Works (25)

Updated: April 4th, 2024 02:19

2023 journal article

Health-Related Quality of Life Outcomes With Two Different Starting Doses of Lenvatinib in Combination With Everolimus for Previously Treated Renal Cell Carcinoma.

The Oncologist.

Contributors: L. Bennett*

MeSH headings : Humans; Carcinoma, Renal Cell / drug therapy; Carcinoma, Renal Cell / pathology; Everolimus / therapeutic use; Kidney Neoplasms / drug therapy; Kidney Neoplasms / pathology; Quality of Life; Vascular Endothelial Growth Factor A; Antineoplastic Agents / administration & dosage
TL;DR: People who received an 18 mg lenvatinib starting dose had favorable HRQOL scores and longer TTD on most scales compared with those who received a 14 mg starting dose, and differences between treatments did not exceed the minimally important thresholds. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2022 journal article

Health-related quality-of-life outcomes in patients with advanced renal cell carcinoma treated with lenvatinib plus pembrolizumab or everolimus versus sunitinib (CLEAR): a randomised, phase 3 study.

The Lancet. Oncology.

Contributors: L. Bennett*

TL;DR: The promising efficacy and safety results of lenvatinib plus pembrolizumab in the first-line setting are focused on, and the HRQOL results are concentrated on, on that combination versus sunitinib. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2021 journal article

Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.

The Lancet. Gastroenterology & Hepatology.

Contributors: L. Bennett*

MeSH headings : Antineoplastic Agents / therapeutic use; Carcinoma, Hepatocellular / diagnosis; Carcinoma, Hepatocellular / drug therapy; Humans; Liver Neoplasms / diagnosis; Liver Neoplasms / drug therapy; Neoplasm Staging; Patient Reported Outcome Measures; Phenylurea Compounds / therapeutic use; Quinolines / therapeutic use; Sorafenib / therapeutic use; Treatment Outcome
TL;DR: HRQOL for patients undergoing treatment for unresectable hepatocellular carcinoma generally favoured the lenvatinib over the sorafenib group, although the differences were not nominally statistically or clinically significant. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2021 journal article

Patients' satisfaction with long-acting injectable somatostatin analog therapy for neuroendocrine tumors.

Journal of Patient-Reported Outcomes.

Contributors: L. Bennett*

TL;DR: Satisfaction with LA SSA injections is high among patients in this population of patients with advanced neuroendocrine tumors, and specific experiences with LASSA injections varied based on the nursing staff administering the injection. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2017 journal article

Utilization and safety of onabotulinumtoxinA for the prophylactic treatment of chronic migraine from an observational study in Europe.

Cephalalgia : an International Journal of Headache.

Contributors: L. Bennett*

MeSH headings : Acetylcholine Release Inhibitors / administration & dosage; Acetylcholine Release Inhibitors / adverse effects; Adult; Blepharoptosis / chemically induced; Botulinum Toxins, Type A / administration & dosage; Botulinum Toxins, Type A / adverse effects; Chronic Disease; Europe / epidemiology; Female; Humans; Injections, Intramuscular; Internationality; Male; Middle Aged; Migraine Disorders / diagnosis; Migraine Disorders / epidemiology; Migraine Disorders / prevention & control; Neck Pain / chemically induced; Pre-Exposure Prophylaxis / methods; Prospective Studies; Treatment Outcome
TL;DR: Utilization of onabotulinumtoxinA treatment for chronic migraine appears to be consistent with the Summary of Product Characteristics and published PREEMPT injection paradigm, and patient demographics/characteristics are consistent with published data on the chronic migraine population. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2013 journal article

Health-related quality of life and disease symptoms in postmenopausal women with HR(+), HER2(-) advanced breast cancer treated with everolimus plus exemestane versus exemestane monotherapy.

Current Medical Research and Opinion.

