Works (99)

Updated: April 3rd, 2024 18:43

2021 journal article

Discovery of a major QTL for root-knot nematode (Meloidogyne incognita) resistance in cultivated sweetpotato (Ipomoea batatas)

Theoretical and Applied Genetics, 134(7), 1945–1955.

By: B. Oloka n, G. da Silva Pereira*, V. Amankwaah n, M. Mollinari n, K. Pecota n, B. Yada*, B. Olukolu*, Z. Zeng n, G. Yencho n

Contributors: B. Oloka n, G. Silva Pereira*, V. Amankwaah n, M. Mollinari n, K. Pecota n, B. Yada*, B. Olukolu*, Z. Zeng n, G. Craig Yencho n

MeSH headings : Animals; Chromosome Mapping; Disease Resistance / genetics; Genetic Linkage; Genotype; Ipomoea batatas / genetics; Ipomoea batatas / parasitology; Plant Diseases / genetics; Plant Diseases / parasitology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Tylenchoidea / pathogenicity
TL;DR: A major dominant QTL for root-knot nematode (RKN) resistance is discovered using a high-density integrated genetic linkage map of hexaploid sweetpotato, which represents a significant step forward in understanding of the genetic architecture of RKN resistance and sets the stage for future utilization of genomics-assisted breeding inSweetpotato breeding programs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: April 4, 2021

2021 journal article

Quantitative Trait Locus Mapping for Common Scab Resistance in a Tetraploid Potato Full-Sib Population

Plant Disease, 105(10), 3048–3054.

By: G. da Silva Pereira*, M. Mollinari n, X. Qu*, C. Thill*, Z. Zeng n, K. Haynes*, G. Yencho n

Contributors: G. Da Pereira, M. Mollinari n, X. Qu*, C. Thill*, Z. Zeng n, K. Haynes*, G. Yencho n

author keywords: disease resistance; polyploid QTL model; single-nucleotide polymorphism; Solanum tuberosum; Streptomyces spp
MeSH headings : Chromosome Mapping; Plant Tubers / genetics; Quantitative Trait Loci / genetics; Solanum tuberosum / genetics; Tetraploidy
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: January 18, 2022

2021 journal article

The recombination landscape and multiple QTL mapping in a Solanum tuberosum cv. ‘Atlantic’-derived F1 population

Heredity, 126(5), 817–830.

By: G. da Silva Pereira n, M. Mollinari n, M. Schumann n, M. Clough n, Z. Zeng n & G. Yencho n

Contributors: G. Silva Pereira n, M. Mollinari n, M. Schumann n, M. Clough n, Z. Zeng n & G. Yencho n

MeSH headings : Phenotype; Plant Breeding; Plant Tubers; Quantitative Trait Loci; Recombination, Genetic; Solanum tuberosum / genetics
TL;DR: Genetic analyses of an F1 population derived from a cross involving ‘Atlantic’, a widely grown chipping variety in the USA, find those on chromosome 5 that have been previously implicated in maturity (StCDF1) and tuber formation (POTH1). (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: March 29, 2021

2020 journal article

Assembly of whole-chromosome pseudomolecules for polyploid plant genomes using outbred mapping populations

Nature Genetics, 52(11), 1256–1264.

MeSH headings : Algorithms; Chromosomes, Plant; Computer Simulation; Genetic Linkage; Genome, Plant; Genotype; Ipomoea / genetics; Plant Breeding; Poaceae / genetics; Polyploidy; Protein Array Analysis; Solanum tuberosum / genetics
TL;DR: PolyGembler, a method for grouping and ordering contigs into complete pseudomolecules by combining long-read sequencing and genotype information from an outbred mapping population, improves the accuracy for assembly of polyploidy plant genomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: November 24, 2020

2020 journal article

Sequencing depth and genotype quality: accuracy and breeding operation considerations for genomic selection applications in autopolyploid crops

Theoretical and Applied Genetics, 133(12), 3345–3363.

MeSH headings : Crops, Agricultural / genetics; Crops, Agricultural / growth & development; Genotype; Ipomoea batatas / genetics; Ipomoea batatas / growth & development; Phenotype; Plant Breeding; Polymorphism, Single Nucleotide; Polyploidy; Quantitative Trait Loci; Selection, Genetic; Sequence Analysis, DNA
TL;DR: It is concluded that genomic selection can help accelerate the rate of genetic gains in potato and sweetpotato, however, application of genomic selection should be considered as part of optimizing the entire breeding program. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: September 21, 2020

2019 journal article

Genomic Selection with Allele Dosage in Panicum maximum Jacq.

G3-GENES GENOMES GENETICS, 9(8), 2463–2475.

author keywords: Plant Breeding; Guinea Grass; Quantitative Genotyping; Polyploidy; Genotyping-by-sequencing (GBS); Recurrent Genomic Selection; Genomic Prediction; GenPred; Shared Data Resources
MeSH headings : Algorithms; Alleles; Gene Dosage; Genome, Plant; Genomics / methods; Panicum / genetics; Phenotype; Plant Breeding; Polyploidy; Selection, Genetic
TL;DR: This work provides bioinformatic and modeling guidelines to consider tetraploid dosage and observed that genomic selection may lead to additional gains in recurrent selection program of P. maximum. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 26, 2019

2017 journal article

Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster

GENOME BIOLOGY AND EVOLUTION, 9(5), 1357–1369.

By: Y. Lee*, Q. Yang*, W. Chi*, S. Turkson*, W. Du*, C. Kemkemer*, Z. Zeng n, M. Long*, X. Zhuang*

author keywords: genome-wide association study; foraging behavior; Drosophila melanogaster; inbreeding depression
TL;DR: It is found that adult foraging behavior has a strong genetic component and, unlike larval foragingbehavior, depends on multiple loci and shed light on the initial stage underlying the evolution of the behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Linkage map construction and QTL analysis for internal heat necrosis in autotetraploid potato

Theoretical and Applied Genetics, 130(10), 2045–2056.

