Works (35)

Updated: March 10th, 2025 12:14

2017 article

Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1

Khan, M. A., Walden, W. E., Theil, E. C., & Goss, D. J. (2017, August 11). Scientific Reports.

By: M. Khan*, W. Walden*, E. Theil n & D. Goss*

MeSH headings : Aconitate Hydratase / genetics; Animals; Cations, Divalent / metabolism; Ferritins / genetics; Iron / metabolism; Iron Regulatory Protein 1 / metabolism; Kinetics; Manganese / metabolism; Protein Binding; RNA, Messenger / metabolism; Rabbits; Response Elements; Temperature
topics (OpenAlex): Trace Elements in Health; Iron Metabolism and Disorders; Plant Micronutrient Interactions and Effects
TL;DR: The observations suggest decreased RNA hydrogen bonding and changed RNA conformation upon IRP1 binding and illustrate how small, conserved, sequence differences among IRE-mRNAs selectively influence thermodynamic and kinetic selectivity of the protein/RNA interactions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 article

Modulating the permeability of ferritin channels

Bernacchioni, C., Ghini, V., Theil, E. C., & Turano, P. (2016, January 1). RSC Advances.

topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; RNA regulation and disease
TL;DR: By changing the electrostatic properties of the residues at the inner edge of each channel, this work can selectively activate/deactivate Fe2+ routes, modulating the rate of iron oxidation at the ferroxidase sites. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 article

Solving Biology’s Iron Chemistry Problem with Ferritin Protein Nanocages

Theil, E. C., Tosha, T., & Behera, R. K. (2016, May 2). Accounts of Chemical Research.

By: E. Theil n, T. Tosha n & R. Behera n

MeSH headings : Animals; DNA / metabolism; Ferric Compounds / chemistry; Ferritins / chemistry; Ferritins / genetics; Ferritins / metabolism; Heme / metabolism; Humans; Iron / chemistry; Iron / metabolism; Oxidoreductases / chemistry; Oxidoreductases / metabolism; Oxygen / chemistry; Oxygen / metabolism; Protein Structure, Quaternary; RNA, Messenger / metabolism
topics (OpenAlex): Iron Metabolism and Disorders; Plant Micronutrient Interactions and Effects; Trace Elements in Health
TL;DR: High ferritin protein cage symmetry (3-fold and 4-fold axes) and amino acid conservation coincide with function, shown by amino acid substitution effects. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 article

Fe2+ substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization

Behera, R. K., Torres, R., Tosha, T., Bradley, J. M., Goulding, C. W., & Theil, E. C. (2015, July 22). JBIC Journal of Biological Inorganic Chemistry.

By: R. Behera, R. Torres*, T. Tosha, J. Bradley*, C. Goulding* & E. Theil n

author keywords: Ferritin; Iron oxidation; Ion channels; Crystal structure; Electrostatics; Di-iron center; Diferric peroxo; Caged iron-oxy biomineral; Oxidoreductase enzyme reactivity
MeSH headings : Amino Acid Substitution; Crystallography, X-Ray; Ferritins / metabolism; Ferritins / ultrastructure; Ferrous Compounds / metabolism; Ion Channels / metabolism; Ion Channels / ultrastructure; Iron / chemistry; Kinetics; Protein Structure, Secondary
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Porphyrin Metabolism and Disorders
TL;DR: The contributions of ion channel size and structure to ferritin activity reflect metal ion transport in ion channels are precisely regulated both in Ferritin protein nanocages and membranes of living cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 article

Is His54 a gating residue for the ferritin ferroxidase site?

