Works (63)

Updated: March 1st, 2024 18:38

2024 journal article

Enhancing ferryl accumulation in H2O2-dependent cytochrome P450s

JOURNAL OF INORGANIC BIOCHEMISTRY, 252.

By: J. Amaya*, O. Manley n, J. Bian*, C. Rutland*, N. Leschinsky*, S. Ratigan*, T. Makris n

co-author countries: United States of America 🇺🇸
author keywords: Cytochrome P450; Compound I; Ferryl; CYP152; Peroxygenase
Sources: Web Of Science, ORCID
Added: February 12, 2024

2023 journal article

A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 8.

By: H. Gering n, X. Li n, H. Tang n, P. Swartz n, W. Chang n & T. Makris n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: September 11, 2023

2023 journal article

Dimer-assisted mechanism of (un)saturated fatty acid decarboxylation for alkene production

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(22).

By: L. Rade*, W. Generoso*, S. Das n, A. Souza*, R. Silveira*, M. Avila*, P. Vieira*, R. Miyamoto* ...

co-author countries: Brazil 🇧🇷 United States of America 🇺🇸
author keywords: CYP152 peroxygenase; decarboxylation activity; molecular mechanism; alkene production; renewable hydrocarbons
MeSH headings : Fatty Acids / metabolism; Alkenes / chemistry; Decarboxylation; Cytochrome P-450 Enzyme System / metabolism; Oxidation-Reduction
Sources: Web Of Science, ORCID
Added: August 7, 2023

2023 journal article

Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

BIOCHEMISTRY, 62(22), 3276–3282.

By: H. Phan n, O. Manley n, S. Skirboll n, L. Cha n, D. Hilovsky n, W. Chang n, P. Thompson n, X. Liu n, T. Makris n

co-author countries: United States of America 🇺🇸
Sources: ORCID, Web Of Science
Added: December 12, 2023

2023 article

Room-Temperature Aerobic C-CN Bond Activation in Nickel(II) Cyanomethyl Dicarboranyl Complex

Islam, M. J., Park, K. C., Manley, O. M. M., Smith, M. D. D., Makris, T. M. M., & Peryshkov, D. V. V. (2023, July 12). ORGANOMETALLICS, Vol. 7.

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: July 24, 2023

2022 journal article

Experimental and Theoretical Examination of the Kinetic Isotope Effect in Cytochrome P450 Decarboxylase OleT

JOURNAL OF PHYSICAL CHEMISTRY B, 126(19), 3493–3504.

co-author countries: United States of America 🇺🇸
MeSH headings : Carboxy-Lyases / metabolism; Cytochrome P-450 Enzyme System / chemistry; Fatty Acids / chemistry; Hydrogen / chemistry; Isotopes; Kinetics
Sources: Web Of Science, ORCID
Added: June 13, 2022

2022 journal article

Modeling the Ligand Effect on the Structure of CYP 450 Within the Density Functional Theory

JOURNAL OF PHYSICAL CHEMISTRY A, 126(18), 2818–2824.

co-author countries: United States of America 🇺🇸
MeSH headings : Cysteine / chemistry; Density Functional Theory; Heme / chemistry; Iron / chemistry; Ligands
Sources: Web Of Science, ORCID
Added: June 6, 2022

2022 journal article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).

By: O. Manley n, H. Phan n, A. Stewart n, D. Mosley n, S. Xue*, L. Cha n, H. Bai n, V. Lightfoot* ...

co-author countries: United States of America 🇺🇸

Contributors: T. Williams n

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
Sources: Web Of Science, ORCID
Added: September 21, 2022

2022 journal article

Stimuli-Modulated Metal Oxidation States in Photochromic MOFs

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144(10), 4457–4468.

By: C. Martin*, K. Park*, G. Leith*, J. Yu*, A. Mathur*, G. Wilson*, G. Gange*, E. Barth* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Metal-Organic Frameworks / chemistry; Metals; Oxidation-Reduction
Sources: Web Of Science, ORCID
Added: April 18, 2022

2022 journal article

Structural and functional characterization of beta-cyanoalanine synthase from Tetranychus urticae

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 142.

