Todd Klaenhammer

Azcarate-Peril, M. A., Roach, J., Marsh, A., Chey, W. D., Sandborn, W. J., Ritter, A. J., … Klaenhammer, T. R. (2021). A double-blind, 377-subject randomized study identifies Ruminococcus, Coprococcus, Christensenella, and Collinsella as long-term potential key players in the modulation of the gut microbiome of lactose intolerant individuals by galacto-oligosaccharides. GUT MICROBES, 13(1). https://doi.org/10.1080/19490976.2021.1957536

Goh, Y. J., Barrangou, R., & Klaenhammer, T. R. (2021). In Vivo Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression. MBIO, 12(1). https://doi.org/10.1128/mBio.03399-20

Klaenhammer, T. R. (2019). Get Cultured: Eat Bacteria. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 10, Vol. 10, pp. 1–20. https://doi.org/10.1146/annurev-food-032818-121826

Stout, E. A., Sanozky-Dawes, R., Goh, Y. J., Crawley, A. B., Klaenhammer, T. R., & Barrangou, R. (2018). Deletion-based escape of CRISPR-Cas9 targeting in Lactobacillus gasseri. MICROBIOLOGY-SGM, 164(9), 1098–1111. https://doi.org/10.1099/mic.0.000689

Bumgardner, S. A., Zhang, L., LaVoy, A. S., Andre, B., Frank, C. B., Kajikawa, A., … Dean, G. A. (2018). Nod2 is required for antigen-specific humoral responses against antigens orally delivered using a recombinant Lactobacillus vaccine platform. PLOS ONE, 13(5). https://doi.org/10.1371/journal.pone.0196950

Daughtry, K. V., Johanningsmeier, S. D., Sanozky-Dawes, R., Klaenhammer, T. R., & Barrangou, R. (2018). Phenotypic and genotypic diversity of Lactobacillus buchneri strains isolated from spoiled, fermented cucumber. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 280, 46–56. https://doi.org/10.1016/j.ijfoodmicro.2018.04.044

Moller, M. S., Goh, Y. J., Rasmussen, K. B., Cypryk, W., Celebioglu, H. U., Klaenhammer, T. R., … Abou Hachem, M. (2017). An Extracellular Cell-Attached Pullulanase Confers Branched alpha-Glucan Utilization in Human Gut Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(12). https://doi.org/10.1128/aem.00402-17

Stout, E., Klaenhammer, T., & Barrangou, R. (2017). CRISPR-Cas Technologies and Applications in Food Bacteria. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 8, Vol. 8, pp. 413–437. https://doi.org/10.1146/annurev-food-072816-024723

Selle, K., Goh, Y. J., Johnson, B. R., Sarah, O. F., Andersen, J. M., Barrangou, R., & Klaenhammer, T. R. (2017). Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus. Frontiers in Microbiology, 8. https://doi.org/10.3389/fmicb.2017.00553

Theilmann, M. C., Goh, Y. J., Nielsen, K. F., Klaenhammer, T. R., Barrangou, R., & Abou Hachem, M. (2017). Lactobacillus acidophilus Metabolizes Dietary Plant Glucosides and Externalizes Their Bioactive Phytochemicals. MBIO, 8(6). https://doi.org/10.1128/mbio.01421-17

Johnson, B. R., O'Flaherty, S., Goh, Y. J., Carroll, I., Barrangou, R., & Klaenhammer, T. R. (2017). The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM. FRONTIERS IN MICROBIOLOGY, 8. https://doi.org/10.3389/fmicb.2017.01185

Johnson, B. R., & Klaenhammer, T. R. (2016). AcmB Is an S-Layer-Associated beta-N-Acetylglucosaminidase and Functional Autolysin in Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(18), 5687–5697. https://doi.org/10.1128/aem.02025-16

Johnson, B. R., Hymes, J., Sanozky-Dawes, R., Henriksen, E. D. C., Barrangou, R., & Klaenhammer, T. R. (2016). Conserved S-Layer-Associated Proteins Revealed by Exoproteomic Survey of S-Layer-Forming Lactobacilli. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(1), 134–145. https://doi.org/10.1128/aem.01968-15

List, G., Mashayekhi, M., Bertini, R. L., & Nevers, B. (2016). Development of a Transportation System Simulation Manual Framework From Theory to Practice. TRANSPORTATION RESEARCH RECORD, (2561), 45–52. https://doi.org/10.3141/2561-06

Celebioglu, H. U., Ejby, M., Majumder, A., Kobler, C., Goh, Y. J., Thorsen, K., … Svensson, B. (2016). Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic. PROTEOMICS, 16(9), 1361–1375. https://doi.org/10.1002/pmic.201500212

Hymes, J. P., Johnson, B. R., Barrangou, R., & Klaenhammer, T. R. (2016). Functional Analysis of an S-Layer-Associated Fibronectin-Binding Protein in Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(9), 2676–2685. https://doi.org/10.1128/aem.00024-16

Douglas, G. L., Azcarate-Peril, M. A., & Klaenhammer, T. R. (2016). Genomic evolution of lactic acid bacteria: From single gene function to the pan-genome. Biotechnology of Lactic Acid Bacteria: Novel Applications, 2nd Edition, 32–54. https://doi.org/10.1002/9781118868386.ch3

Durmaz, E., Hu, Y., Aroian, R. V., & Klaenhammer, T. R. (2016). Intracellular and Extracellular Expression of Bacillus thuringiensis Crystal Protein Cry5B in Lactococcus lactis for Use as an Anthelminthic. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(4), 1286–1294. https://doi.org/10.1128/aem.02365-15

O'Flaherty, S., & Klaenhammer, T. R. (2016). Multivalent Chromosomal Expression of the Clostridium botulinum Serotype A Neurotoxin Heavy-Chain Antigen and the Bacillus anthracis Protective Antigen in Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(20), 6091–6101. https://doi.org/10.1128/aem.01533-16

Hymes, J. P., & Klaenhammer, T. R. (2016). [Review of Stuck in the Middle: Fibronectin-Binding Proteins in Gram-Positive Bacteria]. FRONTIERS IN MICROBIOLOGY, 7. https://doi.org/10.3389/fmicb.2016.01504

Selle, K., Klaenhammer, T. R., & Barrangou, R. (2015). CRISPR-based screening of genomic island excision events in bacteria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(26), 8076–8081. https://doi.org/10.1073/pnas.1508525112

