Taufika Islam Williams

mass spectrometry, proteomics, glycomics, nanoscale/microscale LC, OMICS, systems biology

Taufika is originally from Dhaka, Bangladesh. She graduated with a BA from Transylvania University in Lexington, KY in 1998, double-majoring in Chemistry and Mathematics. She went on to receive her MS in Analytical Chemistry from Purdue University in West Lafayette, IN, under the guidance of Dr. R. Graham Cooks. Her thesis focused on the study of gas-phase fundamental ion chemistry using mass spectrometric techniques. Taufika then began her doctoral studies at the University of Kentucky, in the laboratory of Dr. Bert C. Lynn, completing her PhD in Analytical Chemistry in 2005 (summa cum laude). Her dissertation centered on methods development in biological mass spectrometry, with applications in small molecule research and proteomics. Completion of doctoral studies was followed by a North Carolina Biotechnology Center - Kenan Institute postdoctoral fellowship at NCSU under the guidance of Dr. David C. Muddiman in the Department of Chemistry. During this time, Taufika focused on advanced mass spectrometry techniques in the study of glycomics and ovarian cancer detection. Upon completion of the post-doc, she joined the NCSU Department of Chemistry as the Director of the NCSU Mass Spectrometry Facility (MSF). Today, she continues her career at NCSU with a joint appointment as a Senior Research Scholar at the Molecular Education, Technology, and Research Innovation Center (METRIC) and as a Research Associate Professor at the Department of Chemistry. She is also the Proteomics Section Leader for the Center for Human Health and the Environment (CHHE), as well as the METRIC Lead at the Plant Sciences Initiative (PSI) at NCSU. Taufika's focus is in the area of proteomics/glycomics/metabolomics and mass spectrometry. She enjoys collaborating with NCSU researchers in these cutting-edge areas of bioanalytical chemistry, teaching proteomics graduate courses, collaborator and graduate student training on mass spectrometry and proteomics techniques, as well as conducting her own research. Taufika is the Chair Elect of the NCSU Council on the Status of Women (CSW) and a member of the NCSU Department of Chemistry Diversity, Equity and Inclusion (DEI) Committee.

Works (72)

Updated: April 3rd, 2024 18:27

2024 journal article

Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis

FRONTIERS IN IMMUNOLOGY, 14.

By: V. Adams n, L. Collins n, T. Williams n, J. Holmes n, P. Hess n, H. Atkins n, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n, V. Adams n, L. Collins n, J. Holmes n, P. Hess n, H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n, L. Collins n & A. Kennedy n

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: January 28, 2024

2023 article

A bottom-up proteomics workflow for a system containing multiple organisms

Bai, H., Collins, L. B. B., Andre, M. R., Breitschwerdt, E. B. B., & Williams, T. I. (2023, January 3). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 1.

By: H. Bai n, L. Collins n, M. Andre n, E. Breitschwerdt n & T. Williams n

Contributors: H. Bai n, L. Collins n, M. André n, E. Breitschwerdt n & T. Williams n

TL;DR: A bottom-up proteomics workflow was developed to study a system containing multiple organisms to promote a thorough understanding of how each interacts with the others and can be readily applied to other label-free proteomics work involving multiple proteomes from taxonomically distinct organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: November 25, 2022

2023 article

Discovery Proteomics and Absolute Protein Quantification Can Be Performed Simultaneously on an Orbitrap-Based Mass Spectrometer

Williams, T. I., Kowalchyk, C., Collins, L. B., & Reading, B. J. (2023, March 22). ACS OMEGA, Vol. 3.

By: T. Williams n, C. Kowalchyk*, L. Collins n & B. Reading n

Contributors: T. Williams n, C. Kowalchyk*, L. Collins n & B. Reading n

TL;DR: A comparative study on data-dependent acquisition (DDA) and PRM-based workflows to quantify egg yolk protein precursors or vitellogenins (VTGs) Aa, Ab, and C in striped bass (Morone saxatilis) concludes that DDA is able to deliver both discovery data and absolute quantification data in the same experiment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: ORCID, Web Of Science
Added: March 23, 2023

2023 article

Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing

Oh, Y. H., Mendola, K. M., Choe, L. H., Min, L., Lavoie, A. R., Sripada, S. A., … Lenhoff, A. M. (2023, October 25). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 10.

By: Y. Oh*, K. Mendola*, L. Choe*, L. Min*, A. Lavoie n, S. Sripada n, T. Williams n, K. Lee* ...

author keywords: bioprocessing; Chinese hamster ovary cells; host-cell proteins; monoclonal antibodies; purification
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: November 6, 2023

2023 journal article

Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing

Biotechnology and Bioengineering.

Contributors: T. Williams, Y. Oh, K. Mendola, L. Choe, L. Min, A. Lavoie, K. Lee, Y. Yigzaw ...

Ed(s): T. Williams

Source: ORCID
Added: January 28, 2024

2023 journal article

Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach

MICROBIAL CELL FACTORIES, 22(1).

MeSH headings : Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces / genetics; Saccharomyces / metabolism; Probiotics / metabolism; Endopeptidases / metabolism
TL;DR: A quadruple protease-deficient Sb strain is constructed that produces 5045 mg/L secretory NPA, an improvement of tenfold over wild-type Sb and highlights the ability of proteomics to highlight under-explored mediators of this process. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 19, 2023

2023 journal article

Pseudo-affinity capture of <i>K. phaffii</i> host cell proteins in flow-through mode: Purification of protein therapeutics and proteomic study

SEPARATION AND PURIFICATION TECHNOLOGY, 326.