By: L. Daneshian*, I. Renggli*, R. Hanaway*, L. Offermann*, C. Schlachter*, S. Henry*, R. Prakash*, N. Wybouw* ...

co-author countries: Belgium 🇧🇪 Canada 🇨🇦 Spain 🇪🇸 United States of America 🇺🇸
author keywords: beta-cyanoalanine synthase; Cyanide detoxification; Cyanoalanine; Herbivory; Spider mite
MeSH headings : Animals; Cyanides / metabolism; Cysteine; Lyases / chemistry; Lyases / genetics; Lyases / metabolism; Plants / metabolism; Tetranychidae / metabolism
Sources: Web Of Science, ORCID
Added: May 2, 2022

2021 article

BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate

Manley, O. M., Tang, H., Xue, S., Guo, Y., Chang, W.-chen, & Makris, T. M. (2021, December 13). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12.

By: O. Manley n, H. Tang n, S. Xue*, Y. Guo*, W. Chang n & T. Makris n

co-author countries: United States of America 🇺🇸
MeSH headings : Carbon / chemistry; Carbon / metabolism; Ferric Compounds / chemistry; Oxidoreductases / metabolism; Oxygen / chemistry; Spectroscopy, Mossbauer; Streptomyces / enzymology; Substrate Specificity
Sources: Web Of Science, ORCID
Added: January 3, 2022

2020 journal article

Direct Identification of Mixed-Metal Centers in Metal-Organic Frameworks: Cu3(BTC)2Transmetalated with Rh2+Ions

Journal of Physical Chemistry Letters, 11(19), 8138–8144.

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: December 12, 2023

2020 journal article

Enhanced P450 fatty acid decarboxylase catalysis by glucose oxidase coupling and co-assembly for biofuel generation

Bioresource Technology, 311.

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: L. Zhang*, O. Manley*, D. Ma*, Y. Yin*, T. Makris* & Q. Wang*

Source: ORCID
Added: December 12, 2023

2020 journal article

Microfluidic-assisted polymer-protein assembly to fabricate homogeneous functionalnanoparticles

Materials Science and Engineering C, 111.

By: L. Zhang*, A. Beatty*, L. Lu*, A. Abdalrahman*, T. Makris*, G. Wang*, Q. Wang*

co-author countries: United States of America 🇺🇸

Contributors: L. Zhang*, A. Beatty*, L. Lu*, A. Abdalrahman*, T. Makris*, G. Wang*, Q. Wang*

Source: ORCID
Added: December 12, 2023

2019 chapter

CHAPTER 6: Cytochrome P450 Decarboxylases

In RSC Metallobiology: Vol. 2019-January (pp. 127–143).

By: T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: T. Makris*

Source: ORCID
Added: December 12, 2023

2019 journal article

Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues

Journal of Biological Chemistry, 294(33), 12444–12458.

By: M. Blahut*, C. Wise*, M. Bruno*, G. Dong*, T. Makris*, P. Frantom*, J. Dunkle*, F. Outten*

co-author countries: United States of America 🇺🇸

Contributors: M. Blahut*, C. Wise*, M. Bruno*, G. Dong*, T. Makris*, P. Frantom*, J. Dunkle*, F. Outten*

Source: ORCID
Added: December 12, 2023

2019 journal article

Oxidative Decarboxylase UndA Utilizes a Dinuclear Iron Cofactor

Journal of the American Chemical Society, 141(22), 8684–8688.

By: O. Manley*, R. Fan*, Y. Guo* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: O. Manley*, R. Fan*, Y. Guo* & T. Makris*

Source: ORCID
Added: December 12, 2023

2019 journal article

Plasmin-Cleavable Nanoparticles for On-Demand Release of Morphogens in Vascularized Osteogenesis

Biomacromolecules, 20(8), 2973–2988.

By: S. Kader*, M. Monavarian*, D. Barati*, S. Moeinzadeh*, T. Makris* & E. Jabbari*

co-author countries: Iraq 🇮🇶 United States of America 🇺🇸

Contributors: S. Kader*, M. Monavarian*, D. Barati*, S. Moeinzadeh*, T. Makris* & E. Jabbari*

Source: ORCID
Added: December 12, 2023

2019 journal article

Structural and functional characterization of an intradiol ring-cleavage dioxygenase from the polyphagous spider mite herbivore Tetranychus urticae Koch

Insect Biochemistry and Molecular Biology, 107, 19–30.