Sun, Z., Harris, H. M. B., McCann, A., Guo, C., Argimon, S., Zhang, W., … Paul W. O'Toole. (2015). Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera. NATURE COMMUNICATIONS, 6. https://doi.org/10.1038/ncomms9322

Goh, Y. J., & Klaenhammer, T. R. (2015). Genetic Mechanisms of Prebiotic Oligosaccharide Metabolism in Probiotic Microbes. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 6, Vol. 6, pp. 137–156. https://doi.org/10.1146/annurev-food-022814-015706

Kajikawa, A., Zhang, L., LaVoy, A., Bumgardner, S., Klaenhammer, T. R., & Dean, G. A. (2015). Mucosal Immunogenicity of Genetically Modified Lactobacillus acidophilus Expressing an HIV-1 Epitope within the Surface Layer Protein. PLOS ONE, 10(10). https://doi.org/10.1371/journal.pone.0141713

Sanozky-Dawes, R., Selle, K., O'Flaherty, S., Klaenhammer, T., & Barrangou, R. (2015). Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri. MICROBIOLOGY-SGM, 161, 1752–1761. https://doi.org/10.1099/mic.0.000129

Lightfoot, Y. L., Selle, K., Yang, T., Goh, Y. J., Sahay, B., Zadeh, M., … Mohamadzadeh, M. (2015). SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO JOURNAL, 34(7), 881–895. https://doi.org/10.15252/embj.201490296

Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & O'Flaherty, S. (2015, February). Sortase-deficient lactobacilli: effect on immunomodulation and gut retention. MICROBIOLOGY-SGM, Vol. 161, pp. 311–321. https://doi.org/10.1099/mic.0.000007

Sanders, M. E., Klaenhammer, T. R., Ouwehand, A. C., Pot, B., Johansen, E., Heimbach, J. T., … Lenoir-Wijnkoop, I. (2014). Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics. ANNALS REPORTS, Vol. 1309, pp. 1–18. https://doi.org/10.1111/nyas.12363

Johnson, B. R., & Klaenhammer, T. R. (2014). [Review of Impact of genomics on the field of probiotic research: historical perspectives to modern paradigms]. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 106(1), 141–156. https://doi.org/10.1007/s10482-014-0171-y

Goh, Y. J., & Klaenhammer, T. R. (2014). [Review of Insights into glycogen metabolism in Lactobacillus acidophilus: impact on carbohydrate metabolism, stress tolerance and gut retention]. MICROBIAL CELL FACTORIES, 13. https://doi.org/10.1186/s12934-014-0094-3

Barrangou, R., & Klaenhammer, T. R. (2014). Microbiology bacteria get vaccinated. Nature, 513(7517), 175–176.

Moller, M. S., Goh, Y. J., Viborg, A. H., Andersen, J. M., Klaenhammer, T. R., Svensson, B., & Abou Hachem, M. (2014). Recent insight in alpha-glucan metabolism in probiotic bacteria. BIOLOGIA, 69(6), 713–721. https://doi.org/10.2478/s11756-014-0367-7

Baugher, J. L., Durmaz, E., & Klaenhammer, T. R. (2014). Spontaneously Induced Prophages in Lactobacillus gasseri Contribute to Horizontal Gene Transfer. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80(11), 3508–3517. https://doi.org/10.1128/aem.04092-13

Goh, Y. J., & Klaenhammer, T. R. (2013). A functional glycogen biosynthesis pathway in Lactobacillus acidophilus: expression and analysis of the glg operon. MOLECULAR MICROBIOLOGY, 89(6), 1187–1200. https://doi.org/10.1111/mmi.12338

Selle, K., & Klaenhammer, T. R. (2013). [Review of Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health]. FEMS MICROBIOLOGY REVIEWS, 37(6), 915–935. https://doi.org/10.1111/1574-6976.12021

Johnson, B., Selle, K., O'Flaherty, S., Goh, Y. J., & Klaenhammer, T. (2013). Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM. MICROBIOLOGY-SGM, 159, 2269–2282. https://doi.org/10.1099/mic.0.070755-0

Savaiano, D. A., Ritter, A. J., Klaenhammer, T. R., James, G. M., Longcore, A. T., Chandler, J. R., … Foyt, H. L. (2013). Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial. NUTRITION JOURNAL, 12. https://doi.org/10.1186/1475-2891-12-160

Petschow, B., Dore, J., Hibberd, P., Dinan, T., Reid, G., Blaser, M., … Sanders, M. E. (2013). Probiotics, prebiotics, and the host microbiome: the science of translation. ANNALS REPORTS, 1306, 1–17. https://doi.org/10.1111/nyas.12303

Abou Hachem, M., Andersen, J. M., Barrangou, R., Moller, M. S., Fredslund, F., Majumder, A., … Svensson, B. (2013). [Review of Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria]. BIOCATALYSIS AND BIOTRANSFORMATION, 31(4), 226–235. https://doi.org/10.3109/10242422.2013.828048

Call, E. K., & Klaenhammer, T. R. (2013). [Review of Relevance and application of sortase and sortase-dependent proteins in lactic acid bacteria]. FRONTIERS IN MICROBIOLOGY, 4. https://doi.org/10.3389/fmicb.2013.00073

Andersen, J. M., Barrangou, R., Abou Hachem, M., Lahtinen, S. J., Goh, Y. J., Svensson, B., & Klaenhammer, T. R. (2013). Transcriptional analysis of oligosaccharide utilization by Bifidobacterium lactis Bl-04. BMC GENOMICS, 14(1). https://doi.org/10.1186/1471-2164-14-312

Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., … Mohamadzadeh, M. (2012). Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(26), 10462–10467. https://doi.org/10.1073/pnas.1207230109

Carroll, I. M., Ringel-Kulka, T., Siddle, J. P., Klaenhammer, T. R., & Ringel, Y. (2012). Characterization of the fecal microbiota using high-throughput sequencing reveals a stable microbial community during storage. PLoS One, 7(10). https://doi.org/10.1371/journal.pone.0046953

Kajikawa, A., Zhang, L., Long, J., Nordone, S., Stoeker, L., LaVoy, A., … Dean, G. (2012). Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery. CLINICAL AND VACCINE IMMUNOLOGY, 19(9), 1374–1381. https://doi.org/10.1128/cvi.00049-12

O'Flaherty, S., & Klaenhammer, T. R. (2012). Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(14), 5028–5032. https://doi.org/10.1128/aem.00504-12

