Works (44)

Updated: September 7th, 2023 05:00

2023 article

Scalable Bayesian Divergence Time Estimation With Ratio Transformations

Ji, X., Fisher, A. A., Su, S., Thorne, J. L., Potter, B., Lemey, P., … Suchard, M. A. (2023, July 17). SYSTEMATIC BIOLOGY.

author keywords: Bayesian inference; divergence time estimation; effective sample size; Hamiltonian Monte Carlo; pathogens; phylogenetics; ratio transformation
Source: Web Of Science
Added: September 5, 2023

2022 article

Convergent evolution of polyploid genomes from across the eukaryotic tree of life

Hao, Y., Fleming, J., Petterson, J., Lyons, E., Edger, P. P., Pires, J. C., … Conant, G. C. (2022, May 10). G3-GENES GENOMES GENETICS, Vol. 5.

By: Y. Hao*, J. Fleming n, J. Petterson n, E. Lyons*, P. Edger*, J. Pires*, J. Thorne n, G. Conant n

author keywords: polyploidy; convergent evolution; reciprocal gene loss; evolutionary model
MeSH headings : Diploidy; Eukaryota; Evolution, Molecular; Humans; Phylogeny; Polyploidy
Sources: Web Of Science, ORCID
Added: May 23, 2022

2022 journal article

Correlations between alignment gaps and nucleotide substitution or amino acid replacement

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(34).

By: T. Seo*, B. Redelings* & J. Thorne n

Source: Web Of Science
Added: July 31, 2023

2022 journal article

Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers A pilot study

EVOLUTION MEDICINE AND PUBLIC HEALTH, 10(1), 221–230.

By: E. Gunady*, K. Ware*, S. Plumlee*, N. Devos*, D. Corcoran*, J. Prinz*, H. Misetic*, F. Ciccarelli* ...

author keywords: liver cancer; mutation; prosimians; non-human primates; TP53; ARID1A; CTNNB1
Sources: Web Of Science, ORCID
Added: May 23, 2022

2021 article

Measuring Phylogenetic Information of Incomplete Sequence Data

Seo, T.-K., Gascuel, O., & Thorne, J. L. (2021, September 1). SYSTEMATIC BIOLOGY.

By: T. Seo*, O. Gascuel* & J. Thorne n

MeSH headings : Evolution, Molecular; INDEL Mutation; Models, Genetic; Models, Statistical; Phylogeny; Sequence Alignment
Source: Web Of Science
Added: March 14, 2022

2021 article

Pedigree-based and phylogenetic methods support surprising patterns of mutation rate and spectrum in the gray mouse lemur

Campbell, C. R., Tiley, G. P., Poelstra, J. W., Hunnicutt, K. E., Larsen, P. A., Lee, H.-J., … Yoder, A. D. (2021, July 16). HEREDITY.

By: C. Campbell*, G. Tiley*, J. Poelstra*, K. Hunnicutt*, P. Larsen*, H. Lee*, J. Thorne n, M. Reis*, A. Yoder*

MeSH headings : Animals; Cheirogaleidae / genetics; Genome; Mice; Mutation Rate; Pedigree; Phylogeny
Source: Web Of Science
Added: August 2, 2021

2020 journal article

Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life

MOLECULAR BIOLOGY AND EVOLUTION, 37(1), 11–17.

By: J. Somarelli*, A. Boddy*, H. Gardner*, S. DeWitt*, J. Tuohy*, K. Megquier*, M. Sheth*, S. Hsu* ...

author keywords: veterinary oncology; cross-species studies; cancer drug discovery; evolutionary biology
MeSH headings : Animals; Drug Discovery; Humans; Neoplasms / drug therapy; Neoplasms / veterinary
Source: Web Of Science
Added: March 10, 2020

2020 journal article

Incorporating Nearest-Neighbor Site Dependence into Protein Evolution Models

JOURNAL OF COMPUTATIONAL BIOLOGY, 27(3), 361–375.

By: G. Larson*, J. Thorne n & S. Schmidler*

author keywords: diffusion process; dynamic programming; evolution; phylogeny; protein structure
MeSH headings : Computational Biology / methods; Evolution, Molecular; Models, Statistical; Proteins / chemistry; Proteins / metabolism; Sequence Alignment; Sequence Analysis, Protein; Structural Homology, Protein
Source: Web Of Science
Added: April 20, 2020

2018 article

Modeling Dependence in Evolutionary Inference for Proteins

RESEARCH IN COMPUTATIONAL MOLECULAR BIOLOGY, RECOMB 2018, Vol. 10812, pp. 122–137.