Bernacchioni, C., Ciambellotti, S., Theil, E. C., & Turano, P. (2015, February 26). Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics.

author keywords: Ferritin; Ferroxidase site; Reaction kinetics; Mutagenesis
MeSH headings : Binding Sites; Ceruloplasmin / chemistry; Crystallography, X-Ray; Ferritins / chemistry; Histidine / chemistry; Histidine / metabolism; Iron / chemistry
topics (OpenAlex): Iron Metabolism and Disorders; Porphyrin Metabolism and Disorders; Trace Elements in Health
TL;DR: The data here reported are consistent with a role for His54 as a metal ion trap that maintains the correct levels of access of iron to the active site and taking advantage of the comparative sequence analysis of other ferritins. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A role for iron and oxygen chemistry in preserving soft tissues, cells and molecules from deep time

By: M. Schweitzer, W. Zheng, T. Cleland, M. Goodwin, E. Boatman, E. Theil, M. Marcus, S. Fakra

Source: NC State University Libraries
Added: August 6, 2018

2014 article

Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C 4 cage axes

Theil, E. C., Turano, P., Ghini, V., Allegrozzi, M., & Bernacchioni, C. (2014, February 6). JBIC Journal of Biological Inorganic Chemistry.

By: E. Theil*, P. Turano, V. Ghini*, M. Allegrozzi* & C. Bernacchioni*

author keywords: Ferritin; Protein nanocage; Ferric oxo; Di-iron protein; Nanobiomineral
MeSH headings : Catalysis; Ferric Compounds / chemistry; Ferric Compounds / metabolism; Ferritins / chemistry; Ferritins / metabolism; Iron / chemistry; Iron / metabolism; Protein Structure, Secondary
topics (OpenAlex): Porphyrin Metabolism and Disorders; Iron Metabolism and Disorders; Endoplasmic Reticulum Stress and Disease
TL;DR: Conserved amino acids facilitate dissolution of ferritin-protein-caged iron biominerals in variants with altered subunit interfaces for trimers (ion channels), E130I, and external dimer surfaces (E88A) as controls, and altered tetramer sub unit interfaces (L165I and H169F). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 article

IRE mRNA riboregulators use metabolic iron (Fe2+) to control mRNA activity and iron chemistry in animals

Theil, E. C. (2014, September 11). Metallomics.

By: E. Theil n

MeSH headings : Animals; Ferritins / chemistry; Ferritins / genetics; Ferritins / metabolism; Humans; Iron / chemistry; Iron / metabolism; Iron-Regulatory Proteins / chemistry; Iron-Regulatory Proteins / genetics; Iron-Regulatory Proteins / metabolism; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA, Messenger / metabolism
topics (OpenAlex): RNA modifications and cancer; RNA Research and Splicing; RNA and protein synthesis mechanisms
TL;DR: The high conservation of the primary sequence in IRE-mRNA control elements has facilitated their identification and analysis of metal-assisted riboregulator function, and expansion of RNA search analyses beyond primary will likely reveal other, metal-dependent families of mRNA riboreGulators. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 article

Loop Electrostatics Modulates the Intersubunit Interactions in Ferritin

Bernacchioni, C., Ghini, V., Pozzi, C., Pisa, F. D., Theil, E. C., & Turano, P. (2014, August 22). ACS Chemical Biology.

MeSH headings : Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Ferritins / chemistry; Ferritins / genetics; Microscopy, Electron, Transmission; Mutagenesis, Site-Directed; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Static Electricity
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; RNA modifications and cancer
TL;DR: It is demonstrated that the electrostatic pairing at the center of the L-loops has a specific kinetic role in the self-assembly of ferritin nanocages. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Moving Fe 2+ from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates

Behera, R. K., & Theil, E. C. (2014, May 19). Proceedings of the National Academy of Sciences.

