@article{ben-horin_ciesielski_lucas_noble_wilbur_2024, title={Pathology associated with summer oyster mortality in North Carolina}, volume={34}, ISSN={["2352-5134"]}, url={http://dx.doi.org/10.1016/j.aqrep.2023.101901}, DOI={10.1016/j.aqrep.2023.101901}, abstractNote={Expansion of oyster aquaculture industries throughout the southeastern United States has been met with recurring, often catastrophic mortality events, limiting capacity for industry growth. Numerous etiologies have been proposed, including regional extensions of enigmatic mortality episodes that have been observed in triploid oysters in Chesapeake Bay as well as the mid-Atlantic and Gulf of Mexico coasts. To better understand associated pathology and begin to address etiology, we conducted a longitudinal histological survey at a commercial oyster farm in North Carolina that experiences recurring mortality. Our survey was timed with dramatic mortality experienced across North Carolina oyster farms, with farmer-reported mortalities exceeding 90% of near market-sized oysters. Surveyed oysters presented with persistent digestive diverticula pathology in the weeks leading up to and through the mortality event and suggest that mortality was ultimately a result of nutritional deprivation. These observations are inconsistent with pathology associated with recent observations of triploid associated mortality in eastern oysters, however similar diverticula pathology has been observed with summer mortality in Pacific oysters. Expanded research into comparative etiology throughout impacted regions and across oyster species will help address oyster mortality events worldwide. Further efforts for eastern oysters are now being concentrated toward understanding variation in resistance to recurring mortality events across commercially available oyster lines.}, journal={AQUACULTURE REPORTS}, author={Ben-Horin, Tal and Ciesielski, Mark and Lucas, Jonathan and Noble, Rachel T. and Wilbur, Ami}, year={2024}, month={Feb} }
 @article{bidegain_ben-horin_powell_klinck_hofmann_2023, title={MarineEpi: A GUI-based Matlab toolbox to simulate marine pathogen transmission}, volume={22}, ISSN={["2352-7110"]}, DOI={10.1016/j.softx.2023.101357}, abstractNote={The Graphical User Interface (GUI) MarineEpi is presented as a Matlab toolbox for easily (i) constructing disease transmission models for different marine host-pathogen systems, (ii) running simulations by specifying initial conditions and model parameters, and (iii) interpreting the resulting time series of the host and pathogen population dynamics. MarineEpi users can generate models for systems in which pathogen transmission occurs through contact with infected individuals (SI), contact with dead infected individuals (SID), contact with environmental pathogens released by infected individuals (SIP), and contact with environmental pathogens released by dead infected individuals (SIPD). MarineEpi is a freely available GUI that provides the capability for marine disease researchers and managers to understand disease dynamics processes and mechanisms using a quantitative modeling framework. In addition, it can be a valuable learning tool for teaching marine disease processes in engineering, environmental science and epidemiology curricula.}, journal={SOFTWAREX}, author={Bidegain, Gorka and Ben-Horin, Tal and Powell, Eric N. and Klinck, John M. and Hofmann, Eileen E.}, year={2023}, month={May} }
 @article{fernandez-velez_bidegain_ben-horin_2023, title={Predicting the Growth of Vibrio parahaemolyticus in Oysters under Varying Ambient Temperature}, volume={11}, ISSN={["2076-2607"]}, url={https://www.mdpi.com/2076-2607/11/5/1169}, DOI={10.3390/microorganisms11051169}, abstractNote={Temperature is a critical factor that influences the proliferation of pathogens in hosts. One example of this is the human pathogen Vibrio parahaemolyticus (V. parahaemolyticus) in oysters. Here, a continuous time model was developed for predicting the growth of Vibrio parahaemolyticus in oysters under varying ambient temperature. The model was fit and evaluated against data from previous experiments. Once evaluated, the V. parahaemolyticus dynamics in oysters were estimated at different post-harvest varying temperature scenarios affected by water and air temperature and different ice treatment timing. The model performed adequately under varying temperature, reflecting that (i) increasing temperature, particularly in hot summers, favors a rapid V. parahaemolyticus growth in oysters, resulting in a very high risk of gastroenteritis