By: G. Larson*, J. Thorne* & S. Schmidler n

author keywords: Protein structure; Evolution; Dynamic programming; Phylogeny; Diffusion process
Source: Web Of Science
Added: March 18, 2019

2016 journal article

A Phylogenetic Approach Finds Abundant Interlocus Gene Conversion in Yeast

MOLECULAR BIOLOGY AND EVOLUTION, 33(9), 2469–2476.

By: X. Ji n, A. Griffing n & J. Thorne n

author keywords: interlocus gene conversion; multigene family evolution
MeSH headings : Base Sequence / genetics; Biological Evolution; Evolution, Molecular; Gene Conversion; Models, Genetic; Multigene Family; Nucleotides / genetics; Phylogeny; Point Mutation; Saccharomyces cerevisiae; Sequence Analysis, DNA / methods; Yeasts / genetics
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Grouping substitution types into different relaxed molecular clocks

By: H. Lee, H. Kishino, N. Rodrigue & J. Thorne

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Mitochondrial genome sequences reveal evolutionary relationships of the Phytophthora 1c clade species

Current Genetics, 61(4), 567–577.

By: E. Lassiter n, C. Russ*, C. Nusbaum*, Q. Zeng*, A. Saville n, R. Olarte n, I. Carbone n, C. Hu n ...

Contriutors: E. Lassiter n, C. Russ*, C. Nusbaum*, Q. Zeng*, A. Saville n, R. Olarte n, I. Carbone n, C. Hu n ...

author keywords: Phytophthora 1 c clade; Mitochondria; Late blight; Phylogenetics
MeSH headings : Biological Evolution; Chimera / microbiology; Colombia; DNA, Mitochondrial / genetics; Ecuador; Genome, Mitochondrial; Solanum lycopersicum / microbiology; Mitochondria / genetics; Peru; Phylogeny; Phylogeography; Phytophthora / classification; Phytophthora / genetics; Phytophthora infestans / classification; Phytophthora infestans / genetics; Plant Diseases / microbiology; Sequence Analysis, DNA; Solanum tuberosum / microbiology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2015 journal article

Relaxing the Molecular Clock to Different Degrees for Different Substitution Types

MOLECULAR BIOLOGY AND EVOLUTION, 32(8), 1948–1961.

By: H. Lee n, N. Rodrigue* & J. Thorne n

author keywords: CpG transition rate; context-dependent substitution; relaxed molecular clock; divergence time estimation
MeSH headings : Animals; Biological Clocks / physiology; CpG Islands / physiology; DNA, Intergenic / genetics; Evolution, Molecular; Humans; Models, Biological
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Roles of Solvent Accessibility and Gene Expression in Modeling Protein Sequence Evolution

EVOLUTIONARY BIOINFORMATICS, 11.

By: K. Wang n, S. Yu n, X. Ji n, C. Lakner n, A. Griffing n & J. Thorne n

author keywords: protein evolution; protein structure; gene expression; codon usage; scaled selection coefficient; solvent accessibility
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Sampling and summary statistics of endpoint-conditioned paths in DNA sequence evolution

Bayesian Phylogenetics: Methods, Algorithms, and Applications, 247–275.

By: A. Hobolth & J. Thorne

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

The interface of protein structure, protein biophysics, and molecular evolution

Protein Science, 21(6), 769–785.

By: D. Liberles*, S. Teichmann*, I. Bahar*, U. Bastolla*, J. Bloom*, E. Bornberg-Bauer*, L. Colwell*, A. de Koning* ...

author keywords: evolutionary modeling; domain evolution; sequence-structure-function relationships; protein dynamics; protein thermodynamics; gene duplication; protein expression; ancestral sequence reconstruction
MeSH headings : Amino Acid Sequence; Animals; Evolution, Molecular; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Proteins / chemistry; Proteins / genetics; RNA, Messenger / genetics; Sequence Alignment
Source: Crossref
Added: August 28, 2020

2012 review

The interface of protein structure, protein biophysics, and molecular evolution

[Review of ]. Protein Science, 21(6), 769–785.