By: R. Behera & E. Theil n

author keywords: iron traffic; oxidoreductase enzyme activity; antioxidant; ferrihydrite; BioIron
MeSH headings : Animals; Antioxidants / chemistry; Antioxidants / metabolism; Anura; Catalysis; Conserved Sequence; Ferric Compounds / chemistry; Ferric Compounds / metabolism; Ferritins / chemistry; Ferritins / genetics; Ferritins / metabolism; Heme / chemistry; Heme / metabolism; Hydroxides / chemistry; Hydroxides / metabolism; Ion Channels / chemistry; Ion Channels / metabolism; Iron / chemistry; Iron / metabolism; Metals / chemistry; Metals / metabolism; Minerals / chemistry; Minerals / metabolism; Models, Chemical; Mutagenesis, Site-Directed; Oxidoreductases / chemistry; Oxidoreductases / metabolism; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity; Sulfates / chemistry; Sulfates / metabolism
topics (OpenAlex): Porphyrin Metabolism and Disorders; Iron Metabolism and Disorders; Endoplasmic Reticulum Stress and Disease
TL;DR: M Monitoring rapid diferric peroxo formation in WT ferritin and E57 and E136 variants showed that these conserved residues are required for enzyme activity and thus are functional links betweenferritin ion channels and enzymatic sites. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions

Khan, M. A., Ma, J., Walden, W. E., Merrick, W. C., Theil, E. C., & Goss, D. J. (2014, April 11). Nucleic Acids Research.

By: M. Khan*, J. Ma*, W. Walden*, W. Merrick*, E. Theil* & D. Goss*

MeSH headings : Aconitate Hydratase / genetics; Aconitate Hydratase / metabolism; Animals; Eukaryotic Initiation Factor-4F / metabolism; Ferritins / genetics; Ferritins / metabolism; Iron / metabolism; Iron Regulatory Protein 1 / chemistry; Iron Regulatory Protein 1 / metabolism; Kinetics; Manganese / chemistry; Potassium / chemistry; RNA, Messenger / chemistry; RNA, Messenger / metabolism; Rabbits; Regulatory Sequences, Ribonucleic Acid
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA Research and Splicing; RNA modifications and cancer
TL;DR: Rapid rates of protein/RNA complex assembly and dissociation for two IRE-RNAs with IRP1, and quantitatively different metal ion response kinetics that coincide with the different iron responses in vivo are reported, suggesting this regulatory system to respond rapidly to change in cellular iron. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 article

Spectroscopic Studies of Single and Double Variants of M Ferritin: Lack of Conversion of a Biferrous Substrate Site into a Cofactor Site for O2 Activation

Kwak, Y., Schwartz, J. K., Haldar, S., Behera, R. K., Tosha, T., Theil, E. C., & Solomon, E. I. (2014, January 7). Biochemistry.

By: Y. Kwak*, J. Schwartz*, S. Haldar, R. Behera, T. Tosha, E. Theil n, E. Solomon*

MeSH headings : Amino Acid Sequence; Animals; Catalytic Domain; Circular Dichroism; Ferritins / chemistry; Ferritins / genetics; Ferrous Compounds / chemistry; Histidine / chemistry; Iron / chemistry; Ligands; Models, Molecular; Mutation; Oxygen / chemistry; Oxygen / metabolism; Rana catesbeiana; Ribonucleotide Reductases / chemistry
topics (OpenAlex): Porphyrin Metabolism and Disorders; Metal-Catalyzed Oxygenation Mechanisms; Iron Metabolism and Disorders
TL;DR: Correlation of this double variant and the cofactor sites to their O2 reactivities indicates that electrostatic and steric changes in the active site and, in particular, the hydrophobic nature of a cofactor site associated with its second sphere protein environment, make important contributions to the activation of O2 by the binuclear non-heme iron enzymes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 article

Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease

Theil, E. C. (2013, October 8). Inorganic Chemistry.

By: E. Theil n

MeSH headings : Anemia / drug therapy; Animals; Catalytic Domain; Drug Delivery Systems / methods; Ferritins / chemistry; Ferritins / genetics; Ferritins / metabolism; Hemosiderin / metabolism; Humans; Iron Overload / drug therapy; Molecular Targeted Therapy / methods; Nanostructures / administration & dosage; RNA, Messenger; Transfusion Reaction
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Porphyrin Metabolism and Disorders
TL;DR: Current concepts of ferritin structure/function/genetic regulation are discussed and related to possible therapeutic targets such as mini-ferritin/Dps protein active sites (selective pathogen inhibition in infection), nanocage pores (iron chelation in therapeutic hypertransfusion), mRNA noncoding, IRE riboregulator, and protein nanovessels to deliver medicinal or sensor cargo are discussed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

METALLOENZYMES Cage redesign explains assembly

Nature Chemical Biology, 9(3), 143–144.

