Taufika Islam Williams

https://orcid.org/0000-0002-5838-4647

mass spectrometry, proteomics, glycomics, nanoscale/microscale LC, OMICS, systems biology

Taufika is originally from Dhaka, Bangladesh. She graduated with a BA from Transylvania University in Lexington, KY in 1998, double-majoring in Chemistry and Mathematics. She went on to receive her MS in Analytical Chemistry from Purdue University in West Lafayette, IN, under the guidance of Dr. R. Graham Cooks. Her thesis focused on the study of gas-phase fundamental ion chemistry using mass spectrometric techniques. Taufika then began her doctoral studies at the University of Kentucky, in the laboratory of Dr. Bert C. Lynn, completing her PhD in Analytical Chemistry in 2005 (summa cum laude). Her dissertation centered on methods development in biological mass spectrometry, with applications in small molecule research and proteomics. Completion of doctoral studies was followed by a North Carolina Biotechnology Center - Kenan Institute postdoctoral fellowship at NCSU under the guidance of Dr. David C. Muddiman in the Department of Chemistry. During this time, Taufika focused on advanced mass spectrometry techniques in the study of glycomics and ovarian cancer detection. Upon completion of the post-doc, she joined the NCSU Department of Chemistry as the Director of the NCSU Mass Spectrometry Facility (MSF). Today, she continues her career at NCSU with a joint appointment as a Senior Research Scholar at the Molecular Education, Technology, and Research Innovation Center (METRIC) and as a Research Associate Professor at the Department of Chemistry. She is also the Proteomics Section Leader for the Center for Human Health and the Environment (CHHE), as well as the METRIC Lead at the Plant Sciences Initiative (PSI) at NCSU. Taufika's focus is in the area of proteomics/glycomics/metabolomics and mass spectrometry. She enjoys collaborating with NCSU researchers in these cutting-edge areas of bioanalytical chemistry, teaching proteomics graduate courses, collaborator and graduate student training on mass spectrometry and proteomics techniques, as well as conducting her own research. Taufika is the Chair Elect of the NCSU Council on the Status of Women (CSW) and a member of the NCSU Department of Chemistry Diversity, Equity and Inclusion (DEI) Committee.

Works (68)

Updated: May 9th, 2023 14:20

2023 article

A bottom-up proteomics workflow for a system containing multiple organisms

Bai, H., Collins, L. B. B., Andre, M. R., Breitschwerdt, E. B. B., & Williams, T. I. (2023, January 3). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 1.

By: H. Bai n, L. Collins, M. Andre n, E. Breitschwerdt & T. Williams

Sources: ORCID, Web Of Science
Added: November 25, 2022

2023 article

Discovery Proteomics and Absolute Protein Quantification Can Be Performed Simultaneously on an Orbitrap-Based Mass Spectrometer

Williams, T. I., Kowalchyk, C., Collins, L. B., & Reading, B. J. (2023, March 22). ACS OMEGA, Vol. 3.

By: T. Williams, C. Kowalchyk*, L. Collins & B. Reading

Sources: ORCID, Web Of Science
Added: March 23, 2023

2023 article

Understanding K. phaffii (Pichia pastoris) Host Cell Proteins: Proteomic Analysis and Flow-through Affinity Clearance

Sripada, S. A., Elhanafi, D., & Collins, L. (2023, February 1). (T. I. Williams, Ed.). Biotechnology and Bioengineering, Vol. 01.

By: S. Sripada n, D. Elhanafi n & L. Collins n

Ed(s): T. Williams

Source: ORCID
Added: February 2, 2023

2022 journal article

Filtered Cerebrospinal Fluid From Patients With Amyotrophic Lateral Sclerosis Displays an Altered Proteome and Affects Motor Phenotype in a Mouse Model

Cureus, 12.

By: V. Venkatraman, A. Filiano, L. Xu, L. Collins, E. Luo, K. Ripple, G. Castro, J. Boua ...