By: D. Liberles, S. Teichmann, I. Bahar, U. Bastolla, J. Bloom, E. Bornberg-Bauer, L. Colwell, A. Koning ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Coordinated Genome-Wide Modifications within Proximal Promoter Cis-regulatory Elements during Vertebrate Evolution

GENOME BIOLOGY AND EVOLUTION, 3, 66–74.

By: K. Yokoyama*, J. Thorne n & G. Wray*

author keywords: gene expression; transcriptional regulation; protein-DNA coevolution; cis-regulatory evolution
MeSH headings : Animals; Evolution, Molecular; Gene Expression; Genome; Humans; Mice; Models, Genetic; Models, Statistical; Phylogeny; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Transcriptional Activation; Vertebrates / genetics
Source: Web Of Science
Added: August 6, 2018

2011 journal article

History Can Matter: Non-Markovian Behavior of Ancestral Lineages

SYSTEMATIC BIOLOGY, 60(3), 276–290.

By: R. Cartwright n, N. Lartillot* & J. Thorne n

author keywords: Ancestral lineage; ancestral process; Hill-Robertson effect; population genetics
MeSH headings : Computer Simulation; Evolution, Molecular; Genetic Fitness; Genetic Variation; Markov Chains; Models, Genetic; Polymorphism, Genetic; Selection, Genetic
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Estimates of natural selection due to protein tertiary structure inform the ancestry of biallelic loci

Gene, 441(1-2), 45–52.

By: S. Choi n, E. Stone n, H. Kishino* & J. Thorne n

MeSH headings : Evolution, Molecular; Gene Frequency; Humans; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Proteins / genetics; Selection, Genetic
Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Basing population genetic inferences and models of molecular evolution upon desired stationary distributions of DNA or protein sequences

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 363(1512), 3931–3939.

By: S. Choi n, B. Redelings n & J. Thorne n

author keywords: variable-length Markov model; profile hidden Markov model; insertion-deletion model; scaled selection coefficient; fitness; Pfam
MeSH headings : Computer Simulation; DNA / genetics; Evolution, Molecular; Genetics, Population; INDEL Mutation / genetics; Markov Chains; Models, Genetic; Population Density; Proteins / genetics; Selection, Genetic
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Rates of nucleotide substitution in Cornaceae (Cornales)—Pattern of variation and underlying causal factors

Molecular Phylogenetics and Evolution, 49(1), 327–342.

By: Q. Xiang n, J. Thorne n, T. Seo n, W. Zhang n, D. Thomas n & R. Ricklefs*

author keywords: Comus; Cornaceae; Divergence time; Rate of molecular evolution; Rate of morphological evolution; Speciation
MeSH headings : Bayes Theorem; Chloroplasts / genetics; Cornus / anatomy & histology; Cornus / classification; Cornus / genetics; DNA, Chloroplast / genetics; DNA, Plant / genetics; Evolution, Molecular; Fossils; Genes, Plant; Genetic Speciation; Genome, Chloroplast; Models, Genetic; Nucleotides / genetics; Phylogeny; Sequence Analysis, DNA
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

A tabu search algorithm for maximum parsimony phylogeny inference

EUROPEAN JOURNAL OF OPERATIONAL RESEARCH, 176(3), 1908–1917.

By: Y. Lin n, S. Fang n & J. Thorne n

author keywords: tabu search; OR in biology; bioinformatics; phylogeny inference; maximum parsimony
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Population genetics without intraspecific data

MOLECULAR BIOLOGY AND EVOLUTION, 24(8), 1667–1677.

By: J. Thorne n, S. Choi n, J. Yu*, P. Higgs* & H. Kishino*

author keywords: dependence among sites; fixation probability; protein structure; RNA structure
MeSH headings : Animals; Annexin A5 / genetics; Computational Biology; Computer Simulation; Evolution, Molecular; Genetic Variation; Genetics, Population; Likelihood Functions; Mice; Models, Biological; Models, Genetic; Nucleic Acid Conformation; Phenotype; Phylogeny; RNA / chemistry; RNA / genetics; Rats; Selection, Genetic
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Protein evolution constraints and model-based techniques to study them

CURRENT OPINION IN STRUCTURAL BIOLOGY, 17(3), 337–341.