Abou Hachem, M., Fredslund, F., Andersen, J. M., Larsen, R. J., Majumder, A., Ejby, M., … Svensson, B. (2012). Raffinose family oligosaccharide utilisation by probiotic bacteria: insight into substrate recognition, molecular architecture and diversity of GH36 alpha-galactosidases. BIOCATALYSIS AND BIOTRANSFORMATION, 30(3), 316–325. https://doi.org/10.3109/10242422.2012.674717

Klaenhammer, T. R., Kleerebezem, M., Kopp, M. V., & Rescigno, M. (2012). The impact of probiotics and prebiotics on the immune system. NATURE REVIEWS IMMUNOLOGY, 12(10), 728–734. https://doi.org/10.1038/nri3312

Andersen, J. M., Barrangou, R., Abou Hachem, M., Lahtinen, S. J., Goh, Y.-J., Svensson, B., & Klaenhammer, T. R. (2012). Transcriptional Analysis of Prebiotic Uptake and Catabolism by Lactobacillus acidophilus NCFM. PLOS ONE, 7(9). https://doi.org/10.1371/journal.pone.0044409

Gordon, J. I., & Klaenhammer, T. R. (2011, March 15). A rendezvous with our microbes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 108, pp. 4513–4515. https://doi.org/10.1073/pnas.1101958108

Stoeker, L., Nordone, S., Gunderson, S., Zhang, L., Kajikawa, A., LaVoy, A., … Dean, G. A. (2011). Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector. CLINICAL AND VACCINE IMMUNOLOGY, 18(11), 1834–1844. https://doi.org/10.1128/cvi.05277-11

Douglas, G. L., & Klaenhammer, T. R. (2011). Directed Chromosomal Integration and Expression of the Reporter Gene gusA3 in Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(20), 7365–7371. https://doi.org/10.1128/aem.06028-11

Kajikawa, A., Nordone, S. K., Zhang, L., Stoeker, L. L., LaVoy, A. S., Klaenhammer, T. R., & Dean, G. A. (2011). Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(18), 6587–6596. https://doi.org/10.1128/aem.05153-11

Altermann, E., & Klaenhammer, T. R. (2011). Group-specific comparison of four lactobacilli isolated from human sources using differential blast analysis. GENES AND NUTRITION, 6(3), 319–340. https://doi.org/10.1007/s12263-010-0191-9

Baugher, J. L., & Klaenhammer, T. R. (2011). [Review of Invited review: Application of omics tools to understanding probiotic functionality]. JOURNAL OF DAIRY SCIENCE, 94(10), 4753–4765. https://doi.org/10.3168/jds.2011-4384

Guarner, F., Sanders, M. E., Gibson, G., Klaenhammer, T., Cabana, M., Scott, K., … Hill, C. (2011, December). Probiotic and prebiotic claims in Europe: seeking a clear roadmap. https://doi.org/10.1017/s0007114511002248

Mohamadzadeh, M., Pfeiler, E. A., Brown, J. B., Zadeh, M., Gramarossa, M., Managlia, E., … Klaenhammer, T. R. (2011). Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 4623–4630. https://doi.org/10.1073/pnas.1005066107

O'Flaherty, S., & Klaenhammer, T. R. (2011). The Impact of Omic Technologies on the Study of Food Microbes. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2, Vol. 2, pp. 353–371. https://doi.org/10.1146/annurev-food-030810-110338

Andersen, J. M., Barrangou, R., Abou Hachem, M., Lahtinen, S., Goh, Y. J., Svensson, B., & Klaenhammer, T. R. (2011). Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(43), 17785–17790. https://doi.org/10.1073/pnas.1114152108

Duong, T., Miller, M. J., Barrangou, R., Azcarate-Peril, M. A., & Klaenhammer, T. R. (2010). Construction of vectors for inducible and constitutive gene expression in Lactobacillus. Microbial Biotechnology, 4(3), 357–367. https://doi.org/10.1111/j.1751-7915.2010.00200.x

Goh, Y. J., & Klaenhammer, T. R. (2010). Functional Roles of Aggregation-Promoting-Like Factor in Stress Tolerance and Adherence of Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(15), 5005–5012. https://doi.org/10.1128/aem.00030-10

Sarah J. O'Flaherty, & Klaenhammer, T. R. (2010). Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells. MICROBIOLOGY-SGM, 156, 3360–3367. https://doi.org/10.1099/mic.0.043158-0

Douglas, G. L., & Klaenhammer, T. R. (2010). Genomic Evolution of Domesticated Microorganisms. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 1, Vol. 1, pp. 397–414. https://doi.org/10.1146/annurev.food.102308.124134

Damelin, L. H., Mavri-Damelin, D., Klaenhammer, T. R., & Tiemessen, C. T. (2010). Plasmid Transduction Using Bacteriophage Phi adh for Expression of CC Chemokines by Lactobacillus gasseri ADH. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(12), 3878–3885. https://doi.org/10.1128/aem.00139-10

Mohamadzadeh, M., Durmaz, E., Zadeh, M., Pakanati, K. C., Gramarossa, M., Cohran, V., & Klaenhammer, T. R. (2010). Targeted expression of anthrax protective antigen by Lactobacillus gasseri as an anthrax vaccine. FUTURE MICROBIOLOGY, 5(8), 1289–1296. https://doi.org/10.2217/fmb.10.78

O'Flaherty, S., & Klaenhammer, T. R. (2010, April). The role and potential of probiotic bacteria in the gut, and the communication between gut microflora and gut/host. INTERNATIONAL DAIRY JOURNAL, Vol. 20, pp. 262–268. https://doi.org/10.1016/j.idairyj.2009.11.011

Barrangou, R., Azcarate-Peril, A., Altermann, E., Duong, T., & Klaenhammer, T. R. (2009). Compositions comprising promoter sequences and methods of use.

Mohamadzadeh, M., Duong, T., Sandwick, S. J., Hoover, T., & Klaenhammer, T. R. (2009). Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(11), 4331–4336. https://doi.org/10.1073/pnas.0900029106

Goh, Y. J., Azcarate-Peril, M. A., O'Flaherty, S., Durmaz, E., Valence, F., Jardin, J., … Klaenhammer, T. R. (2009). Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105. https://doi.org/10.1128/AEM.02502-08

Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., Sinderen, D., & Paul W. O'Toole. (2009). [Review of Genome-scale analyses of health-promoting bacteria: probiogenomics]. NATURE REVIEWS MICROBIOLOGY, 7(1), 61–U77. https://doi.org/10.1038/nrmicro2047

Goh, Y. J., & Klaenhammer, T. R. (2009). [Review of Genomic features of Lactobacillus species]. Frontiers in Bioscience, 14, 1362–1386.

