Works (25)
Updated: August 13th, 2023 21:16
2022 journal article
Health-Related Quality of Life Outcomes With Two Different Starting Doses of Lenvatinib in Combination With Everolimus for Previously Treated Renal Cell Carcinoma.
The Oncologist.
MeSH headings : Humans; Carcinoma, Renal Cell / drug therapy; Carcinoma, Renal Cell / pathology; Everolimus / therapeutic use; Kidney Neoplasms / drug therapy; Kidney Neoplasms / pathology; Quality of Life; Vascular Endothelial Growth Factor A; Antineoplastic Agents / administration & dosage
academic.oup.com (publisher PDF)
Source: ORCID
Added: April 18, 2023
2022 journal article
Health-related quality-of-life outcomes in patients with advanced renal cell carcinoma treated with lenvatinib plus pembrolizumab or everolimus versus sunitinib (CLEAR): a randomised, phase 3 study.
The Lancet. Oncology.
Source: ORCID
Added: April 18, 2023
2021 journal article
Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.
The Lancet. Gastroenterology & Hepatology.
MeSH headings : Antineoplastic Agents / therapeutic use; Carcinoma, Hepatocellular / diagnosis; Carcinoma, Hepatocellular / drug therapy; Humans; Liver Neoplasms / diagnosis; Liver Neoplasms / drug therapy; Neoplasm Staging; Patient Reported Outcome Measures; Phenylurea Compounds / therapeutic use; Quinolines / therapeutic use; Sorafenib / therapeutic use; Treatment Outcome
Source: ORCID
Added: April 18, 2023
2021 journal article
Patients' satisfaction with long-acting injectable somatostatin analog therapy for neuroendocrine tumors.
Journal of Patient-Reported Outcomes.
Source: ORCID
Added: April 18, 2023
2017 journal article
Utilization and safety of onabotulinumtoxinA for the prophylactic treatment of chronic migraine from an observational study in Europe.
Cephalalgia : an International Journal of Headache.
MeSH headings : Acetylcholine Release Inhibitors / administration & dosage; Acetylcholine Release Inhibitors / adverse effects; Adult; Blepharoptosis / chemically induced; Botulinum Toxins, Type A / administration & dosage; Botulinum Toxins, Type A / adverse effects; Chronic Disease; Europe / epidemiology; Female; Humans; Injections, Intramuscular; Internationality; Male; Middle Aged; Migraine Disorders / diagnosis; Migraine Disorders / epidemiology; Migraine Disorders / prevention & control; Neck Pain / chemically induced; Pre-Exposure Prophylaxis / methods; Prospective Studies; Treatment Outcome
Source: ORCID
Added: April 18, 2023
2013 journal article
Health-related quality of life and disease symptoms in postmenopausal women with HR(+), HER2(-) advanced breast cancer treated with everolimus plus exemestane versus exemestane monotherapy.
Current Medical Research and Opinion.
MeSH headings : Adult; Aged; Androstadienes / adverse effects; Androstadienes / therapeutic use; Antineoplastic Agents / therapeutic use; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Breast Neoplasms / drug therapy; Breast Neoplasms / metabolism; Disease Progression; Disease-Free Survival; Everolimus; Female; Health Status; Humans; Immunosuppressive Agents / therapeutic use; Middle Aged; Placebos / therapeutic use; Quality of Life; Receptor, ErbB-2 / metabolism; Receptors, Estrogen / metabolism; Receptors, Progesterone / metabolism; Sirolimus / adverse effects; Sirolimus / analogs & derivatives; Sirolimus / therapeutic use; Surveys and Questionnaires; Treatment Outcome
Source: ORCID
Added: April 18, 2023
2013 journal article
Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3, randomized, controlled, BOLERO-2 trial.
Cancer.