By: E. Theil & P. Turano

Source: NC State University Libraries
Added: August 6, 2018

2011 article

New Dimensions of RNA in Molecular Recognition and Catalysis

Theil, E. C., & Westhof, E. (2011, December 20). Accounts of Chemical Research.

By: E. Theil* & E. Westhof*

MeSH headings : Catalysis; RNA / chemistry; RNA / metabolism; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Untranslated / chemistry; RNA, Untranslated / metabolism
topics (OpenAlex): RNA and protein synthesis mechanisms; Advanced biosensing and bioanalysis techniques; RNA modifications and cancer
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Identification and Characterization of the Iron Regulatory Element in the Ferritin Gene of a Plant (Soybean)

Wei, J., & Theil, E. C. (2000, June 1). Journal of Biological Chemistry.

By: J. Wei n & E. Theil n

MeSH headings : Base Sequence; Ferritins / genetics; Genes, Reporter; Glucuronidase / genetics; Iron / metabolism; Iron-Regulatory Proteins; Iron-Sulfur Proteins / metabolism; Luciferases / genetics; Molecular Sequence Data; Mutagenesis, Insertional; Plant Leaves; Promoter Regions, Genetic; RNA, Messenger / genetics; RNA-Binding Proteins / metabolism; Recombinant Proteins / biosynthesis; Sequence Deletion; Soybeans / genetics
topics (OpenAlex): Plant Micronutrient Interactions and Effects; Iron Metabolism and Disorders; Trace Elements in Health
TL;DR: DNA and DNA were used to show that an 86-base pair fragment controlled iron-mediated derepression of the ferritin gene, and FRE/factor binding was abrogated by increased tissue iron, in analogy to mRNA (IRE)/iron regulatory protein in animals. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 article

Internal Loop/Bulge and Hairpin Loop of the Iron-Responsive Element of Ferritin mRNA Contribute to Maximal Iron Regulatory Protein 2 Binding and Translational Regulation in the Iso-iron-responsive Element/Iso-iron Regulatory Protein Family

Ke, Y., Sierzputowska-Gracz, H., Gdaniec, Z., & Theil, E. C. (2000, April 26). Biochemistry.

By: Y. Ke n, H. Sierzputowska-Gracz n, Z. Gdaniec n & E. Theil n

MeSH headings : Animals; Copper / chemistry; Ferritins / antagonists & inhibitors; Ferritins / biosynthesis; Ferritins / chemistry; Ferritins / genetics; Hot Temperature; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins / chemistry; Iron-Sulfur Proteins / genetics; Iron-Sulfur Proteins / physiology; Lizards; Magnesium / chemistry; Multigene Family; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Phenanthrolines / chemistry; Protein Binding / genetics; Protein Biosynthesis; Protein Denaturation; Protein Isoforms / chemistry; Protein Isoforms / genetics; RNA, Messenger / chemistry; RNA-Binding Proteins / chemistry; RNA-Binding Proteins / genetics; RNA-Binding Proteins / physiology; Rabbits; Rana catesbeiana; Repressor Proteins / genetics; Repressor Proteins / physiology; Ribonuclease T1 / chemistry
topics (OpenAlex): Iron Metabolism and Disorders; RNA regulation and disease; Trace Elements in Health
TL;DR: The lower stability and greater helix distortion in the ferritin IL/B-IRE compared to the C-bulge iso-IREs create a combinatorial set of RNA/protein interactions that control protein synthesis rates with a range of signal sensitivities. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 article

The ferritin iron entry and exit problem

Theil, E. C., Takagi, H., Small, G. W., He, L., Tipton, A. R., & Danger, D. (2000, January 1). Inorganica Chimica Acta.