Schroeter, J., & Klaenhammer, T. (2009). [Review of Genomics of lactic acid bacteria]. FEMS MICROBIOLOGY LETTERS, 292(1), 1–6. https://doi.org/10.1111/j.1574-6968.2008.01442.x

Gunderson, S., Nordone, S., LaVoy, A., Zhang, L., Klaenhammer, T., & Dean, G. (2009). Immunogenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV. RETROVIROLOGY, Vol. 6. https://doi.org/10.1186/1742-4690-6-s3-p163

Klaenhammer, T. R., Russell, W. M., Altermann, E., & Buck, B. L. (2009). Lactobacillus acidophillus nucleic acid sequences encoding cell surface protein homologues and uses therefore.

Klaenhammer, T. R., Altermann, E., Azcarate-Peril, M. A., McAuliffe, O., & Russell, W. M. (2009). Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor.

Klaenhammer, T. R., Russell, W. M., Altermann, E., & Azcarate-Peril, A. (2009). Nucleic acid sequences encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor.

Engelbrektson, A., Korzenik, J. R., Pittler, A., Sanders, M. E., Klaenhammer, T. R., Leyer, G., & Kitts, C. L. (2009). Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. JOURNAL OF MEDICAL MICROBIOLOGY, 58(5), 663–670. https://doi.org/10.1099/jmm.0.47615-0

Pfeiler, E. A., & Klaenhammer, T. R. (2009). Role of Transporter Proteins in Bile Tolerance of Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(18), 6013–6016. https://doi.org/10.1128/AEM.00495-09

Buck, B. L., Azcarate-Peril, M. A., & Klaenhammer, T. R. (2009). Role of autoinducer-2 on the adhesion ability of Lactobacillus acidophilus. JOURNAL OF APPLIED MICROBIOLOGY, 107(1), 269–279. https://doi.org/10.1111/j.1365-2672.2009.04204.x

Azcarate-Peril, M. A., Tallon, R., & Klaenhammer, T. R. (2009). Temporal gene expression and probiotic attributes of Lactobacillus acidophilus during growth in milk. JOURNAL OF DAIRY SCIENCE, 92(3), 870–886. https://doi.org/10.3168/jds.2008-1457

Stoeker, L., Nordone, S., LaVoy, A., Tallon, R., Klaenhammer, T., & Dean, G. (2009). Toll-like receptor activation profiles of wild-type, recombinant, and mutant Lactobacillus: implications for vaccine design. RETROVIROLOGY, Vol. 6. https://doi.org/10.1186/1742-4690-6-s3-p133

Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625. https://doi.org/10.1128/AEM.00054-08

Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). Functional genomics of probiotic Lactobacilli. JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162. https://doi.org/10.1097/MCG.0b013e31817da140

Durmaz, E., Miller, M. J., Azcarate-Peril, M. A., Toon, S. P., & Klaenhammer, T. R. (2008, August). Genome sequence and characteristics of Lrm1, a prophage from industrial Lactobacillus rhamnosus strain M1. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4601–4609. https://doi.org/10.1128/AEM.00010-08

Klaenhammer, T. R., Altermann, E., Barrangou, R., Russell, W. M., & Duong, T. (2008). Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor.

Klaenhammer, T. R., Altermann, E., Buck, B. L., & Russell, W. M. (2008). Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore. Washington, DC: U.S. Patent and Trademark Office.

Klaenhammer, T. R., Altermann, E., & Russell, W. M. (2008). Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore.

Klaenhammer, T., Azcarate-Peril, A., & Altermann, E. (2008). Lactobacillus acidophilus nucleic acids and uses thereof.

Konstantinov, S. R., Smidt, H., Vos, W. M., Bruijns, S. C. M., Singh, S. K., Valence, F., … Kooyk, Y. (2008). S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(49), 19474–19479. https://doi.org/10.1073/pnas.0810305105

Mohamadzadeh, M., & Klaenhammer, T. R. (2008). Specific Lactobacillus species differentially activate Toll-like receptors and downstream signals in dendritic cells. EXPERT REVIEW OF VACCINES, 7(8), 1155–1164. https://doi.org/10.1586/14760584.7.8.1155

Mohamadzadeh, M., Duong, T., Hoover, T., & Klaenhammer, T. R. (2008). [Review of Targeting mucosal dendritic cells with microbial antigens from probiotic lactic acid bacteria]. EXPERT REVIEW OF VACCINES, 7(2), 163–174. https://doi.org/10.1586/14760584.7.2.163

Durmaz, E., & Klaenhammer, T. R. (2007). AbiZ phage resistance gene. Washington, DC: U.S. Patent and Trademark Office.

Durmaz, E., & Klaenhammer, T. R. (2007). Abortive phage resistance mechanism AbiZ speeds the lysis clock to cause premature lysis of phage-infected Lactococcus lactis. JOURNAL OF BACTERIOLOGY, 189(4), 1417–1425. https://doi.org/10.1128/JB.00904-06

Carroll, I. M., Andrus, J. M., Bruno-Barcena, J. M., Klaenhammer, T. R., Hassan, H. M., & Threadgill, D. S. (2007). Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(4), G729–G738. https://doi.org/10.1152/ajpgi.00132.2007

Pfeiler, E. A., Azcarate-Peril, M. A., & Klaenhammer, T. R. (2007). Characterization of a novel bile-inducible operon encoding a two-component regulatory system in Lactobacillus acidophilus. JOURNAL OF BACTERIOLOGY, 189(13), 4624–4634. https://doi.org/10.1128/JB.00337-07

Dobson, A. E., Sanozky-Dawes, R. B., & Klaenhammer, T. R. (2007). Identification of an operon and inducing peptide involved in the production of lactacin B by Lactobacillus acidophilus. JOURNAL OF APPLIED MICROBIOLOGY, 103(5), 1766–1778. https://doi.org/10.1111/j.1365-2672.2007.03417.x