By: S. Sripada n, D. Elhanafi*, L. Collins n, T. Williams n, M. Linova*, J. Woodley*, C. Boi, S. Menegatti n

Contributors: S. Sripada n, D. Elhanafi*, L. Collins n, T. Williams n, M. Linova*, J. Woodley*, C. Boi, S. Menegatti n

author keywords: Komagataella phaffii; Chromatography; Protein purification; Monoclonal antibodies; Antibody fragment; Proteomics
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: October 23, 2023

2022 journal article

Filtered Cerebrospinal Fluid From Patients With Amyotrophic Lateral Sclerosis Displays an Altered Proteome and Affects Motor Phenotype in a Mouse Model

Cureus, 12.

By: V. Venkatraman n, A. Filiano n, L. Xu n, L. Collins n, E. Luo n, K. Ripple n, G. Castro n, J. Boua n ...

TL;DR: The ability to filter proteins from the CSF of ALS patients and identified potentially pathologic proteins that were reduced in quantity is demonstrated and could be a novel solution for patients suffering from this deadly and irreversible condition. (via Semantic Scholar)
Source: ORCID
Added: December 29, 2022

2022 article

Improving Therapeutic Protein Secretion in the Probiotic YeastSaccharomyces boulardiiusing a Multifactorial Engineering Approach

Durmusoglu, D., Al’Abri, I., Williams, T. I., Collins, L. B., Martínez, J. L., & Crook, N. (2022, December 31). BioRxiv.

Contributors: D. Durmusoglu n, I. Al'Abri n, T. Williams n, L. Collins n, J. Martínez* & N. Crook n

Source: ORCID
Added: January 1, 2023

2022 article

Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain

Muthusamy, N., Williams, T. I., O'Toole, R., Brudvig, J. J., Adler, K. B., Weimer, J. M., … Ghashghaei, H. T. (2022, January 24). GEROSCIENCE, Vol. 1.

By: N. Muthusamy n, T. Williams n, R. O'Toole*, J. Brudvig*, K. Adler n, J. Weimer*, D. Muddiman n, H. Ghashghaei n

Contributors: N. Muthusamy n, T. Williams n, R. O’Toole*, J. Brudvig*, K. Adler n, J. Weimer*, D. Muddiman n, H. Ghashghaei n

author keywords: Aging; Behavior; Clca3; Ependymal cells; Forebrain; Marcks; Mass spectrometry; Neuroinflammation
MeSH headings : Mice; Animals; Phosphorylation; Ependyma / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Proteome / metabolism; Membrane Proteins / metabolism; Protein Kinase C / metabolism; Homeostasis; Prosencephalon / metabolism; Mammals / metabolism
TL;DR: This study provides first line of evidence for potential mechanisms that may mediate differential Marcks functions in young and old ECs, and their effect on forebrain homeostasis during aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science
Added: January 31, 2022

2022 journal article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).

By: O. Manley n, H. Phan n, A. Stewart n, D. Mosley n, S. Xue*, L. Cha n, H. Bai n, V. Lightfoot* ...

Contributors: T. Williams n

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
TL;DR: High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: September 21, 2022

2022 article

Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents

Sripada, S. A., Chu, W., Williams, T. I., Teten, M. A., Mosley, B. J., Carbonell, R. G., … Menegatti, S. (2022, April 22). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 119.

By: S. Sripada n, W. Chu n, T. Williams n, M. Teten n, B. Mosley n, R. Carbonell n, A. Lenhoff*, S. Cramer* ...

Contributors: S. Sripada n, W. Chu n, T. Williams n, M. Teten n, B. Mosley n, R. Carbonell n, A. Lenhoff*, S. Cramer* ...

author keywords: CHO; flow-through chromatography; host cell proteins; monoclonal antibodies; peptide-based adsorbents
MeSH headings : Animals; Antibodies, Monoclonal / chemistry; CHO Cells; Cell Culture Techniques; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Peptides / chemistry; Proteomics / methods
TL;DR: An ensemble of peptide ligands that target the HCPs in Chinese hamster ovary (CHO) cell culture fluids and enable mAb purification via flow‐through affinity chromatography are introduced and their integration into LigaGuard™, an affinity adsorbent featuring an equilibrium binding capacity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: April 10, 2022

2022 journal article

Using Proteomic Approaches to Unravel the Response of Ctenocephalides felis felis to Blood Feeding and Infection With Bartonella henselae

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 12.

By: M. Andre n, P. Neupane n, M. Lappin*, B. Herrin*, V. Smith*, T. Williams n, L. Collins n, H. Bai n ...

Contributors: M. André n, P. Neupane n, M. Lappin*, B. Herrin*, V. Smith*, T. Williams n, L. Collins n, H. Bai n ...

author keywords: bartonellosis; cat flea; cat scratch disease; flea-pathogen interface; proteome
MeSH headings : Animals; Bartonella henselae / genetics; Cat Diseases; Cats; Ctenocephalides; Felis; Proteomics; Siphonaptera
TL;DR: Flea-differentially abundant proteins (FDAP) are investigated in unfed fleas, fleas fed on uninfected cats, and flea fed on B. henselae-infected cats to help understand the complex interactions between cat fleas and B. Henselae over an infection time course, thus helping understand the dual effect of vaccine targeting both flea fitness and pathogen competence. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: January 29, 2022

2021 article

Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests

PROTEOMIC PROFILING, 2 EDITION, Vol. 2261, pp. 489–506.

