chen*, K. Linden*, D. Hinton*, S. Kashiwada*, E. Rosenfeldt* & S. Kullman*

author keywords: endocrine disrupting compounds (EDCs); low-pressure (LP) HgUV lamps; yeast estrogen screen (YES); vitellogenin (VTG); medaka (Oryzias latipes)
MeSH headings : Animals; Benzhydryl Compounds; Estrogen Receptor alpha / metabolism; Estrogens / metabolism; Estrogens / toxicity; Hydrogen Peroxide / chemistry; Larva / drug effects; Male; Oryzias; Oxidation-Reduction; Phenols / chemistry; Phenols / radiation effects; Phenols / toxicity; Photolysis; Ultraviolet Rays; Vitellogenins / metabolism; Water Pollutants, Chemical / chemistry; Water Pollutants, Chemical / radiation effects; Water Pollutants, Chemical / toxicity; Water Purification / methods; Yeasts / drug effects; Yeasts / metabolism
TL;DR: Investigation of the use of direct photolysis with low-pressure Hg UV lamps and UV+hydrogen peroxide and advanced oxidation process (AOP) for the degradation of a prototypic endocrine disrupter, bisphenol A (BPA), in laboratory water demonstrates that UV alone did not effectively degrade BPA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: August 28, 2020

2006 journal article

Dynamic Gene Expression Changes Precede Dioxin-Induced Liver Pathogenesis in Medaka Fish

Toxicological Sciences, 89(2), 524–534.

By: D. Volz, D. Hinton, J. Law & S. Kullman*

author keywords: medaka; dioxin; liver; aryl hydrocarbon receptor; gene expression; transcription
MeSH headings : Animals; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A2 / genetics; Dose-Response Relationship, Drug; Gene Expression / drug effects; Gene Expression Profiling; Injections, Intraperitoneal; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Oligonucleotide Array Sequence Analysis; Oryzias; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / genetics; Reverse Transcriptase Polymerase Chain Reaction; Time Factors
TL;DR: The data suggest that the cellular response to dioxin involves both AHRE- and non-AHRE-mediated transcription, and that coupling gene expression profiling with analysis of morphologic pathogenesis is essential for establishing temporal relationships between transcriptional changes, toxicity, and adaptation to hepatic injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2005 journal article

2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka (Oryzias latipes)

Toxicological Sciences, 85(1), 572–584.

By: D. Volz*, D. Bencic, D. Hinton, J. Law & S. Kullman*

author keywords: Japanese medaka; TCDD; gene expression; brain; liver; testis
MeSH headings : Animals; Brain / drug effects; Brain / metabolism; Brain / pathology; Environmental Pollutants / toxicity; Gene Expression / drug effects; Gene Expression Profiling; Injections, Intraperitoneal; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Oligonucleotide Array Sequence Analysis; Organ Specificity; Oryzias / genetics; Polychlorinated Dibenzodioxins / toxicity; Reverse Transcriptase Polymerase Chain Reaction; Testis / drug effects; Testis / metabolism; Testis / pathology
TL;DR: In this study, suppression subtractive hybridization was exploited as a screening tool to assess qualitative gene expression changes in whole brain, liver, and testis of adult male Japanese medaka exposed for 48 h to a single intraperitoneal-injected dose of TCDD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2005 journal article

Functional characterization of medaka CYP3A38 and CYP3A40: Kinetics and catalysis by expression in a recombinant baculovirus system

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 141(4), 338–348.

By: S. Kashiwada*, D. Hinton* & S. Kullman*

author keywords: medaka; CYP3A; baculovirus; cytochrome P450; kinetics; testosterone; BFC; metabolism
MeSH headings : Amino Acid Sequence; Animals; Baculoviridae / genetics; Catalysis; Cytochrome P-450 CYP3A / chemistry; Cytochrome P-450 CYP3A / metabolism; Kinetics; Molecular Sequence Data; Oryzias / metabolism; Oxazines / metabolism; Recombinant Proteins / metabolism; Testosterone / metabolism
TL;DR: Describing the catalytic and kinetic activities of two medaka CYP3A paralogs with benzyloxyresorufin (BFC), a fluorescent 3A-selective substrate, and testosterone suggests that differences in kinetics and catalytic activities are a result of amino acid substitutions in SRS regions 1, 3 and 5 within the CYP1A38 and CYP2A40 protein sequence. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2005 journal article

Resolving mechanisms of toxicity while pursuing ecotoxicological relevance?

Marine Pollution Bulletin, 51(8-12), 635–648.