By: M. Schumann n, Z. Zeng n, M. Clough n & G. Yencho n

MeSH headings : Chromosome Mapping; Genetic Linkage; Hot Temperature / adverse effects; Necrosis / genetics; Plant Tubers; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Solanum tuberosum / genetics; Tetraploidy
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Quantitative trait loci influencing forking defects in an outbred pedigree of loblolly pine

BMC Genetics, 17(1).

By: J. Xiong n, S. McKeand n, F. Isik n, J. Wegrzyn*, D. Neale*, Z. Zeng n, L. da Costa e Silva*, R. Whetten n

author keywords: QTL; Stem forking; Outbred; Pinus taeda; MAS; Tree breeding; Wood quality
MeSH headings : Algorithms; Breeding; Chromosome Mapping; Genetic Association Studies; Genetic Linkage; Genetic Markers; Genotype; Models, Statistical; Pedigree; Phenotype; Pinus taeda / genetics; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Quantitative Trait, Heritable
TL;DR: The hypothesis that marker-assisted selection can be used to decrease the rate of stem defects in breeding populations of loblolly pine is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Mapping epistatic quantitative trait loci

BMC GENETICS, 15.

By: C. Laurie*, S. Wang n, L. Carlini-Garcia* & Z. Zeng n

author keywords: Quantitative trait loci; Epistasis; Model selection; Sequential search
MeSH headings : Algorithms; Chromosome Mapping / methods; Epistasis, Genetic; Lod Score; Models, Genetic; Quantitative Trait Loci
TL;DR: This paper developed a three-stage search strategy that provides an effective and powerful solution to map multiple QTL with complex epistatic pattern and has been implemented in the user-friendly computer software Windows QTL Cartographer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Improved Sparse Multi-Class SVM and Its Application for Gene Selection in Cancer Classification

Cancer Informatics, 12, CIN.S10212.

By: L. Huang n, H. Zhang n, Z. Zeng n & P. Bushel n

author keywords: support vector machine (SVM); multi-class SVM; variable selection; shrinkage methods; classification; microarray; cancer classification
TL;DR: The method is improved by introducing soft-thresholding type penalties to incorporate variable selection into multi-class classification for high dimensional data and demonstrates that the new methods can select a small number of genes for building accurate multi- class classification rules. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: July 20, 2019

2012 journal article

Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile

Scientific Reports, 2(1).

By: R. Kaddurah-Daouk*, P. Yuan*, S. Boyle*, W. Matson*, Z. Wang n, Z. Zeng n, H. Zhu n, G. Dougherty* ...

MeSH headings : Adult; Biogenic Monoamines / cerebrospinal fluid; Biosynthetic Pathways; Case-Control Studies; Depressive Disorder, Major / cerebrospinal fluid; Female; Humans; Male; Metabolome; Middle Aged; Multivariate Analysis; Remission, Spontaneous; Severity of Illness Index
TL;DR: The reductions in metabolites associated with tryptophan and tyrosine pathways in rMDD may relate to the vulnerability this population shows for developing depressive symptoms under tryPTophan or catecholamine depletion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2012 chapter

Composite Interval Mapping and Multiple Interval Mapping: Procedures and Guidelines for Using Windows QTL Cartographer

In Methods in Molecular Biology (pp. 75–119).

By: L. Silva n, S. Wang n & Z. Zeng n

MeSH headings : Animals; Drosophila melanogaster / genetics; Inbreeding; Models, Statistical; Quantitative Trait Loci / genetics; Software
TL;DR: This chapter provides an introduction of composite interval mapping and multiple interval mapping methods for mapping QTL from inbred line crosses and also detailed instructions to perform the analyses in Windows QTL Cartographer. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2012 journal article

Merging pharmacometabolomics with pharmacogenomics using ‘1000 Genomes’ single-nucleotide polymorphism imputation

Pharmacogenetics and Genomics, 22(4), 247–253.

author keywords: 1000 Genomes; HapMap; imputation; major depressive disorder; pharmacometabolomics; pharmacogenomics; selective serotonin reuptake inhibitors; tag single-nucleotide polymorphisms
MeSH headings : Citalopram / adverse effects; Citalopram / therapeutic use; Depressive Disorder / drug therapy; Depressive Disorder / genetics; Genome-Wide Association Study / methods; Glycine / biosynthesis; Glycine / genetics; Glycine / metabolism; Glycine Dehydrogenase / genetics; HapMap Project; Haplotypes; Humans; Metabolic Networks and Pathways / genetics; Metabolomics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Selective Serotonin Reuptake Inhibitors / metabolism
TL;DR: The results indicate that the use of GWAS data to impute SNPs for genes in pathways identified by other ‘omics’ approaches makes it possible to rapidly and cost efficiently identify SNP markers to ‘broaden’ and accelerate pharmacogenomic studies. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

PLoS ONE, 7(7), e38386.

Ed(s): M. Oresic

MeSH headings : Adult; Amino Acids, Essential / blood; Biomarkers, Pharmacological / blood; Cholesterol, LDL / blood; Citrulline / blood; Cystine / blood; Female; Fructose / blood; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Lauric Acids / blood; Male; Metabolomics; Nitric Oxide Synthase / blood; Ornithine / blood; Simvastatin / pharmacology; Simvastatin / therapeutic use; Stearic Acids / blood; Succinic Acid / blood; Xanthine / blood; alpha-Tocopherol / blood
TL;DR: The findings from this study indicate that clusters of metabolites involved in multiple pathways not directly connected with cholesterol metabolism may play a role in modulating the response to simvastatin treatment. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2012 journal article

Multiple trait multiple interval mapping of quantitative trait loci from inbred line crosses

BMC Genetics, 13.