Contributors: L. Bennett*

MeSH headings : Adult; Aged; Androstadienes / adverse effects; Androstadienes / therapeutic use; Antineoplastic Agents / therapeutic use; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Breast Neoplasms / drug therapy; Breast Neoplasms / metabolism; Disease Progression; Disease-Free Survival; Everolimus; Female; Health Status; Humans; Immunosuppressive Agents / therapeutic use; Middle Aged; Placebos / therapeutic use; Quality of Life; Receptor, ErbB-2 / metabolism; Receptors, Estrogen / metabolism; Receptors, Progesterone / metabolism; Sirolimus / adverse effects; Sirolimus / analogs & derivatives; Sirolimus / therapeutic use; Surveys and Questionnaires; Treatment Outcome
TL;DR: These analyses confirm that EVE’s+ EXE provides clinical benefit without adversely impacting HRQOL in patients with HR+ ABC who recurred/progressed on prior NSAIs versus endocrine therapy alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 18, 2023

2013 journal article

Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3, randomized, controlled, BOLERO-2 trial.

Cancer.

Contributors: L. Bennett*

MeSH headings : Adult; Aged; Androstadienes / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Aromatase Inhibitors / administration & dosage; Breast Neoplasms / drug therapy; Breast Neoplasms / pathology; Breast Neoplasms / psychology; Disease Progression; Double-Blind Method; Drug Administration Schedule; Everolimus; Female; Health Status; Humans; Middle Aged; Odds Ratio; Postmenopause; Proportional Hazards Models; Quality of Life; Sirolimus / administration & dosage; Sirolimus / analogs & derivatives; Surveys and Questionnaires; Treatment Outcome
TL;DR: This analysis investigated the treatment effects on health‐related quality of life (HRQOL) in patients with advanced breast cancer who developed disease progression after treatment with nonsteroidal aromatase inhibitors. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2011 journal article

Health-related quality of life in patients with metastatic colorectal cancer treated with panitumumab in first- or second-line treatment.

British Journal of Cancer.

Contributors: L. Bennett*

MeSH headings : Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents / therapeutic use; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / pathology; Colorectal Neoplasms / physiopathology; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Panitumumab; Quality of Life
TL;DR: The addition of panitumumab to FOLFOX4 or FOLFIRI in first- or second-line treatment of wild-type KRAS mCRC significantly improved progression-free survival without compromising HRQoL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 18, 2023

2010 journal article

Health-related quality of life and colorectal cancer-specific symptoms in patients with chemotherapy-refractory metastatic disease treated with panitumumab.

International Journal of Colorectal Disease.

Contributors: L. Bennett*

MeSH headings : Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents / therapeutic use; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; Drug Resistance, Neoplasm; Health; Humans; Least-Squares Analysis; Linear Models; Neoplasm Metastasis; Panitumumab; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins p21(ras); Quality of Life; ras Proteins / genetics
TL;DR: Panitumumab-treated patients with wild-type KRAS mCRC maintained better control of CRC symptoms and quality of life compared with BSC alone, extending the understanding of the benefits of panitumuab treatment beyond improvements in progression-free survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 18, 2023

2009 journal article

Help-seeking behavior of women with self-reported distressing sexual problems.

Journal of Women's Health (2002).

Contributors: L. Bennett*

MeSH headings : Adolescent; Aged; Cross-Sectional Studies; Female; Gynecology; Health Surveys; Humans; Information Services; Middle Aged; Patient Acceptance of Health Care / statistics & numerical data; Patient Education as Topic; Primary Health Care; Sexual Dysfunction, Physiological / diagnosis; Sexual Dysfunction, Physiological / therapy; Stress, Psychological; United States; Young Adult
TL;DR: The authors' results suggest inadequacies in the U.S. medical care system in addressing sexual problems in women by including discussions about sexual health during routine visits can increase the likelihood that adequate care can be offered. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2005 journal article

An assessment of patient preference and adherence to treatment with Wellbutrin SR: a web-based survey.

Journal of Affective Disorders.

Contributors: L. Bennett*

MeSH headings : Adult; Aged; Antidepressive Agents, Second-Generation / administration & dosage; Antidepressive Agents, Second-Generation / adverse effects; Bupropion / administration & dosage; Bupropion / adverse effects; Delayed-Action Preparations; Depressive Disorder / drug therapy; Depressive Disorder / psychology; Drug Administration Schedule; Female; Health Surveys; Humans; Male; Middle Aged; Patient Compliance / psychology; Patient Satisfaction; Quality of Life / psychology
TL;DR: The results of this study support the value of the recently released once-daily formulation, Wellbutrin XL, because greater adherence has been shown to facilitate symptom relief, improvements in quality of life, and reductions in healthcare expenses. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2004 journal article

Exploration of low-dose estrogen effects: identification of No Observed Transcriptional Effect Level (NOTEL).