By: D. Hinton*, S. Kullman*, R. Hardman*, D. Volz*, P. Chen*, M. Carney*, D. Bencic*

MeSH headings : Animals; Animals, Genetically Modified / metabolism; Carcinogenicity Tests / methods; Ecology / methods; Endocrine Disruptors / metabolism; Environmental Pollutants / metabolism; Models, Animal; Oligonucleotide Array Sequence Analysis / methods; Toxicology / methods; Toxicology / trends
TL;DR: Studies resolving mechanisms of toxicity are reviewed and ways to address biocomplexity, mixtures of contaminants, and the need to relate individual level responses to populations and communities are discussed. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2004 journal article

Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity

Marine Environmental Research, 58(2-5), 469–473.

By: S. Kullman*, S. Kashiwada* & D. Hinton*

MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Catalysis; Coumarins / metabolism; Cytochrome P-450 CYP3A; Fluorescence; Kinetics; Models, Chemical; Oryzias / metabolism; Oxidoreductases, N-Demethylating / metabolism; Phenols / metabolism; Protein Binding; Substrate Specificity
TL;DR: This study demonstrates that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models, and describes both homotropic and heterotropic cooperative interactions. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2004 chapter book

Bioinformatics Tools

By: K. Johnson, S. Kullman* & S. Lin

Sources: Crossref, ORCID
Added: September 13, 2022

2003 journal article

Analysis of medaka CYP3A gene regulation, promoter regulatory regions and cloning of the orphan nuclear receptor PXR

The MDIBL Bulletin, 42, 29–31.

By: S. Kullman & D. Hinton

Source: NC State University Libraries
Added: September 16, 2022

2003 journal article

Estrogen signaling in trout liver: Activation of the ras p21/MAP-kinase pathway

Environmental Science, 10, 223–227.

By: S. Kullman, F. Matsumura & D. Hinton

Source: NC State University Libraries
Added: September 16, 2022

2003 journal article

ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 539(1-2), 43–53.

By: Z. Liu*, S. Kullman*, D. Bencic*, M. Torten* & D. Hinton*

author keywords: ras mutations; diethylnitrosamine; medaka; hepatic carcinogenesis
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; DNA Mutational Analysis; Diethylnitrosamine; Genes, ras; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Molecular Sequence Data; Mutation; Oryzias
TL;DR: Results show that ras mutations are induced by DEN and are present in over 30% of the fish that developed tumors and the first in vivo report of ras point mutations at codon 16 is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: September 15, 2022

2002 journal article

Molecular cloning of rainbow trout (Oncorhynchus mykiss) eggshell zona radiata protein complementary DNA: mRNA expression in 17β-estradiol- and nonylphenol-treated fish

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 132(2), 315–326.

By: A. Arukwe, S. Kullman*, K. Berg*, A. Goksøyr* & D. Hinton*

author keywords: eggshell protein; cDNA cloning; liver; gene expression; xenoestrogen; biomarkers; environmental monitoring
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA Primers / genetics; DNA, Complementary / genetics; Egg Proteins / genetics; Egg Shell / chemistry; Estradiol / pharmacology; Gene Expression Profiling; Gene Expression Regulation / drug effects; Molecular Sequence Data; Oncorhynchus mykiss / genetics; Phenols / pharmacology; Phylogeny; Polymerase Chain Reaction; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Estrogen / genetics; Vitellogenins / genetics
TL;DR: The differential time-dependent transcriptional and translational expression and use of Zrp, ER and Vtg as sensitive biomarkers in environmental monitoring of endocrine disrupters in fish is discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: September 15, 2022

2002 journal article

Toxicant induced differential gene expression and production of an aquatic gene array

The MDIBL Bulletin, 41, 58–61.

By: S. Kullman & D. Hinton

Source: NC State University Libraries
Added: September 16, 2022

2001 journal article

Differential biomarker gene and protein expressions in nonylphenol and estradiol-17β treated juvenile rainbow trout (Oncorhynchus mykiss)

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 129(1), 1–10.

By: A. Arukwe*, S. Kullman & D. Hinton

author keywords: estrogen-receptor; Zr-protein; vitellogenin; biomarkers; gene expression; xenoestrogen; rainbow trout
MeSH headings : Animals; Biomarkers; Blotting, Northern; Egg Proteins / genetics; Egg Proteins / metabolism; Enzyme-Linked Immunosorbent Assay; Estradiol / metabolism; Estradiol / pharmacology; Gene Expression Regulation / drug effects; Oncorhynchus mykiss / genetics; Oncorhynchus mykiss / metabolism; Phenols / metabolism; Phenols / pharmacology; Protein Biosynthesis; RNA, Messenger / metabolism; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Transcriptional Activation; Vitellogenins / genetics; Vitellogenins / metabolism
TL;DR: The time- and dose-dependent transcriptional and translational expression of biomarker genes in nonylphenol and E(2) treated juvenile rainbow trout is reported and it is concluded that Vtg and Zr-protein gene transcriptions require only basal or minimal ER concentration, in addition to other mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: September 15, 2022

2001 journal article

Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes)

Molecular Reproduction and Development, 58(2), 149–158.