Source: ORCID
Added: December 29, 2022

2022 article

Improving Therapeutic Protein Secretion in the Probiotic YeastSaccharomyces boulardiiusing a Multifactorial Engineering Approach

Durmusoglu, D., Al’Abri, I., Williams, T. I., Collins, L. B., Martínez, J. L., & Crook, N. (2022, December 31).

By: D. Durmusoglu n, I. Al’Abri n, T. Williams, L. Collins n, J. Martínez* & N. Crook

Source: ORCID
Added: January 1, 2023

2022 article

Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain

Muthusamy, N., Williams, T. I., O'Toole, R., Brudvig, J. J., Adler, K. B., Weimer, J. M., … Ghashghaei, H. T. (2022, January 24). GEROSCIENCE, Vol. 1.

By: N. Muthusamy, T. Williams, R. O'Toole*, J. Brudvig*, K. Adler, J. Weimer*, D. Muddiman, H. Ghashghaei n

author keywords: Aging; Behavior; Clca3; Ependymal cells; Forebrain; Marcks; Mass spectrometry; Neuroinflammation
Sources: ORCID, Web Of Science
Added: January 31, 2022

2022 journal article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis

Proceedings of the National Academy of Sciences, 119(39).

By: O. Manley n, H. Phan n, A. Stewart n, D. Mosley n, S. Xue*, L. Cha n, H. Bai n, V. Lightfoot* ...

Source: ORCID
Added: September 21, 2022

2022 article

Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents

Sripada, S. A., Chu, W., Williams, T. I., Teten, M. A., Mosley, B. J., Carbonell, R. G., … Menegatti, S. (2022, April 22). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 119.

By: S. Sripada, W. Chu, T. Williams, M. Teten n, B. Mosley n, R. Carbonell, A. Lenhoff*, S. Cramer* ...

author keywords: CHO; flow-through chromatography; host cell proteins; monoclonal antibodies; peptide-based adsorbents
Sources: ORCID, Web Of Science
Added: April 10, 2022

2022 journal article

Using Proteomic Approaches to Unravel the Response of Ctenocephalides felis felis to Blood Feeding and Infection With Bartonella henselae

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 12.

By: M. Andre n, P. Neupane, M. Lappin*, B. Herrin*, V. Smith*, T. Williams, L. Collins, H. Bai n ...

author keywords: bartonellosis; cat flea; cat scratch disease; flea-pathogen interface; proteome
Sources: ORCID, Web Of Science
Added: January 29, 2022

2021 article

Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests

PROTEOMIC PROFILING, 2 EDITION, Vol. 2261, pp. 489–506.

By: R. Lavoie n, T. Islam n, W. Blackburn*, R. Carbonell & S. Menegatti

author keywords: Proteomics; Mass spectrometry; Host cell proteins; Monoclonal antibodies; Peptide ligands; Flow-through chromatography
Sources: ORCID, Web Of Science
Added: April 8, 2021

2021 article

Discovery proteomics of human placental tissue

Mellinger, A. L., McCoy, K., Minior, D. A. T., & Williams, T. I. (2021, December 23). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 9.

By: A. Mellinger, K. McCoy*, D. Minior* & T. Williams

Sources: ORCID, Web Of Science
Added: September 8, 2021

2021 journal article

Removal of host cell proteins from cell culture fluids by weak partitioning chromatography using peptide-based adsorbents

SEPARATION AND PURIFICATION TECHNOLOGY, 257.

By: R. Lavoie n, W. Chu, J. Lavoie, Z. Hetzler n, T. Williams, R. Carbonell, S. Menegatti

author keywords: Host cell proteins; Monoclonal antibodies; Flow-through chromatography; Weak partitioning mode; Polishing; Proteomics; Peptide ligands
Sources: Web Of Science, ORCID
Added: January 11, 2021

2020 journal article

Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis

BIOTECHNOLOGY AND BIOENGINEERING, 117(2), 438–452.