Klaenhammer, T. R., Azcarate-Peril, M. A., Altermann, E., & Barrangou, R. (2007, March). Influence of the dairy environment on gene expression and substrate(1-3). JOURNAL OF NUTRITION, Vol. 137, pp. 748S–750S. https://doi.org/10.1093/jn/137.3.748s

Sturino, J. M., & Klaenhammer, T. R. (2007). Inhibition of bacteriophage replication in Streptococcus thermophilus by subunit poisoning of primase. MICROBIOLOGY-SGM, 153, 3295–3302. https://doi.org/10.1099/mic.0.2007/007567-0

Callanan, M. J., Russell, W. M., & Klaenhammer, T. R. (2007). Modification of Lactobacillus beta-glucuronidase activity by random mutagenesis. GENE, 389(2), 122–127. https://doi.org/10.1016/j.gene.2006.10.022

Pfeiler, E. A., & Klaenhammer, T. R. (2007). [Review of The genomics of lactic acid bacteria]. TRENDS IN MICROBIOLOGY, 15(12), 546–553. https://doi.org/10.1016/j.tim.2007.09.010

Engelbrektson, A. L., Korzenik, J. R., Sanders, M. E., Clement, B. G., Leyer, G., Klaenhammer, T. R., & Kitts, C. L. (2006). Analysis of treatment effects on the microbial ecology of the human intestine. FEMS MICROBIOLOGY ECOLOGY, 57(2), 239–250. https://doi.org/10.1111/j.1574-6941.2006.00112.x

Duong, T., Barrangou, R., Russell, W. M., & Klaenhammer, T. R. (2006). Characterization of the tre locus and analysis of trehalose cryoprotection in Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 72(2), 1218–1225. https://doi.org/10.1128/AEM.72.2.1218-1225.2006

Ventura, M., Canchaya, C., Bernini, V., Altermann, E., Barrangou, R., McGrath, S., … Sinderen, D. (2006). Comparative genomics and transcriptional analysis of prophages identified in the Genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 72(5), 3130–3146. https://doi.org/10.1128/AEM.72.5.3130-3146.2006

Makarova, K., Slesarev, A., Wolf, Y., Sorokin, A., Mirkin, B., Koonin, E., … Mills, D. (2006). Comparative genomics of the lactic acid bacteria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(42), 15611–15616. https://doi.org/10.1073/pnas.0607117103

Sturino, J. M., & Klaenhammer, T. R. (2006). [Review of Engineered bacteriophage-defence systems in bioprocessing]. NATURE REVIEWS MICROBIOLOGY, 4(5), 395–404. https://doi.org/10.1038/nrmicro1393

Barrangou, R., Azcarate-Peril, M. A., Duong, T., Conners, S. B., Kelly, R. M., & Klaenhammer, T. R. (2006). Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(10), 3816–3821. https://doi.org/10.1073/pnas.0511287103

Azcarate-Peril, M. A., Bruno-Barcena, J. M., Hassan, H. M., & Klaenhammer, T. R. (2006). Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 72(3), 1891–1899. https://doi.org/10.1128/AEM.72.3.1891-1899.2006

Altermann, E., Russell, W. M., Azcarate-Peril, M. A., Barrangou, R., Buck, B. L., McAuliffe, O., … Klaenhammer, T. R. (2005). Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(11), 3906–3912. https://doi.org/10.1073/pnas.0409188102

Buck, B. L., Altermann, E., Svingerud, T., & Klaenhammer, T. R. (2005). Functional analysis of putative adhesion factors in Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(12), 8344–8351. https://doi.org/10.1128/AEM.71.12.8344-8351.2005

McAuliffe, O., Cano, R. J., & Klaenhammer, T. R. (2005). Genetic analysis of two bile salt hydrolase activities in Lactobacillus acidophilus NCFM. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(8), 4925–4929. https://doi.org/10.1128/AEM.71.8.4925-4929.2005

Klaenhammer, T. R., Peril, A. A., Barrangou, R., Duong, T., & Altermann, E. (2005). Genomic Perspectives on Probiotic Lactic Acid Bacteria. Bioscience and Microflora, 24(2), 31–33. https://doi.org/10.12938/bifidus.24.31

Klaenhammer, T. R., Barrangou, R., Buck, B. L., Azcarate-Peril, M. A., & Altermann, E. (2005). [Review of Genomic features of lactic acid bacteria effecting bioprocessing and health]. FEMS MICROBIOLOGY REVIEWS, 29(3), 393–409. https://doi.org/10.1016/j.femsre.2005.04.007

Mohamadzadeh, M., Olson, S., Kalina, W. V., Ruthel, G., Demmin, G. L., Warfield, K. L., … Klaenhammer, T. R. (2005). Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(8), 2880–2885. https://doi.org/10.1073/pnas.0500098102

Bruno-Barcena, J. M., Azcarate-Peril, M. A., Klaenhammer, T. R., & Hassan, H. M. (2005). Marker-free chromosomal integration of the manganese superoxide dismutase gene (sodA) from Streptococcus thermophilus into Lactobacillus gasseri. FEMS MICROBIOLOGY LETTERS, 246(1), 91–101. https://doi.org/10.1016/j.femsle.2005.03.044

Azcarate-Peril, M. A., McAuliffe, O., Altermann, E., Lick, S., Russell, W. M., & Klaenhammer, T. R. (2005). Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(10), 5794–5804. https://doi.org/10.1128/AEM.71.10.5794-5804.2005

Rastall, R. A., Gibson, G. R., Gill, H. S., Guarner, F., Klaenhammer, T. R., Pot, B., … Sanders, M. E. (2005). [Review of Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications]. FEMS MICROBIOLOGY ECOLOGY, 52(2), 145–152. https://doi.org/10.1016/j.femsec.2005.01.003

Altermann, E., & Klaenhammer, T. R. (2005). PathwayVoyager: pathway mapping using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. BMC Genomics, 6.

Lu, Z., Altermann, E., Breidt, F., Predki, P., Fleming, H. P., & Klaenhammer, T. R. (2005). Sequence analysis of the Lactobacillus plantarum bacteriophage Phi JL-1. GENE, 348, 45–54. https://doi.org/10.1016/j.gene.2004.12.052

Sturino, J. M., & Klaenhammer, T. R. (2004). Antisense RNA expression strategies effective against Streptococcus thermophilus bacteriophages. Washington, DC: U.S. Patent and Trademark Office.

