Works (110)

Updated: May 15th, 2024 04:31

2024 article

A survey of the use of ultrasound by small animal veterinary clinicians

Zelachowski, K. A., Rishniw, M., & Defrancesco, T. C. (2024, April 26). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 4.

By: K. Zelachowski*, M. Rishniw* & T. Defrancesco n

author keywords: centesis; point of care ultrasound; training; ultrasound; VIN survey
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 1, 2024

2024 journal article

Cardiovascular images: pacemaker-lead fracture and excessive coiling in a dog

JOURNAL OF VETERINARY CARDIOLOGY, 52, 68–71.

By: A. McManamey n, M. Lake n & T. DeFrancesco n

author keywords: Bradycardia; Myopathy; Pacing; Complication; Twiddler's
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 29, 2024

2024 article

Clinical outcome of idiopathic juvenile ventricular arrhythmias in 25 dogs

Reuter, A., DeFrancesco, T. C., Robertson, J. B., & Meurs, K. M. (2024, February). JOURNAL OF VETERINARY CARDIOLOGY, Vol. 51, pp. 188–194.

By: A. Reuter*, T. DeFrancesco n, J. Robertson* & K. Meurs n

author keywords: German Shepherd; Ventricular premature beats; Sudden cardiac death
TL;DR: In most cases, idiopathic juvenile ventricular arrhythmias had a favorable long-term prognosis with reduced ectopy over time in this case series. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 28, 2024

2023 journal article

Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic results of the RAPACAT trial

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(11), 1628–1637.

By: J. Kaplan*, V. Rivas n, A. Walker*, L. Grubb, A. Farrell, S. Fitzgerald, S. Kennedy, C. Pjauregui ...

Contributors: J. Kaplan*, V. Rivas n, A. Walker*, L. Grubb, A. Farrell, S. Fitzgerald, S. Kennedy, C. Pjauregui ...

author keywords: HCM; sirolimus; occult; cat; mTOR
TL;DR: It is demonstrated that DR rapamycin was well tolerated and may prevent or delay progressive LV hypertrophy in cats with subclinical HCM and no demographic, echocardiographic, or clinicopathologic values were significantly different between study groups at baseline, confirming successful randomization. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 6, 2024

2023 journal article

Echocardiographic caudal vena cava measurements in healthy cats and in cats with congestive heart failure and non-cardiac causes of cavitary effusions

JOURNAL OF VETERINARY CARDIOLOGY, 48, 7–18.

author keywords: Feline; Point-of-care ultra-sound; Cardiac; Cardiogenic pulmonary edema; Pleural; Ascites
TL;DR: Caudal vena cava measurements are larger in cats with cavitary effusions and cats with CPE than healthy cats, and decreased CVC-CI, was helpful in distinguishing between cardiogenic and noncardiogenic etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 11, 2023

2023 journal article

Evaluation of Renin-Angiotensin-Aldosterone System Components and Enzymes in Systemically Hypertensive Cats Receiving Amlodipine

ANIMALS, 13(22).

By: D. Adin*, C. Atkins n, O. Domenig, C. Glahn, T. Defrancesco n & K. Meurs n

author keywords: feline; blood pressure; kidney
TL;DR: The findings suggest that the use of concurrent RAAS-suppressant therapy, specifically aldosterone antagonism, in amlodipine-treated SHT cats with chronic kidney disease might be indicated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023

2023 journal article

Pacemaker-lead-associated thrombosis in dogs: a multicenter retrospective study

Journal of Veterinary Cardiology.

By: C. McGrath*, A. Dixon*, C. Hirst*, E. Bode*, T. DeFrancesco n, R. Fries*, S. Gordon*, D. Hogan ...

TL;DR: Dogs with PLAT had shorter survival times from implantation compared to those without PLAT, are associated with proteinuria, can cause significant morbidity, and is associated with reduced survival times. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 29, 2023

2023 article

Pharmacokinetics of pimobendan after oral administration to dogs with myxomatous mitral valve disease

McManamey, A. K., DeFrancesco, T. C., Meurs, K. M., & Papich, M. G. (2023, September 30). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.

By: A. McManamey*, T. DeFrancesco n, K. Meurs n & M. Papich n

author keywords: canine; heart failure; valvular heart disease; Vetmedin
TL;DR: The pharmacokinetic parameters were highly variable among this group of dogs with MMVD, and the variability was not associated with the dog's age, body weight or condition score, stage of heart disease, dose, serum creatinine, or alkaline phosphatase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 1, 2023

2023 journal article

Population pharmacokinetics of single dose oral pimobendan in the ferret (Mustela putorius furo)

JOURNAL OF EXOTIC PET MEDICINE, 48, 1–5.

By: M. Cabot n, M. Papich n, T. Harrison n, A. Thomson n, T. Defrancesco n & S. Ozawa n

author keywords: Ferret; Pimobendan; Pharmacokinetic; Mustela putorius furo; O-desmethylpimobendan; Heart failure
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 29, 2024

2023 journal article

The Role of Point-of-Care Ultrasound in Managing Cardiac Emergencies

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 53(6), 1429–1443.

By: J. Ward* & T. Defrancesco n

author keywords: Echocardiography; Congestive heart failure; Respiratory distress; Pulmonary edema; Ascites; Pleural effusion; Pericardial effusion; Cardiac tamponade
TL;DR: POCUS can be helpful in the diagnosis of left-sided and right-sided congestive heart failure, pericardial effusion and tamponade, and severe pulmonary hypertension and can help clinicians monitor resolution or recurrence of these conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2022 journal article

Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure*

JOURNAL OF VETERINARY CARDIOLOGY, 40, 99–109.

By: A. Walker*, T. DeFrancesco n, J. Bonagura n, B. Keene n, K. Meurs n, S. Tou n, K. Kurtz*, B. Aona* ...

author keywords: Canine; Survival; Grain-free; Echocardiography; Nutritional
MeSH headings : Animals; Dogs; Cardiomyopathy, Dilated / diagnosis; Cardiomyopathy, Dilated / veterinary; Diet / veterinary; Dog Diseases / diagnosis; Echocardiography / veterinary; Edible Grain; Heart Failure / complications; Heart Failure / therapy; Heart Failure / veterinary; Retrospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2022 article

Bilateral lysis of aortic saddle thrombus with early tissue plasminogen activator (BLASTT): a prospective, randomized, placebo-controlled study in feline acute aortic thromboembolism

Guillaumin, J., DeFrancesco, T. C., Scansen, B. A., Quinn, R., Whelan, M., Hanel, R., … Bonagura, J. D. (2022, November 9). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 11.

By: J. Guillaumin*, T. DeFrancesco n, B. Scansen*, R. Quinn*, M. Whelan*, R. Hanel*, I. Goy-Thollot*, I. Bublot, J. Robertson n, J. Bonagura n

author keywords: Thrombolysis; thrombosis; alteplase; rTPA; embolism; ischemic neuropathy
MeSH headings : Cats; Animals; Tissue Plasminogen Activator / therapeutic use; Anticoagulants; Prospective Studies; Venous Thromboembolism / veterinary; Research Design; Cat Diseases / drug therapy
TL;DR: Survition and complication rates of acute FATE were not different with or without thrombolysis, and high in-hospital mortality decreased the statistical power to detect a statistically significant difference between treatments with regard to the primary outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 28, 2022

2022 journal article

Dilated cardiomyopathy in cats: survey of veterinary cardiologists and retrospective evaluation of a possible association with diet

JOURNAL OF VETERINARY CARDIOLOGY, 39, 22–34.

By: S. Karp*, L. Freeman*, J. Rush*, W. Arsenault*, S. Cunningham*, T. DeFrancesco n, E. Karlin*, N. Laste ...

author keywords: Nutrition; Diet; Heart failure; Pulses; Feline
MeSH headings : Animals; Cardiologists; Cardiomyopathy, Dilated / veterinary; Cat Diseases / epidemiology; Cat Diseases / etiology; Cats; Diet / veterinary; Dogs; Humans; Retrospective Studies
TL;DR: A survey of cardiologists on their recent experiences with cats that have dilated cardiomyopathy (DCM) and to retrospectively review individual cases of feline DCM found that cats eating high PL diets that changed diets after diagnosis had a significantly longer survival time than that of cats eating low pea/lentil (low PL) diets that did not change diets after diagnosed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2021 journal article

A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat

ORPHANET JOURNAL OF RARE DISEASES, 16(1).

author keywords: Hypertrophic cardiomyopathy; ALMS1; Feline; Mitogenic; Sphynx
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cats / genetics; Cell Cycle Proteins / genetics; Exons; Mice; Mutation / genetics
TL;DR: This study demonstrates a novel form of cardiomyopathy associated with ALMS1 in the cat, and suggests that variants in genes involved with cardiac development and cell regulation, like the AL MS1 gene, may deserve further consideration for association with familial hypertrophic cardiopathy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021

2021 journal article

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy

ANIMAL GENETICS, 52(4), 542–544.