By: S. Kullman* & D. Hinton*

author keywords: CYP3A; embryo; development
TL;DR: It is demonstrated that CYP3A40 is expressed early in embryonic development and continues throughout adult stages, while CYP2A38, however, is tightly regulated during embryonicDevelopment and is only expressed post‐hatch Mol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: September 15, 2022

2000 journal article

Identification and Characterization of a cDNA Encoding Cytochrome P450 3A from the Fresh Water Teleost Medaka (Oryzias latipes)

Archives of Biochemistry and Biophysics, 380(1), 29–38.

By: S. Kullman*, J. Hamm* & D. Hinton*

author keywords: medaka; cytochrome P450; CYP3A; steroid metabolism
MeSH headings : Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Northern; Blotting, Western; Cell Line; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; DNA, Complementary / metabolism; Female; Fishes / genetics; Gene Library; Humans; Isoenzymes / biosynthesis; Isoenzymes / genetics; Liver / metabolism; Male; Microsomes, Liver / metabolism; Molecular Sequence Data; Oxidoreductases, N-Demethylating / biosynthesis; Oxidoreductases, N-Demethylating / genetics; RNA / metabolism; Recombinant Proteins / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sex Factors; Testosterone / metabolism
TL;DR: Results suggests that O. latipes contains multiple forms of CYP3A, andComparisons of the deduced amino acid sequence to other known cytochrome P450 sequences indicate that this gene product is most similar to the CYP2A gene family. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 13, 2022

1997 journal article

Identification of a novel cytochrome P-450 gene from the white rot fungus Phanerochaete chrysosporium

Applied and Environmental Microbiology, 63(7), 2741–2746.

By: S. Kullman* & F. Matsumura*

MeSH headings : Amino Acid Sequence; Base Sequence; Basidiomycota / genetics; Blotting, Northern; Blotting, Western; Cloning, Molecular; Cytochrome P-450 Enzyme System / genetics; Gene Expression Regulation, Fungal; Heme / genetics; Heme / immunology; Molecular Sequence Data; Nitrogen / metabolism; Open Reading Frames; Polymerase Chain Reaction; RNA, Fungal / analysis; Sequence Homology, Amino Acid
TL;DR: Northern blot analysis suggests that CYP63-1A is expressed under both nitrogen-rich and nitrogen-deficient culture conditions and thus not under the same regulatory constraints as the well-studied lignin and manganese peroxidases. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 13, 2022

1996 journal article

Metabolic pathways utilized by Phanerochaete chrysosporium for degradation of the cyclodiene pesticide endosulfan

Applied and Environmental Microbiology, 62(2), 593–600.

By: S. Kullman* & F. Matsumura*

MeSH headings : Basidiomycota / metabolism; Biodegradation, Environmental; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Endosulfan / chemistry; Endosulfan / metabolism; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Chlorinated; Hydrolysis; Insecticides / chemistry; Insecticides / metabolism; Oxidation-Reduction; Peroxidases / metabolism; Piperonyl Butoxide / pharmacology
TL;DR: It is concluded that metabolism of this compound does not involve the action of extracellular peroxidases, and it is suggested that the metabolism of endosulfan is mediated by two divergent pathways, one hydrolytic and the other oxidative. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 13, 2022

1995 report

Bioremediation Principles: Laboratory Manual

Department of Civil and Environmental Engineering and US Department of Defense, Bioremediation course development for Marie Island Remediation.

By: S. Kullman, K. Lindenauer & M. Fuller

Source: NC State University Libraries
Added: September 16, 2022

1993 journal article

Development of antibodies against hydroxyatrazine and hydroxysimazine: Application to environmental samples

Journal of Agricultural and Food Chemistry, 41(9), 1523–1529.

By: A. Lucas, H. Bekheit, M. Goodrow, A. Jones, S. Kullman*, F. Matsumura, J. Woodrow, J. Seiber, B. Hammock

TL;DR: This ELISA provided a valuable method to quantify hydroxyatrazine and hydroxysimazine in a series of traditionally difficult matrices for the investigation of the bioremediation of atrazine. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 15, 2022

Education

Updated: May 28th, 2014 11:01

University of California Davis Davis, CA, US
PhD Phamacology/Toxicology

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