By: R. Lavoie n, A. Fazio n, T. Williams, R. Carbonell & S. Menegatti

author keywords: host cell proteins; monoclonal antibodies; polishing; peptide ligands; protein purification
Sources: Web Of Science, ORCID
Added: December 2, 2019

2019 journal article

A substitute variety for agronomically and medicinally important Serenoa repens (saw palmetto)

SCIENTIFIC REPORTS, 9(1).

By: Y. Jaiswal*, D. Weber*, A. Yerke*, Y. Xue*, D. Lehman, T. Williams, T. Xiao*, D. Haddad*, L. Williams

Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 conference paper

Egg Characteristics and Striped Bass Fertility

Presented at the Mass Spectrometry Research Symposium, North Carolina State University, Raleigh, NC.

By: T. Williams, C. Kowalchyk, J. Fischer & B. Reading

Event: Mass Spectrometry Research Symposium at North Carolina State University, Raleigh, NC

Source: NC State University Libraries
Added: April 26, 2021

2019 conference paper

Exploring Egg Characteristics of Striped Bass

Presented at the American Society for Mass Spectrometry Meeting, Atlanta, GA.

By: T. Williams, C. Kowalchyk, J. Fischer & B. Reading

Event: American Society for Mass Spectrometry Meeting at Atlanta, GA on July 2-6, 2019

Source: NC State University Libraries
Added: April 26, 2021

2018 journal article

Conrad Bessant (Ed.): Proteome informatics

Analytical and Bioanalytical Chemistry, 410(14), 3231–3233.

By: T. Williams

Sources: Crossref, ORCID
Added: November 29, 2020

2014 journal article

Proportional Accumulation of Yolk Proteins Derived From Multiple Vitellogenins is Precisely Regulated During Vitellogenesis in Striped Bass (Morone saxatilis)

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 321(6), 301–315.

By: V. Williams, B. Reading, H. Amano*, N. Hiramatsu*, J. Schilling, S. Salger, T. Williams, K. Gross, C. Sullivan

Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Dynamics of the Striped Bass (Morone saxatilis) Ovary Proteome Reveal a Complex Network of the Translasome

Journal of Proteome Research, 12(4), 1691–1699.

By: B. Reading, V. Williams, R. Chapman*, T. Williams & C. Sullivan

author keywords: ribosome; proteasome; translasome; ovary; reproduction; mass-spectrometry; support vector machines; teleost; fish
Sources: ORCID, Crossref, Web Of Science
Added: August 6, 2018

2013 conference paper

The North Carolina State University Mass Spectrometry Facility at the Cutting Edge of Scientific Research

Presented at the Workshop on Allergy and Inflammation, North Carolina State University, Raleigh, NC.

By: V. Kandhi & T. Williams

Event: Workshop on Allergy and Inflammation at North Carolina State University, Raleigh, NC

Source: NC State University Libraries
Added: August 13, 2021

2012 journal article

Re-evaluating the role of ascorbic acid and phenolic glycosides in ozone scavenging in the leaf apoplast of Arabidopsis thaliana L.

Plant, Cell & Environment, 8.

By: F. Booker*, K. Burkey* & A. Jones*

author keywords: Air pollution; flavonoids; kaempferol; reactive oxygen; sinapoyl malate; vitamin C
Source: ORCID
Added: April 8, 2021

2011 conference paper

Behavioral Response Profiles of Odorant Binding Proteins in Drosophila melanogaster

Presented at the 6th Annual North Carolina State University Graduate Student Research Symposium, Raleigh, NC.

By: S. Swarup, T. Williams & R. Anholt

Event: 6th Annual North Carolina State University Graduate Student Research Symposium at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2011 conference paper

Functional Dissection of Odorant Binding Protein Genes in Drosophila melanogaster

Presented at the Center for Integrative Genomics (CIG) Symposium, Université de Lausanne, Lausanne, Switzerland.

By: S. Swarup, T. Williams & R. Anholt

Event: Center for Integrative Genomics (CIG) Symposium at Université de Lausanne, Lausanne, Switzerland

Source: NC State University Libraries
Added: August 13, 2021

2011 journal article

Functional dissection of Odorant binding protein genes in Drosophila melanogaster

GENES BRAIN AND BEHAVIOR, 10(6), 648–657.