By: . K. O'Donnell n, D. Adin n, C. Atkins n, T. DeFrancesco n, B. Keene n, S. Tou n, K. Meurs n

author keywords: cardiomyopathy; feline; genetic; HCM; mutation
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cat Diseases / genetics; Cat Diseases / metabolism; Cats; Female; Genetic Variation; Male; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism
TL;DR: The lack of these MYBPC3 and MYH7 variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 journal article

Focused Canine Cardiac Ultrasound

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 51(6), 1203–1216.

By: T. DeFrancesco n & J. Ward*

author keywords: Echocardiography; Congestive heart failure; Dyspnea; Respiratory distress; Pulmonary edema; Ascites; Pleural effusion; Pericardial effusion
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dogs; Echocardiography / veterinary; Heart Defects, Congenital / veterinary; Heart Failure / veterinary; Pericardial Effusion / diagnostic imaging; Pericardial Effusion / veterinary
TL;DR: Focused cardiac ultrasound can be helpful in the diagnosis of left-sided and right-sided congestive heart failure, pericardial effusion and tamponade, and severe pulmonary hypertension, and can provide estimates of fluid responsiveness in hypotensive dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021

2021 journal article

Focused ultrasound of the caudal vena cava in dogs with cavitary effusions or congestive heart failure: A prospective, observational study

PLOS ONE, 16(5).

By: Y. Chou*, J. Ward*, L. Barron n, S. Murphy*, M. Tropf*, G. Lisciandro, L. Yuan*, J. Mochel*, T. DeFrancesco n

MeSH headings : Animals; Dogs; Female; Heart Failure / diagnosis; Heart Failure / pathology; Heart Failure / veterinary; Male; Pericardial Effusion / diagnosis; Pericardial Effusion / veterinary; Prospective Studies; Ultrasonography; Vena Cava, Inferior / diagnostic imaging
TL;DR: Whether ultrasonographic indices of caudal vena cava (CVC) differ between dogs with right-sided CHF, left-sidedCHF, and noncardiac causes of cavitary effusion (NC) is investigated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021

2021 personal communication

Letter to the editor regarding "Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: The VALVE trial"

Atkins, C., Keene, B., DeFrancesco, T. C., Tou, S., Chetboul, V., Cote, E., … Stepien, R. L. (2021, March).

By: C. Atkins n, B. Keene n, T. DeFrancesco n, S. Tou n, V. Chetboul*, E. Cote*, S. Ettinger, P. Fox* ...

MeSH headings : Animals; Dogs; Furosemide / therapeutic use; Mitral Valve; Pyridazines / therapeutic use; Ramipril / therapeutic use
TL;DR: The VALVE trial did not assess the efficacy of RAAS suppression using biomarkers, and the question of whether ramipril adequately or optimally suppressed RAAS, while failing to improve survival in the face of these diuretic dosages, remains unanswered. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2021 journal article

Myxomatous mitral valve disease in Miniature Schnauzers and Yorkshire Terriers: 134 cases (2007-2016)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 259(12), 1428–1432.

By: D. DeProspero n, . Kerry A. O'Donnell, T. DeFrancesco n, B. Keene n, S. Tou n, D. Adin n, C. Atkins n, K. Meurs n

MeSH headings : Animals; Dog Diseases / epidemiology; Dogs; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / veterinary; Prospective Studies
TL;DR: Features of the disease among Miniature Schnauzers and Yorkshire Terriers were similar, but there were also a few discernable differences between these 2 breeds and from historical findings for dogs with MMVD of other breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 article

Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease

Williams, B., Friedenberg, S. G., Keene, B. W., Tou, S. P., DeFrancesco, T. C., & Meurs, K. M. (2021, June 27). HUMAN GENETICS, Vol. 6.

By: B. Williams n, S. Friedenberg*, B. Keene n, S. Tou n, T. DeFrancesco n & K. Meurs n

MeSH headings : Animals; Breeding; Dog Diseases / genetics; Dogs; Genetic Variation; Genome-Wide Association Study; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Mutation; Whole Genome Sequencing
TL;DR: The findings indicate that development of MMVD in the dog may be related to a combination of genetic and environmental factors that impact specific molecular pathways rather than a single shared genetic variant across or within breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2021 journal article

Utility of point-of-care lung ultrasound for monitoring cardiogenic pulmonary edema in dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(1), 68–77.

By: S. Murphy*, J. Ward*, A. Viall*, M. Tropf*, R. Walton*, J. Fowler*, W. Ware*, T. DeFrancesco n

author keywords: B‐ lines; canine; lung rockets; point‐ of‐ care; pulmonary edema
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dogs; Lung / diagnostic imaging; Point-of-Care Systems; Prospective Studies; Pulmonary Edema / diagnostic imaging; Pulmonary Edema / veterinary; Ultrasonography / veterinary
TL;DR: LUS could be a useful tool for monitoring resolution of pulmonary edema in dogs with L-CHF, and patterns of edema resolution differed between LUS and TXR. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 21, 2020

2020 journal article

Atenolol in cats with subclinical hypertrophic cardiomyopathy: a double-blind, placebo-controlled, randomized clinical trial of effect on quality of life, activity, and cardiac biomarkers

JOURNAL OF VETERINARY CARDIOLOGY, 30, 77–91.

By: A. Coleman n, T. DeFrancesco n, E. Griffiths n, B. Lascelles n, D. Kleisch n, C. Atkins n, B. Keene n

author keywords: Feline; Beta-btocker; Accelerometry
MeSH headings : Administration, Oral; Animals; Anti-Arrhythmia Agents / administration & dosage; Anti-Arrhythmia Agents / therapeutic use; Atenolol / administration & dosage; Atenolol / therapeutic use; Biomarkers / blood; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / blood; Cat Diseases / drug therapy; Cats; Double-Blind Method; Female; Male; Quality of Life; Treatment Outcome
TL;DR: This study failed to identify an effect of subclinical HCM on owner-assessed QOL or activity or a treatment effect of atenolol on these variables at the dosage evaluated, and these findings do not support a treatment benefit of atanolol for the goal of symptom reduction in cats with sub clinical HCM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 21, 2020

2020 journal article

Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 600–606.

By: D. Adin*, C. Atkins n, O. Domenig, T. DeFrancesco n, B. Keene n, S. Tou n, J. Stern*, K. Meurs n

author keywords: ACE-inhibitor; enalapril; genotype; pharmacogenetic; pharmacogenomic
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Genetic Predisposition to Disease; Genotype; Humans; Mitral Valve Prolapse / enzymology; Mitral Valve Prolapse / genetics; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Polymorphism, Genetic; Renin-Angiotensin System / physiology; Retrospective Studies
TL;DR: The results support the use of aldosterone receptor antagonists with ACE‐inhibitors when RAAS inhibition is indicated for dogs, especially those positive for the ACE gene polymorphism, which did not alter baseline RAAS activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 16, 2020

2020 journal article

Retrospective evaluation of the safety and tolerability of pimobendan in cats with obstructive vs nonobstructive cardiomyopathy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(6), 2211–2222.

By: J. Ward*, E. Kussin*, M. Tropf*, S. Tou n, T. DeFrancesco n & B. Keene n

author keywords: cardiac; cardiomyopathy; feline; hypertrophic; positive inotrope
MeSH headings : Animals; Cardiomyopathies / drug therapy; Cardiomyopathies / veterinary; Cardiotonic Agents / adverse effects; Cat Diseases / drug therapy; Cats; Heart Failure / drug therapy; Heart Failure / veterinary; Pyridazines / adverse effects; Retrospective Studies
TL;DR: Pimobendan is well tolerated in cats with cardiomyopathy and CHF, regardless of the presence of OTO, and was discontinued due to adverse effects in 4/260 cats. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 26, 2020

2019 journal article

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Human Genetics, 138(5), 515–524.

By: K. Meurs n, S. Friedenberg*, J. Kolb*, C. Saripalli*, P. Tonino*, K. Woodruff n, N. Olby n, B. Keene n ...