By: L. Silva, S. Wang & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

PLOS ONE, 6(10).

By: R. Kaddurah-Daouk*, R. Baillie*, H. Zhu n, Z. Zeng n, M. Wiest*, U. Nguyen*, K. Wojnoonski, S. Watkins*, M. Trupp*, R. Krauss

MeSH headings : Bile Acids and Salts / metabolism; Cholesterol, LDL / blood; Demography; Female; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Humans; Liver-Specific Organic Anion Transporter 1; Male; Metabolomics; Metagenome / drug effects; Middle Aged; Models, Biological; Organic Anion Transporters / genetics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Simvastatin / pharmacology; Treatment Outcome
TL;DR: Interactions between genome, gut microbiome and environmental influences should be considered in the study and management of cardiovascular disease and metabolic profiles could provide valuable information about treatment outcomes and could contribute to a more personalized approach to therapy. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

High-Confidence Discovery of Genetic Network Regulators in Expression Quantitative Trait Loci Data

GENETICS, 187(3), 955–964.

By: C. Duarte* & Z. Zeng n

MeSH headings : Algorithms; Bayes Theorem; Chromosome Mapping; Computational Biology; Computer Simulation; Gene Expression Profiling / statistics & numerical data; Gene Regulatory Networks; Genes, Regulator / genetics; Genetic Markers / genetics; Models, Genetic; Quantitative Trait Loci / genetics; Saccharomyces cerevisiae / genetics
TL;DR: This work introduces the concept of “shielding” in which a specific gene expression variable (the shielder) renders a set of other gene expression variables (the shielded genes) independent of the eQTL, and proposes a novel test for controlling the shielder false-positive rate at a predetermined level by requiring a threshold number of shielded genes per shielder. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

QTL Mapping for Days to Flowering under Drought Condition in Rice (Oryza sativa L.) Genome

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 39(1), 58.

By: S. Chakraborty n & Z. Zeng n

TL;DR: The five common QTL detected by at least two models could be considered as stable QTL for days to flowering under drought and might be of practical use in marker assisted selection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Crossref
Added: July 20, 2019

2010 journal article

Current Progress on Statistical Methods for Mapping Quantitative Trait Loci from Inbred Line Crosses

JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 20(2), 454–481.

By: L. Silva n & Z. Zeng n

author keywords: Inbred lines; Quantitative trait loci; Statistical methods
MeSH headings : Algorithms; Animals; Animals, Inbred Strains; Bayes Theorem; Crosses, Genetic; Data Interpretation, Statistical; Genome-Wide Association Study / statistics & numerical data; Genotype; Likelihood Functions; Models, Statistical; Phenotype; Quantitative Trait Loci; Reproducibility of Results
TL;DR: The progress of research in this area on one trait and multiple traits by maximum likelihood and Bayesian methods is reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics

Clinical Pharmacology & Therapeutics, 89(1), 97–104.

By: Y. Ji*, S. Hebbring*, H. Zhu n, G. Jenkins*, J. Biernacka*, K. Snyder*, M. Drews*, O. Fiehn* ...

MeSH headings : Biomarkers, Pharmacological / blood; Cell Line; Chromosomes, Human, Pair 9 / genetics; Citalopram / therapeutic use; DNA-Binding Proteins / metabolism; Depressive Disorder, Major / blood; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / genetics; Drug Monitoring / methods; Female; Genetic Association Studies; Glycine / blood; Glycine / metabolism; Glycine Dehydrogenase (Decarboxylating) / genetics; Humans; Introns / genetics; Linkage Disequilibrium; Male; Metabolome / drug effects; Nuclear Proteins / metabolism; Polymorphism, Single Nucleotide; Selective Serotonin Reuptake Inhibitors / therapeutic use
TL;DR: A possible role for glycine in SSRI response is highlighted and the use of pharmacometabolomics‐informed pharmacogenomic research strategy to identify citalopram/escitaloprams treatment outcome biomarkers is illustrated to “inform” pharmacogenomics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2010 journal article

Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study

Metabolomics, 6(2), 191–201.

By: R. Kaddurah-Daouk*, R. Baillie*, H. Zhu n, Z. Zeng n, M. Wiest*, U. Nguyen*, S. Watkins*, R. Krauss

author keywords: Cardiovascular disease; Lipidomics; Metabolomics; Pharmacogenomics; Pharmacometabolomics; Simvastatin
TL;DR: There was no overlap of lipids whose changes correlated with LDL-C or CRP responses to simvastatin suggesting that distinct metabolic pathways govern statin effects on these two biomarkers. (via Semantic Scholar)
Sources: Crossref, Web Of Science, ORCID
Added: August 6, 2018

2010 report

Power, sample size and confidence interval for quantitative trait loci mapping on multiple traits

By: L. E Silva, S. Chang & Z. Zeng

Source: NC State University Libraries
Added: August 16, 2021

2010 journal article

QTL Identification Using Combined Linkage and Linkage Disequilibrium Mapping for Milk Production Traits on BTA6 in Chinese Holstein Population

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 23(10), 1261–1267.

By: F. Hu n, J. Liu*, Z. Zeng n, X. Ding*, C. Yin*, Y. Gong*, Q. Zhang*

author keywords: Fine Mapping; QTL; Bos Taurus autosome 6; Milk Production Traits
TL;DR: The aim of the present study was to refine the position of previously detected quantitative trait loci (QTL) on bovine chromosome 6 affecting milk production traits in Chinese Holstein dairy cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A Joint Association Test for Multiple SNPs in Genetic Case-Control Studies

GENETIC EPIDEMIOLOGY, 33(2), 151–163.

