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Works (8)
Updated: April 8th, 2024 08:24
2024 article
Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces
Chen, T.-Y., Chen, J., Ruszczycky, M. W., Hilovsky, D., Hostetler, T., Liu, X., … Chang, W.-chen. (2024, March 19). ACS CATALYSIS, Vol. 3.
author keywords: isonitriles; Fe/2OG enzymes; metallophores; Mycobacterium; natural products
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2023 article
Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration
Wang, B., Lu, Y., Cha, L., Chen, T.-Y., Palacios, P. M., Li, L., … Chen, C. (2023, September 6). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 9.
author keywords: Biocatalysis; Hydrogen Atom Transfer; Mukaiyama Hydration; Nonheme Fe/2OG-Dependent Oxygenase
TL;DR:
It is shown that various enzymes of this family, when reconstituted with Fe(II) or Fe(III), can catalyze Mukaiyama hydration-a redox neutral transformation and demonstrates that Fe/2OG enzymes have utility in catalysis beyond the current scope of catalytic oxidation.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 11, 2023
2022 journal article
Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis
ACS CATALYSIS, 12(4), 2270–2279.
author keywords: isocyanide; oxygenase; natural product; reaction mechanism; desaturation; C-N bond formation
TL;DR:
The results indicate that isocyanide formation likely entails a two-step sequence involving an imine intermediate that undergoes decarboxylation-assisted desaturation to yield the isOCyanide product.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022
2022 journal article
Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate
NATURE COMMUNICATIONS, 13(1).
MeSH headings : Iron / metabolism; Ketoglutaric Acids / metabolism; Tyrosine
TL;DR:
It is suggested that a carbocation might be deployed to enable chemically divergent desaturations through decarboxylation and deprotonation and hints at substrate promiscuity of these enzymes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022
2021 article
A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase
Chen, T.-Y., & Chang, W.-chen. (2021, July 13). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 118.
MeSH headings : Bacteriophages / enzymology; Cytosine / metabolism; DNA Replication; Glycosylation; Glycosyltransferases / metabolism; Methyltransferases / metabolism; Mixed Function Oxygenases / metabolism; Substrate Specificity; Viral Proteins / metabolism
TL;DR:
Through bioinfor-matic screening, the authors identify and characterize tailoring enzymes, such as glycosyltransferases, that collaborate with phage C5-MT and TET to further elaborate DNA at 5hmC site.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021
2020 journal article
Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
CHINESE JOURNAL OF CHEMISTRY, 39(2), 463–472.
author keywords: Biosynthesis; Enzymes; Natural products; Reaction mechanisms; Biotransformations
TL;DR:
The current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation are summarized and two fundamentally distinctive approaches are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 1, 2021
2020 journal article
Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis
ACS CATALYSIS, 11(1), 278–282.
author keywords: metalloenzyme; C-H activation; cyclization; desaturation; enzyme mechanism
TL;DR:
A comparison of C–H bond activation and cyclization in the isodomoic acid and kainic acid biosynthesis experiments shows that the former is superior to the latter in terms of both molecular complexity and physical properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 11, 2021
2020 journal article
Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(19), 7367–7371.
author keywords: catalysis; decarboxylation; enzymes; iron; reaction mechanisms
MeSH headings : Catalysis; Glycine / analogs & derivatives; Glycine / chemical synthesis; Hydroxylation; Iron / chemistry; Models, Molecular; Nitriles / chemical synthesis; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / chemistry; X-Ray Diffraction
TL;DR:
The plausible mechanism of three Fe/2OG enzymes, Sav607, ScoE and SfaA, catalyzed isonitrile formation is reported, and the X-ray structures of iron loaded ScoE in complex with its substrate and the intermediate, along with biochemical and biophysical data reveal that -N≡C bond formation involves two cycles of Fe/ 2OG enzyme catalysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 8, 2020
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