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
TL;DR: The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019

2019 journal article

Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

JOURNAL OF VETERINARY CARDIOLOGY, 21, 1–9.

By: D. Adin n, T. DeFrancesco n, B. Keene n, S. Tou n, K. Meurs n, C. Atkins n, B. Aona n, K. Kurtz n ...

author keywords: Nutritional; Heart failure; Dog; Taurine
MeSH headings : Animals; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / veterinary; Diet / adverse effects; Diet / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Edible Grain / adverse effects; Female; Male; Phenotype
TL;DR: Dietary-associated DCM occurs with some GF diets and can improve with nutritional management, including diet change, and the role of taurine supplementation, even without deficiency, is uncertain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Lung ultrasonographic findings in dogs with various underlying causes of cough

Journal of the American Veterinary Medical Association, 255(5), 574–583.

By: J. Ward*, G. Lisciandro, W. Ware*, K. Miles*, A. Viall* & T. DeFrancesco n

MeSH headings : Animals; Cough / diagnostic imaging; Cough / veterinary; Dog Diseases / diagnostic imaging; Dogs; Lung / diagnostic imaging; Pulmonary Edema / diagnostic imaging; Pulmonary Edema / veterinary; Sensitivity and Specificity; Ultrasonography / methods; Ultrasonography / veterinary
TL;DR: In dogs with a clinical history of cough, this imaging modality could be diagnostically useful, particularly to help exclude the possibility of underlying CPE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: October 18, 2020

2019 journal article

Myxomatous mitral valve disease in the miniature poodle: A retrospective study

VETERINARY JOURNAL, 244, 94–97.

By: K. Meurs n, D. Adin n, . K. O'Donnell n, B. Keene n, C. Atkins n, T. DeFrancesco n, S. Tou n

author keywords: Canine; Genetic; Miniature poodle; Mitral valve; Myxomatous valve
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / genetics; Dogs; Female; Male; Mitral Valve Prolapse / diagnostic imaging; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / genetics; Mitral Valve Prolapse / veterinary; North Carolina / epidemiology; Pedigree; Records; Retrospective Studies; Severity of Illness Index
TL;DR: In the miniature poodles reported here, MMVD appears to be a fairly late onset disease and often is a mild phenotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2018 journal article

A survey of point-of-care ultrasound use in veterinary general practice

Education in the Health Professions, 1(2), 50.

By: T. DeFrancesco n & K. Royal n

TL;DR: This study is the first to document the common use of US in small animal general practices and highlights the need for instruction of basic US skills for veterinary students and small animal practitioners. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019

2018 journal article

Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease

Pharmacogenetics and Genomics, 28(2), 37–40.

By: K. Meurs*, L. Olsen*, M. Reimann*, B. Keene*, C. Atkins*, D. Adin*, B. Aona*, J. Condit* ...

author keywords: angiotensin-converting enzyme; angiotensin-converting enzyme inhibitor; dog; polymorphism; valve
TL;DR: Dogs with the ACE variant had lower levels of ACE activity even in more advanced mitral valve disease than dogs without the variant, and the CKCS appears to have a high prevalence of theACE variant. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2020

2018 journal article

Distribution of alveolar-interstitial syndrome in dogs and cats with respiratory distress as assessed by lung ultrasound versus thoracic radiographs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 28(5), 415–428.

By: J. Ward*, G. Lisciandro* & T. DeFrancesco n

author keywords: canine; congestive heart failure; feline; noncardiogenic pulmonary edema; point-of-care ultrasound
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cats; Dog Diseases / diagnostic imaging; Dogs; Female; Lung Diseases, Interstitial / complications; Lung Diseases, Interstitial / diagnostic imaging; Lung Diseases, Interstitial / veterinary; Male; Prospective Studies; Pulmonary Alveoli / diagnostic imaging; Radiography, Thoracic / veterinary; Respiratory Distress Syndrome / complications; Respiratory Distress Syndrome / diagnostic imaging; Respiratory Distress Syndrome / veterinary; Sensitivity and Specificity; Ultrasonography / veterinary
TL;DR: LUS and TXR were both useful to detect and categorize distribution of alveolar or interstitial pulmonary pathology and both detected differences in distribution of AIS based on final diagnosis, suggesting that a regional pattern-based approach to thoracic imaging may prove diagnostically useful. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 journal article

Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration

VETERINARY JOURNAL, 232, 16–19.

By: K. Meurs n, S. Friedenberg*, B. Williams n, B. Keene n, C. Atkins n, D. Adin n, B. Aona n, T. DeFrancesco n ...

author keywords: Canine; Cavalier King Charles spaniel; Dachshund; Genetic; Mitral valve; Myxomatous valve
MeSH headings : Animals; DNA / blood; Dog Diseases / genetics; Dogs; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / genetics; Mutation; Species Specificity; Whole Genome Sequencing / veterinary
TL;DR: Although mitral valve disease in the CKCS and Dachshund is a familial disease, it was hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated withthe development of canine MMVD and this work identified genetic cause in the genes responsible for the human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Evaluation of point-of-care thoracic ultrasound and NT-proBNP for the diagnosis of congestive heart failure in cats with respiratory distress

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(5), 1530–1540.

By: J. Ward*, G. Lisciandro, W. Ware*, A. Viall*, B. Aona n, K. Kurtz n, Y. Reina-Doreste n, T. DeFrancesco n

author keywords: B-lines; biomarker; cardiac; feline; lung; point-of-care; respiratory
MeSH headings : Animals; Biomarkers / blood; Cat Diseases / blood; Cat Diseases / diagnosis; Cats; Echocardiography / veterinary; False Negative Reactions; False Positive Reactions; Female; Heart Failure / blood; Heart Failure / diagnosis; Heart Failure / veterinary; Male; Natriuretic Peptide, Brain / blood; Peptide Fragments / blood; Point-of-Care Systems; Retrospective Studies
TL;DR: Lung ultrasound and blood NT‐proBNP were significant predictors of CHF in a multivariate model and point‐of‐care diagnostic techniques of LUS, FCU, and NT‐ proBNP are useful to diagnoseCHF in cats with respiratory distress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 5, 2018

2017 journal article

Accuracy of point-of-care lung ultrasonography for the diagnosis of cardiogenic pulmonary edema in dogs and cats with acute dyspnea

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 250(6), 666–675.

By: J. Ward*, G. Lisciandro, B. Keene*, S. Tou* & T. DeFrancesco*

MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Dog Diseases / diagnosis; Dogs; Dyspnea / diagnosis; Dyspnea / veterinary; Observer Variation; Point-of-Care Systems; Prospective Studies; Pulmonary Edema / diagnosis; Pulmonary Edema / veterinary; Ultrasonography / instrumentation; Ultrasonography / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).

By: K. Meurs n, J. Stern n, C. Atkins n, D. Adin n, B. Aona n, J. Condit n, T. DeFrancesco n, Y. Reina-Doreste n ...

author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
TL;DR: It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Furosemide continuous rate infusion diluted with 5% dextrose in water or hypertonic saline in normal adult dogs: a pilot study

JOURNAL OF VETERINARY CARDIOLOGY, 19(1), 44–56.

By: D. Adin n, C. Atkins n, M. Papich n, T. DeFrancesco n, E. Griffiths n, M. Penteado*, K. Kurtz n, A. Klein n

author keywords: Lasix; Diuretic; Sodium; Salt
MeSH headings : Animals; Cross-Over Studies; Diuretics / administration & dosage; Diuretics / adverse effects; Diuretics / pharmacokinetics; Dogs; Furosemide / administration & dosage; Furosemide / adverse effects; Furosemide / pharmacokinetics; Glucose / administration & dosage; Infusions, Intravenous / veterinary; Male; Pilot Projects; Saline Solution, Hypertonic / administration & dosage; Single-Blind Method; Water
TL;DR: Diuresis was similar for both furosemide CRI methods; however, the H-SAL method induced less renin-angiotensin-aldosterone system activation than the DEX method, suggesting that dilution of a furo Semine CRI with 2.4% hypertonic saline may be well tolerated in heart failure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. DeFrancesco n, S. Tou n, C. Williams n, M. Breen n, K. Meurs n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR: The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2017 journal article

Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion

Journal of Veterinary Cardiology, 19(2), 132–143.

