@article{prange_2024, title={Improving outcomes in equine skin cancer}, ISSN={["2042-3292"]}, DOI={10.1111/eve.13986}, abstractNote={Summary Skin diseases are an important health problem in horses, and the skin is the most common location for tumours. Equine sarcoids, melanomas and squamous cell carcinomas make up over 95% of cutaneous tumours, but information about the effective treatment of these common forms of skin cancer is limited. In the absence of reliable therapies for advanced cases, cancer screening, reliable diagnostics and early treatment become even more important.}, journal={EQUINE VETERINARY EDUCATION}, author={Prange, Timo}, year={2024}, month={May} }
 @article{fesmire_peal_ruff_moyer_mcparland_derks_o'neil_emke_johnson_ghosh_et al._2024, title={Investigation of integrated time nanosecond pulse irreversible electroporation against spontaneous equine melanoma}, volume={11}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2024.1232650}, abstractNote={IntroductionIntegrated time nanosecond pulse irreversible electroporation (INSPIRE) is a novel tumor ablation modality that employs high voltage, alternating polarity waveforms to induce cell death in a well-defined volume while sparing the underlying tissue. This study aimed to demonstrate the in vivo efficacy of INSPIRE against spontaneous melanoma in standing, awake horses.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Fesmire, Chris C. and Peal, Bridgette and Ruff, Jennifer and Moyer, Elizabeth and McParland, Thomas J. and Derks, Kobi and O'Neil, Erin and Emke, Carrie and Johnson, Brianna and Ghosh, Shatorupa and et al.}, year={2024}, month={Jan} }
 @article{jacobs_o'neil_prange_2022, title={Efficacy of a commercial dry sleeve cryotherapy system for cooling the equine metacarpus}, ISSN={["1532-950X"]}, DOI={10.1111/vsu.13847}, abstractNote={Abstract}, journal={VETERINARY SURGERY}, author={Jacobs, Carrie C. and O'Neil, Erin and Prange, Timo}, year={2022}, month={Jul} }
 @article{halleran_minch_slyvester_jacob_prange_baynes_foster_2021, title={Comparison of the Intestinal Pharmacokinetics of Two Different Florfenicol Dosing Regimens and Its Impact on the Prevalence and Phenotypic Resistance of E. coli and Enterococcus over Time}, volume={9}, ISSN={["2076-2607"]}, DOI={10.3390/microorganisms9091835}, abstractNote={In order to mitigate the food animal sector’s role in the growing threat of antimicrobial resistance (AMR), the World Health Organization (WHO) suggests the use of lower tier antimicrobials, such as florfenicol. Florfenicol has two dosing schemes used to treat primarily bovine respiratory disease. In this study, the objective was to characterize the plasma and gastrointestinal pharmacokinetics of each dosing regimen and assess the effect of these dosing regimens on the prevalence of resistant indicator bacteria over time. Twelve steers underwent abdominal surgery to facilitate the placement of ultrafiltration probes within the lumen of the ileum and colon, as well as placement of an interstitial probe. Following surgery, cattle were dosed with either 20 mg/kg IM every 48 h of florfenicol given twice (n = 6) or a single, subcutaneous dose (40 mg/kg, n = 6). Plasma, interstitial fluid, gastrointestinal ultrafiltrate, and feces were collected. Pharmacokinetic analysis demonstrated high penetration of florfenicol within the gastrointestinal tract for both the high and low dose group (300%, 97%, respectively). There was no significant difference noted between dosing groups in proportion or persistence of phenotypically resistant bacterial isolates; however, the percent of resistant isolates was high throughout the study period. The recommendation for the use of a lower tier antimicrobial, such as florfenicol, may allow for the persistence of co-resistance for antibiotics of high regulatory concern.}, number={9}, journal={MICROORGANISMS}, author={Halleran, Jennifer L. and Minch, Ryker and Slyvester, Hannah J. and Jacob, Megan E. and Prange, Timo and Baynes, Ronald and Foster, Derek M.}, year={2021}, month={Sep} }
 @article{halleran_callahan_jacob_sylvester_prange_papich_foster_2021, title={Effects of danofloxacin dosing regimen on gastrointestinal pharmacokinetics and fecal microbiome in steers}, volume={11}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-021-90647-z}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Halleran, J. L. and Callahan, B. J. and Jacob, M. E. and Sylvester, H. J. and Prange, T. and Papich, M. G. and Foster, D. M.}, year={2021}, month={May} }