Sturino, J. M., & Klaenhammer, T. R. (2004). Antisense RNA targeting of primase interferes with bacteriophage replication in Streptococcus thermophilus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(3), 1735–1743. https://doi.org/10.1128/AEM.70.3.1735-1743.2004

Sturino, J. M., & Klaenhammer, T. R. (2004). [Review of Bacteriophage defense systems and strategies for lactic acid bacteria]. ADVANCES IN APPLIED MICROBIOLOGY, VOL 56, 56, 331-+. https://doi.org/10.1016/S0065-2164(04)56011-2

Majhenic, A. C., Venema, K., Allison, G. E., Matijasic, B. B., Rogelj, I., & Klaenhammer, T. R. (2004). DNA analysis of the genes encoding acidocin LF221 A and acidocin LF221 B, two bacteriocins produced by Lactobacillus gasseri LF221. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 63(6), 705–714. https://doi.org/10.1007/s00253-003-1424-2

Yildirim, S., Lin, W., Hitchins, A. D., Jaykus, L. A., Altermann, E., Klaenhammer, T. R., & Kathariou, S. (2004). Epidemic clone I-specific genetic markers in strains of Listeria monocytogenes serotype 4b from foods. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(7), 4158–4164. https://doi.org/10.1128/AEM.70.7.4158-4164.2004

Yildirim, S., Lin, W., Hitchins, A. D., Jaykus, L. A., Altermann, E., Klaenhammer, T. R., & Kathariou, S. (2004, December). Epidemic clone I-specific genetic markers in strains of Listeria monocytogenes serotype 4b from foods (vol 70, pg 4158, 2004). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 70, pp. 7581–7581. https://doi.org/10.1128/aem.70.12.7581.2004

Bruno-Barcena, J. M., Andrus, J. M., Libby, S. L., Klaenhammer, T. R., & Hassan, H. M. (2004). Expression of a heterologous manganese superoxide dismutase gene in intestinal lactobacilli provides protection against hydrogen peroxide toxicity. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(8), 4702–4710. https://doi.org/10.1128/AEM.70.8.4702-4710.2004

Evans, M. R., Swaminathan, B., Graves, L. M., Altermann, E., Klaenhammer, T. R., Fink, R. C., … Kathariou, S. (2004). Genetic markers unique to Listeria monocytogenes serotype 4b differentiate epidemic clone II (hot dog outbreak strains) from other lineages. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(4), 2383–2390. https://doi.org/10.1128/AEM.70.4.2383-2390.2004

Azcarate-Peril, M. A., Altermann, E., Hoover-Fitzula, R. L., Cano, R. J., & Klaenhammer, T. R. (2004). Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(9), 5315–5322. https://doi.org/10.1128/AEM.70.9.5315-5322.2004

Altermann, E., Buck, B. L., Cano, R., & Klaenhammer, T. R. (2004). Identification and phenotypic characterization of the cell-division protein CdpA. GENE, 342(1), 189–197. https://doi.org/10.1016/j.gene.2004.08.004

Barrangou, R., Klaenhammer, T. R., & Altermann, E. (2004). Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof. Washington, DC: U.S. Patent and Trademark Office.

Pridmore, R. D., Berger, B., Desiere, F., Vilanova, D., Barretto, C., Pittet, A. C., … Schell, M. A. (2004). The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(8), 2512–2517. https://doi.org/10.1073/pnas.0307327101

Roberts, R. J., Belfort, M., Bestor, T., Bhagwat, A. S., Bickle, T. A., Bitinaite, J., … Xu, S. Y. (2003). A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. NUCLEIC ACIDS RESEARCH, 31(7), 1805–1812. https://doi.org/10.1093/nar/gkg274

Ventura, M., Canchaya, C., Meylan, V., Klaenhammer, T. R., & Zink, R. (2003). Analysis, characterization, and loci of the tuf genes in Lactobacillus and Bifidobacterium species and their direct application for species identification. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 69(11), 6908–6922. https://doi.org/10.1128/AEM.69.11.6908-6922.2003

Barrangou, R., Altermann, E., Hutkins, R., Cano, R., & Klaenhammer, T. R. (2003). Functional and comparative genomic analyses of an operon involved in fructooligosaccharide utilization by Lactobacillus acidophilus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(15), 8957–8962. https://doi.org/10.1073/pnas.1332765100

Lu, Z., Breidt, F., Fleming, H. P., Altermann, E., & Klaenhammer, T. R. (2003). Isolation and characterization of a Lactobacillus plantarum bacteriophage, Phi JL-1, from a cucumber fermentation. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 84(2), 225–235. https://doi.org/10.1016/S0168-1605(03)00111-9

Andrus, J. M., Bowen, S. W., Klaenhammer, T. R., & Hassan, H. M. (2003). Molecular characterization and functional analysis of the manganese-containing superoxide dismutase gene (sodA) from Streptococcus thermophilus AO54. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 420(1), 103–113. https://doi.org/10.1016/j.abb.2003.09.007

Russell, W. M., & Klaenhammer, T. R. (2003). Polynucleotide encoding a Lactobacillus gasseri beta-glucuronidase polypeptide. Washington, DC: U.S. Patent and Trademark Office.

Barrangou, R., Yoon, S. S., Breidt, F., Fleming, H. P., & Klaenhammer, T. R. (2002). Characterization of six Leuconostoc fallax bacteriophages isolated from an industrial sauerkraut fermentation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 68(11), 5452–5458. https://doi.org/10.1128/AEM.68.11.5452-5458.2002

Klaenhammer, T., Altermann, E., Arigoni, F., Bolotin, A., Breidt, F., Broadbent, J., … al. (2002). Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek, 82(1-4), 29–58. https://doi.org/10.1007/978-94-017-2029-8_3

Sturino, J. M., & Klaenhammer, T. R. (2002). Expression of antisense RNA targeted against Streptococcus thermophilus bacteriophages. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 68(2), 588–596. https://doi.org/10.1128/AEM.68.2.588-596.2002

Mermelstein, N. H., Fennema, O. R., Batt, C. A., Goff, H. D., Griffiths, M. W., Hoover, D. G., … al. (2002). Food research trends - 2003 and beyond. Food Technology, 56(12), 30-.