By: T. Wang*, H. Jacob*, S. Ghosh*, X. Wang* & Z. Zeng n

author keywords: haplotype association; retrospective likelihood; latent variable; logistic mixture model; EM algorithm
MeSH headings : Algorithms; Alleles; Case-Control Studies; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Likelihood Functions; Linkage Disequilibrium; Logistic Models; Models, Genetic; Models, Statistical; Molecular Epidemiology / statistics & numerical data; Polymorphism, Single Nucleotide
TL;DR: A latent variable approach to test for association of multiple tightly linked SNPs in case‐control studies and an expectation‐maximization (EM)‐based algorithm to fit the penetrance model and estimate the joint haplotype frequencies of the DSL and markers simultaneously are proposed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Contribution of genetic effects to genetic variance components with epistasis and linkage disequilibrium

BMC GENETICS, 10.

By: T. Wang* & Z. Zeng n

MeSH headings : Alleles; Epistasis, Genetic; Genetic Variation; Genotype; Linkage Disequilibrium; Models, Genetic; Quantitative Trait Loci; Regression Analysis
TL;DR: The Cockerham type models are allelic based models with a focus on partition of genotypic variances into various genetic variance components, which are contributed by allelic effects and their interactions, while the F∞ regression models are genotype-based models focusing on modeling and testing of within-locusgenotypic effects and locus-by- locus genotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains

Genetic Epidemiology, 33(2), 181–181.

By: Y. Kim n, S. Feng n & Z. Zeng n

TL;DR: Measuring and Partitioning the High-Order Linkage Disequilibrium by Multiple Order Markov Chains by Multiple order Markov chains and Zhao-Bang Zeng Bioinformatics Research Center. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Crossref
Added: April 4, 2021

2009 article

Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains (vol 32, pg 301, 2008)

Genetic Epidemiology, Vol. 33, pp. 181–181.

By: Y. Kim, S. Feng & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Multiple interval mapping for gene expression QTL analysis

GENETICA, 137(2), 125–134.

By: W. Zou n & Z. Zeng n

author keywords: eQTL; FDR; MIM; Model selection
MeSH headings : Chromosome Mapping / methods; Computer Simulation; Gene Expression; Genomics / methods; Models, Genetic; Quantitative Trait Loci / genetics; Yeasts
TL;DR: A statistical method to claim expression quantitative trait loci (eQTL) in a genome is developed based on multiple interval mapping (MIM), a model selection procedure, and uses false discovery rate (FDR) to measure the statistical significance of the large number of eQTL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 article

The Third International Conference of Quantitative Genetics

Weir, B. S., Hill, W. G., Zhu, J., & Zeng, Z.-B. (2009, June). GENETICA, Vol. 136, pp. 211–212.

By: B. Weir*, W. Hill*, J. Zhu* & Z. Zeng n

MeSH headings : Animals; China; Genetics; Humans; Internationality
TL;DR: The wide range of topics and methods discussed in these papers show the diversity of applications of quantitative genetics and of the technologies employed, and were run as a single session in order to foster interactions and exchange of ideas and problems among those working on these different systems, species and technologies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

From classical genetics to quantitative genetics to systems biology: Modeling epistasis

PLoS Genetics, 4(3).

By: D. Aylor & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants

BMC Genomics, 9.

By: L. Huang, A. Heinloth, Z. Zeng, R. Paules & P. Bushel

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains

GENETIC EPIDEMIOLOGY, 32(4), 301–312.

By: Y. Kim n, S. Feng n & Z. Zeng n

author keywords: multilocus linkage disequilibrium; multiple order Markov chains; partition of multilocus LID
MeSH headings : Biometry; Databases, Genetic; Epidemiologic Methods; Gene Frequency; Haplotypes; Humans; Likelihood Functions; Linkage Disequilibrium; Markov Chains; Models, Genetic
TL;DR: Non‐homogeneous, multiple order Markov Chain models are employed as a statistical framework to measure and partition the LD among multiple markers into components due to different orders of marker associations and the results reveal that the most LD in the HapMap data is attributed to the LD between adjacent pairs of markers across the whole region. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Quantitative Trait Loci Mapping and The Genetic Basis of Heterosis in Maize and Rice

GENETICS, 180(3), 1707–1724.

MeSH headings : Chromosome Mapping; Crosses, Genetic; Epistasis, Genetic; Hybrid Vigor / genetics; Models, Genetic; Oryza / genetics; Quantitative Trait Loci; Zea mays / genetics
TL;DR: The results show that heterosis in maize is mainly due to dominant gene action, although overdominance of individual QTL could not completely be ruled out due to the mapping resolution and limitations of NC design III. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Statistical Methods for Mapping Multiple QTL

International Journal of Plant Genomics, 2008, 1–8.

By: W. Zou n & Z. Zeng n

TL;DR: This article focuses the discussion on the statistical methods for mapping multiple QTL by maximum likelihood and Bayesian methods and also on determining appropriate thresholds for the analysis. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2007 journal article

A semiparametric approach for composite functional mapping of dynamic quantitative traits

GENETICS, 177(3), 1859–1870.

MeSH headings : Algorithms; Chromosome Mapping / methods; Chromosome Mapping / statistics & numerical data; Likelihood Functions; Models, Genetic; Models, Statistical; Monte Carlo Method; Oryza / genetics; Oryza / growth & development; Polymorphism, Restriction Fragment Length; Quantitative Trait Loci; Regression Analysis
TL;DR: A statistical framework for mapping QTL that affect dynamic traits by capitalizing on the strengths of functional mapping and composite interval mapping is presented, leading to the identification of multiple QTL, some of which are linked on the same chromosome, that control the developmental trajectory of leaf age. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Speed-mapping quantitative trait loci using microarrays

NATURE METHODS, 4(10), 839–841.