By: S. Swarup, T. Williams & R. Anholt n

author keywords: Behavioral genetics; chemoreception; olfaction; proteomics; RNAi
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 conference paper

Proteomics of Olfaction: Identification and Relative Quantification of Odorant Binding Proteins in the Antennae of Drosophila melanogaster

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: T. Williams, S. Swarup, S. Zhou & R. Anholt

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: August 13, 2021

2010 journal article

The Soluble Proteome of the Drosophila Antenna

Chemical Senses, 35(1), 21–30.

By: R. Anholt & T. Williams

author keywords: chemosensation; mass spectrometry; odorant-binding proteins; olfaction; proteomics
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 conference paper

Accurate Mass Measurements in FTMS with Automatic Gain Control

Presented at the Pharmaceutical Interest Group, American Society for Mass Spectrometry, Philadelphia, PA.

By: T. Williams

Event: Pharmaceutical Interest Group, American Society for Mass Spectrometry at Philadelphia, PA

Source: NC State University Libraries
Added: March 6, 2022

2009 journal article

Construction of Coordination-Driven Self-Assembled [5+5] Pentagons Using Metal-Carbonyl Dipyridine Ligands

INORGANIC CHEMISTRY, 48(13), 5590–5592.

By: L. Zhao*, K. Ghosh*, Y. Zheng*, M. Lyndon, T. Williams & P. Stang*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Development of a nanoLC LTQ Orbitrap Mass Spectrometric Method for Profiling Glycans Derived from Plasma from Healthy, Benign Tumor Control, and Epithelial Ovarian Cancer Patients

ANALYTICAL CHEMISTRY, 81(3), 1130–1136.

By: M. Bereman, T. Williams & D. Muddiman

Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 conference paper

Proteomic Profiling of Populus trichocarpa for the Interrogation of Molecular Mechanisms behind Wood Formation

Presented at the American Society for Mass Spectrometry, Philadelphia, PA.

By: T. Williams, Y. Sun, T. Yeh, J. Sampson, D. Muddiman & V. Chiang

Event: American Society for Mass Spectrometry at Philadelphia, PA

Source: NC State University Libraries
Added: March 6, 2022

2009 conference paper

The Development of Nano LC Mass Spectrometric Methods for Profiling Glycans in Epithelial Ovarian Cancer (EOC) and Control Plasma

Presented at the 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Chicago, IL.

By: M. Bereman, T. Williams, K. Kalli, W. Cliby & D. Muddiman

Event: 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy at Chicago, IL

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

A Combinatorial Approach: The Use of MALDI-MS and Nano LC-MS for Glycan Biomarker Discovery

Presented at the Protein Biomarkers Meeting, Philadelphia, PA.

By: T. Williams, M. Bereman, D. Nielsen, K. Kalli, W. Cliby & D. Muddiman

Event: Protein Biomarkers Meeting at Philadelphia, PA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Analysis of O-linked Glycans Derived from Normal and Diseased EOC Plasma by Nano LC-ESI-FTICR Mass Spectrometry

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: M. Bereman, T. Williams, A. Hawkridge & D. Muddiman

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: March 6, 2022

2008 speech

Applications of Carbohydrate Profiling in Ovarian Cancer Plasma Glycoproteins

Presented at the Longwood University, Farmville, VA.

By: T. Williams & D. Muddiman

Event: Longwood University at Farmville, VA

Source: NC State University Libraries
Added: March 6, 2022

2008 journal article

Calibration laws based on multiple linear regression applied to matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(12), 1659–1663.

By: D. Williams n, M. Chadwick n, T. Williams & D. Muddiman

author keywords: multiple linear regression; polypropylene glycol; calibration; matrix-assisted laser desorption/ionization (MALDI); Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); space-charge effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 conference paper

Epithelial Ovarian Cancer Detection by Glycan Profiling in Blood

Presented at the North Carolina State University, Raleigh, NC.