in humans after consumption of a serving of raw oysters, (ii) pathogen inactivation due to day/night oscillations and, more evidently, due to ice treatments, and (iii) ice treatment is much more effective, limiting the risk of illness when applied immediately onboard compared to dockside. The model resulted in being a promising tool for improving the understanding of the V. parahaemolyticus–oyster system and supporting studies on the public health impact of pathogenic V. parahaemolyticus associated with raw oyster consumption. Although robust validation of the model predictions is needed, the initial results and evaluation showed the potential of the model to be easily modified to match similar systems where the temperature is a critical factor shaping the proliferation of pathogens in hosts.}, number={5}, journal={MICROORGANISMS}, author={Fernandez-Velez, Iker and Bidegain, Gorka and Ben-Horin, Tal}, year={2023}, month={Apr} }
 @article{proestou_sullivan_lundgren_ben-horin_witkop_hart_2023, title={Understanding Crassostrea virginica tolerance of Perkinsus marinus through global gene expression analysis}, url={http://dx.doi.org/10.3389/fgene.2023.1054558}, DOI={10.3389/fgene.2023.1054558}, abstractNote={Disease tolerance, a host’s ability to limit damage from a given parasite burden, is quantified by the relationship between pathogen load and host survival or reproduction. Dermo disease, caused by the protozoan parasite P. marinus, negatively impacts survival in both wild and cultured eastern oyster (C. virginica) populations. Resistance to P. marinus has been the focus of previous studies, but tolerance also has important consequences for disease management in cultured and wild populations. In this study we measured dermo tolerance and evaluated global expression patterns of two sensitive and two tolerant eastern oyster families experimentally challenged with distinct doses of P. marinus (0, 106, 107, and 108 parasite spores per gram wet weight, n = 3–5 individuals per family per dose). Weighted Gene Correlation Network Analysis (WGCNA) identified several modules correlated with increasing parasite dose/infection intensity, as well as phenotype. Modules positively correlated with dose included transcripts and enriched GO terms related to hemocyte activation and cell cycle activity. Additionally, these modules included G-protein coupled receptor, toll-like receptor, and tumor necrosis factor pathways, which are important for immune effector molecule and apoptosis activation. Increased metabolic activity was also positively correlated with treatment. The module negatively correlated with infection intensity was enriched with GO terms associated with normal cellular activity and growth, indicating a trade-off with increased immune response. The module positively correlated with the tolerant phenotype was enriched for transcripts associated with “programmed cell death” and contained a large number of tripartite motif-containing proteins. Differential expression analysis was also performed on the 108 dosed group using the most sensitive family as the comparison reference. Results were consistent with the network analysis, but signals for “programmed cell death” and serine protease inhibitors were stronger in one tolerant family than the other, suggesting that there are multiple avenues for disease tolerance. These results provide new insight for defining dermo response traits and have important implications for applying selective breeding for disease management.}, journal={Frontiers in Genetics}, author={Proestou, Dina A. and Sullivan, Mary E. and Lundgren, Kathryn Markey and Ben-Horin, Tal and Witkop, Erin M. and Hart, Keegan M.}, year={2023}, month={Jan} }
 @article{runde_buckel_bacheler_tharp_rudershausen_harms_ben‐horin_2022, title={Evaluation of six methods for external attachment of electronic tags to fish: assessment of tag retention, growth and fish welfare}, volume={101}, ISSN={0022-1112 1095-8649}, url={http://dx.doi.org/10.1111/jfb.14989}, DOI={10.1111/jfb.14989}, abstractNote={Abstract}, number={3}, journal={Journal of Fish Biology}, publisher={Wiley}, author={Runde, Brendan J. and Buckel, Jeffrey A. and Bacheler, Nathan M. and Tharp, Ryan M. and Rudershausen, Paul J. and Harms, Craig A. and Ben‐Horin, Tal}, year={2022}, month={Jan}, pages={419–430} }