MeSH headings : Adult; Aged; Androstadienes / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Aromatase Inhibitors / administration & dosage; Breast Neoplasms / drug therapy; Breast Neoplasms / pathology; Breast Neoplasms / psychology; Disease Progression; Double-Blind Method; Drug Administration Schedule; Everolimus; Female; Health Status; Humans; Middle Aged; Odds Ratio; Postmenopause; Proportional Hazards Models; Quality of Life; Sirolimus / administration & dosage; Sirolimus / analogs & derivatives; Surveys and Questionnaires; Treatment Outcome
Source: ORCID
Added: April 18, 2023
2011 journal article
Health-related quality of life in patients with metastatic colorectal cancer treated with panitumumab in first- or second-line treatment.
British Journal of Cancer.
MeSH headings : Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents / therapeutic use; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / pathology; Colorectal Neoplasms / physiopathology; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Panitumumab; Quality of Life
Source: ORCID
Added: April 18, 2023
2010 journal article
Health-related quality of life and colorectal cancer-specific symptoms in patients with chemotherapy-refractory metastatic disease treated with panitumumab.
International Journal of Colorectal Disease.
MeSH headings : Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents / therapeutic use; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; Drug Resistance, Neoplasm; Health; Humans; Least-Squares Analysis; Linear Models; Neoplasm Metastasis; Panitumumab; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins p21(ras); Quality of Life; ras Proteins / genetics
Source: ORCID
Added: April 18, 2023
2009 journal article
Help-seeking behavior of women with self-reported distressing sexual problems.
Journal of Women's Health (2002).
MeSH headings : Adolescent; Aged; Cross-Sectional Studies; Female; Gynecology; Health Surveys; Humans; Information Services; Middle Aged; Patient Acceptance of Health Care / statistics & numerical data; Patient Education as Topic; Primary Health Care; Sexual Dysfunction, Physiological / diagnosis; Sexual Dysfunction, Physiological / therapy; Stress, Psychological; United States; Young Adult
Source: ORCID
Added: April 18, 2023
2005 journal article
An assessment of patient preference and adherence to treatment with Wellbutrin SR: a web-based survey.
Journal of Affective Disorders.
MeSH headings : Adult; Aged; Antidepressive Agents, Second-Generation / administration & dosage; Antidepressive Agents, Second-Generation / adverse effects; Bupropion / administration & dosage; Bupropion / adverse effects; Delayed-Action Preparations; Depressive Disorder / drug therapy; Depressive Disorder / psychology; Drug Administration Schedule; Female; Health Surveys; Humans; Male; Middle Aged; Patient Compliance / psychology; Patient Satisfaction; Quality of Life / psychology
Source: ORCID
Added: April 18, 2023
2004 journal article
Exploration of low-dose estrogen effects: identification of No Observed Transcriptional Effect Level (NOTEL).
Toxicologic Pathology.
MeSH headings : Analysis of Variance; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Proliferation / drug effects; Dose-Response Relationship, Drug; Epithelial Cells / drug effects; Estrogens / genetics; Estrogens / toxicity; Female; Gene Expression Regulation, Neoplastic; Humans; No-Observed-Adverse-Effect Level; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic / drug effects
Source: ORCID
Added: April 18, 2023
2004 journal article
Identification of putative gene based markers of renal toxicity.
Environmental Health Perspectives.
MeSH headings : Animals; Anti-Bacterial Agents / toxicity; Antimetabolites, Antineoplastic / toxicity; Antineoplastic Agents / toxicity; Cisplatin / toxicity; Dose-Response Relationship, Drug; Endpoint Determination; Gene Expression Profiling; Genetic Markers; Gentamicins / toxicity; Kidney / drug effects; Kidney / pathology; Male; Oligonucleotide Array Sequence Analysis; Puromycin / toxicity; Rats; Rats, Sprague-Dawley
Source: ORCID
Added: April 18, 2023
2003 journal article
ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.
Radiation Research.