Toxicologic Pathology.

Contributors: L. Bennett*

MeSH headings : Analysis of Variance; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Proliferation / drug effects; Dose-Response Relationship, Drug; Epithelial Cells / drug effects; Estrogens / genetics; Estrogens / toxicity; Female; Gene Expression Regulation, Neoplastic; Humans; No-Observed-Adverse-Effect Level; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic / drug effects
TL;DR: The utility of gene expression profiling is demonstrated as a means to identify concentrations that do not elicit a change in gene expression, or simply a No Observed Transcriptional Effect Level (NOTEL). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 18, 2023

2004 journal article

Identification of putative gene based markers of renal toxicity.

Environmental Health Perspectives.

Contributors: L. Bennett*

MeSH headings : Animals; Anti-Bacterial Agents / toxicity; Antimetabolites, Antineoplastic / toxicity; Antineoplastic Agents / toxicity; Cisplatin / toxicity; Dose-Response Relationship, Drug; Endpoint Determination; Gene Expression Profiling; Genetic Markers; Gentamicins / toxicity; Kidney / drug effects; Kidney / pathology; Male; Oligonucleotide Array Sequence Analysis; Puromycin / toxicity; Rats; Rats, Sprague-Dawley
TL;DR: It is concluded that renal gene expression profiling coupled with analysis of classical end points affords promising opportunities to reveal potential new mechanistic markers of renal toxicity. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2003 journal article

ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.

Radiation Research.

Contributors: L. Bennett*

MeSH headings : Algorithms; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cells, Cultured; Cyclin E / metabolism; DNA Damage; DNA, Complementary / metabolism; DNA-Binding Proteins; Down-Regulation; Expressed Sequence Tags; Fibroblasts / metabolism; G1 Phase; G2 Phase; Gamma Rays; Gene Expression Regulation; Histones / metabolism; Humans; Models, Biological; Multigene Family; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Protein Serine-Threonine Kinases / biosynthesis; Protein Serine-Threonine Kinases / genetics; RNA / metabolism; Reverse Transcriptase Polymerase Chain Reaction; S Phase; Transcription Factors / metabolism; Transcription, Genetic; Tumor Suppressor Protein p53 / metabolism; Tumor Suppressor Proteins; Ultraviolet Rays; Up-Regulation
TL;DR: Investigation of changes in gene expression in response to γ irradiation, oxidative stress, and UV irradiation focuses on the dependence on ATM, as well as novel indications of involvement of ATM in regulation of transcription factors such as SP1, AP1 and MTF1. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2003 journal article

Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure.

American Journal of Physiology. Heart and Circulatory Physiology.

Contributors: L. Bennett*

MeSH headings : Adult; Aged; Antigens, Differentiation / genetics; Apoptosis / physiology; CASP8 and FADD-Like Apoptosis Regulating Protein; Cardiac Output, Low / genetics; Cardiac Output, Low / metabolism; Cardiac Output, Low / physiopathology; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / physiopathology; Carrier Proteins / genetics; Carrier Proteins / metabolism; DNA-Binding Proteins; Disease Progression; Female; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; NF-kappa B / metabolism; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phosphorylation; Proteins / genetics; Signal Transduction / physiology; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor-alpha / metabolism; bcl-Associated Death Protein
TL;DR: DNA microarray profiling is used to investigate changes in the expression of genes involved in apoptosis that occur in human idiopathic dilated cardiomyopathic hearts that had progressed to heart failure and identifies several pathways that are altered in human heart failure that provides new targets for therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 18, 2023

2003 journal article

Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

Carcinogenesis.

Contributors: L. Bennett*

MeSH headings : Animals; Base Sequence; Carcinogens; DNA Primers; Gene Expression Regulation, Neoplastic / genetics; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Male; Mice; Oxazepam / toxicity; Polymerase Chain Reaction; Pyrimidines / toxicity
TL;DR: There appeared to be more distinct than common changes in the expression of carcinogenesis-related genes/proteins between the two compounds, suggesting that the major carcinogenic pathways are different for these compounds and may be distinct for different chemical classes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 18, 2023

2003 journal article

Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.

