Tianyue Jiang

Works (9)

Updated: July 13th, 2023 21:18

2015 journal article

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

BIOMATERIALS, 50, 67–74.

By: R. Mo n, T. Jiang n, W. Sun n & Z. Gu n

author keywords: ATP responsive; Graphene oxide; DNA; Drug delivery; Nanomedicine
MeSH headings : Adenosine Triphosphate / pharmacology; Antineoplastic Agents / pharmacology; Cell Death / drug effects; DNA, Single-Stranded / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Endocytosis / drug effects; Graphite / chemistry; HeLa Cells; Humans; Intracellular Space / metabolism; Nanoparticles / chemistry; Particle Size; Spectrometry, Fluorescence
TL;DR: This study applied adenosine-5'-triphosphate (ATP), the primary "energy molecule", as a trigger for enhanced release of preloaded drugs responding to the intracellular ATP concentration that is significantly higher than the extracellular level, for targeted on-demand delivery of anticancer drugs inside specific cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

ATP-triggered anticancer drug delivery

NATURE COMMUNICATIONS, 5.

By: R. Mo n, T. Jiang n, R. DiSanto n, W. Tai  n & Z. Gu*

MeSH headings : Adenosine Triphosphate / chemistry; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Apoptosis; Cell Line; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Carriers / chemistry; Female; Humans; MCF-7 Cells; Mice; Mice, Nude; Nanoparticles / chemistry; Polymers / chemistry; Xenograft Model Antitumor Assays
TL;DR: Nanocarriers are developed that take advantage of high ATP levels in tumour cells and show that these nanoparticles encapsulating the chemotherapeutic doxorubicin can inhibit tumour growth in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(42), 14722–14725.

By: W. Sun*, T. Jiang*, Y. Lu*, M. Reiff*, R. Mo* & Z. Gu*

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; DNA / chemistry; DNA / metabolism; Deoxyribonucleases / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Liberation; Humans; MCF-7 Cells; Models, Molecular; Molecular Conformation; Nanoparticles / chemistry
TL;DR: In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 review

Emerging micro-and nanotechnology based synthetic approaches for insulin delivery

[Review of ]. CHEMICAL SOCIETY REVIEWS, 43(10), 3595–3629.

By: R. Mo n, T. Jiang n, J. Di n, W. Tai  n & Z. Gu n

MeSH headings : Diabetes Mellitus / drug therapy; Drug Delivery Systems; Equipment Design; Humans; Insulin / administration & dosage; Insulin / therapeutic use; Insulin Infusion Systems; Nanotechnology / instrumentation
TL;DR: This review outlines recent developments in the controlled delivery of insulin, including oral, nasal, pulmonary, transdermal, subcutaneous and closed-loop insulin delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(23), 5815–5820.

By: R. Mo n, T. Jiang n & Z. Gu n

author keywords: ATP; drug delivery; liposomes; nanomedicine; stimuli-responsive materials
MeSH headings : Adenosine Triphosphate / metabolism; Animals; Drug Delivery Systems / methods; Humans; Liposomes / metabolism; MCF-7 Cells; Mice; Nanomedicine / methods
TL;DR: Directly delivering extrinsic liposomal ATP promoted the drug release from the fusogenic liposome in the acidic intracellular compartments upon a pH-sensitive membrane fusion and anticancer efficacy was enhanced both in vitro and in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs

BIOMATERIALS, 35(25), 7194–7203.

By: W. Tai  n, R. Mo  n, Y. Lu n, T. Jiang n & Z. Gu n

author keywords: Graft copolymer; Micelle; Combination therapy; Bio-inspired; Ring open polymerization; Nanomedicine
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Camptothecin / chemistry; Camptothecin / pharmacology; Cell Line, Tumor; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Endocytosis / drug effects; Female; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Nude; Micelles; Nanostructures / chemistry; Polyethylene Glycols / chemistry; Polymers / chemistry; Xenograft Model Antitumor Assays
TL;DR: In vivo study validated that the nanocarriers exhibited strong accumulation in tumor sites and showed a prominent anticancer activity against the lung cancer xenograft mice model compared with free drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Molecule Drugs for Enhanced Therapeutic Efficacy

ADVANCED FUNCTIONAL MATERIALS, 24(16), 2295–2304.

By: T. Jiang n, R. Mo n, A. Bellotti  n, J. Zhou * & Z. Gu n

author keywords: drug delivery; combination cancer therapy; site-specific delivery; nanomedicine; apoptosis
TL;DR: With the programmed choreography, Gelipo significantly improves the inhibition of the tumor growth in the MDA‐MB‐231 xenograft tumor animal model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Recent progress in multidrug delivery to cancer cells by liposomes

Mo, R., Jiang, T., & Gu, Z. (2014, June). NANOMEDICINE, Vol. 9, pp. 1117–1120.

By: R. Mo*, T. Jiang n & Z. Gu n

author keywords: chemotherapy; co-delivery; combination cancer therapy; drug delivery; gene therapy; liposome; protein therapy
MeSH headings : Antineoplastic Agents / administration & dosage; Drug Delivery Systems; Genetic Therapy; Humans; Liposomes / chemistry; Neoplasms / drug therapy; Neoplasms / therapy
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

journal article

Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene

Jiang, T. Y., Sun, W. J., Zhu, Q. W., Burns, N. A., Khan, S. A., Mo, R., & Gu, Z. Advanced Materials, 27(6), 1021–1028.

By: T. Jiang, W. Sun, Q. Zhu, N. Burns, S. Khan , R. Mo, Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

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