 @article{prange_2020, title={Noninfectious causes of subcutaneous emphysema}, volume={32}, ISSN={["2042-3292"]}, DOI={10.1111/eve.13061}, abstractNote={Equine Veterinary EducationVolume 32, Issue 6 p. 307-309 Clinical Commentary Noninfectious causes of subcutaneous emphysema T. Prange, Corresponding Author T. Prange tprange@ncsu.edu orcid.org/0000-0001-7920-8223 North Carolina State University, Raleigh, North Carolina, USACorresponding author email: tprange@ncsu.eduSearch for more papers by this author T. Prange, Corresponding Author T. Prange tprange@ncsu.edu orcid.org/0000-0001-7920-8223 North Carolina State University, Raleigh, North Carolina, USACorresponding author email: tprange@ncsu.eduSearch for more papers by this author First published: 15 February 2019 https://doi.org/10.1111/eve.13061Read the full textAboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume32, Issue6June 2020Pages 307-309 RelatedInformation}, number={6}, journal={EQUINE VETERINARY EDUCATION}, author={Prange, T.}, year={2020}, month={Jun}, pages={307–309} }
 @article{foster_jacob_farmer_callahan_theriot_kathariou_cernicchiaro_prange_papich_2019, title={Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers}, volume={14}, ISSN={["1932-6203"]}, DOI={10.1371/journal.pone.0223378}, abstractNote={Antimicrobial drug concentrations in the gastrointestinal tract likely drive antimicrobial resistance in enteric bacteria. Our objective was to determine the concentration of ceftiofur and its metabolites in the gastrointestinal tract of steers treated with ceftiofur crystalline-free acid (CCFA) or ceftiofur hydrochloride (CHCL), determine the effect of these drugs on the minimum inhibitory concentration (MIC) of fecal Escherichia coli, and evaluate shifts in the microbiome. Steers were administered either a single dose (6.6 mg/kg) of CCFA or 2.2 mg/kg of CHCL every 24 hours for 3 days. Ceftiofur and its metabolites were measured in the plasma, interstitium, ileum and colon. The concentration and MIC of fecal E. coli and the fecal microbiota composition were assessed after treatment. The maximum concentration of ceftiofur was higher in all sampled locations of steers treated with CHCL. Measurable drug persisted longer in the intestine of CCFA-treated steers. There was a significant decrease in E. coli concentration (P = 0.002) within 24 hours that persisted for 2 weeks after CCFA treatment. In CHCL-treated steers, the mean MIC of ceftiofur in E. coli peaked at 48 hours (mean MIC = 20.45 ug/ml, 95% CI = 10.29–40.63 ug/ml), and in CCFA-treated steers, mean MIC peaked at 96 hours (mean MIC = 10.68 ug/ml, 95% CI = 5.47–20.85 ug/ml). Shifts in the microbiome of steers in both groups were due to reductions in Firmicutes and increases in Bacteroidetes. CCFA leads to prolonged, low intestinal drug concentrations, and is associated with decreased E. coli concentration, an increased MIC of ceftiofur in E. coli at specific time points, and shifts in the fecal microbiota. CHCL led to higher intestinal drug concentrations over a shorter duration. Effects on E. coli concentration and the microbiome were smaller in this group, but the increase in the MIC of ceftiofur in fecal E. coli was similar.}, number={10}, journal={PLOS ONE}, author={Foster, Derek M. and Jacob, Megan E. and Farmer, Kyle A. and Callahan, Benjamin J. and Theriot, Casey M. and Kathariou, Sophia and Cernicchiaro, Natalia and Prange, Timo and Papich, Mark G.}, year={2019}, month={Oct} }
 @article{fowler_gilbertie_watson_prange_osborne_schnabel_2019, title={Effects of acellular equine amniotic allografts on the healing of experimentally induced full-thickness distal limb wounds in horses}, volume={48}, ISSN={["1532-950X"]}, DOI={10.1111/vsu.13304}, abstractNote={Abstract}, number={8}, journal={VETERINARY SURGERY}, author={Fowler, Alexander W. and Gilbertie, Jessica M. and Watson, Victoria E. and Prange, Timo and Osborne, Jason A. and Schnabel, Lauren V}, year={2019}, month={Nov}, pages={1416–1428} }
 @article{ferguson_jacob_theriot_callahan_prange_papich_foster_2018, title={Dosing Regimen of Enrofloxacin Impacts Intestinal Pharmacokinetics and the Fecal Microbiota in Steers}, volume={9}, ISSN={1664-302X}, url={http://dx.doi.org/10.3389/fmicb.2018.02190}, DOI={10.3389/fmicb.2018.02190}, abstractNote={Objective: The intestinal concentrations of antimicrobial drugs that select for resistance in fecal bacteria of cattle are poorly understood. Our objective was to associate active drug concentrations in the intestine of steers with changes in the resistance profile and composition of the fecal microbiome. Methods: Steers were administered either a single dose (12.5 mg/kg) or 3 multiple doses (5 mg/kg) of enrofloxacin subcutaneously every 24 h. Enrofloxacin and ciprofloxacin concentrations in intestinal fluid were measured over 96 h, and the abundance and MIC of E. coli in culture and the composition of the fecal microbiota by 16S rRNA gene sequencing were assessed over 192 h after initial treatment. Results: Active