Tuhidul Islam

Works (3)

Updated: July 5th, 2023 15:38

2019 journal article

Optimization of Sequence, Display, and Mode of Operation of IgG-Binding Peptide Ligands to Develop Robust, High-Capacity Affinity Adsorbents That Afford High IgG Product Quality

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1).

By: T. Islam n, A. Naik n, Y. Hashimoto *, S. Menegatti n  & R. Carbonell n

author keywords: affinity chromatography; peptide ligand; antibody purification; binding capacity; process optimization; aggregate removal
TL;DR: The use of peptide ligand HWRGWV and its cognate sequences to develop affinity adsorbents that compete with Protein A in terms of binding capacity and quality of the eluted product demonstrate the potential of peptides as alternative to Protein A for the purification of therapeutic antibodies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 11, 2019

2018 journal article

Silica resins and peptide ligands to develop disposable affinity adsorbents for antibody purification

BIOCHEMICAL ENGINEERING JOURNAL, 145, 53–61.

By: A. Naika, T. Islam n, T. Terasaka*, Y. Ohara *, Y. Hashimoto *, S. Menegatti n , R. Carbonell n

author keywords: Silica resins; Peptide ligands; Monoclonal antibodies; Llama antibodies; Rabbit antibodies
TL;DR: It is demonstrated that porous silica, a non-traditional substrate for protein purification, shows great promise as potentially single-use affinity adsorbent forprotein purification. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 13, 2019

2016 journal article

Design of protease-resistant peptide ligands for the purification of antibodies from human plasma

Journal of Chromatography A, 1445, 93–104.

By: S. Menegatti n , B. Bobay  n, K. Ward n, T. Islam n, W. Kish n, A. Naik n, R. Carbonell n

author keywords: Peptide affinity ligands; Polyclonal antibodies; Affinity chromatography; Proteolysis; Protease; Molecular docking
MeSH headings : Animals; Antibodies / isolation & purification; Binding Sites; Blood Chemical Analysis / methods; Chromatography, Affinity; Chymotrypsin / metabolism; Humans; Ligands; Peptides / chemistry; Protein Binding; Trypsin / metabolism
TL;DR: A strategy is presented for developing variants of peptide ligands with enhanced biochemical stability for the purification of antibodies from animal sera and higher selectivity than the original sequences, due to electrical neutrality. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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