By: T. Williams & D. Muddiman

Event: North Carolina State University at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Glycan Analysis by Nano LC-MS: Applications for Biomarker Discovery in Epithelial Ovarian Cancer (EOC)

Presented at the Atlanta Athens Mass Spectrometry Discussion Group Symposium, University of Georgia, Athens, GA.

By: M. Bereman, T. Williams, K. Kalli, W. Cliby & D. Muddiman

Event: Atlanta Athens Mass Spectrometry Discussion Group Symposium at University of Georgia, Athens, GA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Glycan Profiling in Plasma: Fundamentals and Applications to Ovarian Cancer

Presented at the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA.

By: T. Williams & D. Muddiman

Event: Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy at New Orleans, LA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

In Search of Epithelial Ovarian Cancer Molecular Markers by MALDI-FT-ICR-MS and NANO-LC-LTQ-ORBITRAP-MS

Presented at the Mass Spectrometry Applications to the Clinical Laboratory, University of California - San Diego, San Diego, CA.

By: T. Williams, M. Bereman, D. Nielsen, K. Kalli, W. Cliby & D. Muddiman

Event: Mass Spectrometry Applications to the Clinical Laboratory at University of California - San Diego, San Diego, CA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Innovative Technology Development Directed at the Elucidation of Biomarkers for the Detection of Early-Stage Ovarian Cancer

Presented at the Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program of the National Cancer Institute, Cambridge, MA.

By: T. Williams, M. Bereman, D. Williams & D. Muddiman

Event: Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program of the National Cancer Institute at Cambridge, MA

Source: NC State University Libraries
Added: March 6, 2022

2008 journal article

Investigations with O-linked protein glycosylations by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(9), 1215–1223.

By: T. Williams, D. Saggese, K. Toups, J. Frahm, H. An*, B. Li*, C. Lebrilla*, D. Muddiman

author keywords: Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); matrix-assisted laser desorption/ionization (MALDI); mucin; O-linked glycans; protein glycosylations
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 conference paper

Mining the Plasma Glycome for Epithelial Ovarian Cancer Biomarker Discovery

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: T. Williams, D. Nielsen, W. Cliby, K. Kalli & D. Muddiman

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: March 6, 2022

2008 journal article

Studying O-linked protein glycosylations in human plasma

JOURNAL OF PROTEOME RESEARCH, 7(6), 2562–2568.

By: T. Williams, D. Saggese & D. Muddiman

author keywords: protein O-glycosylations; plasma; epithelial ovarian cancer (EOC); matrix-assisted laser desorption/iozation (MALDI); Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 conference paper

The Development of a Nano-LC Mass Spectrometric Method for Profiling Glycans in Epithelial Ovarian Cancer (EOC) and Control Plasma

Presented at the Triangle Chromatography Symposium and Instrument Exhibit, Raleigh, NC.

By: M. Bereman, T. Williams & D. Muddiman

Event: Triangle Chromatography Symposium and Instrument Exhibit at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

Calibration Laws Based on Multiple Linear Regression Applied to MALDI-FT-ICR-MS

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: M. Chadwick, T. Williams, D. Williams & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 journal article

Carbohydrate analysis by desorption electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

ANALYTICAL CHEMISTRY, 79(22), 8812–8815.

By: M. Bereman, T. Williams & D. Muddiman

Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 conference paper

Characterization and Biological Applications of Desorption Electrospray Ionization Coupled to Hybrid FT-ICR Mass Spectrometry

Presented at the Southeastern Regional Meeting of the American Chemical Society, Greenville, SC.

By: M. Bereman, T. Williams & D. Muddiman

Event: Southeastern Regional Meeting of the American Chemical Society at Greenville, SC

Source: NC State University Libraries
Added: March 6, 2022

2007 journal article

Effect of matrix crystal structure on ion abundance of carbohydrates by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(5), 807–811.

By: T. Williams, D. Saggese, R. Wilcox, J. Martin & D. Muddiman

Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 review

Epithelial ovarian cancer: Disease etiology, treatment, detection, and investigational gene, metabolite, and protein biomarkers

[Review of ]. JOURNAL OF PROTEOME RESEARCH, 6(8), 2936–2962.