drug concentrations in the ileum and colon exceeded plasma and interstitial fluid concentrations, but were largely eliminated by 48 h after the last dose. The concentration of E. coli in the feces significantly decreased during peak drug concentrations, but returned to baseline by 96 h in both groups. The median MIC of E. coli isolates increased for 24 h in the single dose group, and for 48 h in the multiple dose group. The median MIC was higher in the multiple dose group when compared to the single dose group starting 12 h after the initial dose. The diversity of the fecal microbiota did not change in either treatment group, and taxa-specific changes were primarily seen in phyla commonly associated with the rumen. Conclusions: Both dosing regimens of enrofloxacin achieve high concentrations in the intestinal lumen, and the rapid elimination mitigates long-term impacts on fecal E. coli resistance and the microbiota.}, journal={Frontiers in Microbiology}, publisher={Frontiers Media SA}, author={Ferguson, Kaitlyn M. and Jacob, Megan E. and Theriot, Casey M. and Callahan, Benjamin J. and Prange, Timo and Papich, Mark G. and Foster, Derek M.}, year={2018}, month={Sep} }
 @article{shrauner_blikslager_davis_campbell_law_lustgarten_prange_2017, title={Feasibility and safety of lumbosacral epiduroscopy in the standing horse}, volume={49}, ISSN={["2042-3306"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84978052421&partnerID=MN8TOARS}, DOI={10.1111/evj.12591}, abstractNote={Summary}, number={3}, journal={EQUINE VETERINARY JOURNAL}, author={Shrauner, B. and Blikslager, A. and Davis, J. and Campbell, N. and Law, M. and Lustgarten, M. and Prange, T.}, year={2017}, month={May}, pages={322–328} }
 @article{prange_shrauner_blikslager_2016, title={Epiduroscopy of the lumbosacral vertebral canal in the horse: Technique and endoscopic anatomy}, volume={48}, ISSN={["2042-3306"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84939825449&partnerID=MN8TOARS}, DOI={10.1111/evj.12470}, abstractNote={Summary}, number={1}, journal={EQUINE VETERINARY JOURNAL}, author={Prange, T. and Shrauner, B. D. and Blikslager, A. T.}, year={2016}, month={Jan}, pages={125–129} }
 @misc{prange_shrauner_blikslager_2016, title={Epiduroscopy of the lumbosacral vertebral canal in the horse: Technique and endoscopic anatomy Response}, volume={48}, ISSN={["2042-3306"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84949784656&partnerID=MN8TOARS}, DOI={10.1111/evj.12494}, abstractNote={See correspondence by Josephson and article by Prange et al.}, number={1}, journal={EQUINE VETERINARY JOURNAL}, author={Prange, T. and Shrauner, B. D. and Blikslager, A. T.}, year={2016}, month={Jan}, pages={131–131} }
 @article{garcia-pereira_prange_seller_obert_2016, title={Evaluation of epiduroscopy for detection of vertebral canal and spinal cord lesions in dogs}, volume={77}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.77.7.766}, abstractNote={Abstract}, number={7}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Garcia-Pereira, Fernando L. and Prange, Timo and Seller, Aaron and Obert, Victoria}, year={2016}, month={Jul}, pages={766–770} }
 @article{lustgarten_redding_schnabel_prange_seiler_2016, title={Navigational ultrasound imaging: A novel imaging tool for aiding interventional therapies of equine musculoskeletal injuries}, volume={48}, ISSN={["2042-3306"]}, DOI={10.1111/evj.12410}, abstractNote={Summary}, number={2}, journal={EQUINE VETERINARY JOURNAL}, author={Lustgarten, M. and Redding, W. R. and Schnabel, L. V. and Prange, T. and Seiler, G. S.}, year={2016}, month={Mar}, pages={195–200} }
 @inbook{jarrett_bailey_messenger_prange_gaines_posner_2016, title={Recovery of horses from general anesthesia following induction with either propofol or midazolam followed by ketamine}, volume={253}, DOI={10.2460/javma.253.1.101}, abstractNote={Abstract}, number={1}, booktitle={Journal of the American Veterinary Medical Association}, author={Jarrett, M.A. and Bailey, K.M. and Messenger, K.M. and Prange, T. and Gaines, B. and Posner, L.P.}, year={2016}, month={Jul}, pages={101–107} }
 @article{prange_partlow_parks_2016, title={Surgical repair of a mandibular degloving injury in a 5-month-old colt}, volume={28}, ISSN={["2042-3292"]}, DOI={10.1111/eve.12442}, abstractNote={Summary}, number={12}, journal={EQUINE VETERINARY EDUCATION}, author={Prange, T. and Partlow, J. L. and Parks, J.}, year={2016}, month={Dec}, pages={668–671} }