By: E. Theil*, H. Takagi n, G. Small n, L. He n, A. Tipton & D. Danger n

author keywords: ferritin; iron biominerals; ferroxidation; iron/dioxygen catalysis
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Hemoglobinopathies and Related Disorders
TL;DR: The entry and exit of Fe(II) ions in ferritin are endpoints in the process which concentrates iron as a solid (hydrated ferric oxide) to be used by living cells, suggesting a regulation-sensitive biological signal for iron exit. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 article

Crystal structure of bullfrog M ferritin at 2.8 Å resolution: analysis of subunit interactions and the binuclear metal center

Ha, Y., Shi, D., Small, G. W., Theil, E. C., & Allewell, N. M. (1999, July 1). JBIC Journal of Biological Inorganic Chemistry.

By: Y. Ha*, D. Shi*, G. Small n, E. Theil n & N. Allewell*

author keywords: crystallography; iron oxidation; iron storage; multisubunit proteins
MeSH headings : Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Conserved Sequence; Crystallography, X-Ray; Ferritins / chemistry; Ferritins / metabolism; Magnesium / metabolism; Models, Molecular; Molecular Sequence Data; Protein Conformation; Rana catesbeiana; Sequence Homology, Amino Acid; Tyrosine / analysis; Tyrosine / metabolism
topics (OpenAlex): Iron Metabolism and Disorders
TL;DR: The crystal structure of the homopolymer of recombinant frog M ferritin is determined and it is suggested that Gln137 and Asp140 are a vestige of the second GluxxHis site, resulting from single nucleotide mutations of Glu and His codons and giving rise to Ala140 or Ser140 present in other eukaryotic H-type ferritins, by additional singleucleotide mutations. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 article

Iron Regulatory Element and Internal Loop/Bulge Structure for Ferritin mRNA Studied by Cobalt(III) Hexammine Binding, Molecular Modeling, and NMR Spectroscopy

Gdaniec, Z., Sierzputowska-Gracz, H., & Theil, E. C. (1999, April 1). Biochemistry.

By: Z. Gdaniec, H. Sierzputowska-Gracz* & E. Theil*

topics (OpenAlex): RNA and protein synthesis mechanisms
TL;DR: The ferritin IRE, a highly conserved mRNA translation regulatory element in animal mRNA, was studied by molecular modeling (using MC-SYM and DOCKING) and by NMR spectroscopy and is the best characterized IRE in terms of structure and function. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 article

Direct Spectroscopic and Kinetic Evidence for the Involvement of a Peroxodiferric Intermediate during the Ferroxidase Reaction in Fast Ferritin Mineralization

Pereira, A. S., Small, W., Krebs, C., Tavares, P., Edmondson, D. E., Theil, E. C., & Huynh, B. H. (1998, June 25). Biochemistry.

MeSH headings : Animals; Anura; Ceruloplasmin / chemistry; Ferric Compounds / chemistry; Ferritins / chemistry; Ferritins / genetics; Humans; Kinetics; Oxidation-Reduction; Recombinant Proteins / chemistry; Spectroscopy, Mossbauer
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Arsenic contamination and mitigation
TL;DR: The proposal that a single protein site, with a structure homologous to the diiron centers in MMOH and R2, is involved in the ferritin ferroxidation step is confirmed by the observed kinetics, spectroscopic properties, and purity of the initial peroxodiferric species formed in the frog M ferritIn. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 article

Evidence for reutilization of nodule iron in soybean seed development

Burton, J. W., Harlow, C., & Theil, E. C. (1998, May 1). Journal of Plant Nutrition.