By: C. Schlachter*, L. Daneshian*, J. Amaya*, V. Klapper*, N. Wybouw*, T. Borowski*, T. Leeuwen*, V. Grbic* ...

co-author countries: Belgium 🇧🇪 Canada 🇨🇦 Spain 🇪🇸 Netherlands 🇳🇱 Poland 🇵🇱 United States of America 🇺🇸

Contributors: C. Schlachter*, L. Daneshian*, J. Amaya*, V. Klapper*, N. Wybouw*, T. Borowski*, T. Van Leeuwen*, V. Grbic* ...

Source: ORCID
Added: December 12, 2023

2019 journal article

The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

ACS Chemical Biology, 14(12), 2932–2941.

By: M. Kaniusaite*, R. Goode*, R. Schittenhelm*, T. Makris* & M. Cryle*

co-author countries: Australia 🇦🇺 United States of America 🇺🇸

Contributors: M. Kaniusaite*, R. Goode*, R. Schittenhelm*, T. Makris* & M. Cryle*

Source: ORCID
Added: December 12, 2023

2018 journal article

A Distal Loop Controls Product Release and Chemo- and Regioselectivity in Cytochrome P450 Decarboxylases

Biochemistry, 57(3), 344–353.

By: J. Amaya*, C. Rutland*, N. Leschinsky* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: J. Amaya*, C. Rutland*, N. Leschinsky* & T. Makris*

Source: ORCID
Added: December 12, 2023

2018 journal article

Catalytic N−H Bond Activation and Breaking by a Well-Defined CoII1O4 Site of a Heterogeneous Catalyst

ChemCatChem, 10(4), 736–742.

By: K. Khivantsev*, A. Biancardi*, M. Fathizadeh*, F. Almalki*, J. Grant*, H. Tien*, A. Shakouri*, D. Blom* ...

co-author countries: United States of America 🇺🇸

Contributors: K. Khivantsev*, A. Biancardi*, M. Fathizadeh*, F. Almalki*, J. Grant*, H. Tien*, A. Shakouri*, D. Blom* ...

Source: ORCID
Added: December 12, 2023

2018 journal article

Dioxygen Activation by the Biofuel-Generating Cytochrome P450 OleT

ACS Catalysis, 8(10), 9342–9352.

By: C. Wise*, C. Hsieh*, N. Poplin* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: C. Wise*, C. Hsieh*, N. Poplin* & T. Makris*

Source: ORCID
Added: December 12, 2023

2018 journal article

Enhanced Arylamine N -Oxygenase Activity of Polymer-Enzyme Assemblies by Facilitating Electron-Transferring Efficiency

Biomacromolecules, 19(3), 918–925.

By: L. Zhang*, Y. Xu*, T. Makris* & Q. Wang*

co-author countries: United States of America 🇺🇸

Contributors: L. Zhang*, Y. Xu*, T. Makris* & Q. Wang*

Source: ORCID
Added: December 12, 2023

2018 journal article

On the Structure and Reaction Mechanism of Human Acireductone Dioxygenase

Chemistry - A European Journal, 24(20), 5225–5237.

By: A. Mi?aczewska, E. Kot*, J. Amaya*, T. Makris*, M. Zaj?c, J. Korecki*, A. Chumakov*, B. Trzewik* ...

co-author countries: France 🇫🇷 Poland 🇵🇱 United States of America 🇺🇸

Contributors: A. Miłaczewska*, E. Kot*, J. Amaya*, T. Makris*, M. Zając*, J. Korecki*, A. Chumakov*, B. Trzewik* ...

Source: ORCID
Added: December 12, 2023

2018 journal article

Structure and function of the cytochrome P450 peroxygenase enzymes

Biochemical Society Transactions, 46(1), 183–196.

By: A. Munro*, K. McLean*, J. Grant* & T. Makris*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸

Contributors: A. Munro*, K. McLean*, J. Grant* & T. Makris*

Source: ORCID
Added: December 12, 2023

2017 journal article

Activation of C-H Bonds of Alkyl- and Arylnitriles by the TaCl5-PPh3 Lewis Pair

Inorganic Chemistry, 56(19), 11798–11803.