By: T. Williams, K. Toups, D. Saggese, K. Kalli n, W. Cliby n & D. Muddiman

author keywords: biomarkers; epithelial ovarian cancer; proteomics; mass spectrometry; detection; treatments
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 conference paper

Investigations with O-linked Protein Glycosylations by MALDI-FT-ICR-MS

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: D. Saggese, T. Williams, R. Wilcox, J. Martin, H. An, B. Li, C. Lebrilla, D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

MALDI-FT-ICR-MS Quantification of Peptides and Oligosaccharides using Stable-Isotope Labels

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: K. Toups, T. Williams, J. Zheng, J. Frahm & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

O-linked Protein Glycosylations in Plasma as Biomarkers for Epithelial Ovarian Cancer

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: T. Williams, J. Sampson, A. Hawkridge, W. Cliby & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

Plasma Biomarker Discovery and Analysis using FT-ICR Mass Spectrometry

Presented at the Federation of Analytical Chemistry and Spectroscopy Societies, Memphis, TN.

By: D. Muddiman, A. Hawkridge, T. Williams, W. Cliby & J. Burnett

Event: Federation of Analytical Chemistry and Spectroscopy Societies at Memphis, TN

Source: NC State University Libraries
Added: March 6, 2022

2007 journal article

Proteomic profile changes in membranes of ethanol-tolerant Clostridium thermocellum

Applied Microbiology and Biotechnology, 74(2), 422–432.

By: T. Williams, J. Combs*, B. Lynn* & H. Strobel*

author keywords: Clostridium thermocellum; ethanol tolerance; proteomics
Sources: ORCID, Crossref
Added: April 8, 2021

2007 conference paper

The Development and Characterization of a Desorption Electrospray Ionization Source Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (DESI-FT-ICR-MS) for Biological Analyses

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: M. Bereman, T. Williams & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2006 journal article

A novel Bicine running buffer system for doubled sodium dodecyl sulfate – polyacrylamide gel electrophoresis of membrane proteins

Electrophoresis, 27(14), 2984–2995.

By: T. Williams, J. Combs*, A. Thakur*, H. Strobel* & B. Lynn*

author keywords: Bicine; doubled SDS-PAGE; MALDI-TOF-MS; membrane proteome
Sources: ORCID, Crossref
Added: April 8, 2021

2006 journal article

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

Neurobiology of Aging, 27(8), 1094–1099.

By: T. Williams, B. Lynn*, W. Markesbery* & M. Lovell*

author keywords: early Alzheimer's disease; Mild Cognitive Impairment; lipid peroxidation; oxidative stress; Alzheimer's disease
Source: ORCID
Added: April 8, 2021

2005 journal article

Analysis of derivatized biogenic aldehydes by LC tandem mass spectrometry.

Analytical Chemistry, 5(10), 3383–3389.

By: T. Williams, M. Lovell & B. Lynn

Source: ORCID
Added: April 8, 2021

2005 thesis

METHODS DEVELOPMENT IN BIOLOGICAL MASS SPECTROMETRY: APPLICATIONS IN SMALL MOLECULE RESEARCH AND PROTEOMICS

https://uknowledge.uky.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1291&context=gradschool_diss

Source: ORCID
Added: January 31, 2022

2005 speech

Methods Development in Biological Mass Spectrometry: Applications in Small Molecule Research and Proteomics

Presented at the North Carolina State University, Raleigh, NC.

By: T. Williams & B. Lynn

Event: North Carolina State University at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2005 conference paper

Proteomic Profile Changes in Membranes of Ethanol-Tolerant Clostridium thermocellum

Presented at the American Society for Microbiology, Atlanta, GA.

By: T. Williams, J. Combs, B. Lynn & H. Strobel

Event: American Society for Microbiology at Atlanta, GA

Source: NC State University Libraries
Added: March 6, 2022

2005 conference paper

The Membrane Proteome of Clostridium Thermocellum by MALDI-TOF-MS

Presented at the American Society for Mass Spectrometry, San Antonio, TX.