 @article{prange_2015, title={Management of tracheal perforations: Potential complications and pitfalls}, volume={27}, ISSN={["2042-3292"]}, DOI={10.1111/eve.12472}, abstractNote={Equine Veterinary EducationVolume 27, Issue 11 p. 566-568 Clinical Commentary Management of tracheal perforations: Potential complications and pitfalls T. Prange, Corresponding Author T. Prange North Carolina State University, Raleigh, USACorresponding author email: [email protected]Search for more papers by this author T. Prange, Corresponding Author T. Prange North Carolina State University, Raleigh, USACorresponding author email: [email protected]Search for more papers by this author First published: 13 October 2015 https://doi.org/10.1111/eve.12472Citations: 5Read the full textAboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Barber, S. and Stashak, T.S. (2008) Management of wounds of the head. In: Equine Wound Management. Eds: T.S. Stashak and C. Theoret, Wiley-Blackwell, Veterinary Wound Management Society, Ames. pp 273- 333. Bednarski, R.M. (2009) Tracheal and nasal intubation. In: Equine Anesthesia, 2nd edn., Ed: W. Hubbell, W.B. Saunders, St Louis. pp 277- 287. Braz, J.R., Navarro, L.H., Takata, I.H. and Nascimento Júnior, P. (1999) Endotracheal tube cuff pressure: need for precise measurement. São Paulo Med. J. 117, 243- 247. Busschers, E., Epstein, K.L., Holt, D.E. and Parente, E.J. (2010) Extraluminal, C shaped polyethylene prostheses in two ponies with tracheal collapse. Vet. Surg. 39, 776- 783. Byars, T.D. and McGorum, B.C. (2007) 46 - Disorders of the thoracic wall, pleura, mediastinum, and diaphragm. In: Equine Respiratory Medicine and Surgery, Ed: J. Schumacher, W.B. Saunders, Edinburgh. pp 659- 676. Caron, J.P. and Townsend, H.G.G. (1984) Tracheal perforation and widespread subcutaneous emphysema in a horse. Can. Vet. J. 25, 339- 341. Derksen, F.J., Robinson, N.E. and Stick, J.A. (1981) Technique for reversible vagal blockade in the standing conscious pony. Am. J. Vet. Res. 42, 523- 525. Dixon, P.M., Railton, D.I. and McGorum, B.C. (1993) Temporary bilateral laryngeal paralysis in a horse associated with general anaesthesia and post anaesthetic myositis. Vet. Rec. 132, 29- 32. Epstein, K.L. (2010) Diagnosing the ‘hidden’ consequences of cervical trauma. Equine Vet. Educ. 22, 564- 565. Feller-Kopman, D., Berkowitz, D., Boiselle, P. and Ernst, A. (2007) Large-volume thoracentesis and the risk of reexpansion pulmonary edema. Ann. Thoracic Surgery 84, 1656- 1661. Gillen, A., Munsterman, A., Pinto, N., Caldwell, F., Wooldridge, A., Cuming, R. and Hanson, R. (2015) Management of apposing, full-thickness tracheal perforations in two horses. Equine Vet. Educ. 27, 561- 565. Graham, S.B., Schilpp, D., Bradley, W.M., Cook, G. and Gayle, J. (2010) Treatment of traumatic tracheal collapse with extraluminal titanium mesh screens. Equine Vet. Educ. 22, 557- 563. Green, S.L., Cochrane, S.M. and Smith-Maxie, L. (1992) Horner's syndrome in ten horses. Can. Vet. J. 33, 330- 333. Hahn, C.N. (2003) Horner's syndrome in horses. Equine Vet. Educ. 15, 86- 90. Hance, S.R. and Robertson, J.T. (1992) Subcutaneous emphysema from an axillary wound that resulted in pneumomediastinum and bilateral pneumothorax in a horse. J. Am. Vet. Med. Assoc. 200, 1107- 1110. Kruger, K. and Davis, J.L. (2013) Management and complications associated with treatment of cervical oesophageal perforations in horses. Equine Vet. Educ. 25, 247- 255. Light, R.W., Jenkinson, S.G., Minh, V.D. and George, R.B. (1980)Observations on pleural fluid pressures as fluid is withdrawn during thoracentesis. Am. Rev. Resp. Dis. 121, 799- 804. Marble, S.L., Edens, L.M., Shiroma, J.T. and Savage, C.J. (1996) Subcutaneous emphysema in a neonatal foal. J. Am. Vet. Med. Assoc. 208, 97- 99. Nordin, U. (1977) The trachea and cuff-induced tracheal injury. An experimental study on causative factors and prevention. Acta Otolaryngol. Suppl. 345, 1- 71. Ohnesorge, B., Gehlen, H. and Deegen, E. (2002) Equine respiratory diseases. In: Disorders of the Trachea in Horses. Ed: P. Lekeux, International Veterinary Information Service(www.ivis.org), Ithaca. pp 1- 5. Peroni, J.F. (2015) Thoracic and airway trauma. In: Robinson's Current Therapy in Equine Medicine, 7th edn., Ed: N.E. Robinson, W.B. Saunders, St. Louis. pp 15- 18. Robertson, J.T. and Spurlock, G.H. (1986) Tracheal reconstruction in a foal. J. Am. Vet. Med. Assoc. 189, 313- 314. Sprayberry, K.A. and Barrett, E.J. (2015) Thoracic trauma in horses. Resp. Med. Surg. 31, 199- 219. Stick, J.A. (2012) Trachea. In: Equine Surgery 4th edn., Ed: J.A. Stick, W.B. Saunders, St Louis. pp 643- 649. Tate, L.P., Koch, D.B., Sembrat, R.F. and Boles, C.L. (1981) Tracheal reconstruction by resection and end-to-end anastomosis in the horse. J. Am. Vet. Med. Assoc. 178, 253- 258. Tetens, J., Hubert, J.D., Eddy, A.L. and Moore, R.M. (2000) Dynamic tracheal collapse as a cause of exercise intolerance in a Thoroughbred. J. Am. Vet. Med. Assoc. 