By: J. Burton n, C. Harlow n & E. Theil n

topics (OpenAlex): Legume Nitrogen Fixing Symbiosis; Plant Micronutrient Interactions and Effects; Soybean genetics and cultivation
TL;DR: The 59Fe distribution as well as immunoreactive ferritin were examined throughout development in nodule, leaf, and seed tissue, and leaves, nodules, and seeds accounted for 75 to 87% of the total plant 59Fe throughout the reproductive perio... (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 article

Iron Regulatory Element and Internal Loop/Bulge Structure for Ferritin mRNA Studied by Cobalt(III) Hexammine Binding, Molecular Modeling, and NMR Spectroscopy

Gdaniec, Z., Sierzputowska-Gracz, H., & Theil, E. C. (1998, January 23). Biochemistry.

By: Z. Gdaniec n, H. Sierzputowska-Gracz n & E. Theil n

MeSH headings : Animals; Anura; Binding Sites / drug effects; Binding Sites / genetics; Chlorides / metabolism; Chlorides / pharmacology; Cobalt / metabolism; Cobalt / pharmacology; Ferritins / genetics; Indicators and Reagents; Iron-Regulatory Proteins; Iron-Sulfur Proteins / chemistry; Iron-Sulfur Proteins / drug effects; Iron-Sulfur Proteins / genetics; Iron-Sulfur Proteins / metabolism; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Protons; RNA, Messenger / chemistry; RNA, Messenger / metabolism; RNA-Binding Proteins / chemistry; RNA-Binding Proteins / drug effects; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA Research and Splicing; RNA regulation and disease
TL;DR: Distortion of the IRE helix by the internal loop/bulge near a conserved unpaired C required for IRP binding and adjacent to an IRP cross-linking site suggests a role for the pocket in ferritin IRE/IRP interactions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Localized Unfolding at the Junction of Three Ferritin Subunits

Takagi, H., Shi, D., Ha, Y., Allewell, N. M., & Theil, E. C. (1998, July 1). Journal of Biological Chemistry.

By: H. Takagi n, D. Shi*, Y. Ha*, N. Allewell* & E. Theil n

MeSH headings : Amino Acid Substitution; Animals; Crystallography, X-Ray; Ferritins / genetics; Ferritins / metabolism; Iron / metabolism; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Folding; Ranidae; Spectrophotometry, Atomic; Structure-Activity Relationship
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Plant Micronutrient Interactions and Effects
TL;DR: The junction of three ferritin subunits appears to be a dynamic aperture with a “shutter” that cytoplasmic factors might open or close to regulate iron release in vivo. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Loops and Bulge/Loops in Iron-responsive Element Isoforms Influence Iron Regulatory Protein Binding

Ke, Y., Wu, J., Leibold, E. A., Walden, W. E., & Theil, E. C. (1998, September 1). Journal of Biological Chemistry.

By: Y. Ke n, J. Wu*, E. Leibold*, W. Walden* & E. Theil n

MeSH headings : 5-Aminolevulinate Synthetase / genetics; Aconitate Hydratase / genetics; Animals; Base Composition; Base Sequence; Cloning, Molecular; Ferritins / genetics; Gene Expression Regulation; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins / genetics; Iron-Sulfur Proteins / metabolism; Liver / metabolism; Nucleic Acid Conformation; RNA, Messenger / biosynthesis; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Rabbits; Receptors, Transferrin / genetics; Recombinant Proteins / metabolism; Saccharomyces cerevisiae
topics (OpenAlex): RNA Research and Splicing; RNA and protein synthesis mechanisms; RNA modifications and cancer
TL;DR: The results predict mRNA-specific variation in IRE-dependent regulation in vivo and may relate to previously observed differences in iron-induced ferritin and m-aconitase synthesis in liver and cultured cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 patent

Methods of identifying transition metal complexes that selectively cleave regulatory elements of mRNA and uses thereof

Washington, DC: U.S. Patent and Trademark Office.

By: E. Theil

Source: NC State University Libraries
Added: August 6, 2018

1998 book

Principles of chemistry in biology: A teaching companion

Washington, DC: American Chemical Society; Distributed by Oxford University Press.

Elizabeth Theil

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

The iron responsive element (IRE) family of mRNA regulators: Regulation of iron transport and uptake compared in animals, plants, and microorganisms

Iron Transport and Storage in Microorganisms, Plants and Animals, 35(1998), 403–434.