 @article{audemard_ben-horin_kator_reece_2022, title={Vibrio vulnificus and Vibrio parahaemolyticus in Oysters under Low Tidal Range Conditions: Is Seawater Analysis Useful for Risk Assessment?}, volume={11}, ISSN={["2304-8158"]}, DOI={10.3390/foods11244065}, abstractNote={Human-pathogenic Vibrio bacteria are acquired by oysters through filtering seawater, however, the relationships between levels of these bacteria in measured in oysters and overlying waters are inconsistent across regions. The reasons for these discrepancies are unclear hindering our ability to assess if -or when- seawater samples can be used as a proxy for oysters to assess risk. We investigated whether concentrations of total and human pathogenic Vibrio vulnificus (vvhA and pilF genes) and Vibrio parahaemolyticus (tlh, tdh and trh genes) measured in seawater reflect concentrations of these bacteria in oysters (Crassostrea virginica) cultured within the US lower Chesapeake Bay region. We measured Vibrio spp. concentrations using an MPN-qPCR approach and analyzed the data using structural equation modeling (SEM). We found seawater concentrations of these bacteria to predictably respond to temperature and salinity over chlorophyll a, pheophytin or turbidity. We also inferred from the SEM results that Vibrio concentrations in seawater strongly predict their respective concentrations in oysters. We hypothesize that such seawater-oyster coupling can be observed in regions of low tidal range. Due to the ease of sampling and processing of seawater samples compared to oyster samples, we suggest that under low tidal range conditions, seawater samples can foster increased spatial and temporal coverage and complement data associated with oyster samples.}, number={24}, journal={FOODS}, author={Audemard, Corinne and Ben-Horin, Tal and Kator, Howard I. and Reece, Kimberly S.}, year={2022}, month={Dec} }
 @article{ben-horin_audemard_calvo_reece_bushek_2021, title={Pathogenic Vibrio parahaemolyticus Increase in Intertidal-Farmed Oysters in the Mid-Atlantic Region, but Only at Low Tide}, volume={12}, ISSN={["1548-8454"]}, DOI={10.1002/naaq.10218}, abstractNote={Abstract}, journal={NORTH AMERICAN JOURNAL OF AQUACULTURE}, author={Ben-Horin, Tal and Audemard, Corinne and Calvo, Lisa and Reece, Kimberly S. and Bushek, David}, year={2021}, month={Dec} }
 @misc{cantrell_groner_ben-horin_grant_revie_2020, title={Modeling Pathogen Dispersal in Marine Fish and Shellfish}, volume={36}, ISSN={["1471-5007"]}, DOI={10.1016/j.pt.2019.12.013}, abstractNote={In marine ecosystems, oceanographic processes often govern host contacts with infectious agents. Consequently, many approaches developed to quantify pathogen dispersal in terrestrial ecosystems have limited use in the marine context. Recent applications in marine disease modeling demonstrate that physical oceanographic models coupled with biological models of infectious agents can characterize dispersal networks of pathogens in marine ecosystems. Biophysical modeling has been used over the past two decades to model larval dispersion but has only recently been utilized in marine epidemiology. In this review, we describe how biophysical models function and how they can be used to measure connectivity of infectious agents between sites, test hypotheses regarding pathogen dispersal, and quantify patterns of pathogen spread, focusing on fish and shellfish pathogens.}, number={3}, journal={TRENDS IN PARASITOLOGY}, author={Cantrell, Danielle L. and Groner, Maya L. and Ben-Horin, Tal and Grant, Jon and Revie, Crawford W.}, year={2020}, month={Mar}, pages={239–249} }
 @article{cantrell_groner_ben-horin_grant_revie_2020, title={Modeling pathogen dispersal in marine fish and shellfish}, journal={Trends in Parasitology}, publisher={Elsevier Current Trends}, author={Cantrell, Danielle L and Groner, Maya L and Ben-Horin, Tal and Grant, Jon and Revie, Crawford W}, year={2020} }
 @article{ben-horin_bidegain_leo_groner_hofmann_mccallum_powell_2020, title={Modelling marine diseases}, ISBN={["978-0-19-882164-9"]}, DOI={10.1093/oso/9780198821632.003.0012}, abstractNote={The unique characteristics of marine ecosystems have pushed investigators to refine well-tested and widely applied epidemiological modeling methods to understand marine disease dynamics. This chapter begins by reviewing models used to quantify within-host parasite dynamics in open marine ecosystems where infection is near universal. These models are powerful tools for quantifying how diseases respond to changing environmental conditions and, when reliable environmental data are available, can forecast marine disease risks into the future. This chapter then describes epidemiological models that consider transmission processes and parasite life histories unique to marine systems, and then incorporates disease processes in fisheries assessment models. Finally, because disease dynamics vary across local host populations, this chapter concludes by overviewing ocean circulation models and their use in understanding parasite dispersal and spread in marine ecosystems.}, journal={MARINE DISEASE ECOLOGY}, author={Ben-Horin, Tal and Bidegain, Gorka and Leo, Giulio and Groner, Maya L. and Hofmann, Eileen and McCallum, Hamish and Powell, Eric}, year={2020}, pages={233–255} }