By: C. Lai*, J. Leips n, W. Zou n, J. Roberts*, K. Wollenberg*, L. Parnell*, Z. Zeng n, J. Ordovas*, T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Female; Gene Expression Profiling / methods; Longevity / genetics; Male; Oligonucleotide Array Sequence Analysis / methods; Polymorphism, Genetic / genetics; Quantitative Trait Loci
TL;DR: A rapid, economical method for high-resolution quantitative trait locus (QTL) mapping using microarrays for selective genotyping of pooled DNA samples is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

The Hill–Robertson effect is a consequence of interplay between linkage, selection and drift: a commentary on ‘The effect of linkage on limits to artificial selection’ by W. G. Hill and A. Robertson

Genetics Research, 89(5-6), 309–310.

By: Z. Zeng n

MeSH headings : Alleles; Genetic Drift; Genetic Linkage; Population Density; Selection, Genetic
UN Sustainable Development Goal Categories
Source: Crossref
Added: July 20, 2019

2007 journal article

The role of epistasis in the manifestation of heterosis: A systems-oriented approach

GENETICS, 177(3), 1815–1825.

By: A. Melchinger*, H. Utz*, H. Piepho, Z. Zeng n & C. Schoen

MeSH headings : Animals; Breeding; Chromosome Mapping; Epistasis, Genetic; Genes, Dominant; Genetic Markers; Hybrid Vigor; Mathematics; Models, Genetic; Quantitative Trait Loci; Systems Biology
TL;DR: A new type of heterotic effect is defined denoted as augmented dominance effect di* that comprises the dominance effect at each QTL minus half the sum of additive × additive interactions with all other QTL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

eQTL Viewer: visualizing how sequence variation affects genome-wide transcription

BMC Bioinformatics, 8(7).

By: W. Zou, D. Aylor & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

A population-based latent variable approach for association mapping of quantitative trait loci

ANNALS OF HUMAN GENETICS, 70, 506–523.

By: T. Wang*, B. Weir n & Z. Zeng n

author keywords: association mapping; maximum likelihood; haplotype; latent variable; EM algorithm
MeSH headings : Algorithms; Chromosome Mapping; Computer Simulation; Genetics, Population / methods; Humans; Likelihood Functions; Linkage Disequilibrium / genetics; Models, Genetic; Quantitative Trait Loci; Statistics as Topic
TL;DR: Under a general likelihood framework, an EM‐based algorithm is developed to estimate genetic effects of the QTL and haplotype frequencies of theQTL and markers jointly and provides a joint test for association between a quantitative trait and marker genotypes without requiring adjustment for the multiple testing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Models and partition of variance for quantitative trait loci with epistasis and linkage disequilibrium

BMC Genetics, 7.

By: T. Wang & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Multiple-interval mapping for ordinal traits

GENETICS, 173(3), 1649–1663.

By: J. Li n, S. Wang* & Z. Zeng n

MeSH headings : Algorithms; Chromosome Mapping; Computer Simulation; Crosses, Genetic; Epistasis, Genetic; Models, Statistical; Quantitative Trait Loci
TL;DR: This study extends MIM to ordinal traits on the basis of a threshold model and inherits the properties and advantages of MIM and can fit a model of multiple QTL effects and epistasis on the underlying liability score. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Validation of two major quantitative trait loci for fusarium head blight resistance in Chinese wheat line W14

PLANT BREEDING, 125(1), 99–101.

By: J. Chen n, C. Griffey n, M. Maroof n, E. Stromberg n, R. Biyashev n, W. Zhao n, M. Chappell n, T. Pridgen n, Y. Dong n, Z. Zeng n

author keywords: Triticum aestivum; Fusarium head blight; microsatellite; QTL mapping
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Genetic architecture of transcript-level variation in differentiating xylem of a eucalyptus hybrid

GENETICS, 169(4), 2295–2303.

By: M. Kirst n, C. Basten n, A. Myburg*, Z. Zeng n & R. Sederoff n

MeSH headings : Cell Differentiation; Chimera; Chromosome Mapping; Crosses, Genetic; Eucalyptus / genetics; Gene Expression Regulation; Genes, Plant; Genetic Linkage; Genetic Markers; Genetic Variation; Genome, Plant; Genotype; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phylogeny; Quantitative Trait Loci; RNA, Messenger / metabolism
TL;DR: To analyze and compare the genetic architecture of transcript regulation in different genetic backgrounds of Eucalyptus, microarrays were used to examine variation in mRNA abundance in the differentiating xylem of a E. grandis pseudobackcross population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Mixture model equations for marker-assisted genetic evaluation

JOURNAL OF ANIMAL BREEDING AND GENETICS, 122(4), 229–239.

By: Y. Liu n & Z. Zeng n

MeSH headings : Animals; Animals, Domestic / genetics; Genetic Markers; Genotype; Linear Models; Male; Models, Genetic; Quantitative Trait Loci / genetics
TL;DR: A set of mixture model equations was derived based on the normal mixture model and the EM algorithm for evaluating linear models with uncertain independent variables to provide a general framework to deal with the issues of uncertain incidence matrices in linear models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Modeling quantitative trait loci and interpretation of models

GENETICS, 169(3), 1711–1725.

By: Z. Zeng n, T. Wang* & W. Zou n

MeSH headings : Gene Frequency; Linkage Disequilibrium; Models, Genetic; Models, Statistical; Quantitative Trait Loci; Regression Analysis
TL;DR: A quantitative genetic model relates the genotypic value of an individual to the alleles at the loci that contribute to the variation in a population in terms of additive, dominance, and epistatic effects and proposes a number of models to describe this relationship. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

QTL mapping and the genetic basis of adaptation: recent developments

GENETICA, 123(1-2), 25–37.