216, 722- 724. Trivedi, L., Jha, P., Bajiya, N.R. and Tripathi, D. (2010) We should care more about intracuff pressure: the actual situation in government sector teaching hospital. Indian J. Anaesth. 54, 314- 317. Trostle, S., Semrad, S. and Hendrickson, D. (1995) Tracheal perforation in horses. Comp. Cont. Educ. Pract. Vet 17, 952- 958. Wong, D.M., Sponseller, B.A., Riedesel, E.A., Couetil, L.L. and Kersh, K. (2008) The use of intraluminal stents for tracheal collapse in two horses: case management and long-term treatment. Equine Vet. Educ. 20, 80- 90. Wylie, C.E., Foote, A.K., Rasotto, R., Cameron, I.J. and Greet, T.R.C. (2015) Tracheal necrosis as a fatal complication of endotracheal intubation. Equine Vet. Educ. 27, 170- 175. Citing Literature Volume27, Issue11November 2015Pages 566-568 ReferencesRelatedInformation}, number={11}, journal={EQUINE VETERINARY EDUCATION}, author={Prange, T.}, year={2015}, month={Nov}, pages={566–568} }
 @article{newman_prange_jennings_barlow_davis_2013, title={Pharmacokinetics of tobramycin following intravenous, intramuscular, and intra-articular administration in healthy horses}, volume={36}, ISSN={["1365-2885"]}, DOI={10.1111/jvp.12048}, abstractNote={The objectives of this study were to examine the pharmacokinetics of tobramycin in the horse following intravenous (IV), intramuscular (IM), and intra‐articular (IA) administration. Six mares received 4 mg/kg tobramycin IV, IM, and IV with concurrent IA administration (IV+IA) in a randomized 3‐way crossover design. A washout period of at least 7 days was allotted between experiments. After IV administration, the volume of distribution, clearance, and half‐life were 0.18 ± 0.04 L/kg, 1.18 ± 0.32 mL·kg/min, and 4.61 ± 1.10 h, respectively. Concurrent IA administration could not be demonstrated to influence IV pharmacokinetics. The mean maximum plasma concentration (Cmax) after IM administration was 18.24 ± 9.23 μg/mL at 1.0 h (range 1.0–2.0 h), with a mean bioavailability of 81.22 ± 44.05%. Intramuscular administration was well tolerated, despite the high volume of drug administered (50 mL per 500 kg horse). Trough concentrations at 24 h were below 2 μg/mL in all horses after all routes of administration. Specifically, trough concentrations at 24 h were 0.04 ± 0.01 μg/mL for the IV route, 0.04 ± 0.02 μg/mL for the IV/IA route, and 0.02 ± 0.02 for the IM route. An additional six mares received IA administration of 240 mg tobramycin. Synovial fluid concentrations were 3056.47 ± 1310.89 μg/mL at 30 min after administration, and they persisted for up to 48 h with concentrations of 14.80 ± 7.47 μg/mL. Tobramycin IA resulted in a mild chemical synovitis as evidenced by an increase in synovial fluid cell count and total protein, but appeared to be safe for administration. Monte Carlo simulations suggest that tobramycin would be effective against bacteria with a minimum inhibitory concentration (MIC) of 2 μg/mL for IV administration and 1 μg/mL for IM administration based on Cmax:MIC of 10.}, number={6}, journal={JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS}, author={Newman, J. C. and Prange, T. and Jennings, S. and Barlow, B. M. and Davis, J. L.}, year={2013}, month={Dec}, pages={532–541} }
 @article{prange_2013, title={Small colon obstructions in foals}, volume={25}, ISSN={["0957-7734"]}, DOI={10.1111/eve.12040}, abstractNote={The interesting report by Pilati et al . (2013) describes the uncommon case of a small colon obstruction by an ovarian pedicle. Obstruction of the small colon, however, is a common cause for colic in foals.}, number={6}, journal={EQUINE VETERINARY EDUCATION}, author={Prange, T.}, year={2013}, month={Jun}, pages={293–296} }
 @article{prange_carr_stick_garcia pereira_patterson_derksen_2011, title={Cervical vertebral canal endoscopy in a horse with cervical vertebral stenotic myelopathy}, volume={44}, ISSN={0425-1644}, url={http://dx.doi.org/10.1111/j.2042-3306.2011.00395.x}, DOI={10.1111/j.2042-3306.2011.00395.x}, abstractNote={Summary}, number={1}, journal={Equine Veterinary Journal}, publisher={Wiley}, author={Prange, T. and Carr, E. A. and Stick, J. A. and Garcia Pereira, F. L. and Patterson, J. S. and Derksen, F. J.}, year={2011}, month={Jun}, pages={116–119} }
 @article{prange_derksen_stick_garcia-pereira_carr_2011, title={Cervical vertebral canal endoscopy in the horse: Intra- and post operative observations}, volume={43}, ISSN={["2042-3306"]}, DOI={10.1111/j.2042-3306.2010.00310.x}, abstractNote={REASONS FOR PERFORMING STUDY
Despite modern medical diagnostic imaging, it is not possible to identify reliably the exact location of spinal cord compression in horses with cervical vertebral stenotic myelopathy (CVSM). Vertebral canal endoscopy has been successfully used in man and a technique for cervical vertebral canal endoscopy (CVCE) has been described in equine cadavers.