By: M. Nolan n, M. Arkans n, D. LaVine n, T. DeFrancesco n, J. Myers*, E. Griffith n, L. Posner n, B. Keene n ...

author keywords: Heart-base tumor; Cardiac hemangiosarcoma; Canine
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / radiotherapy; Dogs; Echocardiography; Female; Heart Atria; Heart Neoplasms / complications; Heart Neoplasms / radiotherapy; Heart Neoplasms / veterinary; Hemangiosarcoma / complications; Hemangiosarcoma / radiotherapy; Hemangiosarcoma / veterinary; Hemorrhage / complications; Hemorrhage / veterinary; Male; Pericardial Effusion / complications; Pericardial Effusion / veterinary; Pilot Projects; Postoperative Complications / veterinary; Treatment Outcome
TL;DR: RT alone, or in combination with chemotherapy, may provide clinical benefit to dogs with presumptive diagnoses of cardiac hemangiosarcoma, and appears to have reduced the frequency of periacardial tamponade that necessitated pericardiocentesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014)

JOURNAL OF VETERINARY CARDIOLOGY, 18(3), 199–212.

By: J. Ward n, T. DeFrancesco n, S. Tou n, C. Atkins n, E. Griffith n & B. Keene n

author keywords: Dog; Arrhythmia; Bradycardia; Sinus arrest; Pacemaker
MeSH headings : Animals; Dog Diseases / mortality; Dogs; Prognosis; Sick Sinus Syndrome / mortality; Sick Sinus Syndrome / veterinary; Sinoatrial Node / physiopathology; Survival Analysis; Treatment Outcome
TL;DR: Sinus node dysfunction and SSS represent a spectrum of sinoatrial node disease, which for some dogs may also involve a component of autonomic dysfunction, and medical management is often useful, particularly in atropine responsive dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(1), 65–73.

By: A. Lantis n, M. Ames n, C. Atkins n, T. Defrancesco n, B. Keene n & S. Werre n

MeSH headings : Aldosterone / metabolism; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Benzazepines / administration & dosage; Benzazepines / pharmacology; Diuretics / administration & dosage; Diuretics / pharmacology; Dogs / physiology; Dogs / urine; Drug Therapy, Combination; Furosemide / administration & dosage; Furosemide / pharmacology; Peptidyl-Dipeptidase A; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: Benazepril decreased plasma ACE activity but did not prevent furosemide-induced RAAS activation, indicating aldosterone breakthrough (escape), particularly noteworthy in that breakthrough is observed at the time of initiation of RAAS suppression, as opposed to developing after months of therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Complication Rates Associated with Transvenous Pacemaker Implantation in Dogs with High-Grade Atrioventricular Block Performed During versus After Normal Business Hours

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(1), 157–163.

By: J. Ward n, T. DeFrancesco n, S. Tou n, C. Atkins n, E. Griffith n & B. Keene n

author keywords: Canine; Heart block; Transvenous
MeSH headings : Animals; Atrioventricular Block / therapy; Atrioventricular Block / veterinary; Cardiovascular Surgical Procedures / adverse effects; Cardiovascular Surgical Procedures / veterinary; Dog Diseases / therapy; Dogs; Pacemaker, Artificial / veterinary; Postoperative Complications / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: AH transvenous pacemaker placement is associated with a higher rate of major complications (especially infections) compared to BH placement, and this difference may be because of a variety of human factor differences AH versus BH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Management of acute heart failure in cats

Journal of Veterinary Cardiology, 17, S173–S189.

By: L. Ferasin* & T. DeFrancesco n

author keywords: Cat; Heart failure; CHF; Dyspnoea; Therapy
MeSH headings : Acute Disease; Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cat Diseases / therapy; Cats; Heart Failure / diagnosis; Heart Failure / pathology; Heart Failure / therapy; Heart Failure / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2015 journal article

Mitral valve disease in a dog

Plumb's Therapeutics Brief. https://www.cliniciansbrief.com/article/mitral-valve-disease-dog

By: T. DeFrancesco

Source: NC State University Libraries
Added: December 22, 2020

2015 chapter

Myocarditis

In E. Cote (Ed.), Clinical Veterinary Advisor: Dogs and Cats (3rd ed., pp. 685–686). St. Louis, MO: Elsevier (Mosby).

By: T. DeFrancesco

Ed(s): E. Cote

Source: NC State University Libraries
Added: October 18, 2020

2015 chapter

Pacemaker: Transthoracic Cardiac Pacing

In E. Cote (Ed.), Clinical Veterinary Advisor: Dogs and Cats (3rd ed.). St. Louis, MO: Elsevier (Mosby).

By: T. DeFrancesco

Ed(s): E. Cote

Source: NC State University Libraries
Added: December 22, 2020

2015 journal article

Relationship of Plasma N- terminal Pro- brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(1), 171–179.

By: P. Fox*, M. Oyama*, M. Hezzell*, J. Rush*, T. Nguyenba, T. DeFrancesco n, L. Lehmkuhl, H. Kellihan* ...

author keywords: Biomarkers; Canine; Heart disease; Respiratory distress
MeSH headings : Animals; Cross-Sectional Studies; Dog Diseases / blood; Dog Diseases / classification; Dog Diseases / metabolism; Dogs; Dyspnea / blood; Dyspnea / diagnosis; Dyspnea / veterinary; Enzyme-Linked Immunosorbent Assay / methods; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Heart Failure / blood; Heart Failure / classification; Heart Failure / veterinary; Male; Natriuretic Peptide, Brain / blood; Peptide Fragments / blood
TL;DR: Plasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress and increased significantly as a function of HD severity using the ACVIM‐HD classification scheme. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 chapter

Temporary Cardiac Pacing

In Small Animal Critical Care Medicine (pp. 1049–1054).

By: T. DeFrancesco*

Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2014 journal article

Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.

By: Y. Reina-Doreste*, J. Stern*, B. Keene*, S. Tou*, C. Atkins*, T. DeFrancesco*, M. Ames*, T. Hodge*, K. Meurs*

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
TL;DR: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 chapter

Focused or COAST3 : echo (heart)

In G. Liscandro (Ed.), Focused Ultrasound Techniques for the Small Animal Practitioner (1st ed., pp. 189–205). Ames, IA: Wiley & Sons, Inc.

By: T. DeFrancesco

Ed(s): G. Liscandro

Source: NC State University Libraries
Added: October 18, 2020

2014 journal article

Outcome of positive-pressure ventilation in dogs and cats with congestive heart failure: 16 cases (1992-2012)

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 24(5), 586–593.

By: T. Edwards*, A. Coleman*, B. Brainard*, T. DeFrancesco n, B. Hansen n, B. Keene n, A. Koenig*

author keywords: cardiogenic; cardiovascular; heart failure; parenchymal disease; pulmonary edema; respiratory tract; small animal
MeSH headings : Animals; Cat Diseases / therapy; Cats; Dog Diseases / therapy; Dogs; Female; Heart Failure / therapy; Heart Failure / veterinary; Male; Positive-Pressure Respiration / veterinary; Retrospective Studies; Survival Rate; Time Factors; Treatment Outcome
TL;DR: Dogs and cats undergoing positive-pressure ventilation for CHF have a good overall prognosis for hospital discharge and require PPV for a relatively short duration and azotemia, oliguria or anuria, and the use of pentobarbital are negatively associated with outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1437–1440.

By: K. Meurs n, J. Stern n, D. Sisson*, M. Kittleson*, S. Cunningham*, M. Ames n, C. Atkins n, T. DeFrancesco n ...

author keywords: Boxer; Dilated cardiomyopathy; Mutation; Striatin
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / veterinary; Case-Control Studies; Confidence Intervals; DNA / chemistry; DNA / genetics; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Female; Genotype; Male; Membrane Proteins / genetics; Polymerase Chain Reaction / veterinary; Sequence Deletion / genetics
TL;DR: This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype, and suggests that there is at least 1 other cause of DCm in the boxer dog. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy

RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617.

By: A. Kane n, T. DeFrancesco n, M. Boyle*, D. Malarkey*, J. Ritchey*, C. Atkins n, J. Cullen n, J. Kornegay*, B. Keene n

author keywords: Cardiomyopathy; Carrier; GRMD; Duchenne muscular dystrophy
MeSH headings : Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Electrocardiography, Ambulatory / veterinary; Female; Heart / physiopathology; Heterozygote; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Muscular Dystrophy, Animal / physiopathology; Myocardium / pathology
TL;DR: Despite cardiac mosaic dystrophin expression and degenerative cardiac lesions, GRMD carriers at up to 3 years of age could not be distinguished statistically from normal controls by echocardiography or 24-h Holter monitoring. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Management of Cardiac Emergencies in Small Animals

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 43(4), 817-+.