By: R. Lavoie n, T. Islam n, W. Blackburn*, R. Carbonell n & S. Menegatti n

Contributors: R. Lavoie n, T. Williams n, R. Blackburn*, R. Carbonell n & S. Menegatti n

author keywords: Proteomics; Mass spectrometry; Host cell proteins; Monoclonal antibodies; Peptide ligands; Flow-through chromatography
MeSH headings : Animals; CHO Cells; Cricetulus; Enzyme-Linked Immunosorbent Assay; Humans; Ligands; Microscopy, Fluorescence; Peptide Library; Peptides / metabolism; Protein Binding; Proteins / isolation & purification; Proteins / metabolism; Proteomics; Solid Phase Extraction; Tandem Mass Spectrometry
TL;DR: This work describes the development of HCP-binding peptide ligands, especially focusing on the steps of peptide selection via library screening and quantification of H CP removal via proteomics by mass spectrometry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science
Added: April 8, 2021

2021 article

Discovery proteomics of human placental tissue

Mellinger, A. L., McCoy, K., Minior, D. A. T., & Williams, T. I. (2021, December 23). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 9.

By: A. Mellinger n, K. McCoy*, D. Minior* & T. Williams n

Contributors: A. Mellinger n, K. McCoy*, D. Minior* & T. Williams n

TL;DR: A label-free proteomics protocol for the interrogation of the placental proteome is described, which has been applied towards exploring differential protein expression patterns in placentas from women who have been exposed to drugs during pregnancy relative to those who have not. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: September 8, 2021

2021 journal article

Removal of host cell proteins from cell culture fluids by weak partitioning chromatography using peptide-based adsorbents

SEPARATION AND PURIFICATION TECHNOLOGY, 257.

By: R. Lavoie n, W. Chu n, J. Lavoie n, Z. Hetzler n, T. Williams n, R. Carbonell n, S. Menegatti n

Contributors: R. Lavoie n, W. Chu n, J. Lavoie n, Z. Hetzler n, T. Williams n, R. Carbonell n, S. Menegatti n

author keywords: Host cell proteins; Monoclonal antibodies; Flow-through chromatography; Weak partitioning mode; Polishing; Proteomics; Peptide ligands
TL;DR: Proteomic analysis of the effluents demonstrated that 6HP+4MP-Toyopearl adsorbent removes HCPs known for their immunogenicity or IgG co-elution or degradation, demonstrating the potential of these peptide-based resins as HCP scrubbers in mAb purification processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: January 11, 2021

2020 journal article

Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis

BIOTECHNOLOGY AND BIOENGINEERING, 117(2), 438–452.

By: R. Lavoie n, A. Fazio n, T. Williams n, R. Carbonell n & S. Menegatti n

Contributors: R. Lavoie n, A. Fazio n, T. Williams n, R. Carbonell n & S. Menegatti n

author keywords: host cell proteins; monoclonal antibodies; polishing; peptide ligands; protein purification
MeSH headings : Animals; Antibodies, Monoclonal / isolation & purification; CHO Cells; Cricetinae; Cricetulus; Ligands; Peptides / chemistry; Peptides / metabolism; Protein Binding; Proteins / analysis; Proteins / chemistry; Proteins / isolation & purification; Proteins / metabolism; Proteomics / methods; Recombinant Proteins / isolation & purification
TL;DR: A family of synthetic peptides that target HCPs and exhibit low binding to IgG product are developed and found that these peptide ligands exhibit superior HCP binding capability compared to those of the benchmark commercial resins commonly used in mAb purification. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: December 2, 2019

2019 journal article

A substitute variety for agronomically and medicinally important Serenoa repens (saw palmetto)

SCIENTIFIC REPORTS, 9(1).

Contributors: Y. Jaiswal*, D. Weber*, A. Yerke*, Y. Xue*, D. Lehman n, T. Williams n, T. Xiao*, D. Haddad*, L. Williams*

MeSH headings : Conservation of Natural Resources; Fruit / anatomy & histology; Fruit / chemistry; Fruit / metabolism; Humans; Lipid Metabolism; Lipids / analysis; Male; Metabolomics; Phytotherapy / methods; Plant Extracts / therapeutic use; Plants, Medicinal / anatomy & histology; Plants, Medicinal / chemistry; Plants, Medicinal / metabolism; Prostatic Hyperplasia / drug therapy; Secondary Metabolism; Serenoa / chemistry; Serenoa / metabolism; Spatial Analysis; Water / analysis; Water / metabolism
TL;DR: The first study, to propose the use of the S. repens forma glauca (silver variety) as a qualitative substitute for the wild variety, to support its conservation and provide a new strategy for studying phenotypic traits and metabolite synthesis of closely related plant varieties. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 conference paper

Egg Characteristics and Striped Bass Fertility

Presented at the Mass Spectrometry Research Symposium, North Carolina State University, Raleigh, NC.

By: T. Williams, C. Kowalchyk, J. Fischer & B. Reading

Event: Mass Spectrometry Research Symposium at North Carolina State University, Raleigh, NC

Source: NC State University Libraries
Added: April 26, 2021

2019 conference paper

Exploring Egg Characteristics of Striped Bass

Presented at the American Society for Mass Spectrometry Meeting, Atlanta, GA.

By: T. Williams, C. Kowalchyk, J. Fischer & B. Reading

Event: American Society for Mass Spectrometry Meeting at Atlanta, GA on July 2-6, 2019

Source: NC State University Libraries
Added: April 26, 2021

2018 journal article

Conrad Bessant (Ed.): Proteome informatics

Analytical and Bioanalytical Chemistry, 410(14), 3231–3233.

By: T. Williams n

TL;DR: The book Proteome informatics describes the bioinformatics of proteome analyses in the very context of proteomics workflows, highlighting the essential fund of knowledge that will enable the proteomics expert to exploit and construct algorithms that can effectively interrogate gigabytes of data. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 29, 2020

2014 journal article

Proportional Accumulation of Yolk Proteins Derived From Multiple Vitellogenins is Precisely Regulated During Vitellogenesis in Striped Bass (Morone saxatilis)

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 321(6), 301–315.