OBJECTIVE
To determine the feasibility and safety of CVCE in healthy mature horses.


METHODS
Six healthy mature horses were anaesthetised. A flexible videoendoscope was subsequently introduced via the atlanto-occipital space into the epidural space (epiduroscopy, Horses 1-3) or the subarachnoid space (myeloscopy, Horses 4-6) and advanced to the 8th cervical nerve. Neurological examinations were performed after surgery and lumbosacral cerebrospinal fluid (CSF) analysed in horses that had undergone myeloscopy.


RESULTS
All procedures were completed successfully and all horses recovered from anaesthesia. Anatomical structures in the epidural space (including the dura mater, nerve roots, fat and blood vessels) and subarachnoid space (including the spinal cord, blood vessels, arachnoid trabeculations, nerve roots and the external branch of the accessory nerve) were identified. During epiduroscopy, a significant increase in mean arterial pressure was recognised, when repeated injections of electrolyte solution into the epidural space were performed. In one horse of the myeloscopy group, subarachnoid haemorrhage and air occurred, resulting in transient post operative ataxia and muscle fasciculations. No complications during or after myeloscopy were observed in the other horses. CSF analysis indicated mild inflammation on Day 7 with values approaching normal 21 days after surgery.


CONCLUSIONS
Endoscopic examination of the epidural and subarachnoid space from the atlanto-occipital space to the 8th cervical nerve is possible and can be safely performed in healthy horses.