By: E. Theil

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Translational Regulation of Bioiron

Theil, E. C. (1998, January 1).

By: E. Theil*

Ed(s):

topics (OpenAlex): Mitochondrial Function and Pathology
TL;DR: The problem of acquiring and concentrating iron is solved by the use of environmental iron to regulate expression of both iron-storage (ferritin) and iron-uptake (TfR) genes; changes in expression of ferritin and TfR are also regulated by growth factors and hormones and during cell differentiation. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1997 article

Preliminary Analysis of Amphibian Red Cell M Ferritin in a Novel Tetragonal Unit Cell

Ha, Y., Theil, E. C., & Allewell, N. M. (1997, September 1). Acta Crystallographica Section D Biological Crystallography.

By: Y. Ha, E. Theil* & N. Allewell*

topics (OpenAlex): Herpesvirus Infections and Treatments; Glycosylation and Glycoproteins Research; T-cell and Retrovirus Studies
TL;DR: Recombinant amphibian red cell M ferritin crystallizes in approximately 2 M (NH(4))(2)SO(4) at pH 4.6 in a space group that has not been reported previously and has a novel intermolecular interaction mediated by interdigitation of the DE loops of two molecules at the fourfold molecular axes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 article

Rapid and Parallel Formation of Fe3+Multimers, Including a Trimer, during H-Type Subunit Ferritin Mineralization

Pereira, A. S., Tavares, P., Lloyd, S. G., Danger, D., Edmondson, D. E., Theil, E. C., & Huynh, B. H. (1997, June 1). Biochemistry.

MeSH headings : Animals; Anura; Biopolymers; Electron Spin Resonance Spectroscopy; Ferric Compounds / chemistry; Ferritins / chemistry; Minerals / chemistry; Oxidation-Reduction; Recombinant Proteins / chemistry; Spectroscopy, Mossbauer
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Plant Micronutrient Interactions and Effects
TL;DR: The subsequent decay of these multiple Fe3-oxy species to the superparamagnetic mineral suggests that Fe3+ species in different environments may be translocated as intact units from the protein shell into the ferritin cavity where the conversion to a solid mineral occurs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Sustainable solution for dietary iron deficiency through plant biotechnology and breeding to increase seed ferritin control

European Journal of Clinical Nutrition, 51(Suppl. 4), S28–31.

By: E. Theil, J. Burton & J. Beard

Source: NC State University Libraries
Added: August 6, 2018

1997 article

The influence of conserved tyrosine 30 and tissue-dependent differences in sequence on ferritin function: use of blue and purple Fe(III) species as reporters of ferroxidation

Fetter, J., Cohen, J., Danger, D., Sanders-Loehr, J., & Theil, E. C. (1997, October 1). JBIC Journal of Biological Inorganic Chemistry.

By: J. Fetter n, J. Cohen*, D. Danger n, J. Sanders-Loehr* & E. Theil n

topics (OpenAlex): Iron Metabolism and Disorders; Hemoglobinopathies and Related Disorders; Porphyrin Metabolism and Disorders
TL;DR: The impact of Y30F on rates of formation of Fe(III)-protein complexes in ferritin, combined with Mössbauer spectroscopic studies, indicate that at least one of the pathways for Fe oxidation/transfer in Ferritin is through the center of the four-helix bundle and is influenced by structural features dependent on tyrosine 30. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

Regulation of ferritin and transferrin receptor messenger-rnas

Journal of Biological Chemistry, 265(9), 4771–4774.

By: E. Theil

Source: NC State University Libraries
Added: August 6, 2018

1987 article

Ferritin: Structure, Gene Regulation, And Cellular Function In Animals, Plants, And Microorganisms

Theil, E. (1987, January 1). Annual Review of Biochemistry.

By: E. Theil*

topics (OpenAlex): CRISPR and Genetic Engineering; Cassava research and cyanide; Hemoglobinopathies and Related Disorders
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.