Sichen Zhang

Works (4)

Updated: July 5th, 2023 14:20

2021 journal article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894–8908.

By: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz n, M. Xie n, X. Mei n ...

Contributors: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz n, M. Xie n, X. Mei n ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
TL;DR: In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021

2021 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2020 journal article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

BIOACTIVE MATERIALS, 6(6), 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 review

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

[Review of ]. BIOACTIVE MATERIALS, 6(7), 1957–1972.

By: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang *, K. Cheng n

Contributors: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang *, K. Cheng n

author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
TL;DR: A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

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