MeSH headings : Algorithms; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cells, Cultured; Cyclin E / metabolism; DNA Damage; DNA, Complementary / metabolism; DNA-Binding Proteins; Down-Regulation; Expressed Sequence Tags; Fibroblasts / metabolism; G1 Phase; G2 Phase; Gamma Rays; Gene Expression Regulation; Histones / metabolism; Humans; Models, Biological; Multigene Family; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Protein Serine-Threonine Kinases / biosynthesis; Protein Serine-Threonine Kinases / genetics; RNA / metabolism; Reverse Transcriptase Polymerase Chain Reaction; S Phase; Transcription Factors / metabolism; Transcription, Genetic; Tumor Suppressor Protein p53 / metabolism; Tumor Suppressor Proteins; Ultraviolet Rays; Up-Regulation
Source: ORCID
Added: April 18, 2023
2003 journal article
Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.
Carcinogenesis.
MeSH headings : Animals; Base Sequence; Carcinogens; DNA Primers; Gene Expression Regulation, Neoplastic / genetics; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Male; Mice; Oxazepam / toxicity; Polymerase Chain Reaction; Pyrimidines / toxicity
Source: ORCID
Added: April 18, 2023
2003 journal article
Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.
Molecular Carcinogenesis.
MeSH headings : Adult; Cells, Cultured; Cluster Analysis; Cyclin E; Cyclin-Dependent Kinases / drug effects; Cyclin-Dependent Kinases / metabolism; Cyclin-Dependent Kinases / radiation effects; DNA Damage / genetics; Dose-Response Relationship, Radiation; Enzyme Activation / drug effects; Enzyme Activation / radiation effects; Female; Fibroblasts / drug effects; Fibroblasts / radiation effects; G1 Phase / drug effects; G1 Phase / radiation effects; Gamma Rays / adverse effects; Gene Expression Profiling; Gene Expression Regulation / drug effects; Gene Expression Regulation / radiation effects; Genetic Variation; Humans; MAP Kinase Signaling System / radiation effects; Male; Oligonucleotide Array Sequence Analysis / methods; Oxidative Stress; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction / methods; S Phase / drug effects; S Phase / radiation effects; Ultraviolet Rays / adverse effects; tert-Butylhydroperoxide / pharmacology
Source: ORCID
Added: April 18, 2023
2002 journal article
Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure.
American Journal of Physiology. Heart and Circulatory Physiology.
MeSH headings : Adult; Aged; Antigens, Differentiation / genetics; Apoptosis / physiology; CASP8 and FADD-Like Apoptosis Regulating Protein; Cardiac Output, Low / genetics; Cardiac Output, Low / metabolism; Cardiac Output, Low / physiopathology; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / physiopathology; Carrier Proteins / genetics; Carrier Proteins / metabolism; DNA-Binding Proteins; Disease Progression; Female; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; NF-kappa B / metabolism; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phosphorylation; Proteins / genetics; Signal Transduction / physiology; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor-alpha / metabolism; bcl-Associated Death Protein
Source: ORCID
Added: April 18, 2023
2002 journal article
Computational selection of distinct class- and subclass-specific gene expression signatures.
Journal of Biomedical Informatics.
MeSH headings : Algorithms; Animals; Base Sequence; Cluster Analysis; DNA Mutational Analysis / methods; Feasibility Studies; Gene Expression Profiling / classification; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Liver / drug effects; Liver / metabolism; Models, Genetic; Models, Statistical; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis / methods; Pattern Recognition, Automated; Peroxisome Proliferators / pharmacology; Phenobarbital / pharmacology; RNA, Messenger / classification; RNA, Messenger / genetics; Rats; Reproducibility of Results; Sensitivity and Specificity; Sequence Alignment / methods; Sequence Analysis, DNA / methods
Source: ORCID
Added: April 18, 2023
2002 journal article
Gene expression analysis reveals chemical-specific profiles.
Toxicological Sciences : an Official Journal of the Society of Toxicology.