By: T. DeFrancesco n

author keywords: Heart failure; Arrhythmia; Pericardial effusion; Syncope; Feline aortic thromboembolism; Focused echocardiography; Cardiac biomarkers
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / therapy; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Emergency Medical Services; Heart Diseases / diagnosis; Heart Diseases / therapy; Heart Diseases / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Cutting balloon catheterization for interventional treatment of cor triatriatum dexter: 2 Cases

Journal of Veterinary Cardiology, 14(4), 525–530.

By: N. LeBlanc*, T. DeFrancesco n, A. Adams*, C. Atkins n, S. Tou n, J. Fudge*, B. Keene n

author keywords: Conventional balloon angioplasty; Congenital heart disease; Cardiac anomalies
MeSH headings : Animals; Catheterization / instrumentation; Catheterization / veterinary; Cor Triatriatum / surgery; Cor Triatriatum / veterinary; Dog Diseases / surgery; Dogs; Female; Male; Treatment Outcome
TL;DR: Cutting balloon dilatation was performed successfully in two dogs with cor triatriatum dexter and clinical signs of ascites and, in both cases described, clinical signs resolved completely following cutting balloon Dilatation of the anomalous membrane. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2012 journal article

Electrocardiographic review – 5 cases

Clinician's Brief. Retrieved from www.cliniciansbrief.com

By: T. DeFrancesco

Source: NC State University Libraries
Added: October 18, 2020

2012 journal article

Pacemaker malfunction due to mechanical failure of the lead–header interface

Journal of Veterinary Cardiology, 14(4), 519–523.

By: A. Coleman*, T. DeFrancesco n & G. Chanoit*

author keywords: Pacemaker complications; Ventricular impedance measurements; Pacemaker set screw
MeSH headings : Animals; Dog Diseases / therapy; Dogs; Electrodes, Implanted / veterinary; Equipment Failure / veterinary; Female; Pacemaker, Artificial / veterinary
TL;DR: It is hypothesized that either the presence of a loose or cross-threaded set screw or operator error at the time of device implantation may have caused the diagnosis of mechanical failure of the lead-header interface. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2011 journal article

Cardiac biomarkers

NAVC Clinicians’ Brief.

By: T. DeFrancesco

Source: NC State University Libraries
Added: October 18, 2020

2011 journal article

Clinical progression of X-linked muscular dystrophy in two German Shorthaired Pointers

Journal of the American Veterinary Medical Association, 238(2), 207–212.

By: N. Olby n, N. Sharp, P. Nghiem, B. Keene, T. DeFrancesco*, J. Sidley, J. Kornegay, S. Schatzberg

MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Male; Muscular Dystrophy, Animal / genetics; X Chromosome
TL;DR: The clinical progression of muscular dystrophy in the 2 GSHPs was compared with that for other breeds and species with dystrophin-deficient conditions, and the potential basis for the phenotypic variation observed between these littermates, along with potential therapeutic ramifications for dogs and humans was evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2011 journal article

Comparison of Polymerase Chain Reaction with Bacterial 16s Primers to Blood Culture to Identify Bacteremia in Dogs with Suspected Bacterial Endocarditis

Journal of Veterinary Internal Medicine, 25(4), 959–962.

By: K. Meurs*, A. Heaney*, C. Atkins, T. DeFrancesco*, P. Fox*, B. Keene, H. Kellihan*, M. Miller* ...

author keywords: Bartonella; Canine; Infectious; Molecular; Valvular
MeSH headings : Animals; Bacteremia / blood; Bacteremia / microbiology; Bacteremia / veterinary; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Dog Diseases / blood; Dog Diseases / microbiology; Dogs; Endocarditis, Bacterial / blood; Endocarditis, Bacterial / microbiology; Endocarditis, Bacterial / veterinary; Female; Male; Polymerase Chain Reaction / veterinary; Prospective Studies; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / genetics
TL;DR: The results of this study suggest that although single sample PCR with 16s primers was not more sensitive than blood culture for detection of bacteremia in dogs with suspect endocarditis, performing both techniques simultaneously did increase the likelihood of identification of bacteria in blood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2011 journal article

Detection of tumour necrosis factor-alpha in dogs with lymphoma

VETERINARY AND COMPARATIVE ONCOLOGY, 9(4), 290–295.

By: J. Hofer n, T. DeFrancesco n & L. Williams n

author keywords: biomarker; cancer; canine; cytokine; lymphoma
MeSH headings : Animals; Biomarkers, Tumor / blood; Case-Control Studies; Dog Diseases / blood; Dog Diseases / pathology; Dogs; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Lymphoma / blood; Lymphoma / pathology; Lymphoma / veterinary; Male; North Carolina; Tumor Necrosis Factor-alpha / blood
TL;DR: Serum TNF-α appears to have limited value as a tumour marker in dogs with lymphoma, and the Immulite® automated ELISA failed to detect canine T NF-α. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 article

ECG of the Month

Tou, S. P., DeFrancesco, T. C., & Keene, B. W. (2011, July 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 239, pp. 55–57.

By: S. Tou n, T. DeFrancesco* & B. Keene*

MeSH headings : Animals; Bundle-Branch Block / diagnosis; Bundle-Branch Block / veterinary; Dog Diseases / diagnosis; Dogs; Electrocardiography / veterinary; Male; Tachycardia, Sinus / veterinary
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Effects of furosemide and the combination of furosemide and the labeled dosage of pimobendan on the circulating renin-angiotensin-aldosterone system in clinically normal dogs

American Journal of Veterinary Research, 72(12), 1646–1651.

By: A. Lantis n, C. Atkins, T. DeFrancesco*, B. Keene & S. Werre

MeSH headings : Administration, Oral; Aldosterone / urine; Animals; Bicarbonates / blood; Blood Chemical Analysis / veterinary; Blood Pressure; Chlorides / blood; Creatinine / urine; Diuretics / administration & dosage; Diuretics / analysis; Diuretics / pharmacology; Diuretics / urine; Dogs; Female; Furosemide / administration & dosage; Furosemide / analysis; Furosemide / pharmacology; Furosemide / urine; Male; Potassium / blood; Pyridazines / administration & dosage; Pyridazines / analysis; Pyridazines / pharmacology; Pyridazines / urine; Renin-Angiotensin System; Sodium / blood; Sodium Potassium Chloride Symporter Inhibitors / pharmacology; Vasodilator Agents / administration & dosage; Vasodilator Agents / analysis; Vasodilator Agents / pharmacology; Vasodilator Agents / urine; Weight Loss
TL;DR: The results in clinically normal dogs suggested that furosemide, administered with or without pimobendan, should be accompanied by RAAS-suppressive treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2011 journal article

Multicenter Evaluation of Plasma N-Terminal Probrain Natriuretic Peptide (NT-pro BNP) as a Biochemical Screening Test for Asymptomatic (occult) Cardiomyopathy in Cats

Journal of Veterinary Internal Medicine, 25(5), 1010–1016.

By: P. Fox, J. Rush, C. Reynolds, T. DeFrancesco, B. Keene, C. Atkins, S. Gordon, K. Schober ...

Source: NC State University Libraries
Added: August 6, 2018

2011 chapter

Myocarditis

In E. Cote (Ed.), Clinical Veterinary Advisor: Dogs and Cats (2nd ed., pp. 743–744). St. Louis, MO: Mosby.

By: T. DeFrancesco

Ed(s): E. Cote

Source: NC State University Libraries
Added: October 18, 2020

2011 chapter

Pacemaker: Transthoracic Cardiac Pacing

In E. Cote (Ed.), Clinical Veterinary Advisor: Dogs and Cats (2nd ed., pp. 1320–1321). St. Louis, MO: Mosby.

By: T. DeFrancesco

Ed(s): E. Cote

Source: NC State University Libraries
Added: October 18, 2020

2010 chapter

Aortic Thromboembolism

In E. Mazzaferro (Ed.), Blackwell's five-minute veterinary consult clinical companion: Small animal emergency and critical care (1st ed., pp. 55–65). Ames, Iowa: Blackwell Publishing.

By: T. DeFrancesco

Ed(s): E. Mazzaferro

Source: NC State University Libraries
Added: October 18, 2020

2009 journal article

Acute Effect of Pimobendan and Furosemide on the Circulating Renin-Angiotensin-Aldosterone System in Healthy Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 23(5), 1003–1006.