POTENTIAL RELEVANCE
Cervical vertebral canal endoscopy might allow accurate identification of the compression site in horses with CVSM and aid diagnosis of other lesions within the cervical vertebral canal.}, number={4}, journal={EQUINE VETERINARY JOURNAL}, author={Prange, T. and Derksen, F. J. and Stick, J. A. and Garcia-Pereira, F. L. and Carr, E. A.}, year={2011}, month={Jul}, pages={404–411} }
 @article{fowlie_o'neill_bladon_o'meara_prange_caron_2010, title={Comparison of conventional and alternative arthroscopic approaches to the palmar/plantar pouch of the equine distal interphalangeal joint}, volume={43}, ISSN={0425-1644}, url={http://dx.doi.org/10.1111/j.2042-3306.2010.00176.x}, DOI={10.1111/j.2042-3306.2010.00176.x}, abstractNote={REASONS FOR PERFORMING THE STUDY
The conventional arthroscopic approach to the palmar/plantar aspect of the distal interphalangeal joint (DIPJ) may result in the inadvertent penetration of the digital flexor tendon sheath (DFTS) and the navicular bursa (NB). This iatrogenic communication would be undesirable subsequent to arthroscopic lavage of a septic DIPJ.


HYPOTHESIS
A lateral/medial approach to the palmar/plantar aspect of the DIPJ will result in a significantly lower rate of inadvertent penetration of the DFTS and NB, whilst still providing adequate intra-articular evaluation.


METHODS
The conventional palmar/plantar approach or a novel lateral/medial approach to the DIPJ was performed on cadaver fore- and hindlimbs (30 limbs/approach). Subsequently, India ink was injected into the dorsal pouch of the DIPJ, and the DFTS (n = 60) and NB (n = 20) were examined for the presence/absence of ink. In addition, observations of the number of attempts made to access the joint, evidence of iatrogenic intra-articular trauma and occurrence of incomplete visualisation of the palmar/plantar pouch were recorded.


RESULTS
With the conventional approach, DFTS penetration was noted in 18/30 (60%) of the limbs, compared to 1/30 (3.3%) with the lateral/medial approach (P≤0.001). NB penetration was seen in 5/10 limbs with the palmar/plantar approach compared to 0/10 with the lateral/medial approach (P = 0.01). No significant differences were found between the approaches in the number of attempts made to access the joint, the incidence of iatrogenic intra-articular trauma, or the occurrence of incomplete visibility of the palmar/plantar pouch.


CONCLUSIONS
The novel lateral/medial approach to the DIPJ significantly decreases the risk of inadvertent penetration of the DFTS and NB.


POTENTIAL RELEVANCE
The novel lateral/medial approach to the DIPJ is an effective technique to gain access to the palmar/plantar pouches, and is particularly advantageous for arthroscopic lavage of a septic DIPJ.}, number={3}, journal={Equine Veterinary Journal}, publisher={Wiley}, author={Fowlie, J. G. and O'neill, H. D. and Bladon, B. M. and O'meara, B. and Prange, T. and Caron, J. P.}, year={2010}, month={Aug}, pages={265–269} }
 @article{prange_derksen_stick_garcia pereira_2010, title={Endoscopic anatomy of the cervical vertebral canal in the horse: A cadaver study}, volume={43}, ISSN={0425-1644}, url={http://dx.doi.org/10.1111/j.2042-3306.2010.00170.x}, DOI={10.1111/j.2042-3306.2010.00170.x}, abstractNote={REASON FOR PERFORMING STUDY
Localisation of spinal cord compression in horses with cervical vertebral stenotic myelopathy is inexact. Vertebral canal endoscopy has been used in man to localise spinal cord lesions and has the potential to become a useful diagnostic technique in horses.