 @article{aalto_lafferty_sokolow_grewelle_ben-horin_boch_raimondi_bograd_hazen_jacox_et al._2020, title={Models with environmental drivers offer a plausible mechanism for the rapid spread of infectious disease outbreaks in marine organisms}, volume={10}, number={1}, journal={Scientific Reports}, publisher={Nature Publishing Group}, author={Aalto, EA and Lafferty, KD and Sokolow, SH and Grewelle, RE and Ben-Horin, T and Boch, CA and Raimondi, PT and Bograd, SJ and Hazen, EL and Jacox, MG and et al.}, year={2020}, pages={1–10} }
 @article{defining dermo resistance phenotypes in an eastern oyster breeding population_2019, volume={50}, number={8}, journal={Aquaculture Research}, year={2019}, pages={2142–2154} }
 @article{genetic variation in anti-parasite behavior in oysters_2018, volume={594}, journal={Marine Ecology Progress Series}, year={2018}, pages={107–117} }
 @article{ben-horin_burge_bushek_groner_proestou_huey_bidegain_carnegie_2018, title={Intensive oyster aquaculture can reduce disease impacts on sympatric wild oysters}, volume={10}, journal={Aquaculture Environment Interactions}, author={Ben-Horin, Tal and Burge, Colleen A and Bushek, David and Groner, Maya L and Proestou, Dina A and Huey, Lauren I and Bidegain, Gorka and Carnegie, Ryan B}, year={2018}, pages={557–567} }
 @article{teck_lorda_shears_ben-horin_toseland_rathbone_rudie_gaines_2018, title={Quality of a fished resource: Assessing spatial and temporal dynamics}, volume={13}, number={6}, journal={PloS one}, publisher={Public Library of Science}, author={Teck, Sarah J and Lorda, Julio and Shears, Nick T and Ben-Horin, Tal and Toseland, Rebecca E and Rathbone, Sarah T and Rudie, Dave and Gaines, Steven D}, year={2018} }
 @article{bidegain_powell_klinck_hofmann_ben-horin_bushek_ford_munroe_guo_2017, title={Modeling the transmission of Perkinsus marinus in the Eastern oyster Crassostrea virginica}, volume={186}, journal={Fisheries Research}, publisher={Elsevier}, author={Bidegain, Gorka and Powell, Eric N and Klinck, John M and Hofmann, Eileen E and Ben-Horin, T and Bushek, David and Ford, SE and Munroe, Daphne M and Guo, Ximing}, year={2017}, pages={82–93} }
 @article{ben-horin_lafferty_bidegain_lenihan_2016, title={Fishing diseased abalone to promote yield and conservation}, volume={371}, number={1689}, journal={Philosophical Transactions of the Royal Society B: Biological Sciences}, publisher={The Royal Society}, author={Ben-Horin, Tal and Lafferty, Kevin D and Bidegain, Gorka and Lenihan, Hunter S}, year={2016}, pages={20150211} }
 @article{bidegain_powell_klinck_ben-horin_hofmann_2016, title={Marine infectious disease dynamics and outbreak thresholds: contact transmission, pandemic infection, and the potential role of filter feeders}, volume={7}, number={4}, journal={Ecosphere}, author={Bidegain, Gorka and Powell, Eric N and Klinck, John M and Ben-Horin, Tal and Hofmann, Eileen E}, year={2016}, pages={e01286} }
 @article{bidegain_powell_klinck_ben-horin_hofmann_2016, title={Microparasitic disease dynamics in benthic suspension feeders: infective dose, non-focal hosts, and particle diffusion}, volume={328}, journal={Ecological modelling}, publisher={Elsevier}, author={Bidegain, G and Powell, EN and Klinck, JM and Ben-Horin, T and Hofmann, EE}, year={2016}, pages={44–61} }
 @article{ryan_ben-horin_johnson_2015, title={Malaria control and senescence: the importance of accounting for the pace and shape of aging in wild mosquitoes}, volume={6}, number={9}, journal={Ecosphere}, publisher={Ecological Society of America}, author={Ryan, Sadie J and Ben-Horin, Tal and Johnson, Leah R}, year={2015}, pages={1–13} }
 @article{ryan_mcnally_johnson_mordecai_ben-horin_paaijmans_lafferty_2015, title={Mapping physiological suitability limits for malaria in Africa under climate change}, volume={15}, number={12}, journal={Vector-Borne and Zoonotic Diseases}, publisher={Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA}, author={Ryan, Sadie J and McNally, Amy and Johnson, Leah R and Mordecai, Erin A and Ben-Horin, Tal and Paaijmans, Krijn and Lafferty, Kevin D}, year={2015}, pages={718–725} }