By: M. Rahman*, M. Smith*, J. Amaya*, T. Makris* & D. Peryshkov*

co-author countries: United States of America 🇺🇸

Contributors: M. Rahman*, M. Smith*, J. Amaya*, T. Makris* & D. Peryshkov*

Source: ORCID
Added: December 12, 2023

2017 journal article

Divergent mechanisms of iron-containing enzymes for hydrocarbon biosynthesis

Journal of Biological Inorganic Chemistry, 22(2-3), 221–235.

By: C. Wise*, J. Grant*, J. Amaya*, S. Ratigan*, C. Hsieh*, O. Manley*, T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: C. Wise*, J. Grant*, J. Amaya*, S. Ratigan*, C. Hsieh*, O. Manley*, T. Makris*

Source: ORCID
Added: December 12, 2023

2017 journal article

Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy

Chemistry - A European Journal, 23(34), 8315–8319.

By: B. DeHaven*, J. Tokarski*, A. Korous*, F. Mentink‐Vigier*, T. Makris*, A. Brugh*, M. Forbes*, J. Tol*, C. Bowers*, L. Shimizu*

co-author countries: United States of America 🇺🇸

Contributors: B. DeHaven*, J. Tokarski*, A. Korous*, F. Mentink-Vigier*, T. Makris*, A. Brugh*, M. Forbes*, J. Tol*, C. Bowers*, L. Shimizu*

Source: ORCID
Added: December 12, 2023

2017 journal article

Recruitment and Regulation of the Non-ribosomal Peptide Synthetase Modifying Cytochrome P450 Involved in Nikkomycin Biosynthesis

ACS Chemical Biology, 12(5), 1316–1326.

By: C. Wise* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: C. Wise* & T. Makris*

Source: ORCID
Added: December 12, 2023

2017 journal article

The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved to Frustrate, Oxygen Rebound Chemistry

Biochemistry, 56(26), 3347–3357.

By: C. Hsieh*, X. Huang*, J. Amaya*, C. Rutland*, C. Keys*, J. Groves*, R. Austin*, T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: C. Hsieh*, X. Huang*, J. Amaya*, C. Rutland*, C. Keys*, J. Groves*, R. Austin*, T. Makris*

Source: ORCID
Added: December 12, 2023

2016 journal article

Catalytic strategy for carbon-carbon bond scission by the cytochrome p450 olet

Proceedings of the National Academy of Sciences of the United States of America, 113(36), 10049–10054.

By: J. Grant*, M. Mitchell* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: J. Grant*, M. Mitchell* & T. Makris*

Source: ORCID
Added: December 12, 2023

2016 journal article

Expanding the substrate scope and reactivity of cytochrome P450 OleT

Biochemical and Biophysical Research Communications, 476(4), 462–466.

By: C. Hsieh* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: C. Hsieh* & T. Makris*

Source: ORCID
Added: December 12, 2023

2016 journal article

Mixed regiospecificity compromises alkene synthesis by a cytochrome P450 peroxygenase from Methylobacterium populi

Journal of Inorganic Biochemistry, 158, 11–16.

By: J. Amaya*, C. Rutland* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: J. Amaya*, C. Rutland* & T. Makris*

Source: ORCID
Added: December 12, 2023

2015 journal article

An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway

Journal of the American Chemical Society, 137(4), 1608–1617.

By: T. Makris*, V. Vu, K. Meier*, A. Komor, B. Rivard, E. Münck*, L. Que, J. Lipscomb

co-author countries: United States of America 🇺🇸

Contributors: T. Makris*, V. Vu, K. Meier*, A. Komor, B. Rivard, E. Münck*, L. Que, J. Lipscomb

Source: ORCID
Added: December 12, 2023

2015 journal article

Decarboxylation of fatty acids to terminal alkenes by cytochrome P450 compound i

Journal of the American Chemical Society, 137(15), 4940–4943.

By: J. Grant*, C. Hsieh* & T. Makris*

co-author countries: United States of America 🇺🇸

Contributors: J. Grant*, C. Hsieh* & T. Makris*

Source: ORCID
Added: December 12, 2023

2015 journal article

Synthesis, characterization, and properties of reduced europium molybdates and tungstates

Journal of Solid State Chemistry, 229, 173–180.