OBJECTIVE
To establish a surgical approach via the atlanto-occipital space to the cervical vertebral canal in equine cadavers and describe the endoscopic anatomy of the cervical epidural and subarachnoid spaces.


METHODS
The cadavers of 25 mature horses were used to assess 3 surgical methods to approach the cervical vertebral canal, including 2 minimally invasive and one open technique. Once the approach had been made, a flexible videoendoscope was inserted into the epidural space (epiduroscopy) or the subarachnoid space (myeloscopy) and advanced caudally until the intervertebral space between C7 and T1 was reached.


RESULTS
The epidural and subarachnoid spaces could not be accessed reliably using the minimally invasive techniques. Furthermore, damage to the nervous tissues was a frequent complication with these procedures. The open approach allowed successful insertion of the videoendoscope into the epidural and subarachnoid spaces in all horses and no inadvertent damage was observed. Anatomical structures that could be seen in the epidural space included the dura mater, nerve roots, fat and the ventral internal vertebral venous plexus. In the subarachnoid space, the spinal cord, nerve roots, blood vessels, denticulate ligaments and external branch of the accessory nerve were seen.


CONCLUSIONS
Using the open approach, epiduroscopy and myeloscopy over the entire length of the cervical vertebral canal are possible in the mature horse.


POTENTIAL RELEVANCE
Cervical vertebral canal endoscopy may become a valuable tool to localise the site of spinal cord injury in horses with cervical vertebral stenotic myelopathy and could aid in the diagnosis of other diseases of the cervical spinal cord.}, number={3}, journal={Equine Veterinary Journal}, publisher={Wiley}, author={Prange, T. and Derksen, F. J. and Stick, J. A. and Garcia Pereira, F. L.}, year={2010}, month={Aug}, pages={317–323} }
 @article{prange_holcombe_brown_dechant_fubini_embertson_peroni_rakestraw_hauptman_2010, title={Resection and Anastomosis of the Descending Colon in 43 Horses}, volume={39}, ISSN={0161-3499 1532-950X}, url={http://dx.doi.org/10.1111/j.1532-950x.2010.00700.x}, DOI={10.1111/j.1532-950x.2010.00700.x}, abstractNote={OBJECTIVES
To determine (1) the short- (to hospital discharge) and long- (>6 months) term survival, (2) factors associated with short-term survival, and (3) the perioperative course for horses with resection and anastomosis of the descending colon.


STUDY DESIGN
Multicentered case series.


ANIMALS
Horses (n=43) that had descending colon resection and anastomosis.


METHODS
Medical records (January 1995-June 2009) of 7 equine referral hospitals were reviewed for horses that had descending colon resection and anastomosis and were recovered from anesthesia. Retrieved data included history, results of clinical and clinicopathologic examinations, surgical findings, postsurgical treatment and complications, and short-term survival (hospital discharge). Long-term survival was defined as survival > or =6 months after hospital discharge.


RESULTS
Of 43 horses, 36 (84%) were discharged from the hospital. Twenty-eight of 30 horses with follow-up information survived > or =6 months. No significant associations between perioperative factors and short-term survival were identified. Lesions included strangulating lipoma (n=27), postfoaling trauma (4), infarction (4), intraluminal obstruction (2), and other (6). Common postoperative complications included fever and diarrhea. During hospitalization 7 horses were euthanatized or died because of septic peritonitis (3), endotoxemia (3), and colic and ileus (1).


CONCLUSIONS
Descending colon resection and anastomosis has a favorable prognosis for hospital discharge and survival > or =6 months. The most common cause of small colon incarceration was strangulating lipoma.


CLINICAL RELEVANCE
Complications include postoperative fever and diarrhea but the prognosis is good after small colon resection and anastomosis.}, number={6}, journal={Veterinary Surgery}, publisher={Wiley}, author={Prange, Timo and Holcombe, Susan J. and Brown, Jennifer A. and Dechant, Julie E. and Fubini, Susan L. and Embertson, Rolf M. and Peroni, John and Rakestraw, Peter C. and Hauptman, Joe G.}, year={2010}, month={Apr}, pages={748–753} }