By: J. Thorne n

MeSH headings : Evolution, Molecular; Models, Molecular; Protein Folding; Proteins / chemistry; Proteins / genetics
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Quantifying the impact of protein tertiary structure on molecular evolution

MOLECULAR BIOLOGY AND EVOLUTION, 24(8), 1769–1782.

By: S. Choi*, A. Hobolth, D. Robinson, H. Kishino & J. Thorne*

author keywords: molecular evolution; protein structure impact; Gene Ontology; MCMC; Bayes factor
MeSH headings : Bayes Theorem; Computational Biology; Computer Simulation; Data Interpretation, Statistical; Evolution, Molecular; Protein Structure, Tertiary; Proteins / chemistry; Proteins / genetics; Sequence Alignment
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Dependence among sites in RNA evolution

MOLECULAR BIOLOGY AND EVOLUTION, 23(8), 1525–1537.

By: J. Yu n & J. Thorne n

author keywords: RNA secondary structure; dependence among sites; substitution rate
MeSH headings : Animals; Computer Simulation; Evolution, Molecular; Markov Chains; Nucleic Acid Conformation; Phylogeny; RNA / chemistry; RNA / genetics; RNA, Ribosomal / chemistry; RNA, Ribosomal / genetics; Sequence Analysis, RNA
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Testing for spatial clustering of amino acid replacements within protein tertiary structure

JOURNAL OF MOLECULAR EVOLUTION, 62(6), 682–692.

By: J. Yu n & J. Thorne n

author keywords: protein tertiary structure; protein evolution; spatial clustering
MeSH headings : Amino Acid Substitution; Cluster Analysis; Evolution, Molecular; Protein Structure, Tertiary; Statistics, Nonparametric
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Incorporating gene-specific variation when inferring and evaluating optimal evolutionary tree topologies from multilocus sequence data

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(12), 4436–4441.

By: T. Seo n, H. Kishino n & J. Thorne n

MeSH headings : Biological Evolution; Databases, Genetic; Genetic Techniques; Genetic Variation; Likelihood Functions; Models, Genetic; Phylogeny
Source: Web Of Science
Added: August 6, 2018

2004 article

A Bayesian approach to DNA sequence segmentation - Discussion

Thorne, J. L. (2004, September). BIOMETRICS, Vol. 60, pp. 584–585.

By: J. Thorne n

Source: Web Of Science
Added: August 6, 2018

2004 journal article

Estimating absolute rates of synonymous and nonsynonymous nucleotide substitution in order to characterize natural selection and date species divergences

MOLECULAR BIOLOGY AND EVOLUTION, 21(7), 1201–1213.

By: T. Seo n, H. Kishino & J. Thorne*

author keywords: Bayesian method; Markov chain Monte Carlo (MCMC); rate change model; lognormal; evolutionary rate; selection; synonymous rate; nonsynonymous rate
MeSH headings : Animals; Base Sequence / genetics; Bayes Theorem; Electron Transport Complex IV / genetics; Evolution, Molecular; Genetic Variation; Nucleotides / genetics; Polymorphism, Genetic; Primates / genetics; Rodentia / genetics; Selection, Genetic; Sequence Analysis, DNA / methods
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 review

Molecular evidence on plant divergence times

[Review of ]. AMERICAN JOURNAL OF BOTANY, 91(10), 1656–1665.

By: M. Sanderson*, J. Thorne n, N. Wikstrom* & K. Bremer*

author keywords: adaptive radiation; biogeography; divergence time; molecular clock; phylogeny; rates
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Horizontally transferred genes in plant-parasitic nematodes: a high-throughput genomic approach

Genome Biology, 4(6), R39–1.

By: E. Scholl, J. Thorne, J. McCarter & D. Bird

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Protein evolution with dependence among codons due to tertiary structure

MOLECULAR BIOLOGY AND EVOLUTION, 20(10), 1692–1704.

By: D. Robinson n, D. Jones, H. Kishino, N. Goldman & J. Thorne*

author keywords: protein structure; evolution; Markov chain Monte Carlo; Bayesian
MeSH headings : Annexin A5 / chemistry; Annexin A5 / genetics; Codon; Computational Biology; Computer Simulation; Data Interpretation, Statistical; Evolution, Molecular; Markov Chains; Muramidase / chemistry; Muramidase / genetics; Protein Structure, Tertiary; Proteins / chemistry; Proteins / genetics
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Time flies, a new molecular time-scale for brachyceran fly evolution without a clock

Systematic Biology, 52(6), 745–756.