By: D. Abeysinghe*, B. Gerke*, G. Morrison*, C. Hsieh*, M. Smith*, R. Pöttgen*, T. Makris*, H. Loye*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸

Contributors: D. Abeysinghe*, B. Gerke*, G. Morrison*, C. Hsieh*, M. Smith*, R. Pöttgen*, T. Makris*, H. Zur Loye*

Source: ORCID
Added: December 12, 2023

2014 journal article

Catalase (KatA) Plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa

PLoS ONE, 9(3).

Contributors: S. Su*, W. Panmanee*, J. Wilson*, H. Mahtani*, Q. Li*, B. VanderWielen*, T. Makris*, M. Rogers* ...

Source: ORCID
Added: December 12, 2023

2013 journal article

Cyanobacterial aldehyde deformylase oxygenation of aldehydes yields n - 1 aldehydes and alcohols in addition to alkanes

ACS Catalysis, 3(10), 2228–2238.

By: K. Aukema*, T. Makris*, S. Stoian*, J. Richman*, E. Münck*, J. Lipscomb*, L. Wackett*

co-author countries: United States of America 🇺🇸

Contributors: K. Aukema*, T. Makris*, S. Stoian*, J. Richman*, E. Münck*, J. Lipscomb*, L. Wackett*

Source: ORCID
Added: December 12, 2023

2013 journal article

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Biochemistry, 52(38), 6662–6671.

co-author countries: United States of America 🇺🇸

Contributors: T. Makris*, C. Knoot*, C. Wilmot* & J. Lipscomb*

Source: ORCID
Added: December 12, 2023

2012 journal article

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Journal of Biological Chemistry, 287(10), 7357–7365.

By: J. Thompson*, A. Salahudeen*, S. Chollangi*, J. Ruiz*, C. Brautigam*, T. Makris*, J. Lipscomb*, D. Tomchick*, R. Bruick*

co-author countries: United States of America 🇺🇸

Contributors: J. Thompson*, A. Salahudeen*, S. Chollangi*, J. Ruiz*, C. Brautigam*, T. Makris*, J. Lipscomb*, D. Tomchick*, R. Bruick*

Source: ORCID
Added: December 12, 2023

2011 journal article

Active-site structure of a β-hydroxylase in antibiotic biosynthesis

Journal of the American Chemical Society, 133(18), 6938–6941.

Contributors: V. Vu*, T. Makris*, J. Lipscomb* & L. Que Jr.

Source: ORCID
Added: December 12, 2023

2011 article

Dinuclear Iron Cluster-Containing Oxygenase CmlA

Encyclopedia of Inorganic and Bioinorganic Chemistry.

By: C. Knoot*, T. Makris* & J. Lipscomb*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: December 12, 2023

2010 journal article

A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

Proceedings of the National Academy of Sciences of the United States of America, 107(35), 15391–15396.

By: T. Makris*, M. Chakrabarti*, E. Münck* & J. Lipscomb*

co-author countries: United States of America 🇺🇸

Contributors: T. Makris*, M. Chakrabarti*, E. Münck* & J. Lipscomb*

Source: ORCID
Added: December 12, 2023

2008 journal article

Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450

Journal of Physical Chemistry A, 112(50), 13172–13179.

By: I. Denisov*, P. Mak*, T. Makris*, S. Sligar* & J. Kincaid*

co-author countries: United States of America 🇺🇸

Contributors: I. Denisov*, P. Mak*, T. Makris*, S. Sligar* & J. Kincaid*

Source: ORCID
Added: December 12, 2023

2007 journal article

Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry

Biochemistry, 46(49), 14129–14140.

By: T. Makris*, K. Von Koenig*, I. Schlichting* & S. Sligar*

co-author countries: United States of America 🇺🇸

Contributors: T. Makris*, K. Von Koenig*, I. Schlichting* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2007 journal article

Resonance Raman detection of the hydroperoxo intermediate in the cytochrome P450 enzymatic cycle

Journal of the American Chemical Society, 129(20), 6382–6383.

By: P. Mak*, I. Denisov*, D. Victoria*, T. Makris*, T. Deng*, S. Sligar*, J. Kincaid*

co-author countries: United States of America 🇺🇸

Contributors: P. Mak*, I. Denisov*, D. Victoria*, T. Makris*, T. Deng*, S. Sligar*, J. Kincaid*

Source: ORCID
Added: December 12, 2023

2006 journal article

Cytochrome P450 compound I

Journal of the American Chemical Society, 128(14), 4580–4581.