By: T. Williams, J. Combs, H. Strobel & B. Lynn

Event: American Society for Mass Spectrometry at San Antonio, TX

Source: NC State University Libraries
Added: March 6, 2022

2004 conference paper

Analysis of Derivatized Biogenic Aldehydes by HPLC Tandem Mass Spectrometry

Presented at the American Society for Mass Spectrometry, Nashville, TN.

By: T. Williams, M. Lovell & B. Lynn

Event: American Society for Mass Spectrometry at Nashville, TN

Source: NC State University Libraries
Added: March 6, 2022

2003 conference paper

Analysis of Aldehydes and Aldehyde-DNA Adducts by HPLC Tandem Mass Spectrometry

Presented at the Naff Symposium on Chemistry and Molecular Biology, University of Kentucky, Lexington, KY.

By: T. Williams, X. Liu & B. Lynn

Event: Naff Symposium on Chemistry and Molecular Biology at University of Kentucky, Lexington, KY

Source: NC State University Libraries
Added: March 6, 2022

2001 journal article

Proton affinity of deuterated acetonitrile estimated by the kinetic method with full entropy analysis

International Journal of Mass Spectrometry, 210(211), 133–146.

By: T. Williams, J. Denault* & R. Cooks*

author keywords: proton affinity; kinetic method; entropy analysis; kinetic isotope effect; nitrites
Source: ORCID
Added: April 8, 2021

1998 conference paper

Electrochemical Analysis of DNA Bioconjugates

Presented at the American Chemical Society, Dallas, TX.

By: T. Islam & J. Chambers

Event: American Chemical Society at Dallas, TX

Source: NC State University Libraries
Added: March 6, 2022

1997 speech

Electrochemical Analysis of DNA Bioconjugates

Presented at the University of Tennessee, Knoxville, TN.

By: T. Williams & J. Chambers

Event: University of Tennessee at Knoxville, TN

Source: NC State University Libraries
Added: March 6, 2022

1997 conference paper

Promoting Science for Fun at a Local Inner City School

Presented at the American Chemical Society, San Francisco, CA.

By: W. Dupuy, M. Flueck, T. Islam & D. Seebach

Event: American Chemical Society at San Francisco, CA

Source: NC State University Libraries
Added: March 6, 2022

Employment

Updated: August 2nd, 2022 19:30

2017 - present

North Carolina State University Raleigh, NC, US
Senior Research Scholar / Research Associate Professor METRIC / Chemistry

2008 - 2017

North Carolina State University Raleigh, NC, US
NCSU-MSF Director Chemistry

Education

Updated: July 28th, 2020 11:19

2006 - 2008

North Carolina State University Raleigh, NC, US
Postdoctoral Fellow Chemistry

2002 - 2005

University of Kentucky Lexington, KY, US
PhD Chemistry

Purdue University West Lafayette, IN, US
Master of Science or MS Chemistry

1994 - 1998

Transylvania University Lexington, KY, US
Bachelor of Arts or BA Chemistry and Mathematics

Funding History

Funding history based on the linked ORCID record. Updated: January 30th, 2022 15:24

grant November 1, 2021 - April 1, 2022
Isomer Level Identification and Quantification of N-Linked Glycans by LC-SLIM-QTOF-MS
National Institute for Innovation in Manufacturing Biopharmaceuticals
grant May 1, 2020 - March 1, 2022
Center for Human Health and the Environment (CHHE)
National Institutes of Health
grant March 1, 2019 - February 1, 2022
Identification, Characterization and Removal of HCP in CHO Monoclonal Antibody Biomanufacturing Processes
National Institute for Innovation in Manufacturing Biopharmaceuticals
grant August 1, 2005 - January 1, 2010
Molecular Genetics of Olfaction in Drosophila
National Institutes of Health
grant April 1, 1999 - July 1, 2014
Molecular Genetics of Olfaction in Drosophila
National Institutes of Health