By: Z. Zeng n

author keywords: genetic architecture; genetic basis of adaptation; genetic correlation; genotype by environment interaction; microarrays; QTL mapping; quantitative trait loci
MeSH headings : Adaptation, Biological / genetics; Biological Evolution; Chromosome Mapping; Data Interpretation, Statistical; Epistasis, Genetic; Likelihood Functions; Lod Score; Models, Genetic; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Selection, Genetic
TL;DR: Quantitative trait loci (QTL) mapping has been used in a number of evolutionary studies to study the genetic basis of adaptation by mapping individual QTL that explain the differences between differentiated populations and also estimating their effects and interaction in the mapping population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Genetic dissection of hybrid Incompatibilities between Drosophila simulansand D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome

Genetics, 164(4), 1399–1418.

By: Y. Tao, Z. Zeng, J. Li, D. Hartl & C. Laurie

Source: NC State University Libraries
Added: August 6, 2018

2003 chapter

Quantitative Trait Loci Mapping

In D. Cooper (Ed.), Nature encyclopedia of the human genome. New York: Nature Publishing Group.

By: Z. Zeng

Ed(s): D. Cooper

Source: NC State University Libraries
Added: August 16, 2021

2002 journal article

Discussion on the meeting on 'Statistical modelling and analysis of genetic data'

Journal of the Royal Statistical Society: Series B (Statistical Methodology), 64(4), 737–775.

By: D. Balding, A. Carothers, J. Marchini, L. Cardon, A. Vetta, B. Griffiths, B. Weir, W. Hill ...

TL;DR: An unavoidable commitment arising unexpectedly in the 18 hours before the meeting robbed me of the final preparation, so that comments at the meeting were poorly presented, and to leave enough space I shall omit my introductory comments about the role of statisticians in bioinformatics. (via Semantic Scholar)
Source: Crossref
Added: April 4, 2021

2002 journal article

Linkage mapping of sex-specific differences

GENETICAL RESEARCH, 79(1), 85–96.

By: R. Wu*, C. Ma, S. Wu* & Z. Zeng n

MeSH headings : Algorithms; Animals; Chromosome Mapping / methods; Female; Genetic Markers; Humans; Likelihood Functions; Male; Recombination, Genetic / genetics; Sex Characteristics
TL;DR: In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Modeling epistasis of quantitative trait loci using Cockerham's model

Genetics, 160(3), 1243–1261.

By: C. Kao & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Simultaneous maximum likelihood estimation of linkage and linkage phases in outcrossing species

THEORETICAL POPULATION BIOLOGY, 61(3), 349–363.

By: R. Wu*, C. Ma, I. Painter n & Z. Zeng n

author keywords: EM algorithm; linkage phase; outcrossing species; partially informative marker; posterior probability; recombination fraction
MeSH headings : Algorithms; Alleles; Crosses, Genetic; Gene Frequency; Genetic Linkage; Genetic Markers; Likelihood Functions; Markov Chains; Models, Genetic; Plants / genetics; Species Specificity
TL;DR: A general maximum-likelihood-based algorithm for simultaneously estimating linkage and linkage phases for a mixed set of different marker types containing fully informative markers and partially informative markers in a full-sib family derived from two outbred parent plants is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

A general polyploid model for analyzing gene segregation in outcrossing tetraploid species

Genetics, 159(2), 869–882.

By: R. Wu, M. Gallo-Meagher, R. Littell & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

A multivalent pairing model of linkage analysis in autotetraploids

Genetics, 159(3), 1339–1350.

By: S. Wu, R. Wu, C. Ma, Z. Zeng, M. Yang & G. Casella

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

An analysis of polygenes affecting wing shape on chromosome 2 in Drosophila melanogaster

Genetics, 159(3), 1045–1057.

By: K. Weber, R. Eisman, S. Higgins, L. Morey, A. Patty, M. Tausek, Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Joint linkage and linkage disequilibrium mapping in natural populations

Genetics, 157(2), 899–909.

By: R. Wu & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Preliminary interspecific genetic maps of the Populus genome constructed from RAPD markers

GENOME, 44(4), 602–609.

By: T. Yin, M. Huang, M. Wang, L. Zhu, Z. Zeng* & R. Wu*

author keywords: interspecific hybrids; linkage map; poplar; pseudo-testcross mapping strategy
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 chapter

QTL Mapping

In Encyclopedia of Genetics (pp. 1587–1593).

By: Z. Zeng*

Source: Crossref
Added: July 20, 2019

2001 chapter

Quantitative trait loci: statistical methods for mapping their positions

In E. C. R. Reeve & I. Black (Eds.), Encyclopedia of Genetics. London, UK: Fitzroy Dearborn Publishers.

By: Z. Zeng

Ed(s): E. Reeve & I. Black

Source: NC State University Libraries
Added: March 26, 2022

2000 journal article

A general mixture model approach for mapping quantitative trait loci from diverse cross designs involving multiple inbred lines

GENETICAL RESEARCH, 75(3), 345–355.

By: Y. Liu n & Z. Zeng n

MeSH headings : Animals; Chromosome Mapping; Computer Simulation; Crosses, Genetic; Inbreeding; Models, Genetic; Quantitative Trait, Heritable
TL;DR: A general statistical method using mixture model procedures and the EM algorithm is developed for mapping QTL from various cross designs of multiple inbred lines, and its applicability to diverse experimental designs is confirmed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

An integrated genetic map of Populus deltoides based on amplified fragment length polymorphisms

THEORETICAL AND APPLIED GENETICS, 100(8), 1249–1256.

By: R. Wu*, Y. Han*, J. Hu*, J. Fang*, L. Li*, M. Li*, Z. Zeng*

author keywords: AFLP; heteroduplex; intercross marker; linkage map; Populus deltoides; testcross marker
TL;DR: An integrated genetic map for a Populus backcross population derived from two selected P. deltoides clones using AFLP markers is constructed which includes 19 major linkage groups equal to the Populus haploid chromosome number and 24 minor groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Genetic architecture of a morphological shape difference between two Drosophila species

Genetics, 154(1), 299–310.