Barrangou, R., Yoon, S. S., Breidt, F., Fleming, H. P., & Klaenhammer, T. R. (2002). Identification and characterization of Leuconostoc fallax strains isolated from an industrial sauerkraut fermentation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 68(6), 2877–2884. https://doi.org/10.1128/AEM.68.6.2877-2884.2002

Yoon, S. S., Barrangou-Poueys, R., Breidt, F., Klaenhammer, T. R., & Fleming, H. P. (2002). Isolation and characterization of bacteriophages from fermenting sauerkraut. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 68(2), 973–976. https://doi.org/10.1128/AEM.68.2.973-976.2002

Durmaz, E., Madsen, S. A., Israelsen, H., & Klaenhammer, T. R. (2002). Lactococcus lactis lytic bacteriophages of the p335 group are inhibited by overexpression of a truncated CI repressor. JOURNAL OF BACTERIOLOGY, 184(23), 6532–6543. https://doi.org/10.1128/JB.184.23.6532-6543.2002

Tuler, T. R., Callanan, M. J., & Klaenhammer, T. R. (2002). Overexpression of peptidases in Lactococcus and evaluation of their release from leaky cells. JOURNAL OF DAIRY SCIENCE, 85(10), 2438–2450. https://doi.org/10.3168/jds.S0022-0302(02)74326-9

Kullen, M. J., & Klaenhammer, T. R. (2001). Acid-inducible promoters for gene expression. Washington, DC: U.S. Patent and Trademark Office.

Madsen, S. M., Mills, D., Djordjevic, G., Israelsen, H., & Klaenhammer, T. R. (2001). Analysis of the genetic switch and replication region of a P335-type bacteriophage with an obligate lytic lifestyle on Lactococcus lactis. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 67(3), 1128–1139. https://doi.org/10.1128/AEM.67.3.1128-1139.2001

Russell, W. M., & Klaenhammer, T. R. (2001). Efficient system for directed integration into the Lactobacillus acidophilus and Lactobacillus gasseri chromosomes via homologous recombination. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 67(9), 4361–4364. https://doi.org/10.1128/AEM.67.9.4361-4364.2001

Russell, W. M., & Klaenhammer, T. R. (2001). Identification and cloning of gusA, encoding a new beta-glucuronidase from Lactobacillus gasseri ADH. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 67(3), 1253–1261. https://doi.org/10.1128/AEM.67.3.1253-1261.2001

Walker, S. A., & Klaenhammer, T. R. (2001). Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 67(1), 251–259. https://doi.org/10.1128/AEM.67.1.251-259.2001

Sanders, M. E., & Klaenhammer, T. R. (2001). [Review of The scientific basis of Lactobacillus acidophilus NCFM functionality as a probiotic]. JOURNAL OF DAIRY SCIENCE, 84(2), 319–331. https://doi.org/10.3168/jds.S0022-0302(01)74481-5

Walker, S. A., & Klaenhammer, T. R. (2000). An explosive antisense RNA strategy for inhibition of a lactococcal bacteriophage. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 66(1), 310–319. https://doi.org/10.1128/AEM.66.1.310-319.2000

Durmaz, E., & Klaenhammer, T. R. (2000). Genetic analysis of chromosomal regions of Lactococcus lactis acquired by recombinant lytic phages. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 66(3), 895–903. https://doi.org/10.1128/AEM.66.3.895-903.2000

Kullen, M. J., & Klaenhammer, T. R. (2000). Genetic modification of intestinal lactobacilli and bifidobacteria. Current Issues in Molecular Biology, 2(2), 41. https://doi.org/10.21775/cimb.002.041

Klaenhammer, T. R. (2000, February). Probiotic bacteria: Today and tomorrow. JOURNAL OF NUTRITION, Vol. 130, pp. 415S–416S. https://doi.org/10.1093/jn/130.2.415s

Kullen, M. J., Sanozky-Dawes, R. B., Crowell, D. C., & Klaenhammer, T. R. (2000). Use of the DNA sequence of variable regions of the 16S rRNA gene for rapid and accurate identification of bacteria in the Lactobacillus acidophilus complex. JOURNAL OF APPLIED MICROBIOLOGY, 89(3), 511–516. https://doi.org/10.1046/j.1365-2672.2000.01146.x

McCormick, J. K., Klaenhammer, T. R., & Stiles, M. E. (1999). Colicin V can be produced by lactic acid bacteria. LETTERS IN APPLIED MICROBIOLOGY, 29(1), 37–41. https://doi.org/10.1046/j.1365-2672.1999.00571.x

Kullen, M. J., & Klaenhammer, T. R. (1999). Identification of the pH-inducible, proton-translocating F1F0- ATPase (atpBEFHAGDC) operon of Lactobacillus acidophilus by differential display: gene structure, cloning and characterization. Molecular Microbiology, 33(6), 1152–1161. https://doi.org/10.1046/j.1365-2958.1999.01557.x

Klaenhammer, T. R., & Kullen, M. J. (1999, September 15). Selection and design of probiotics. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, Vol. 50, pp. 45–57. https://doi.org/10.1016/S0168-1605(99)00076-8

Walker, D. C., Girgis, H. S., & Klaenhammer, T. R. (1999). The groESL chaperone operon of Lactobacillus johnsonii. Applied and Environmental Microbiology, 65(7), 3033–3041.

Dinsmore, P. K., DJ O'Sullivan, & Klaenhammer, T. R. (1998). A leucine repeat motif in AbiA is required for resistance of Lactococcus lactis to phages representing three species. GENE, 212(1), 5–11. https://doi.org/10.1016/S0378-1119(98)00132-2

Klaenhammer, T. R., Conkling, M. A., O'Sullivan, D., Djordjevic, G., Walker, S. A., & Taylor, C. G. (1998). Bacteriophage-triggered cell suicide systems and fermentation methods employing the same. Washington, DC: U.S. Patent and Trademark Office.

Walker, S. A., Dombroski, C. S., & Klaenhammer, T. R. (1998). Common elements regulating gene expression in temperate and lytic bacteriophages of Lactococcus species. Applied and Environmental Microbiology, 64(3), 1147–1152.

