Works (7)

Updated: July 13th, 2023 21:16

2022 journal article

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner


By: J. Belardinelli*, W. Li*, K. Martin*, M. Zeiler*, E. Lian*, C. Avanzi*, C. Wiersma*, T. Nguyen n ...

author keywords: Mycobacterium abscessus; nontuberculous mycobacteria; biofilm; 2-aminoimidazoles; zinc
MeSH headings : Anti-Bacterial Agents / pharmacology; Biofilms; Humans; Imidazoles / pharmacology; Microbial Sensitivity Tests; Mycobacterium Infections, Nontuberculous; Mycobacterium abscessus; Zinc / pharmacology
Source: Web Of Science
Added: April 18, 2022

2019 journal article

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

CHEMMEDCHEM, 14(9), 927–937.

By: T. Nguyen n, B. Minrovic*, R. Melander* & C. Melander

author keywords: 2-aminoimidazoles; biofilms; mycobacteria; synergy; tuberculosis
MeSH headings : Animals; Antitubercular Agents / chemistry; Antitubercular Agents / pharmacology; Biofilms / drug effects; Imidazoles / chemistry; Male; Mice; Microsomes / drug effects; Microsomes / metabolism; Mycobacterium tuberculosis / drug effects
Source: Web Of Science
Added: July 1, 2019

2019 journal article

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

MEDCHEMCOMM, 10(3), 456–459.

By: T. Nguyen n, M. Peszko n, R. Melander* & C. Melander*

Source: Web Of Science
Added: April 22, 2019

2018 journal article

2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium

MEDCHEMCOMM, 9(9), 1547–1552.

By: W. Huggins n, T. Nguyen n, N. Hahn n, J. Baker n, L. Kuo*, D. Kaur*, R. Melander n, J. Gunn*, C. Melander

Source: Web Of Science
Added: November 12, 2018

2017 journal article

2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability

PLoS One, 12(7).

By: A. Jeon, A. Obregon-Henao, D. Ackart, B. Podell, J. Belardinelli, M. Jackson, T. Nguyen, M. Blackledge ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria


MeSH headings : Acinetobacter baumannii / drug effects; Adjuvants, Pharmaceutic / chemistry; Adjuvants, Pharmaceutic / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Escherichia coli / drug effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Gram-Negative Bacteria / drug effects; Klebsiella pneumoniae / drug effects; Microbial Sensitivity Tests; Polymyxins / pharmacology; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors


author keywords: aminobenzimidazoles; antibiotic resistance; medicinal chemistry; tuberculosis
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Discovery; Lactams / chemical synthesis; Lactams / chemistry; Lactams / pharmacology; Molecular Structure; Mycobacterium smegmatis / drug effects; Mycobacterium smegmatis / enzymology; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / enzymology; beta-Lactamase Inhibitors / chemical synthesis; beta-Lactamase Inhibitors / chemistry; beta-Lactamase Inhibitors / pharmacology; beta-Lactamases / metabolism
Source: Web Of Science
Added: August 6, 2018