MeSH headings : Animals; Clofibrate / chemistry; Clofibrate / toxicity; Computational Biology; DNA, Complementary / analysis; Gemfibrozil / chemistry; Gemfibrozil / toxicity; Gene Expression; Gene Expression Profiling / classification; Gene Expression Profiling / methods; Genomics; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Peroxisome Proliferators / chemistry; Peroxisome Proliferators / toxicity; Phenobarbital / chemistry; Phenobarbital / toxicity; Pyrimidines / chemistry; Pyrimidines / toxicity; RNA, Messenger / analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship
Source: ORCID
Added: April 18, 2023
2002 journal article
Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells.
Neoplasia (New York, N.Y.).
MeSH headings : Blotting, Western; Cell Line; Cell Nucleus / metabolism; Cyclic AMP Response Element-Binding Protein / metabolism; Disease Progression; Endothelial Growth Factors / metabolism; Epithelium / pathology; Fas Ligand Protein; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I / biosynthesis; Insulin-Like Growth Factor I / genetics; Lymphokines / metabolism; Membrane Glycoproteins / metabolism; Models, Biological; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Urokinase-Type Plasminogen Activator / metabolism; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
Source: ORCID
Added: April 18, 2023
2002 journal article
Prediction of compound signature using high density gene expression profiling.
Toxicological Sciences : an Official Journal of the Society of Toxicology.
MeSH headings : Algorithms; Animals; Computational Biology; DNA, Complementary / analysis; Databases, Factual; Diethylhexyl Phthalate / toxicity; Discriminant Analysis; Dose-Response Relationship, Drug; Gene Expression Profiling / classification; Gene Expression Profiling / methods; Genomics; Hexobarbital / toxicity; Liver / drug effects; Liver / metabolism; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Phenytoin / toxicity; Predictive Value of Tests; Protein Biosynthesis; RNA, Messenger / analysis; Rats; Rats, Sprague-Dawley; Reference Standards; Single-Blind Method; Structure-Activity Relationship; Xenobiotics / chemistry; Xenobiotics / toxicity
Source: ORCID
Added: April 18, 2023
2001 journal article
Assessing gene significance from cDNA microarray expression data via mixed models
JOURNAL OF COMPUTATIONAL BIOLOGY, 8(6), 625–637.
co-author countries:
United States of America 🇺🇸
author keywords: ANOVA; cDNA microarray; gene expression; mixed models; statistical significance
MeSH headings : Computational Biology; Gene Expression Profiling / statistics & numerical data; Genes, Fungal; Humans; Lymphoma, B-Cell / genetics; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis / statistics & numerical data; Saccharomyces cerevisiae / genetics
Sources: ORCID, Web Of Science
Added: August 6, 2018
2001 journal article
MAPS: a microarray project system for gene expression experiment information and data validation.
Bioinformatics (Oxford, England).
MeSH headings : Computer Communication Networks; Data Display; Database Management Systems; Oligonucleotide Array Sequence Analysis / standards; Programming Languages
Source: ORCID
Added: April 18, 2023
2000 journal article
Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship.
Pharmaceutical Research.
MeSH headings : Administration, Oral; Biological Availability; Humans; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmacokinetics; Quantitative Structure-Activity Relationship
Source: ORCID
Added: April 18, 2023
Employment
Updated: August 15th, 2022 11:03
2014 - present
RTI Health Solutions Durham, North Carolina, US
Director, Biostatistics
2012 - 2014
SAS Institute Cary, NC, US
Analytical Training Consultant
2002 - 2012
RTI Health Solutions Durham, North Carolina, US
Senior Statistician
2000 - 2002
National Institute of Environmental Health Sciences Durham, North Carolina, US
Statistician/Bioinformatics Scientist
Education
Updated: August 15th, 2022 10:53
2022 - 2024
North Carolina State University Raleigh, North Carolina, US
Master of Science
Mathematics
2021 - 2022
North Carolina State University Raleigh, North Carolina, US
Graduate Certificate
Mathematics
2008 - 2013
University of North Carolina at Chapel Hill Chapel Hill, NC, US
Biostatistics
1996 - 1999
University of Georgia Athens, GA, US
Master of Science
Statistics
1989 - 1993
Georgia Institute of Technology Atlanta, GA, US
Bachelor of Science
Chemistry