Molecular Carcinogenesis.

Contributors: L. Bennett*

MeSH headings : Adult; Cells, Cultured; Cluster Analysis; Cyclin E; Cyclin-Dependent Kinases / drug effects; Cyclin-Dependent Kinases / metabolism; Cyclin-Dependent Kinases / radiation effects; DNA Damage / genetics; Dose-Response Relationship, Radiation; Enzyme Activation / drug effects; Enzyme Activation / radiation effects; Female; Fibroblasts / drug effects; Fibroblasts / radiation effects; G1 Phase / drug effects; G1 Phase / radiation effects; Gamma Rays / adverse effects; Gene Expression Profiling; Gene Expression Regulation / drug effects; Gene Expression Regulation / radiation effects; Genetic Variation; Humans; MAP Kinase Signaling System / radiation effects; Male; Oligonucleotide Array Sequence Analysis / methods; Oxidative Stress; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction / methods; S Phase / drug effects; S Phase / radiation effects; Ultraviolet Rays / adverse effects; tert-Butylhydroperoxide / pharmacology
TL;DR: Interestingly, equivalent cyclin E–associated kinase activity reduction with all the three treatments was associated with greater transcriptional changes after UV radiation than after γ radiation and oxidative stress, and gene expression profiles in response to γ Radiation and oxidative Stress appeared to be more similar than profiles expressed afterUV radiation. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2003 journal article

Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells.

Molecular Cancer Research : MCR.

Contributors: L. Bennett

Source: ORCID
Added: April 18, 2023

2002 journal article

Computational selection of distinct class- and subclass-specific gene expression signatures.

Journal of Biomedical Informatics.

Contributors: L. Bennett*

MeSH headings : Algorithms; Animals; Base Sequence; Cluster Analysis; DNA Mutational Analysis / methods; Feasibility Studies; Gene Expression Profiling / classification; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Liver / drug effects; Liver / metabolism; Models, Genetic; Models, Statistical; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis / methods; Pattern Recognition, Automated; Peroxisome Proliferators / pharmacology; Phenobarbital / pharmacology; RNA, Messenger / classification; RNA, Messenger / genetics; Rats; Reproducibility of Results; Sensitivity and Specificity; Sequence Alignment / methods; Sequence Analysis, DNA / methods
TL;DR: A classification regimen is proposed comprised of analysis of replicate data, outlier diagnostics and gene selection procedures to utilize cDNA microarray data to categorize subclasses of samples exposed to pharmacologic agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: April 18, 2023

2002 journal article

Gene expression analysis reveals chemical-specific profiles.

Toxicological Sciences : an Official Journal of the Society of Toxicology.

Contributors: L. Bennett

MeSH headings : Animals; Clofibrate / chemistry; Clofibrate / toxicity; Computational Biology; DNA, Complementary / analysis; Gemfibrozil / chemistry; Gemfibrozil / toxicity; Gene Expression; Gene Expression Profiling / classification; Gene Expression Profiling / methods; Genomics; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Peroxisome Proliferators / chemistry; Peroxisome Proliferators / toxicity; Phenobarbital / chemistry; Phenobarbital / toxicity; Pyrimidines / chemistry; Pyrimidines / toxicity; RNA, Messenger / analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship
TL;DR: Patterns of gene expression corresponding to liver tissue derived from chemically exposed rats revealed similarity in gene expression profiles between animals treated with different agents from a common class of compounds, but a very distinct gene expression profile was produced using a compound from another class, enzyme inducers (phenobarbital). (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2002 journal article

Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells.

Neoplasia (New York, N.Y.).

Contributors: L. Bennett*

MeSH headings : Blotting, Western; Cell Line; Cell Nucleus / metabolism; Cyclic AMP Response Element-Binding Protein / metabolism; Disease Progression; Endothelial Growth Factors / metabolism; Epithelium / pathology; Fas Ligand Protein; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I / biosynthesis; Insulin-Like Growth Factor I / genetics; Lymphokines / metabolism; Membrane Glycoproteins / metabolism; Models, Biological; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Urokinase-Type Plasminogen Activator / metabolism; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
TL;DR: In summary, IGF-1 inscribes a gene expression profile relevant to cancer progression, and this study provides insight into the mechanism(s) whereby some of these changes occur. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2002 journal article

Prediction of compound signature using high density gene expression profiling.