By: V. Williams n, B. Reading n, H. Amano*, N. Hiramatsu*, J. Schilling n, S. Salger n, T. Williams n, K. Gross n, C. Sullivan n

Contributors: V. Williams n, B. Reading n, H. Amano*, N. Hiramatsu*, J. Schilling n, S. Salger n, T. Islam Williams n, K. Gross n, C. Sullivan n

MeSH headings : Animals; Bass / metabolism; Blotting, Western; Egg Proteins / analysis; Egg Proteins / biosynthesis; Egg Proteins / metabolism; Egg Proteins / physiology; Electrophoresis, Polyacrylamide Gel; Female; Liver / chemistry; Mass Spectrometry; Ovary / chemistry; Real-Time Polymerase Chain Reaction; Vitellogenesis / physiology; Vitellogenins / analysis; Vitellogenins / biosynthesis; Vitellogenins / metabolism; Vitellogenins / physiology
TL;DR: The results indicate that proportional accumulation of multiple Vtgs in the yolk may depend both on the precise rates of their hepatic secretion and specific uptake by oocytes, and composition of the Vtg-derived yolk May vary among Acanthomorph fishes, perhaps reflecting their different early life histories and reproductive strategies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Dynamics of the Striped Bass (Morone saxatilis) Ovary Proteome Reveal a Complex Network of the Translasome

Journal of Proteome Research, 12(4), 1691–1699.

By: B. Reading*, V. Williams*, R. Chapman*, T. Williams* & C. Sullivan*

Contributors: B. Reading*, V. Williams*, R. Chapman*, T. Williams* & C. Sullivan*

author keywords: ribosome; proteasome; translasome; ovary; reproduction; mass-spectrometry; support vector machines; teleost; fish
MeSH headings : Animals; Artificial Intelligence; Bass; Cluster Analysis; Female; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Ontology; Mass Spectrometry / methods; Menstrual Cycle / physiology; Ovary / metabolism; Proteasome Endopeptidase Complex / metabolism; Proteome / metabolism; Ribosomes / genetics; Ribosomes / metabolism
TL;DR: The striped bass ovary proteome is evaluated using label-free quantitative mass spectrometry and a novel machine learning analysis based on K-means clustering and support vector machines to suggest that protein synthesis and degradation are intimately linked. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: ORCID, Crossref, Web Of Science
Added: August 6, 2018

2013 conference paper

The North Carolina State University Mass Spectrometry Facility at the Cutting Edge of Scientific Research

Presented at the Workshop on Allergy and Inflammation, North Carolina State University, Raleigh, NC.

By: V. Kandhi & T. Williams

Event: Workshop on Allergy and Inflammation at North Carolina State University, Raleigh, NC

Source: NC State University Libraries
Added: August 13, 2021

2012 journal article

Re-evaluating the role of ascorbic acid and phenolic glycosides in ozone scavenging in the leaf apoplast of Arabidopsis thaliana L.

Plant, Cell & Environment, 8.

By: F. Booker*, K. Burkey* & A. Jones*

author keywords: Air pollution; flavonoids; kaempferol; reactive oxygen; sinapoyl malate; vitamin C
MeSH headings : Arabidopsis / metabolism; Ascorbic Acid / metabolism; Biomass; Glycosides / metabolism; Ozone / metabolism; Phenols / metabolism; Plant Leaves / metabolism; Reactive Oxygen Species / metabolism
TL;DR: Current understanding of O(3) defence schemes deserves reassessment as mechanisms other than direct scavenging of O (3) by extracellular AA and antioxidant activity of some phenolics may predominate in some plant species. (via Semantic Scholar)
Source: ORCID
Added: April 8, 2021

2011 conference paper

Behavioral Response Profiles of Odorant Binding Proteins in Drosophila melanogaster

Presented at the 6th Annual North Carolina State University Graduate Student Research Symposium, Raleigh, NC.

By: S. Swarup, T. Williams & R. Anholt

Event: 6th Annual North Carolina State University Graduate Student Research Symposium at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2011 conference paper

Functional Dissection of Odorant Binding Protein Genes in Drosophila melanogaster

Presented at the Center for Integrative Genomics (CIG) Symposium, Université de Lausanne, Lausanne, Switzerland.

By: S. Swarup, T. Williams & R. Anholt

Event: Center for Integrative Genomics (CIG) Symposium at Université de Lausanne, Lausanne, Switzerland

Source: NC State University Libraries
Added: August 13, 2021

2011 journal article

Functional dissection of Odorant binding protein genes in Drosophila melanogaster

GENES BRAIN AND BEHAVIOR, 10(6), 648–657.

By: S. Swarup*, T. Williams* & R. Anholt n

Contributors: S. Swarup*, T. Williams* & R. Anholt n

author keywords: Behavioral genetics; chemoreception; olfaction; proteomics; RNAi
MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Gene Expression; Proteomics; Receptors, Odorant / genetics; Smell / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 conference paper

Proteomics of Olfaction: Identification and Relative Quantification of Odorant Binding Proteins in the Antennae of Drosophila melanogaster

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: T. Williams, S. Swarup, S. Zhou & R. Anholt

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: August 13, 2021

2010 journal article

The Soluble Proteome of the Drosophila Antenna

Chemical Senses, 35(1), 21–30.