By: M. Sayer n, C. Atkins n, Y. Fujii n, A. Adams n, T. DeFrancesco n & B. Keene n

author keywords: Furosemide; Heart failure; Inodilator; Pimobendan; Renin-angiotensin-aldosterone system
MeSH headings : Aldosterone / urine; Animals; Blood Urea Nitrogen; Chlorides / blood; Cross-Over Studies; Dogs / blood; Dogs / urine; Female; Furosemide / pharmacology; Male; Phosphorus / blood; Potassium / blood; Pyridazines / pharmacology; Renin-Angiotensin System / drug effects; Sodium / blood; Sodium Potassium Chloride Symporter Inhibitors / pharmacology; Vasodilator Agents / pharmacology
TL;DR: It is suggested that furosemide therapy, with or without pimobendan, should be accompanied by RAAS suppressive therapy, and short-term administration of high-dose pimobendedan, does not activate the RAAS in healthy dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Coagulation effects of low molecular weight heparin compared with heparin in dogs considered to be at risk for clinically significant venous thrombosis

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 19(1), 74–80.

By: K. Scott n, B. Hansen n & T. DeFrancesco n

author keywords: anti-coagulate; blood clot; canine; hypercoagulable
MeSH headings : Animals; Anticoagulants / therapeutic use; Dalteparin / administration & dosage; Dalteparin / therapeutic use; Dog Diseases / drug therapy; Dogs; Risk Factors; Venous Thrombosis / drug therapy; Venous Thrombosis / veterinary
TL;DR: Neither DP nor LDH increased AXa to values considered therapeutic in humans (0.5-1 and 0.75 U/mL, respectively), and both protocols appear to be inadequate to increase AXa in dogs with clinical illness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Ionized Hypocalcemia in Critically Ill Dogs

Journal of Veterinary Internal Medicine, 23(3), 509–513.

By: M. Holowaychuk n, B. Hansen n, T. DeFrancesco n & S. Marks n

author keywords: Canine; Critical care; Intensive care medicine; Sepsis; Systemic inflammatory response syndrome; Trauma
MeSH headings : Animals; Calcium / blood; Calcium / chemistry; Critical Illness; Dog Diseases / blood; Dog Diseases / mortality; Dogs; Hypocalcemia / blood; Hypocalcemia / veterinary; Prospective Studies; Risk Factors; Sepsis / blood; Sepsis / veterinary
TL;DR: In dogs not previously treated with fluids or blood products intravenously, the finding of iHCa upon admission to the ICU predicted a longer duration of ICU and hospital stay. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Isolation or Molecular Detection of Bartonella henselae and Bartonella vinsonii subsp. berkhoffii from Dogs with Idiopathic Cavitary Effusions

Journal of Veterinary Internal Medicine, 23(1), 186–189.

By: N. Cherry n, P. Diniz n, R. Maggi n, J. Hummel n, E. Hardie n, E. Behrend*, E. Rozanski*, T. DeFrancesco n ...

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bartonella / classification; Bartonella / isolation & purification; Bartonella Infections / drug therapy; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Female; Male; Pericardial Effusion / drug therapy; Pericardial Effusion / microbiology; Pericardial Effusion / veterinary; Pleural Effusion / drug therapy; Pleural Effusion / microbiology; Pleural Effusion / veterinary
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2009 chapter

Temporary Transvenous Pacing

In D. Silverstein & K. Hopper (Eds.), Critical Care Medicine for Dogs and Cats (pp. 214–216). St. Louis, MO: Saunders Elsevier.

By: T. DeFrancesco

Ed(s): D. Silverstein & K. Hopper

Source: NC State University Libraries
Added: October 18, 2020

2009 chapter

Transcutaneous Pacing

In D. Silverstein & K. Hopper (Eds.), Small Animal Critical Care Medicine (pp. 217–219). St. Louis, MO: Saunders Elsevier.

By: T. DeFrancesco

Ed(s): D. Silverstein & K. Hopper

Source: NC State University Libraries
Added: October 18, 2020

2009 journal article

Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats

Journal of Veterinary Cardiology, 11(Supplement 1), S51–S61.

By: P. Fox*, M. Oyama*, C. Reynolds*, J. Rush*, T. DeFrancesco n, B. Keene n, C. Atkins n, K. MacDonald* ...

Contributors: P. Fox*, M. Oyama*, C. Reynolds*, J. Rush*, T. DeFrancesco n, B. Keene n, C. Atkins n, K. MacDonald* ...

MeSH headings : Animals; Biomarkers / blood; Case-Control Studies; Cat Diseases / blood; Cat Diseases / diagnosis; Cats; Diagnosis, Differential; Dyspnea / blood; Dyspnea / diagnosis; Dyspnea / etiology; Dyspnea / veterinary; Female; Heart Failure / blood; Heart Failure / complications; Heart Failure / diagnosis; Heart Failure / veterinary; Male; Natriuretic Peptide, Brain / blood; Peptide Fragments / blood; Predictive Value of Tests; Prospective Studies; ROC Curve; Renal Insufficiency / blood; Renal Insufficiency / complications; Renal Insufficiency / diagnosis; Renal Insufficiency / veterinary; Respiration Disorders / blood; Respiration Disorders / complications; Respiration Disorders / diagnosis; Respiration Disorders / veterinary
TL;DR: NT-proBNP accurately discriminated CHF from respiratory disease causes of dyspnea and optimal cut-off values using receiver operating characteristic (ROC) curve analysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 24, 2019

2008 article

ECG of the month

Cruse, A. M., Booth, M. A., & DeFrancesco, T. C. (2008, February 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 232, pp. 510–512.

By: A. Cruse*, M. Booth* & T. DeFrancesco*

MeSH headings : Animals; Atrioventricular Block / diagnosis; Atrioventricular Block / veterinary; Dog Diseases / diagnosis; Dogs; Electrocardiography / methods; Electrocardiography / veterinary; Female; Physical Conditioning, Animal / adverse effects
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Maintaining fluid and electrolyte balance in heart failure

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 38(3), 727-+.

By: T. DeFrancesco n

MeSH headings : Animals; Cat Diseases / physiopathology; Cat Diseases / therapy; Cats; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Heart Failure / physiopathology; Heart Failure / therapy; Heart Failure / veterinary; Water-Electrolyte Balance / physiology; Water-Electrolyte Imbalance / physiopathology; Water-Electrolyte Imbalance / therapy; Water-Electrolyte Imbalance / veterinary
TL;DR: An overview of the pathophysiology of common fluid and electrolyte alterations present in animals with heart failure is given, highlighting specific clinical correlates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Supraventricular tachycardia in dogs: 65 cases (1990-2007)

Finster, S. T., DeFrancesco, T. C., Atkins, C. E., Hansen, B. D., & Keene, B. W. (2008, October). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Vol. 18, pp. 503–510.

By: S. Finster n, T. DeFrancesco n, C. Atkins n, B. Hansen n & B. Keene n

author keywords: atrial tachycardia; atrioventricular nodal reentry tachycardia; pre-excitation
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 chapter

Aortic Thromboembolism

In L. P. Tilley & F. W. K. Smith (Eds.), Blackwell’s Five-Minute Veterinary Consult: Canine and Feline (4th ed., pp. 98–99). Ames, Iowa: Blackwell Publishing Professional.

By: T. DeFrancesco

Ed(s): L. Tilley & F. Smith

Source: NC State University Libraries
Added: October 18, 2020

2007 chapter

Dilated Cardiomyopathy - Cats

In L. P. Tilley & F. W. K. Smith (Eds.), Blackwell’s Five-Minute Veterinary Consult: Canine and Feline (4th ed., pp. 208–209). Ames, Iowa: Blackwell Publishing Professional.

By: T. DeFrancesco

Ed(s): L. Tilley & F. Smith

Source: NC State University Libraries
Added: October 18, 2020

2007 journal article

Estimation of 24-h aldosterone secretion in the dog using the urine aldosterone:Creatinine ratio

Journal of Veterinary Cardiology, 9(1), 1–7.

By: S. Gardner n, C. Atkins n, W. Rausch n, T. DeFrancesco n, D. Chandler & B. Keene n

MeSH headings : Aldosterone / metabolism; Aldosterone / urine; Animals; Creatinine / urine; Dog Diseases / diagnosis; Dog Diseases / urine; Dogs / metabolism; Dogs / urine; Female; Male; Radioimmunoassay / methods; Radioimmunoassay / veterinary; Renin-Angiotensin System / physiology
TL;DR: It is postulated that the urinary aldosterone:creatinine ratio, measured from spot urine samples, would correlate well with 24-h urinary a Aldosterone excretion, and would provide a simple index of ald testosterone excretion that would eliminate the need for 24-H urine collection. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2007 journal article

Prospective clinical evaluation of an ELISA B-type natriuretic peptide assay in the diagnosis of congestive heart failure in dogs presenting with cough or dyspnea

JOURNAL OF VETERINARY INTERNAL MEDICINE, 21(2), 243–250.