Toxicological Sciences : an Official Journal of the Society of Toxicology.

Contributors: L. Bennett

MeSH headings : Algorithms; Animals; Computational Biology; DNA, Complementary / analysis; Databases, Factual; Diethylhexyl Phthalate / toxicity; Discriminant Analysis; Dose-Response Relationship, Drug; Gene Expression Profiling / classification; Gene Expression Profiling / methods; Genomics; Hexobarbital / toxicity; Liver / drug effects; Liver / metabolism; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Phenytoin / toxicity; Predictive Value of Tests; Protein Biosynthesis; RNA, Messenger / analysis; Rats; Rats, Sprague-Dawley; Reference Standards; Single-Blind Method; Structure-Activity Relationship; Xenobiotics / chemistry; Xenobiotics / toxicity
TL;DR: Test the hypothesis that knowledge can be gained regarding the nature of blinded samples, using an initial training set comprised of gene expression profiles derived from rat liver exposed to clofibrate, Wyeth 14,643, gemfibrozil, or phenobarbital for 24 h or 2 weeks of exposure and lends credibility to the concept that the further development of a gene expression database for chemical effects will greatly enhance the hazard identification processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: April 18, 2023

2001 journal article

Assessing gene significance from cDNA microarray expression data via mixed models

JOURNAL OF COMPUTATIONAL BIOLOGY, 8(6), 625–637.

By: R. Wolfinger*, G. Gibson n, E. Wolfinger*, L. Bennett*, H. Hamadeh*, P. Bushel*, C. Afshari*, R. Paules*

Contributors: L. Bennett*

author keywords: ANOVA; cDNA microarray; gene expression; mixed models; statistical significance
MeSH headings : Computational Biology; Gene Expression Profiling / statistics & numerical data; Genes, Fungal; Humans; Lymphoma, B-Cell / genetics; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis / statistics & numerical data; Saccharomyces cerevisiae / genetics
TL;DR: A statistical approach is presented that allows direct control over the percentage of false positives in such a list of differentially expressed genes and, under certain reasonable assumptions, improves on existing methods with respect to the percentages of false negatives. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: August 6, 2018

2001 journal article

MAPS: a microarray project system for gene expression experiment information and data validation.

Bioinformatics (Oxford, England).

Contributors: L. Bennett*

MeSH headings : Computer Communication Networks; Data Display; Database Management Systems; Oligonucleotide Array Sequence Analysis / standards; Programming Languages
TL;DR: Microarray project information is organized to track experiments and results that are validated by performing analysis on stored replicate gene expression data and queried according to the biological classifications of genes deposited on microarray chips. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

2000 journal article

Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship.

Pharmaceutical Research.

Contributors: L. Bennett*

MeSH headings : Administration, Oral; Biological Availability; Humans; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmacokinetics; Quantitative Structure-Activity Relationship
TL;DR: A novel quantitative structure-bioavailability relationship (QSBR) model was developed that was reasonably predictive and stood up to cross-validation and when compared to Lipinski's Rule of Five, was able to reduce false positive predictions. (via Semantic Scholar)
Source: ORCID
Added: April 18, 2023

Employment

Updated: August 15th, 2022 11:03

2014 - present

RTI Health Solutions Durham, North Carolina, US
Director, Biostatistics

2012 - 2014

SAS Institute Cary, NC, US
Analytical Training Consultant

2002 - 2012

RTI Health Solutions Durham, North Carolina, US
Senior Statistician

2000 - 2002

National Institute of Environmental Health Sciences Durham, North Carolina, US
Statistician/Bioinformatics Scientist

Education

Updated: August 15th, 2022 10:53

2021 - 2022

North Carolina State University Raleigh, North Carolina, US
Graduate Certificate Mathematics

2008 - 2013

University of North Carolina at Chapel Hill Chapel Hill, NC, US
Biostatistics

1996 - 1999

University of Georgia Athens, GA, US
Master of Science Statistics

1989 - 1993

Georgia Institute of Technology Atlanta, GA, US
Bachelor of Science Chemistry

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.