Timothy P. Cleland

Works (6)

Updated: July 24th, 2023 21:15

2019 journal article

Paleoproteomics of Mesozoic Dinosaurs and Other Mesozoic Fossils

PROTEOMICS, 19(16), 1800251.

By: M. Schweitzer n , E. Schroeter n , T. Cleland* & W. Zheng n

author keywords: dinosaurs; fossil; mesozoic; protein; soft tissues
MeSH headings : Animals; Biological Evolution; Bone and Bones / anatomy & histology; Bone and Bones / metabolism; Dinosaurs / anatomy & histology; Dinosaurs / classification; Dinosaurs / metabolism; Fossils; Mass Spectrometry / methods; Paleontology / methods; Proteins / analysis; Proteomics / methods
TL;DR: The power and potential of a molecular approach to Mesozoic fossils is discussed, and some criteria for assessing the presence of endogenous biomolecules in very ancient fossil remains are suggested as a starting framework for such studies. (via Semantic Scholar)
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15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: July 22, 2019

2015 journal article

Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis

JOURNAL OF PROTEOME RESEARCH, 14(12), 5252–5262.

By: T. Cleland n, E. Schroeter n , L. Zamdborg*, W. Zheng n, J. Lee*, J. Tran *, M. Bern *, M. Duncan* ...

Contributors: T. Cleland n, E. Schroeter n , L. Zamdborg*, W. Zheng n, J. Lee*, J. Tran *, M. Bern *, M. Duncan* ...

author keywords: Brachylophosaurus canadensis; blood vessels; dinosaur; cytoskeleton; actin; tubulin; myosin; tropomyosin; tap honomy; preservation
MeSH headings : Actins / genetics; Actins / isolation & purification; Amino Acid Sequence; Animals; Blood Vessels / anatomy & histology; Blood Vessels / metabolism; Blood Vessels / microbiology; Bone and Bones / blood supply; Chickens; Dinosaurs / anatomy & histology; Dinosaurs / genetics; Dinosaurs / metabolism; Fluorescent Antibody Technique / methods; Fossils / anatomy & histology; Mass Spectrometry; Models, Biological; Molecular Sequence Data; Myosins / genetics; Myosins / isolation & purification; Phylogeny; Proteomics / methods; Sequence Alignment; Species Specificity; Struthioniformes; Tropomyosin / genetics; Tropomyosin / isolation & purification; Tubulin / genetics; Tubulin / isolation & purification
TL;DR: Test the hypothesis that dinosaur cortical bone fragments recovered after demineralization are endogenous and thus retain proteins in common with extant archosaur blood vessels that can be detected with high-resolution mass spectrometry and confirmed by immunofluorescence and two lines of evidence support this hypothesis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Empirical evaluation of bone extraction protocols

PLoS One, 7(2).

By: T. Cleland, K. Voegele & M. Schweitzer 

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Molecular analyses of dinosaur osteocytes support the presence of endogenous molecules

BONE, 52(1), 414–423.

By: M. Schweitzer n , W. Zheng n, T. Cleland n & M. Bern *

author keywords: Osteocytes; Fossil; Dinosaur; T. rex; Ancient proteins; Ancient DNA
MeSH headings : Animals; Dinosaurs; Mass Spectrometry; Osteocytes / chemistry
TL;DR: These data are the first to support preservation of multiple proteins and to present multiple lines of evidence for material consistent with DNA in dinosaurs, supporting the hypothesis that these structures were part of the once living animals. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Histological, chemical, and morphological reexamination of the "heart" of a small Late Cretaceous Thescelosaurus

NATURWISSENSCHAFTEN, 98(3), 203–211.

By: T. Cleland n, M. Stoskopf n & M. Schweitzer n 

author keywords: Ornithischia; Computed tomography; X-ray diffraction; X-ray photoelectron spectroscopy
MeSH headings : Animals; Dinosaurs / anatomy & histology; Fossils; Heart / anatomy & histology; Heart / diagnostic imaging; Microscopy, Electron, Scanning; Myocardium / chemistry; Myocardium / ultrastructure; Photoelectron Spectroscopy; Tomography, X-Ray Computed; X-Ray Diffraction
TL;DR: The hypothesis that this Thescelosaurus has a preserved heart was controversial, and therefore, the hypothesis was reexamined using higher-resolution computed tomography, paleohistological examination,X-ray diffraction analysis, X-ray photoelectron spectroscopy, and scanning electron microscopy for detailed morphological and chemical examination beyond what was provided in the original work. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Osteogenesis, homology, and function of the intercostal plates in ornithischian dinosaurs (Tetrapoda, Sauropsida)

Zoomorphology, 130(4), 305–313.

By: C. Boyd, T. Cleland & F. Novas

Source: NC State University Libraries
Added: August 6, 2018

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