By: R. Anholt n & T. Williams n

Contributors: R. Anholt n & T. Williams n

author keywords: chemosensation; mass spectrometry; odorant-binding proteins; olfaction; proteomics
MeSH headings : Amino Acid Sequence; Animals; Drosophila melanogaster / metabolism; Female; Male; Mass Spectrometry; Molecular Sequence Data; Nanotechnology; Proteome / chemistry; Proteome / metabolism; Receptors, Odorant / metabolism; Smell; Trypsin / metabolism
TL;DR: A simple method for the large-scale detection of soluble proteins from the Drosophila antenna by chromatographic separation of tryptic peptides followed by tandem mass spectrometry with femtomole detection sensitivities is described. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 conference paper

Accurate Mass Measurements in FTMS with Automatic Gain Control

Presented at the Pharmaceutical Interest Group, American Society for Mass Spectrometry, Philadelphia, PA.

By: T. Williams

Event: Pharmaceutical Interest Group, American Society for Mass Spectrometry at Philadelphia, PA

Source: NC State University Libraries
Added: March 6, 2022

2009 journal article

Construction of Coordination-Driven Self-Assembled [5+5] Pentagons Using Metal-Carbonyl Dipyridine Ligands

INORGANIC CHEMISTRY, 48(13), 5590–5592.

Contributors: L. Zhao*, K. Ghosh*, Y. Zheng*, M. Lyndon n, T. Williams n & P. Stang*

MeSH headings : Crystallography; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Pyridines / chemistry; Spectrometry, Mass, Electrospray Ionization
TL;DR: The coordination-driven self-assembly of two metal-carbonyl-cluster-coordinated dipyridyl donors, with a linear diplatinum(II) acceptor ligand, resulted in a pentagon-hexagon mixture, which was characterized by electrospray ionization time-of-flight mass spectroscopy. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Development of a nanoLC LTQ Orbitrap Mass Spectrometric Method for Profiling Glycans Derived from Plasma from Healthy, Benign Tumor Control, and Epithelial Ovarian Cancer Patients

ANALYTICAL CHEMISTRY, 81(3), 1130–1136.

By: M. Bereman n, T. Williams n & D. Muddiman n

Contributors: M. Bereman n, T. Williams n & D. Muddiman n

MeSH headings : Biomarkers, Tumor / blood; Biomarkers, Tumor / chemistry; Carcinoma / diagnosis; Chromatography, Liquid / methods; Female; Genital Neoplasms, Female / chemistry; Genital Neoplasms, Female / diagnosis; Glycoproteins / blood; Glycoproteins / chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Lectins / blood; Lectins / chemistry; Male; Ovarian Neoplasms / diagnosis; Polysaccharides / blood; Polysaccharides / chemistry; ROC Curve; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: A split-less nano-flow liquid chromatography mass spectrometric analysis of glycans chemically cleaved from glycoproteins in plasma shows similar column efficiencies and excellent retention time reproducibility without an internal standard to correct for retention time shift. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 conference paper

Proteomic Profiling of Populus trichocarpa for the Interrogation of Molecular Mechanisms behind Wood Formation

Presented at the American Society for Mass Spectrometry, Philadelphia, PA.

By: T. Williams, Y. Sun, T. Yeh, J. Sampson, D. Muddiman & V. Chiang

Event: American Society for Mass Spectrometry at Philadelphia, PA

Source: NC State University Libraries
Added: March 6, 2022

2009 conference paper

The Development of Nano LC Mass Spectrometric Methods for Profiling Glycans in Epithelial Ovarian Cancer (EOC) and Control Plasma

Presented at the 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Chicago, IL.

By: M. Bereman, T. Williams, K. Kalli, W. Cliby & D. Muddiman

Event: 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy at Chicago, IL

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

A Combinatorial Approach: The Use of MALDI-MS and Nano LC-MS for Glycan Biomarker Discovery

Presented at the Protein Biomarkers Meeting, Philadelphia, PA.

By: T. Williams, M. Bereman, D. Nielsen, K. Kalli, W. Cliby & D. Muddiman

Event: Protein Biomarkers Meeting at Philadelphia, PA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Analysis of O-linked Glycans Derived from Normal and Diseased EOC Plasma by Nano LC-ESI-FTICR Mass Spectrometry

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: M. Bereman, T. Williams, A. Hawkridge & D. Muddiman

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: March 6, 2022

2008 speech

Applications of Carbohydrate Profiling in Ovarian Cancer Plasma Glycoproteins

Presented at the Longwood University, Farmville, VA.

By: T. Williams & D. Muddiman

Event: Longwood University at Farmville, VA

Source: NC State University Libraries
Added: March 6, 2022

2008 journal article

Calibration laws based on multiple linear regression applied to matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(12), 1659–1663.

By: D. Williams n, M. Chadwick n, T. Williams n & D. Muddiman n

Contributors: D. Williams Jr., M. Chadwick n, T. Williams n & D. Muddiman n

author keywords: multiple linear regression; polypropylene glycol; calibration; matrix-assisted laser desorption/ionization (MALDI); Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); space-charge effects
MeSH headings : Calibration; Cyclotrons; Fourier Analysis; Linear Models; Mass Spectrometry / methods; Multivariate Analysis; Peptide Mapping / methods; Peptide Mapping / statistics & numerical data; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: An evaluation of external mass calibration laws applied to MALDI-FT-ICR-MS is performed to achieve higher mass measurement accuracy (MMA) in Fourier transform ion cyclotron resonance mass spectrometry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 conference paper

Epithelial Ovarian Cancer Detection by Glycan Profiling in Blood

Presented at the North Carolina State University, Raleigh, NC.

By: T. Williams & D. Muddiman

Event: North Carolina State University at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Glycan Analysis by Nano LC-MS: Applications for Biomarker Discovery in Epithelial Ovarian Cancer (EOC)

Presented at the Atlanta Athens Mass Spectrometry Discussion Group Symposium, University of Georgia, Athens, GA.