DJ O'Sullivan, & Klaenhammer, T. R. (1998). Control of expression of LlaI restriction in Lactococcus lactis. MOLECULAR MICROBIOLOGY, 27(5), 1009–1020. https://doi.org/10.1046/j.1365-2958.1998.00748.x

Klaenhammer, T. R. (1998). Functional activities of Lactobacillus probiotics: Genetic mandate. INTERNATIONAL DAIRY JOURNAL, Vol. 8, pp. 497–505. https://doi.org/10.1016/S0958-6946(98)00076-4

Djordjevic, G. M., & Klaenhammer, T. R. (1998). [Review of Inducible gene expression systems in Lactococcus lactis]. MOLECULAR BIOTECHNOLOGY, 9(2), 127–139. https://doi.org/10.1007/BF02760814

Walker, S. A., & Klaenhammer, T. R. (1998). Molecular characterization of a phage-inducible middle promoter and its transcriptional activator from the lactococcal bacteriophage phi 31. Journal of Bacteriology, 180(4), 921–931.

Allison, G. E., & Klaenhammer, T. R. (1998). [Review of Phage resistance mechanisms in lactic acid bacteria]. INTERNATIONAL DAIRY JOURNAL, 8(3), 207–226. https://doi.org/10.1016/S0958-6946(98)00043-0

Klaenhammer, T. R., Connolly, J. F., Fitzgerald, R. J., Stanton, C., & Ross, R. P. (1998). Special issue - Functional foods: Designer foods for the future. International Dairy Journal, 8(5-6), vv.

Djordjevic, G. M., OSullivan, D. J., Walker, S. A., Conkling, M. A., & Klaenhammer, T. R. (1997). A triggered-suicide system designed as a defense against bacteriophages. JOURNAL OF BACTERIOLOGY, 179(21), 6741–6748. https://doi.org/10.1128/jb.179.21.6741-6748.1997

Djordjevic, G. M., & Klaenhammer, T. R. (1997). Bacteriophage-triggered defense systems: Phage adaptation and design improvements. Applied and Environmental Microbiology, 63(11), 4370–4376.

Djordjevic, G. M., & Klaenhammer, T. R. (1997). [Review of Genes and gene expression in Lactococcus bacteriophages]. INTERNATIONAL DAIRY JOURNAL, 7(8-9), 489–508. https://doi.org/10.1016/S0958-6946(97)00060-5

Klaenhammer, T. R., & Moineau, S. (1997). Method of eliminating genetic routes for bacteriophage evolution and products produced thereby. Washington, DC: U.S. Patent and Trademark Office.

Dinsmore, P. K., & Klaenhammer, T. R. (1997). Molecular characterization of a genomic region in a Lactococcus bacteriophage that is involved in its sensitivity to the phage defense mechanism AbiA. JOURNAL OF BACTERIOLOGY, 179(9), 2949–2957. https://doi.org/10.1128/jb.179.9.2949-2957.1997

Klaenhammer, T. R., Sing, W. D., & Hill, C. J. (1997). Phage defense rotation strategy. Washington, DC: U.S. Patent and Trademark Office.

Hill, C. J., & Klaenhammer, T. R. (1996). Bacteriophage resistant recombinant bacteria. Washington, DC: U.S. Patent and Trademark Office.

Klaenhammer, T. R., & Moineau, S. (1996). Method of eliminating genetic routes for bacteriophage evolution and products produced thereby. Washington, DC: U.S. Patent and Trademark Office.

Klaenhammer, T. R. (1995). Genetics of intestinal lactobacilli. INTERNATIONAL DAIRY JOURNAL, Vol. 5, pp. 1019–1058. https://doi.org/10.1016/0958-6946(95)00044-5

Klaenhammer, T. R. (1993). Genetics of bacteriocins produced by lactic-acid bacteria. FEMS Microbiology Reviews, 12(39085), 39–86. https://doi.org/10.1111/j.1574-6976.1993.tb00012.x

Klaenhammer, T. R., Sanozky, R. B., & Steenson, L. R. (1992). PTR2030, a conjugal plasmid and derivatives thereof that confer phage resistance to group N streptococci. Washington, DC: U.S. Patent and Trademark Office.

Klaenhammer, T. R., & Sing, W. D. (1991). A novel rotation strategy using different phage defenses in a single-strain starter culture system. Journal of Dairy Science, 74, 120.

KLAENHAMMER, T. R. (1991, August). DEVELOPMENT OF BACTERIOPHAGE-RESISTANT STRAINS OF LACTIC-ACID BACTERIA. BIOCHEMICAL SOCIETY TRANSACTIONS, Vol. 19, pp. 675–681. https://doi.org/10.1042/bst0190675

Klaenhammer, T. R., Sanozky, R. B., & Steenson, L. R. (1990). pTR2030, a conjugal plasmid and derivatives thereof that confer phage reisistance to group N streptococci. Washington, DC: U.S. Patent and Trademark Office.

Klaenhammer, T. R. (1989). Genetic characterization of multiple mechanisms of phage defense from a prototype phage-insensitive strain, Lactococcus lactis ME2. Journal of Dairy Science, 72(12), 3429. https://doi.org/10.3168/jds.S0022-0302(89)79505-9

Klaenhammer, T. R., & Sanozky-Dawes, R. B. (1989). pTN1060, a conjugal plasmid and derivatives thereof that confer phage resistance to group N streptococci. Washington, DC: U.S. Patent and Trademark Office.

KLAENHAMMER, T. R. (1988). BACTERIOCINS OF LACTIC-ACID BACTERIA. BIOCHIMIE, 70(3), 337–349. https://doi.org/10.1016/0300-9084(88)90206-4

Daeschel, M. A., McFeeters, R. F., Fleming, H. P., Klaenhammer, T. R., & Sanozky, R. B. (1987). Lactic acid bacteria which do not decarboxylate malic acid and fermentation therewith. Washington, DC: U.S. Patent and Trademark Office.

Klaenhammer, T. R. (1987). Plasmid-directed mechanisms for bacteriophage defense in lactic streptococci. FEMS Microbiology Reviews, 46(3), 313. https://doi.org/10.1111/j.1574-6968.1987.tb02468.x

JOERGER, M. C., & KLAENHAMMER, T. R. (1986). CHARACTERIZATION AND PURIFICATION OF HELVETICIN-J AND EVIDENCE FOR A CHROMOSOMALLY DETERMINED BACTERIOCIN PRODUCED BY LACTOBACILLUS-HELVETICUS-481. JOURNAL OF BACTERIOLOGY, 167(2), 439–446. https://doi.org/10.1128/jb.167.2.439-446.1986

Barefoot, S. F., & Klaenhammer, T. R. (1983). Detection and activity of lactacin-b, a bacteriocin produced by lactobacillus-acidophilus. Applied and Environmental Microbiology, 45(6), 1808–1815.