By: Z. Zeng, J. Liu, L. Stam, C. Kao, J. Mercer & C. Laurie

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster

Genetics, 154(1), 213–227.

By: C. Vieira, E. Pasyukova, Z. Zeng, J. Hackett, R. Lyman & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Inferring linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations

Genetics, 156(1), 457–467.

By: Z. Luo, S. Tao & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2000 chapter

Molecular dissection of quantitative traits: new perspectives from populus

In S. M. Jain & S. C. Minocha (Eds.), Molecular biology of woody plants (Vol. 1, pp. 475–490). Dordrecht; Boston: Kluwer Academic.

By: R. Wu, B. Li & Z. Zeng

Ed(s): S. Jain & S. Minocha

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

The case for molecular mapping in forest tree breeding

Plant Breeding Reviews, 19(2000), 41–68.

By: W. Rongling, Z. Zeng, . McKeand & D. O'Malley

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster

Genetics, 153(2), 773–786.

By: K. Weber, R. Eisman, L. Morey, A. Patty, J. Sparks, M. Tausek, Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Estimating the genetic architecture of quantitative traits

GENETICAL RESEARCH, 74(3), 279–289.

By: Z. Zeng n, C. Kao* & C. Basten n

MeSH headings : Algorithms; Animals; Chromosome Mapping; Genetic Markers; Genotype; Models, Genetic; Mutation; Quantitative Trait, Heritable; Selection, Genetic
TL;DR: One application of the analysis is to improve genome-wide marker-assisted selection, particularly when the information about epistasis is used for selection with mating, as well as other areas that require further investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Multiple interval mapping for quantitative trait loci

Genetics, 152(3), 1203–1216.

By: C. Kao, Z. Zeng & R. Teasdale

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Combining information from data in mapping analysis: use of multiple markers and multiple traits

Animal Biotechnology, 8(1), 145–150.

By: Z. Zeng n

UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

General formulas for obtaining the MLEs and the asymptotic variance-covariance matrix in mapping quantitative trait loci when using the EM algorithm

BIOMETRICS, 53(2), 653–665.

By: C. Kao n & Z. Zeng*

author keywords: asymptotic variance-covariance matrix; EM algorithm; epistasis; gene mapping; general formulas; heritability; maximum likelihood; normal mixture model; quantitative trait loci
TL;DR: General formulas for deriving the maximum likelihood estimates and the asymptotic variance-covariance matrix of the positions and effects of quantitative trait loci (QTLs) in a finite normal mixture model when the EM algorithm is used for mapping QTLs are presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Mapping quantitative trait loci with dominant and missing markers in various crosses from two inbred lines

GENETICA, 101(1), 47–58.

By: C. Jiang* & Z. Zeng n

author keywords: dominant markers; genetic mapping; Markov chain; missing data; quantitative trait loci
MeSH headings : Algorithms; Chromosome Mapping / methods; Crosses, Genetic; Genes, Dominant; Genetic Linkage; Genetic Markers; Genetics, Population; Inbreeding; Models, Genetic; Quantitative Trait, Heritable
TL;DR: Simulation results show that if only a proportion of markers contain missing or dominant phenotypes, QTL mapping can be almost as efficient as if there were no missing information in the data, so it is important to combine dominant markers with codominant markers in aQTL mapping study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1997 book

QTL Cartographer: a reference manual and tutorial for QTL mapping

Department of Statistics, NC State University.

By: C. Basten, B. Weir & Z. Zeng

Source: NC State University Libraries
Added: March 26, 2022

1997 journal article

Quantitative genetic analysis of divergence in male secondary sexual traits between Drosophila simulans and Drosophila mauritiana

EVOLUTION, 51(3), 816–832.

By: . True, J. Liu, L. Stam, Z. Zeng* & C. Laurie

author keywords: genitalia; interspecific divergence; morphological evolution; quantitative trait loci mapping; sexual dimorphism
UN Sustainable Development Goal Categories
5. Gender Equality (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(18), 9734–9739.

By: S. Nuzhdin n, E. Pasyukova n, C. Dilda n, Z. Zeng n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Genes, Insect; Longevity / genetics; Male; Mutation; Sex Determination Analysis
TL;DR: Late age-of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of senescence, and sex-specificQTL effects suggest a novel mechanism for maintaining genetic variation for lifespan. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Statistical issues in the search for genes?

Statistical Science, 12(1997), 195–219.

By: R. Doerge, Z. Zeng & B. Weir

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Design III with marker loci

Genetics, 143(3), 1437–1456.

By: C. Cockerham n & Z. Zeng n

MeSH headings : Analysis of Variance; Epistasis, Genetic; Genetic Linkage; Genetic Markers; Mathematical Computing; Plants / genetics; Research Design
Source: NC State University Libraries
Added: March 26, 2022

1996 journal article

Genetic analysis of a morphological shape difference in the male genitalia of Drosophila simulans and D. mauritiana

Genetics, 142(4), 1129–1145.

By: J. Liu, J. Mercer*, L. Stam*, G. Gibson*, Z. Zeng n & C. Laurie*

MeSH headings : Animals; Base Sequence; Crosses, Genetic; DNA Primers; Drosophila / anatomy & histology; Drosophila / genetics; Female; Genitalia, Male / anatomy & histology; Male; Molecular Sequence Data
Source: NC State University Libraries
Added: March 26, 2022

1996 journal article

Statistical methods for mapping quantitative trait loci

Acta Agronomica Sinica, 22, 535–549.