By: M. Bereman, T. Williams, K. Kalli, W. Cliby & D. Muddiman

Event: Atlanta Athens Mass Spectrometry Discussion Group Symposium at University of Georgia, Athens, GA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Glycan Profiling in Plasma: Fundamentals and Applications to Ovarian Cancer

Presented at the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA.

By: T. Williams & D. Muddiman

Event: Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy at New Orleans, LA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

In Search of Epithelial Ovarian Cancer Molecular Markers by MALDI-FT-ICR-MS and NANO-LC-LTQ-ORBITRAP-MS

Presented at the Mass Spectrometry Applications to the Clinical Laboratory, University of California - San Diego, San Diego, CA.

By: T. Williams, M. Bereman, D. Nielsen, K. Kalli, W. Cliby & D. Muddiman

Event: Mass Spectrometry Applications to the Clinical Laboratory at University of California - San Diego, San Diego, CA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Innovative Technology Development Directed at the Elucidation of Biomarkers for the Detection of Early-Stage Ovarian Cancer

Presented at the Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program of the National Cancer Institute, Cambridge, MA.

By: T. Williams, M. Bereman, D. Williams & D. Muddiman

Event: Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program of the National Cancer Institute at Cambridge, MA

Source: NC State University Libraries
Added: March 6, 2022

2008 journal article

Investigations with O-linked protein glycosylations by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(9), 1215–1223.

By: T. Williams n, D. Saggese n, K. Toups n, J. Frahm n, H. An*, B. Li*, C. Lebrilla*, D. Muddiman n

Contributors: T. Williams n, D. Saggese n, K. Toups n, J. Frahm n, H. An*, B. Li*, C. Lebrilla*, D. Muddiman n

author keywords: Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); matrix-assisted laser desorption/ionization (MALDI); mucin; O-linked glycans; protein glycosylations
MeSH headings : Angiotensins / chemistry; Animals; Glycosylation; Mucins / chemistry; Oligosaccharides / chemistry; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Swine; Tandem Mass Spectrometry / methods
TL;DR: A detailed examination of sample preparation and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FT-ICR-MS) analysis of O-linked glycans globally cleaved from mucin glycoproteins is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 conference paper

Mining the Plasma Glycome for Epithelial Ovarian Cancer Biomarker Discovery

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: T. Williams, D. Nielsen, W. Cliby, K. Kalli & D. Muddiman

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: March 6, 2022

2008 journal article

Studying O-linked protein glycosylations in human plasma

JOURNAL OF PROTEOME RESEARCH, 7(6), 2562–2568.

By: T. Williams n, D. Saggese n & D. Muddiman n

Contributors: T. Williams n, D. Saggese n & D. Muddiman n

author keywords: protein O-glycosylations; plasma; epithelial ovarian cancer (EOC); matrix-assisted laser desorption/iozation (MALDI); Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS)
MeSH headings : Blood Proteins / chemistry; Blood Proteins / metabolism; Borohydrides / chemistry; Dialysis / methods; Female; Glycosylation; Hexosamines / analysis; Hexoses / analysis; Hexuronic Acids / analysis; Humans; Middle Aged; Ovarian Neoplasms / blood; Polysaccharides / analysis; Polysaccharides / chemistry; Polysaccharides / isolation & purification; Pronase / metabolism; Solid Phase Extraction / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: The protocol here identifies O-linked carbohydrate patterns in EOC plasma glycoproteins through chemical cleavage and purification of these glycans through chemical Cleavage and Purification ofThese glycans are identified through carbohydrate pattern analysis with MALDI-FT-ICR-MS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 conference paper

The Development of a Nano-LC Mass Spectrometric Method for Profiling Glycans in Epithelial Ovarian Cancer (EOC) and Control Plasma

Presented at the Triangle Chromatography Symposium and Instrument Exhibit, Raleigh, NC.

By: M. Bereman, T. Williams & D. Muddiman

Event: Triangle Chromatography Symposium and Instrument Exhibit at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

Calibration Laws Based on Multiple Linear Regression Applied to MALDI-FT-ICR-MS

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: M. Chadwick, T. Williams, D. Williams & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 journal article

Carbohydrate analysis by desorption electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

ANALYTICAL CHEMISTRY, 79(22), 8812–8815.

By: M. Bereman n, T. Williams n & D. Muddiman n

Contributors: M. Bereman n, T. Williams n & D. Muddiman n

MeSH headings : Carbohydrates / analysis; Cyclotrons; Fourier Analysis; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR: G glycans from mucin are identified by using the high mass measurement accuracy and tandem MS capabilities afforded by the hybrid FT-ICR-MS platform. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 conference paper

Characterization and Biological Applications of Desorption Electrospray Ionization Coupled to Hybrid FT-ICR Mass Spectrometry

Presented at the Southeastern Regional Meeting of the American Chemical Society, Greenville, SC.

By: M. Bereman, T. Williams & D. Muddiman

Event: Southeastern Regional Meeting of the American Chemical Society at Greenville, SC

Source: NC State University Libraries
Added: March 6, 2022

2007 journal article

Effect of matrix crystal structure on ion abundance of carbohydrates by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(5), 807–811.

By: T. Williams n, D. Saggese n, R. Wilcox n, J. Martin n & D. Muddiman n

Contributors: T. Williams n, D. Saggese n, R. Wilcox n, J. Martin n & D. Muddiman n

MeSH headings : Acetylglucosamine / chemistry; Crystallization; Cyclotrons; Ions; N-Acetylneuraminic Acid / chemistry; Powder Diffraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared
TL;DR: Sample preparation techniques for carbohydrate analysis using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) are explored, with particular emphasis on analyte/matrix co-crystallization procedures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 review

Epithelial ovarian cancer: Disease etiology, treatment, detection, and investigational gene, metabolite, and protein biomarkers

[Review of ]. JOURNAL OF PROTEOME RESEARCH, 6(8), 2936–2962.

