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Works (14)
2025 article
An Alternative Mechanism for C–C Desaturation Underscores a Dual-Controlled Mechanism for the Fate of Radical Intermediate in Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenase DfmD
Zhang, X., Wang, L., Liu, J., Chen, T.-Y., Yan, S., Chang, W.-chen, … Wang, B. (2025, June 6). Journal of the American Chemical Society, Vol. 6.
2025 article
Beyond the β–α–β Fold: Characterization of a SnoaL Domain in the Tautomerase Superfamily
Melkonian, T. R., Vuksanovic, N., Person, M. D., Chen, T.-Y., Chang, W.-chen, Allen, K. N., & Whitman, C. P. (2025, April 15). Biochemistry, Vol. 4.
2025 article
Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity
Hostetler, T., Chen, T.-Y., & Chang, W.-C. (2025, January 1). RSC Chemical Biology, Vol. 1.
open access via doi.org (publisher)
2025 article
Multiple Catalytic Branch Points in the Mechanism of Pyrrolidine Formation During Kainoid Biosynthesis Leads to Diverse Reaction Outcomes
Chen, T.-Y., Ruszczycky, M. W., Yao, A., Li, X., Chien, T.-C., & Chang, W.-chen. (2025, August 5). Journal of the American Chemical Society, Vol. 8.
2025 article
Provision of a Redox Donor to Oxy-Ferrous PrnB Is Required for Pyrrolnitrin Synthesis
McMillan, R. B., Gering, H. E., Ledinina, A. E., Xue, S., Karandikar, S., Lin, S., … Makris, T. M. (2025, August 19). Biochemistry, Vol. 8.
2025 article
Studies of Isonitrile Synthases Help Elucidate the Mechanism of Isonitrile Installation
Chen, T.-Y., Kim, W., Guo, M., Yao, A., Zhang, Y. J., & Chang, W.-chen. (2025, June 30). ACS Catalysis, Vol. 6.
2024 article
Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces
Chen, T.-Y., Chen, J., Ruszczycky, M. W., Hilovsky, D., Hostetler, T., Liu, X., … Chang, W.-chen. (2024, March 19). ACS Catalysis, Vol. 3.
2023 article
Repurposing Iron‐ and 2‐Oxoglutarate‐Dependent Oxygenases to Catalyze Olefin Hydration
Wang, B., Lu, Y., Cha, L., Chen, T. Y., Palacios, P. M., Li, L., … Chen, C. (2023, August 28). Angewandte Chemie International Edition, Vol. 9.
2022 article
Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis
Chen, T.-Y., Zheng, Z., Zhang, X., Chen, J., Cha, L., Tang, Y., … Chang, W.-chen. (2022, January 31). ACS Catalysis, Vol. 2.
2022 article
Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate
Kim, W., Chen, T.-Y., Cha, L., Zhou, G., Xing, K., Canty, N. K., … Chang, W.-chen. (2022, September 12). Nature Communications, Vol. 9.
2021 article
A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase
Chen, T.-Y., & Chang, W.-chen. (2021, July 2). Proceedings of the National Academy of Sciences, Vol. 7.
2020 article
Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
Chen, T. Y., Chen, J., Tang, Y., Zhou, J., Guo, Y., & Chang, W. (2020, September 24). Chinese Journal of Chemistry, Vol. 39, pp. 463–472.
2020 article
Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis
Chen, T.-Y., Xue, S., Tsai, W.-C., Chien, T.-C., Guo, Y., & Chang, W.-chen. (2020, December 18). ACS Catalysis, Vol. 12, pp. 278–282.
2020 article
Pathway from N‐Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2‐Oxoglutarate‐Dependent Oxygenases
Chen, T. Y., Chen, J., Tang, Y., Zhou, J., Guo, Y., & Chang, W. (2020, February 19). Angewandte Chemie International Edition, Vol. 59, pp. 7367–7371.