By: Z. Zeng & B. Weir

Source: NC State University Libraries
Added: March 26, 2022

1995 journal article

Mapping of body weight loci on mouse Chromosome X

Mammalian Genome, 6(11), 778–781.

By: T. Dragani*, Z. Zeng n, F. Canzian*, M. Gariboldi*, M. Ghilarducci*, G. Manenti*, M. Pierotti*

MeSH headings : Animals; Body Weight / genetics; Chromosome Mapping; Disease Susceptibility; Female; Genes, Recessive; Liver Neoplasms / genetics; Lung Neoplasms / genetics; Male; Mice; Mice, Inbred Strains
TL;DR: By genetic linkage analysis, the mapping of two loci, named Bw1 and Bw2, on Chromosome (Chr) X that strongly affect adult body weight in two interspecific testcross male populations (HSB and ASB) of mice are reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Crossref
Added: July 20, 2019

1995 journal article

Multiple-trait analysis of genetic-mapping for quantitative trait loci

Genetics, 140(3), 1111–1127.

By: C. Jiang & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

1994 conference paper

A composite interval mapping method for locating multiple QTLs

Proceedings of the 5th World Congress on Genetics Applied to Livestock Production, 21, 37–40.

By: Z. Zeng

Source: NC State University Libraries
Added: March 26, 2022

1994 journal article

Precision mapping of quantitative trait loci

Genetics, 136(4), 1457–1468.

By: Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

1994 conference paper

ZMAP---A QTL Cartographer

Proceedings of the 5th World Congress on Genetics Applied to Livestock Production, 22, 65–66.

By: C. Basten, B. Weir & Z. Zeng

Source: NC State University Libraries
Added: March 26, 2022

1993 journal article

Mutation models and quantitative genetic variation

Genetics, 133(3), 729.

By: Z. Zeng & C. Cockerham

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

THEORETICAL BASIS FOR SEPARATION OF MULTIPLE LINKED GENE EFFECTS IN MAPPING QUANTITATIVE TRAIT LOCI

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 90(23), 10972–10976.

By: Z. Zeng n

author keywords: GENE MAPPING; MOLECULAR GENETIC MARKERS; QUANTITATIVE GENETICS; MULTIPLE REGRESSION; INTERVAL TEST
MeSH headings : Chromosome Mapping / methods; Genetic Linkage; Regression Analysis
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1992 journal article

Correcting the bias of Wright's estimates of the number of genes affecting a quantitative character: A further improved method

Genetics, 131(4), 987.

By: Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

Variance of neutral genetic variances within and between populations for a quantitative character

Genetics, 129(2), 535.

By: Z. Zeng & C. Cockerham

Source: NC State University Libraries
Added: August 6, 2018

1990 conference paper

How important is mutation for selection responses?

Proceedings of the 4th World Congress on Genetics Applied to Livestock Production, 13, 301–305.

By: Z. Zeng & H. Tachida

Source: NC State University Libraries
Added: March 26, 2022

1990 journal article

How informative is Wright's estimator of the number of genes affecting a quantitative character?

Genetics, 126(1), 235.

By: Z. Zeng, D. Houle & C. Cockerham

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

LONG-TERM RESPONSE TO ARTIFICIAL SELECTION WITH MULTIPLE ALLELES - STUDY BY SIMULATIONS

THEORETICAL POPULATION BIOLOGY, 37(1), 254–272.

By: Z. Zeng* & C. Cockerham

MeSH headings : Alleles; Computer Simulation; Gene Frequency / genetics; Genetic Variation / genetics; Genetics, Population; Humans; Models, Genetic; Multigene Family; Mutation; Selection, Genetic
TL;DR: The results show that for certain statistics the effects of multiple alleles can be minimized by an appropriate transformation of parameters for given initial gene frequencies, but the effects cannot, in general, be removed by any single transformation or reparameterization of parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1989 journal article

A GENETIC MODEL OF INTERPOPULATION VARIATION AND COVARIATION OF QUANTITATIVE CHARACTERS

GENETICS RESEARCH, 53(3), 215–221.

By: Z. Zeng n

MeSH headings : Environment; Gene Frequency; Genetic Variation; Genetics, Population; Genotype; Models, Genetic; Models, Theoretical
TL;DR: Evolutionary consequences of natural selection, migration, genotype-environment interaction, and random genetic drift on interpopulation variation and covariation of quantitative characters are analysed in terms of a selection model that partitions natural selection into directional and stabilizing components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1989 journal article

Effects of mutation on selection limits in finite populations with multiple alleles

Genetics, 122(4), 977.

By: Z. Zeng, H. Tachida & C. Cockerham

Source: NC State University Libraries
Added: August 6, 2018

1988 journal article

Long-Term Correlated Response, Interpopulation Covariation, and Interspecific Allometry

Evolution, 42(2), 363.

By: Z. Zeng*

Source: Crossref
Added: July 28, 2019

1987 journal article

Genotypic distribution at the limits to natural and artificial selection with mutation

Theoretical Population Biology, 32(1), 90–113.

By: Z. Zeng*

MeSH headings : Gene Frequency; Genetic Variation; Genetics, Population; Genotype; Models, Genetic; Models, Theoretical; Mutation; Selection, Genetic
TL;DR: It is clear that in the long term truncation introduces departures from normality mainly through gene frequency change, rather than through the generation of linkage disequilibrium under random mating. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

1986 journal article

The selection limit due to the conflict between truncation and stabilizing selection with mutation

Genetics, 114, 1313–1328.

By: Z. Zeng & W. Hill

Source: NC State University Libraries
Added: March 26, 2022

1986 thesis

Theoretical studies on genetic limits to natural and artificial selection with mutation

(Ph.D Thesis). Department of Genetics, The University of Edinburgh.

By: Z. Zeng

Source: NC State University Libraries
Added: March 26, 2022

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