By: T. Williams n, K. Toups n, D. Saggese n, K. Kalli n, W. Cliby n & D. Muddiman n

Contributors: T. Williams n, K. Toups n, D. Saggese n, K. Kalli n, W. Cliby n & D. Muddiman n

author keywords: biomarkers; epithelial ovarian cancer; proteomics; mass spectrometry; detection; treatments
MeSH headings : Biomarkers, Tumor / metabolism; Female; Humans; Neoplasms, Glandular and Epithelial / diagnosis; Neoplasms, Glandular and Epithelial / etiology; Neoplasms, Glandular and Epithelial / metabolism; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / etiology; Ovarian Neoplasms / metabolism
TL;DR: An introduction to ovarian cancer is offered, with particular emphasis on human epithelial ovarian cancer, and a survey of promising new protein, gene, and metabolite biomarkers on the horizon is provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 conference paper

Investigations with O-linked Protein Glycosylations by MALDI-FT-ICR-MS

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: D. Saggese, T. Williams, R. Wilcox, J. Martin, H. An, B. Li, C. Lebrilla, D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

MALDI-FT-ICR-MS Quantification of Peptides and Oligosaccharides using Stable-Isotope Labels

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: K. Toups, T. Williams, J. Zheng, J. Frahm & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

O-linked Protein Glycosylations in Plasma as Biomarkers for Epithelial Ovarian Cancer

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: T. Williams, J. Sampson, A. Hawkridge, W. Cliby & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

Plasma Biomarker Discovery and Analysis using FT-ICR Mass Spectrometry

Presented at the Federation of Analytical Chemistry and Spectroscopy Societies, Memphis, TN.

By: D. Muddiman, A. Hawkridge, T. Williams, W. Cliby & J. Burnett

Event: Federation of Analytical Chemistry and Spectroscopy Societies at Memphis, TN

Source: NC State University Libraries
Added: March 6, 2022

2007 journal article

Proteomic profile changes in membranes of ethanol-tolerant Clostridium thermocellum

Applied Microbiology and Biotechnology, 74(2), 422–432.

By: T. Williams n, J. Combs*, B. Lynn* & H. Strobel*

Contributors: T. Williams n, J. Combs*, B. Lynn* & H. Strobel*

author keywords: Clostridium thermocellum; ethanol tolerance; proteomics
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cell Membrane / metabolism; Clostridium thermocellum / drug effects; Clostridium thermocellum / genetics; Clostridium thermocellum / growth & development; Clostridium thermocellum / metabolism; Ethanol / pharmacology; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Industrial Microbiology / methods; Membrane Proteins / genetics; Membrane Proteins / metabolism; Proteomics
TL;DR: Overall, the results suggested that membrane-associated proteins in the ethanol-adapted strain are either being synthesized in lower quantities or not properly incorporated into the cell membrane. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: April 8, 2021

2007 conference paper

The Development and Characterization of a Desorption Electrospray Ionization Source Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (DESI-FT-ICR-MS) for Biological Analyses

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: M. Bereman, T. Williams & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2006 journal article

A novel Bicine running buffer system for doubled sodium dodecyl sulfate – polyacrylamide gel electrophoresis of membrane proteins

Electrophoresis, 27(14), 2984–2995.

By: T. Williams*, J. Combs*, A. Thakur*, H. Strobel* & B. Lynn*

Contributors: T. Williams*, J. Combs*, A. Thakur*, H. Strobel* & B. Lynn*

author keywords: Bicine; doubled SDS-PAGE; MALDI-TOF-MS; membrane proteome
MeSH headings : Bacterial Proteins / analysis; Bacterial Proteins / isolation & purification; Buffers; Clostridium thermocellum / chemistry; Electrophoresis, Capillary; Electrophoresis, Polyacrylamide Gel / methods; Glycine / analogs & derivatives; Glycine / chemistry; Membrane Proteins / analysis; Membrane Proteins / isolation & purification
TL;DR: The data clearly indicated that Bicine‐dSDS‐PAGE is a superior method for the analysis of membrane proteins, providing enhanced resolution and protein representation. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: April 8, 2021

2006 journal article

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

Neurobiology of Aging, 27(8), 1094–1099.

By: T. Williams*, B. Lynn*, W. Markesbery* & M. Lovell*

Contributors: T. Williams*, B. Lynn*, W. Markesbery* & M. Lovell*

author keywords: early Alzheimer's disease; Mild Cognitive Impairment; lipid peroxidation; oxidative stress; Alzheimer's disease
MeSH headings : Acrolein / metabolism; Aged, 80 and over; Aldehydes / metabolism; Alzheimer Disease / metabolism; Biomarkers / metabolism; Brain / metabolism; Cognition Disorders / metabolism; Female; Humans; Lipid Peroxidation; Male; Tissue Distribution
TL;DR: The results suggest that lipid peroxidation occurs early in the pathogenesis of AD, and levels of HNE in HPG and SMTG and a significant increase in acrolein in all three brain regions studied. (via Semantic Scholar)
Source: ORCID
Added: April 8, 2021

2005 journal article

Analysis of derivatized biogenic aldehydes by LC tandem mass spectrometry.

Analytical Chemistry, 5(10), 3383–3389.