By: M. Newcomb*, R. Zhang*, R. Chandrasena*, J. Halgrimson*, J. Horner*, T. Makris*, S. Sligar*

co-author countries: United States of America 🇺🇸

Contributors: M. Newcomb*, R. Zhang*, R. Chandrasena*, J. Halgrimson*, J. Horner*, T. Makris*, S. Sligar*

Source: ORCID
Added: December 12, 2023

2006 journal article

The status of high-valent metal oxo complexes in the P450 cytochromes

Journal of Inorganic Biochemistry, 100(4), 507–518.

By: T. Makris*, K. Koenig*, I. Schlichting* & S. Sligar*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸

Contributors: T. Makris*, K. Koenig*, I. Schlichting* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2005 journal article

A retinoic acid binding cytochrome P450: CYP120A1 from Synechocystis sp. PCC 6803

Archives of Biochemistry and Biophysics, 436(1), 110–120.

By: N. Ke*, J. Baudry*, T. Makris*, M. Schuler* & S. Sligar*

co-author countries: United States of America 🇺🇸

Contributors: N. Ke*, J. Baudry*, T. Makris*, M. Schuler* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2005 book

Activation of molecular oxygen by cytochrome P450

In Cytochrome P450: Structure, Mechanism, and Biochemistry: Third edition (pp. 149–182).

By: T. Makris*, I. Denisov*, I. Schlichting* & S. Sligar*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸

Contributors: T. Makris*, I. Denisov*, I. Schlichting* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2005 journal article

Structure and chemistry of cytochrome P450

Chemical Reviews, 105(6), 2253–2277.

By: I. Denisov*, T. Makris*, S. Sligar* & I. Schlichting*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸

Contributors: I. Denisov*, T. Makris*, S. Sligar* & I. Schlichting*

Source: ORCID
Added: December 12, 2023

2005 journal article

The influence of substrate on the spectral properties of oxyferrous wild-type and T252A cytochrome P450-CAM

Archives of Biochemistry and Biophysics, 436(1), 40–49.

By: M. Sono*, R. Perera*, S. Jin*, T. Makris*, S. Sligar*, T. Bryson*, J. Dawson*

co-author countries: United States of America 🇺🇸

Contributors: M. Sono*, R. Perera*, S. Jin*, T. Makris*, S. Sligar*, T. Bryson*, J. Dawson*

Source: ORCID
Added: December 12, 2023

2005 journal article

Thirty years of microbial P450 monooxygenase research: Peroxo-heme intermediates - The central bus station in heme oxygenase catalysis

Biochemical and Biophysical Research Communications, 338(1), 346–354.

By: S. Sligar*, T. Makris* & I. Denisov*

co-author countries: United States of America 🇺🇸

Contributors: S. Sligar*, T. Makris* & I. Denisov*

Source: ORCID
Added: December 12, 2023

2003 journal article

Epoxidation of olefins by hydroperoxo-ferric cytochrome P450

Journal of the American Chemical Society, 125(12), 3406–3407.

By: S. Jin*, T. Makris*, T. Bryson*, S. Sligar* & J. Dawson*

co-author countries: United States of America 🇺🇸

Contributors: S. Jin*, T. Makris*, T. Bryson*, S. Sligar* & J. Dawson*

Source: ORCID
Added: December 12, 2023

2003 journal article

Haem-oxygen reactive intermediates: Catalysis by the two-step

Biochemical Society Transactions, 31(3), 516–519.

By: T. Makris*, I. Denisov* & S. Sligar*

co-author countries: United States of America 🇺🇸

Contributors: T. Makris*, I. Denisov* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2003 journal article

Resonance Raman Spectroscopic Studies of Hydroperoxo-Myoglobin at Cryogenic Temperatures

Journal of the American Chemical Society, 125(45), 13714–13718.

By: M. Ibrahim*, I. Denisov*, T. Makris*, J. Kincaid* & S. Sligar*

co-author countries: United States of America 🇺🇸

Contributors: M. Ibrahim*, I. Denisov*, T. Makris*, J. Kincaid* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2002 article

Cryoradiolysis for the study of P450 reaction intermediates

Cytochrome P450 Part C, Vol. 357, pp. 103–115.