 @article{ben-horin_bidegain_huey_narvaez_bushek_2015, title={Parasite transmission through suspension feeding}, volume={131}, journal={Journal of invertebrate pathology}, publisher={Academic Press}, author={Ben-Horin, Tal and Bidegain, Gorka and Huey, Lauren and Narvaez, Diego A and Bushek, David}, year={2015}, pages={155–176} }
 @article{johnson_ben-horin_lafferty_mcnally_mordecai_paaijmans_pawar_ryan_2015, title={Understanding uncertainty in temperature effects on vector-borne disease: a Bayesian approach}, volume={96}, number={1}, journal={Ecology}, publisher={Ecological Society of America}, author={Johnson, Leah R and Ben-Horin, Tal and Lafferty, Kevin D and McNally, Amy and Mordecai, Erin and Paaijmans, Krijn P and Pawar, Samraat and Ryan, Sadie J}, year={2015}, pages={203–213} }
 @article{ryan_mcnally_johnson_mordecai_ben-horin_paaijmans_lafferty_2014, title={Rising suitability and declining severity of malaria transmission in Africa under climate change}, author={Ryan, Sadie J and McNally, Amy and Johnson, Leah R and Mordecai, Erin and Ben-Horin, Tal and Paaijmans, Krijn and Lafferty, Kevin D}, year={2014} }
 @article{lafferty_ben-horin_2013, title={Abalone farm discharges the withering syndrome pathogen into the wild}, volume={4}, journal={Frontiers in microbiology}, publisher={Frontiers}, author={Lafferty, Kevin and Ben-Horin, Tal}, year={2013}, pages={373} }
 @article{iacchei_ben-horin_selkoe_bird_garcı́a-rodrı́guez francisco j_toonen_2013, title={Combined analyses of kinship and FST suggest potential drivers of chaotic genetic patchiness in high gene-flow populations}, volume={22}, number={13}, journal={Molecular Ecology}, author={Iacchei, Matthew and Ben-Horin, Tal and Selkoe, Kimberly A and Bird, Christopher E and Garcı́a-Rodrı́guez Francisco J and Toonen, Robert J}, year={2013}, pages={3476–3494} }
 @article{mordecai_paaijmans_johnson_balzer_ben-horin_moor_mcnally_pawar_ryan_smith_et al._2013, title={Optimal temperature for malaria transmission is dramatically lower than previously predicted}, volume={16}, number={1}, journal={Ecology letters}, author={Mordecai, Erin A and Paaijmans, Krijn P and Johnson, Leah R and Balzer, Christian and Ben-Horin, Tal and Moor, Emily and McNally, Amy and Pawar, Samraat and Ryan, Sadie J and Smith, Thomas C and et al.}, year={2013}, pages={22–30} }
 @article{ben-horin_lenihan_lafferty_2013, title={Variable intertidal temperature explains why disease endangers black abalone}, volume={94}, number={1}, journal={Ecology}, publisher={Ecological Society of America}, author={Ben-Horin, Tal and Lenihan, Hunter S and Lafferty, Kevin D}, year={2013}, pages={161–168} }
 @article{hamilton_wilson_ben-horin_caselle_2011, title={Utilizing spatial demographic and life history variation to optimize sustainable yield of a temperate sex-changing fish}, volume={6}, number={9}, journal={PloS one}, publisher={Public Library of Science}, author={Hamilton, Scott L and Wilson, Jono R and Ben-Horin, Tal and Caselle, Jennifer E}, year={2011} }
 @article{taking the chaos out of genetic patchiness: seascape genetics reveals ecological and oceanographic drivers of genetic patterns in three temperate reef species_2010, url={http://dx.doi.org/10.1111/j.1365-294x.2010.04658.x}, DOI={10.1111/j.1365-294x.2010.04658.x}, abstractNote={Abstract}, journal={Molecular Ecology}, year={2010}, month={Sep} }
 @article{characterization of eight polymorphic microsatellite loci for the california spiny lobster, panulirus interruptus and cross-amplification in other achelate lobsters_2009, url={http://dx.doi.org/10.1007/s12686-009-9047-2}, DOI={10.1007/s12686-009-9047-2}, abstractNote={Microsatellite sequences were isolated from both non-enriched and enriched genomic libraries of California spiny lobster, Panulirus interruptus. Eight consistently amplifying, scorable and polymorphic loci were characterized for 79 individuals collected at Santa Cruz and San Clemente Islands, California, and tested for cross-species amplification in four closely related Panulirus spp., as well as four other species of the order Achelata. The number of alleles observed per locus ranged from three to 54 and observed heterozygosities ranged from 0.57 to 0.98. Quality control testing shows that all loci were reliably scorable, independently segregating, inherited in Mendelian ratios, and had low to moderate (≤14.4%) frequencies of null alleles and high statistical power for detecting fine scale genetic structure.}, journal={Conservation Genetics Resources}, year={2009}, month={Dec} }