By: T. Williams*, M. Lovell* & B. Lynn*

Contributors: T. Williams*, M. Lovell* & B. Lynn*

MeSH headings : Acrolein / analysis; Acrolein / metabolism; Aldehydes / analysis; Aldehydes / metabolism; Alzheimer Disease / etiology; Alzheimer Disease / pathology; Biomarkers / analysis; Biomarkers / metabolism; Chromatography, Liquid / methods; Humans; Lipid Peroxidation; Tandem Mass Spectrometry / methods; Tissue Distribution
TL;DR: The LC-MS/MS methodology developed here will be used in subsequent studies to determine aldehyde concentrations for comparing age-matched controls to AD tissues from human subjects. (via Semantic Scholar)
Source: ORCID
Added: April 8, 2021

2005 thesis

METHODS DEVELOPMENT IN BIOLOGICAL MASS SPECTROMETRY: APPLICATIONS IN SMALL MOLECULE RESEARCH AND PROTEOMICS

https://uknowledge.uky.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1291&context=gradschool_diss

Taufika Williams

Source: ORCID
Added: January 31, 2022

2005 speech

Methods Development in Biological Mass Spectrometry: Applications in Small Molecule Research and Proteomics

Presented at the North Carolina State University, Raleigh, NC.

By: T. Williams & B. Lynn

Event: North Carolina State University at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2005 conference paper

Proteomic Profile Changes in Membranes of Ethanol-Tolerant Clostridium thermocellum

Presented at the American Society for Microbiology, Atlanta, GA.

By: T. Williams, J. Combs, B. Lynn & H. Strobel

Event: American Society for Microbiology at Atlanta, GA

Source: NC State University Libraries
Added: March 6, 2022

2005 conference paper

The Membrane Proteome of Clostridium Thermocellum by MALDI-TOF-MS

Presented at the American Society for Mass Spectrometry, San Antonio, TX.

By: T. Williams, J. Combs, H. Strobel & B. Lynn

Event: American Society for Mass Spectrometry at San Antonio, TX

Source: NC State University Libraries
Added: March 6, 2022

2004 conference paper

Analysis of Derivatized Biogenic Aldehydes by HPLC Tandem Mass Spectrometry

Presented at the American Society for Mass Spectrometry, Nashville, TN.

By: T. Williams, M. Lovell & B. Lynn

Event: American Society for Mass Spectrometry at Nashville, TN

Source: NC State University Libraries
Added: March 6, 2022

2003 conference paper

Analysis of Aldehydes and Aldehyde-DNA Adducts by HPLC Tandem Mass Spectrometry

Presented at the Naff Symposium on Chemistry and Molecular Biology, University of Kentucky, Lexington, KY.

By: T. Williams, X. Liu & B. Lynn

Event: Naff Symposium on Chemistry and Molecular Biology at University of Kentucky, Lexington, KY

Source: NC State University Libraries
Added: March 6, 2022

2001 journal article

Proton affinity of deuterated acetonitrile estimated by the kinetic method with full entropy analysis

International Journal of Mass Spectrometry, 210(211), 133–146.

By: T. Williams*, J. Denault* & R. Cooks*

Contributors: T. Williams*, J. Denault* & R. Cooks*

author keywords: proton affinity; kinetic method; entropy analysis; kinetic isotope effect; nitrites
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: April 8, 2021

1998 conference paper

Electrochemical Analysis of DNA Bioconjugates

Presented at the American Chemical Society, Dallas, TX.

By: T. Islam & J. Chambers

Event: American Chemical Society at Dallas, TX

Source: NC State University Libraries
Added: March 6, 2022

1997 speech

Electrochemical Analysis of DNA Bioconjugates

Presented at the University of Tennessee, Knoxville, TN.

By: T. Williams & J. Chambers

Event: University of Tennessee at Knoxville, TN

Source: NC State University Libraries
Added: March 6, 2022

1997 conference paper

Promoting Science for Fun at a Local Inner City School

Presented at the American Chemical Society, San Francisco, CA.

By: W. Dupuy, M. Flueck, T. Islam & D. Seebach

Event: American Chemical Society at San Francisco, CA

Source: NC State University Libraries
Added: March 6, 2022

Employment

Updated: August 2nd, 2022 19:30

2017 - present

North Carolina State University Raleigh, NC, US
Senior Research Scholar / Research Associate Professor METRIC / Chemistry

2008 - 2017

North Carolina State University Raleigh, NC, US
NCSU-MSF Director Chemistry

Education

Updated: July 28th, 2020 11:19

2006 - 2008

North Carolina State University Raleigh, NC, US
Postdoctoral Fellow Chemistry

2002 - 2005

University of Kentucky Lexington, KY, US
PhD Chemistry

Purdue University West Lafayette, IN, US
Master of Science or MS Chemistry

1994 - 1998

Transylvania University Lexington, KY, US
Bachelor of Arts or BA Chemistry and Mathematics

Funding History

Funding history based on the linked ORCID record. Updated: August 22nd, 2023 13:35

grant November 1, 2021 - April 1, 2022
Isomer Level Identification and Quantification of N-Linked Glycans by LC-SLIM-QTOF-MS
National Institute for Innovation in Manufacturing Biopharmaceuticals
grant May 1, 2020
Center for Human Health and the Environment (CHHE)
National Institutes of Health
grant March 1, 2019 - February 1, 2022
Identification, Characterization and Removal of HCP in CHO Monoclonal Antibody Biomanufacturing Processes
National Institute for Innovation in Manufacturing Biopharmaceuticals
grant August 1, 2005 - January 1, 2010
Molecular Genetics of Olfaction in Drosophila
National Institutes of Health
grant April 1, 1999 - July 1, 2014
Molecular Genetics of Olfaction in Drosophila
National Institutes of Health

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