By: B. Wiegmann, D. Yeates, J. Thorne & H. Kishino

Source: NC State University Libraries
Added: August 6, 2018

2003 review

Time scale of eutherian evolution estimated without assuming a constant rate of molecular evolution

[Review of ]. GENES & GENETIC SYSTEMS, 78(4), 267–283.

By: M. Hasegawa*, J. Thorne n & H. Kishino*

author keywords: Bayesian method; divergence times; variation of evolutionary
MeSH headings : Animals; Bayes Theorem; Evolution, Molecular; Fossils; Genetic Variation; Humans; Mathematics; Models, Biological; Models, Genetic; Phylogeny; Probability; Time Factors
Source: Web Of Science
Added: August 6, 2018

2002 journal article

A viral sampling design for testing the molecular clock and for estimating evolutionary rates and divergence times

BIOINFORMATICS, 18(1), 115–123.

By: T. Seo, J. Thorne*, M. Hasegawa & H. Kishino

MeSH headings : Computational Biology; Evolution, Molecular; HIV-1 / genetics; HIV-1 / isolation & purification; Humans; Models, Genetic; Models, Statistical; Time Factors; Viruses / genetics; Viruses / isolation & purification
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Divergence time and evolutionary rate estimation with multilocus data

SYSTEMATIC BIOLOGY, 51(5), 689–702.

By: J. Thorne n & H. Kishino*

author keywords: Markov chain Monte Carlo; Metropolis-Hastings algorithm; molecular clock; phylogeny
MeSH headings : Algorithms; Bayes Theorem; Biological Evolution; Evolution, Molecular; Markov Chains; Models, Genetic; Monte Carlo Method; Phylogeny; Plants / genetics; Time Factors
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Estimation of effective population size of HIV-1 within a host: A pseudomaximum-likelihood approach

Genetics, 160(4), 1283–1293.

By: T. Seo, J. Thorne, M. Hasegawa & H. Kishino

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Performance of a divergence time estimation method under a probabilistic model of rate evolution

MOLECULAR BIOLOGY AND EVOLUTION, 18(3), 352–361.

By: H. Kishino, J. Thorne* & W. Bruno

author keywords: molecular clock; phylogeny; Markov chain Monte Carlo; Metropolis-Hastings algorithm
MeSH headings : Bayes Theorem; Biological Evolution; Fossils; Models, Genetic; Probability
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Models of protein sequence evolution and their applications

CURRENT OPINION IN GENETICS & DEVELOPMENT, 10(6), 602–605.

By: J. Thorne n

MeSH headings : Amino Acid Sequence; Animals; Codon; Evolution, Molecular; Genetic Variation; Models, Genetic; Mutagenesis, Insertional; Point Mutation; Protein Structure, Secondary; Proteins / genetics; Sequence Deletion
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Assessing the impact of secondary structure and solvent accessibility on protein evolution

Genetics, 149(1), 445–458.

By: N. Goldman, J. Thorne & D. Jones

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Estimating the rate of evolution of the rate of molecular evolution

MOLECULAR BIOLOGY AND EVOLUTION, 15(12), 1647–1657.

By: J. Thorne*, H. Kishino & I. Painter*

author keywords: molecular clock; phylogeny; Markov chain Monte Carlo; Metropolis-Hastings algorithm
MeSH headings : Algorithms; Biological Evolution; Evolution, Molecular; Models, Genetic; Models, Statistical; Phylogeny; Plant Proteins / genetics; Plants / classification; Plants / genetics; Ribulose-Bisphosphate Carboxylase; Time
Source: Web Of Science
Added: August 6, 2018

1998 journal article

PASSML: combining evolutionary inference and protein secondary structure prediction

BIOINFORMATICS, 14(8), 726–733.

By: P. Lio*, N. Goldman, J. Thorne* & D. Jones

MeSH headings : Adenylate Kinase / genetics; Algorithms; Amino Acid Sequence; Animals; Cattle; Databases, Factual; Escherichia coli / genetics; Evolution, Molecular; Humans; Neisseria meningitidis / genetics; Phylogeny; Protein Structure, Secondary; Rats; Saccharomyces cerevisiae / genetics; Schizosaccharomyces / genetics; Sequence Alignment; Software
Source: Web Of Science
Added: August 6, 2018