By: T. DeFrancesco n, J. Rush*, E. Rozanski*, B. Hansen n, B. Keene n, D. Moore*, C. Atkins n

author keywords: brain natriuretic peptide; cardiac biomarkers; heart disease
TL;DR: Measurement of BNP is useful in establishing or in excluding the diagnosis of CHF in dogs with cough or dyspnea, and B-type natriuretic peptide concentrations rose significantly as a function of severity ofCHF. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency

Journal of the American Veterinary Medical Association, 231(7), 1061–1069.

By: C. Atkins n, B. Keene*, W. Brown, J. Coats*, M. Crawford, T. DeFrancesco*, N. Edwards, P. Fox ...

MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Antihypertensive Agents / therapeutic use; Death, Sudden, Cardiac / veterinary; Disease Progression; Disease-Free Survival; Dog Diseases / mortality; Dog Diseases / prevention & control; Dogs; Double-Blind Method; Enalapril / therapeutic use; Female; Heart Failure / mortality; Heart Failure / prevention & control; Heart Failure / veterinary; Kaplan-Meier Estimate; Male; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / veterinary; Severity of Illness Index; Time Factors; Treatment Outcome
TL;DR: Chronic enalapril treatment of dogs with naturally occurring, moderate to severe MR significantly delayed onset of CHF, compared with placebo, on the basis of number ofCHF-free days, number of dogs free of CHFs at days 500 and study end, and increased time to a combined secondary endpoint of CHf-all-cause death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

The effect of amlodipine and the combination of amlodipine and enalapril on the renin-angiotensin-aldosterone system in the dog

Journal of Veterinary Pharmacology and Therapeutics, 30(5), 394–400.

By: C. Atkins*, W. Rausch*, S. Gardner*, T. Defrancesco*, B. Keene* & J. Levine n

MeSH headings : Administration, Oral; Aldosterone / urine; Amlodipine / administration & dosage; Amlodipine / blood; Amlodipine / pharmacology; Animals; Antihypertensive Agents / administration & dosage; Antihypertensive Agents / blood; Antihypertensive Agents / pharmacology; Blood Pressure / drug effects; Blood Urea Nitrogen; Dogs / metabolism; Drug Therapy, Combination; Enalapril / administration & dosage; Enalapril / blood; Enalapril / pharmacology; Heart Rate / drug effects; Male; Renin-Angiotensin System / drug effects
TL;DR: Renin-angiotensin-aldosterone system activation was increased by approximately threefold (P < 0.05) with amlodipine administration, but this effect was blunted by enalapril, such that aldosterone excretion was no longer different from that observed under control conditions, although values for 24-h ald testosterone excretion did not return to pretreament levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2006 journal article

Coil occlusion of residual shunts after surgical closure of patent ductus arteriosus

VETERINARY SURGERY, 35(8), 781–785.

By: Y. Fujii n, B. Keene n, K. Mathews n, C. Atkins n, T. Defrancesco n, E. Hardie n, Y. Wakao n

MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dog Diseases / therapy; Dogs; Ductus Arteriosus, Patent / diagnostic imaging; Ductus Arteriosus, Patent / surgery; Ductus Arteriosus, Patent / therapy; Ductus Arteriosus, Patent / veterinary; Echocardiography, Doppler, Color / veterinary; Embolization, Therapeutic / methods; Embolization, Therapeutic / veterinary; Female; Ligation / adverse effects; Ligation / veterinary; Male; Treatment Outcome
TL;DR: Transcatheter coil embolization appears to be a safe and minimally invasive procedure for complete occlusion of residual PDA flow after incomplete surgical ligation and should be considered for correction of hemodynamically significant residual shunts in dogs that have incomplete PDA Occlusion after open surgical ligate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Analysis of diltiazem in Lipoderm (R) transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studies

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 38(1), 60–65.

By: J. Buur n, R. Baynes n, J. Yeatts n, G. Davidson n & T. DeFrancesco n

author keywords: diltiazem; reverse-phase liquid chromatography; transdermal gel; drug stability; compounded drug analysis
MeSH headings : Calcium Channel Blockers / analysis; Chromatography, High Pressure Liquid / methods; Diltiazem / analysis; Drug Stability; Gels; Pharmaceutical Preparations / chemistry; Reference Standards; Reproducibility of Results
TL;DR: A simple and novel method for the extraction and quantification of diltiazem hydrochloride was developed and applied to homogenization and stability studies and showed excellent linearity from 50 to 250 mg/ml in undiluted gel. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Clinical, echocardiographic, and electrocardiographic abnormalities in Boxers with cardiomyopathy and left ventricular systolic dysfunction: 48 cases (1985-2003)

Journal of the American Veterinary Medical Association, 226(7), 1102–1104.

By: R. Baumwart*, K. Meurs*, C. Atkins, J. Bonagura*, T. DeFrancesco*, B. Keene, S. Koplitz, V. Fuentes ...

Contributors: R. Baumwart*, K. Meurs*, C. Atkins, J. Bonagura*, T. DeFrancesco*, B. Keene, S. Koplitz, V. Fuentes ...

MeSH headings : Animals; Cardiomyopathies / diagnosis; Cardiomyopathies / physiopathology; Cardiomyopathies / veterinary; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Echocardiography / methods; Echocardiography / veterinary; Electrocardiography, Ambulatory / methods; Electrocardiography, Ambulatory / veterinary; Female; Male; Radiography, Thoracic / methods; Radiography, Thoracic / veterinary; Retrospective Studies; Ventricular Dysfunction, Left / diagnosis; Ventricular Dysfunction, Left / physiopathology; Ventricular Dysfunction, Left / veterinary
TL;DR: Boxers with cardiomyopathy and left ventricular dysfunction frequently have arrhythmias of supraventricular or ventricular origin, and the natural history of myocardial disease in Boxers requires further study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID, Web Of Science
Added: October 24, 2019

2003 journal article

Diagnosing congestive heart failure: Could a blood test increase our diagnostic accuracy in heart failure?

Abaxis VetCom, 7, 1–4.

By: T. DeFrancesco

Source: NC State University Libraries
Added: October 18, 2020

2003 book

Getting to the heart of the matter : advances in the management of cardiac patients

(D. K. Hurley & D. P. Devlin, Eds.). Lyon, France: Merial.

By: T. DeFrancesco, C. Atkins, K. Hurley & P. Devlin

Ed(s): D. Hurley & D. Devlin

Source: NC State University Libraries
Added: February 5, 2022

2003 article

Noninvasive transthoracic temporary cardiac pacing in dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 17, pp. 663–667.

By: T. DeFrancesco n, B. Hansen n, C. Atkins n, J. Sidley n & B. Keene n

author keywords: advanced atrioventricular block; bradyarrhythmias; pacemaker; sinus node dysfunction
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers

Journal of the American Veterinary Medical Association, 221(4), 522–527.

By: K. Meurs*, A. Spier, N. Wright, C. Atkins*, T. DeFrancesco*, S. Gordon, R. Hamlin, B. Keene* ...

MeSH headings : Animals; Anti-Arrhythmia Agents / pharmacology; Anti-Arrhythmia Agents / therapeutic use; Arrhythmias, Cardiac / drug therapy; Arrhythmias, Cardiac / veterinary; Atenolol / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Therapy, Combination; Heart Rate; Mexiletine / therapeutic use; Procainamide / therapeutic use; Random Allocation; Sotalol / therapeutic use; Syncope / drug therapy; Syncope / veterinary; Treatment Outcome; Ventricular Premature Complexes / drug therapy; Ventricular Premature Complexes / veterinary
TL;DR: Significant reductions in number of VPC, severity of arrythmia, and maximum and mean HR were observed in dogs treated with mexiletine-atenolol or sotalol; occurrence of syncope was not significantly different between these 2 treatment groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation

Journal of the American Veterinary Medical Association, 221(5), 654–658.

By: C. Atkins n, W. Brown, J. Coats*, M. Crawford, T. DeFrancesco*, J. Edwards, P. Fox, B. Keene* ...