By: I. Denisov, T. Makris* & S. Sugar

Contributors: I. Denisov, T. Makris* & S. Sligar

Source: ORCID
Added: December 12, 2023

2002 journal article

Formation and decay of hydroperoxo-ferric heme complex in horseradish peroxidase studied by cryoradiolysis

Journal of Biological Chemistry, 277(45), 42706–42710.

By: I. Denisov*, T. Makris* & S. Sligar*

co-author countries: Russian Federation 🇷🇺 United States of America 🇺🇸

Contributors: I. Denisov*, T. Makris* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2002 journal article

Mechanistic enzymology of oxygen activation by the cytochromes P450

Drug Metabolism Reviews, 34(4), 691–708.

By: T. Makris*, R. Davydov*, I. Denisov*, B. Hoffman* & S. Sligar*

co-author countries: United States of America 🇺🇸

Contributors: T. Makris*, R. Davydov*, I. Denisov*, B. Hoffman* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2001 journal article

Cryotrapped Reaction Intermediates of Cytochrome P450 Studied by Radiolytic Reduction with Phosphorus-32

Journal of Biological Chemistry, 276(15), 11648–11652.

By: I. Denisov*, T. Makris* & S. Sligar*

co-author countries: United States of America 🇺🇸

Contributors: I. Denisov*, T. Makris* & S. Sligar*

Source: ORCID
Added: December 12, 2023

2001 journal article

Hydroxylation of camphor by reduced oxy-cytochrome p450cam: Mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes

Journal of the American Chemical Society, 123(7), 1403–1415.

By: R. Davydov*, T. Makris*, V. Kofman*, D. Werst*, S. Sligar* & B. Hoffman*

co-author countries: United States of America 🇺🇸

Contributors: R. Davydov*, T. Makris*, V. Kofman*, D. Werst*, S. Sligar* & B. Hoffman*

Source: ORCID
Added: December 12, 2023

1999 journal article

EPR and ENDOR of catalytic intermediates in cryoreduced native and mutant oxy-cytochromes P450cam: Mutation-induced changes in the proton delivery system [15]

Journal of the American Chemical Society, 121(45), 10654–10655.

By: R. Davydov*, I. Macdonald*, T. Makris*, S. Sugar & B. Hoffman*

co-author countries: United States of America 🇺🇸

Contributors: R. Davydov*, I. Macdonald*, T. Makris*, S. Sugar & B. Hoffman*

Source: ORCID
Added: December 12, 2023

Employment

Updated: October 27th, 2021 08:06

2020 - present

North Carolina State University Raleigh, North Carolina, US
Associate Professor Molecular and Structural Biochemistry

2012 - 2020

University of South Carolina Columbia, SC, US
Assistant Professor Chemistry and Biochemistry

Education

Updated: January 17th, 2015 12:13

2006 - 2012

University of Minnesota System Minneapolis, MN, US
Post-Doc Biochemistry Molecular Biology and Biophysics

2003 - 2006

University of Illinois System Urbana, IL, US
Post-doc Biochemistry

1997 - 2003

University of Illinois System Urbana, IL, US
Ph.D Center for Biophysics and Computational Biology

1992 - 1996

University of Pennsylvania Philadelphia, PA, US
B.A. Biology

Funding History

Funding history based on the linked ORCID record. Updated: October 27th, 2021 08:04

grant February 3, 2021 - September 30, 2025
Dioxygen-dependent mechanisms of hydrocarbon biosynthesis
National Institute of Food and Agriculture
grant September 20, 2019 - June 30, 2023
Divergence of Carboxylate-Bridged Diiron Enzymes for Natural Product Biosynthesis
National Institute of General Medical Sciences
grant August 15, 2018 - July 31, 2021
MRI: Acquisition of a High Resolution, Quadrupole Mass Spectrometer to Enable Research and Education at the Interface of Chemistry and Biology
Directorate for Mathematical & Physical Sciences
grant August 1, 2017 - July 31, 2020
In-situ polymerization to immobilize contaminants in groundwater
Directorate for Mathematical & Physical Sciences
grant May 1, 2016 - April 30, 2021
CAREER: Mechanism of Cytochrome P450 Alkene Biosynthesis
National Science Foundation - Directorate for Mathematical & Physical Sciences

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