MeSH headings : Angiotensin-Converting Enzyme Inhibitors / adverse effects; Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Blood Urea Nitrogen; Creatinine / blood; Dog Diseases / drug therapy; Dogs; Enalapril / adverse effects; Enalapril / therapeutic use; Female; Follow-Up Studies; Kidney / drug effects; Kidney Function Tests / veterinary; Male; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / drug therapy; Mitral Valve Insufficiency / veterinary; Time Factors
TL;DR: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Percutaneous Balloon Pericardiotomy as a Treatment for Recurrent Pericardial Effusion in 6 Dogs

Journal of Veterinary Internal Medicine, 16(5), 541–546.

By: J. Sidley n, C. Atkins n, B. Keene n & T. DeFrancesco n

author keywords: cardiac tamponade; chemodectoma; heart base tumor; hemangiosarcoma; idiopathic pericardial effusion
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 article

Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 16, pp. 553–557.

By: T. DeFrancesco n, C. Atkins n, B. Keene n, . Coats n & M. Hauck n

author keywords: cardiomyopathy; congestive heart failure; doxorubicin-induced cardiotoxicity; neoplasia; skeletal muscle trauma
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Relationship between hydration estimate and body weight change after fluid therapy in critically ill dogs and cats

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 12(4), 235–243.

By: B. Hansen n & T. DeFrancesco n

author keywords: assessment; dehydration; packed cell volume; plasma total solids
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

The case of the fainting Boxer: review of Boxer cardiomyopathy

[Review of Boxer]. Waltham FOCUS, 12(3), 28–30.

By: T. DeFrancesco

Source: NC State University Libraries
Added: October 18, 2020

2001 journal article

Natural history of hypertrophic cardiomyopathy and aortic thromboembolism in a family of domestic shorthair cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 15(6), 595–599.

By: C. Baty n, D. Malarkey n, C. Atkins n, T. DeFrancesco n, J. Sidley n & B. Keene n

author keywords: cardiac myocyte disarray; end stage; spontaneous echo contrast; systolic function; ventricular remodeling
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Use of echocardiography for the diagnosis of heartworm disease in cats: 43 cases (1985-1997)

Journal of the American Veterinary Medical Association, 218(1), 66–69.

By: T. DeFrancesco n, C. Atkins*, M. Miller, K. Meurs* & B. Keene*

MeSH headings : Animals; Antibodies, Helminth / analysis; Antigens, Helminth / analysis; Cat Diseases / diagnostic imaging; Cat Diseases / parasitology; Cats; Dirofilaria immitis / immunology; Dirofilaria immitis / isolation & purification; Dirofilariasis / diagnostic imaging; Echocardiography / veterinary; Pulmonary Artery / diagnostic imaging; Pulmonary Artery / pathology; Radiography, Thoracic / veterinary; Retrospective Studies
TL;DR: Although echocardiography was less sensitive than antigen testing, it was a useful adjunctive test in cats that had negative antigen test results in which there was a suspicion of heartworm disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2000 chapter

AMBULATORY ELECTROCARDIOGRAPHY

In Small Animal Cardiology Secrets (pp. 115–118).

By: T. DeFrancesco*

Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2000 chapter

CVT update: Infectious endocarditis

In Kirk's current veterinary therapy : small animal practice (13th Ed.) (p. 768). Philadelphia, PA : W.B. Saunders.

By: T. DeFrancesco

Source: NC State University Libraries
Added: August 6, 2018

2000 chapter

Cardiac Emergencies, Hypertension, Electrocution, and Exam of the Cardiovascular System

In S. Bistner, R. B. Ford, M. R. Raffe, & R. W. Kirk (Eds.), Kirk and Bistner's handbook of veterinary procedures and emergency treatment (7th ed., pp. 54–74, 282–313). Philadelphia, PA: WB Saunders.

By: T. DeFrancesco

Ed(s): S. Bistner, R. Ford, M. Raffe & R. Kirk

Source: NC State University Libraries
Added: October 18, 2020

2000 journal article

Heartworm infection in cats: 50 cases (1985-1997)

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 217(3), 355–358.

By: C. Atkins n, T. DeFrancesco n, . Coats n, J. Sidley n & B. Keene n

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / epidemiology; Cats; Dirofilariasis / diagnosis; Dirofilariasis / epidemiology; Female; Male; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis
TL;DR: Findings suggested that male cats were not predisposed to HWI, domestic shorthair cats were at increased risk, and indoor housing was only partially protective, while sex does not appear to be a risk factor for HWI in cats. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 article

Ocular lesions associated with systemic hypertension in cats: 69 cases (1985-1998)

Maggio, F., DeFrancesco, T. C., Atkins, C. E., Pizzirani, S., Gilger, B. C., & Davidson, M. G. (2000, September 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 217, pp. 695–702.

By: F. Maggio n, T. DeFrancesco n, C. Atkins n, S. Pizzirani n, B. Gilger n & M. Davidson n

MeSH headings : Animals; Blindness / etiology; Blindness / veterinary; Cat Diseases / etiology; Cat Diseases / pathology; Cats; Female; Fundus Oculi; Hypertension / complications; Hypertension / pathology; Hypertension / veterinary; Male; Retinal Diseases / etiology; Retinal Diseases / pathology; Retinal Diseases / veterinary; Retrospective Studies
TL;DR: Retinal lesions, caused predominantly by choroidal injury, are common in cats with hypertension, and primary hypertension in cats may be more common than currently recognized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 personal communication

Untitled

By: C. Atkins & T. DeFrancesco

Source: NC State University Libraries
Added: August 6, 2018

2000 chapter

Update: Infectious Endocarditis

In J. D. Bonagura & R. W. Kirk (Eds.), Kirk’s Current Veterinary Therapy XIII (pp. 768–771). Philadelphia, PA: WB Saunders.

By: T. DeFrancesco

Ed(s): J. Bonagura & R. Kirk

Source: NC State University Libraries
Added: October 18, 2020

1999 journal article

Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments

Journal of the American Veterinary Medical Association, 215(12), 1808–1812.

By: D. Ward, S. Forrester, T. DeFrancesco & G. Troy

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Prevalence of heartworm infection in cats with signs of cardiorespiratory abnormalities

Journal of the American Veterinary Medical Association, 212(4), 517–520.

By: C. Atkins, T. DeFrancesco, M. Miller, K. Meurs & B. Keene

Source: NC State University Libraries
Added: August 6, 2018

1997 review

Feline Heartworm Disease: Should I be concerned?

[Review of Feline Heartworm Disease: Should I be concerned?]. Cardiopet Educator. Cardiopet: Little Falls, NJ.

By: T. DeFrancesco

Source: NC State University Libraries
Added: October 18, 2020

1997 book

Taurine Deficiency in The 5 Minute Veterinary Consult Canine and Feline

In L. P. Tilley & F. W. K. Smith (Eds.), The 5 Minute Veterinary Consult Canine and Feline (p. 1093). Baltimore: Williams and Wilkins.

By: T. DeFrancesco

Ed(s): L. Tilley & F. Smith

Source: NC State University Libraries
Added: October 18, 2020

1996 journal article

Myocardial infarction complicating management of congestive heart failure in a dog

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 32(1), 68–72.

By: T. DeFrancesco n, C. Atkins & B. Keene

MeSH headings : Animals; Antihypertensive Agents / therapeutic use; Diagnosis, Differential; Diuretics / therapeutic use; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Echocardiography; Electrocardiography; Enalapril / therapeutic use; Female; Furosemide / therapeutic use; Heart / drug effects; Heart / physiology; Heart Failure / complications; Heart Failure / drug therapy; Heart Failure / veterinary; Hydralazine / therapeutic use; Myocardial Infarction / complications; Myocardial Infarction / diagnosis; Myocardial Infarction / veterinary; Myocardium / pathology; Vasodilator Agents / therapeutic use
TL;DR: Although a rare diagnosis in the veterinary patient, myocardial infarction must be considered in the differential diagnosis for sudden onset of weakness, tachypnea, and ventricular tachycardia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1995 chapter

Ambulatory (Holter) Electrocardiography

In J. D. Bonagura & R. W. Kirk (Eds.), Kirk’s Current Veterinary Therapy XII (pp. 792–799). Philadelphia: WB Saunders.

By: N. Moise & T. DeFrancesco

Ed(s): J. Bonagura & R. Kirk

Source: NC State University Libraries
Added: October 18, 2020

1993 journal article

What Is Your Diagnosis?

Journal of the American Veterinary Medical Association, 203(5), 645–646.

By: K. Schulz, J. Baruffaldi, C. Carrig & T. DeFrancesco

Source: NC State University Libraries
Added: October 18, 2020

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