Thomas Theis
https://orcid.org/0000-0001-6779-9978
NMR, MRI, Magnetic Resonance, Hyperpolarization, Quantum Mechanics, Molecular Imaging, Biomedical Engineering
Dr. Thomas Theis is Assistant Professor at North Carolina State University and Adjunct Assistant Professor at the University of North Carolina at Chapel Hill. His research is focused on hyperpolarization technology and unconventional NMR and MRI detection schemes. Dr. Theis was born in Heidelberg, Germany, raised in Tenerife, Spain, and completed his undergraduate and masters at the Georg-August University of Goettingen (Germany). Theis received his PhD in 2012 from UC Berkeley (USA) working with Prof. Alexander Pines on "zero-field NMR" and “parahydrogen hyperpolarization schemes” for portable NMR. Dr. Theis conducted postdoctoral research at Duke University (USA) with Prof. Warren Warren focused on "singlet states for hyperpolarization storage", and worked on "low-field NMR" as visiting professor at RWTH Aachen University with Prof. Stephan Appelt (Germany). In 2015, he was promoted to Research Assistant Professor at Duke University developing “cost-efficient hyperpolarization techniques for molecular imaging”. Since 2018, Dr. Theis leads the North Carolina State Hyperpolarization Laboratory.
Works (99)
Updated: September 10th, 2023 04:34
2023 journal article
C-13 Radiofrequency Amplification by Stimulated Emission of Radiation Threshold Sensing of Chemical Reactions
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(20), 11121–11129.
Sources: Web Of Science, ORCID
Added: July 10, 2023
2023 journal article
Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-C-13]ketoisocaproate
METABOLITES, 13(2).
author keywords: NMR; hyperpolarization; carbon-13; ketoisocaproate; signal amplification by reversible exchange; SABRE-SHEATH; branched chain amino acid; BCAT
www.mdpi.com (publisher PDF)
Sources: ORCID, Web Of Science
Added: January 31, 2023
2023 journal article
Exploring synchrony and chaos of parahydrogen-pumped two-compartment radio-frequency amplification by stimulated emission of radiation
PHYSICAL REVIEW A, 108(2).
Sources: ORCID, Web Of Science
Added: August 16, 2023
2023 article
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo
Browning, A., MacCulloch, K., Bedoya, D. G., Dedesma, C., Goodson, B. M., Rosen, M. S., … Theis, T. (2023, March 20).
Source: ORCID
Added: March 21, 2023
2023 journal article
Innentitelbild: Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation (Angew. Chem. 5/2023)
Angewandte Chemie.
Source: ORCID
Added: December 29, 2022
2023 journal article
Inside Cover: Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation (Angew. Chem. Int. Ed. 5/2023)
Angewandte Chemie International Edition.
Source: ORCID
Added: December 29, 2022
2023 article
LIGHT-SABRE Hyperpolarizes 1-13C-Pyruvate Continuously without Magnetic Field Cycling
Pravdivtsev, A. N., Buckenmaier, K., Kempf, N., Stevanato, G., Scheffler, K., Engelmann, J., … Theis, T. (2023, April 4). JOURNAL OF PHYSICAL CHEMISTRY C, Vol. 4.
Sources: ORCID, Web Of Science
Added: April 5, 2023
2023 article
Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole
MacCulloch, K., Browning, A., TomHon, P., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2023, May 10). ANALYTICAL CHEMISTRY, Vol. 5.
MeSH headings : Letrozole; Anastrozole; Magnetic Resonance Spectroscopy; Magnetic Resonance Imaging; Antineoplastic Agents / pharmacology
Sources: ORCID, Web Of Science
Added: May 11, 2023
2023 journal article
Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation
Angewandte Chemie.
Source: ORCID
Added: December 20, 2022
2023 journal article
SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(3).
author keywords: high-pressure; benchtop NMR; SABRE; hyperpolarization; removable solvent
MeSH headings : Solvents / chemistry; Magnetic Resonance Spectroscopy / methods; Magnetic Resonance Imaging; Methanol
Sources: ORCID, Web Of Science
Added: January 31, 2023
2023 journal article
Spin dynamics of [1,2-C-13(2)]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25(24), 16446–16458.
Sources: ORCID, Web Of Science
Added: June 13, 2023
2022 article
Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange
Schmidt, A. B., Maissin, H., Adelabu, I., Nantogma, S., Ettedgui, J., TomHon, P., … Chekmenev, E. Y. (2022, November 15). ACS SENSORS, Vol. 11.
author keywords: Biosensors; magnetic resonance imaging; hyperpolarization; imaging agents; NMR spectroscopy; Parahydrogen; Pyruvate; SABRE
MeSH headings : Humans; Pyruvic Acid; Magnetic Resonance Spectroscopy / methods; Solubility; Magnetic Resonance Imaging / methods; Water
Sources: ORCID, Web Of Science
Added: November 16, 2022
2022 article
Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques
Schmidt, A. B., Bowers, C. R., Buckenmaier, K., Chekmenev, E. Y., Maissin, H., Eills, J., … Hoevener, J.-B. (2022, January 1). ANALYTICAL CHEMISTRY, Vol. 1.
MeSH headings : Hydrogen; Magnetic Resonance Spectroscopy
Sources: Web Of Science, ORCID
Added: January 18, 2022
2022 article
Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-C-13]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH
Nantogma, S., Eriksson, S. L., Adelabu, I., Mandzhieva, I., Browning, A., TomHon, P., … Chekmenev, E. Y. (2022, November 28). JOURNAL OF PHYSICAL CHEMISTRY A, Vol. 11.
MeSH headings : Pyruvic Acid
Sources: ORCID, Web Of Science
Added: November 29, 2022
2022 article
Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation
Nelson, C., Schmidt, A. B., Adelabu, I., Nantogma, S., Kiselev, V. G., Abdurraheem, A., … Chekmenev, E. Y. (2022, December 19). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 12.
author keywords: Carbon-13; Hyperpolarization; NMR Spectroscopy; Parahydrogen; RASER
MeSH headings : Hydrogen / chemistry; Protons; Magnetic Resonance Spectroscopy; Acetates / chemistry
Sources: ORCID, Web Of Science
Added: December 20, 2022
2022 article
Proton-Only Sensing of Hyperpolarized [1,2-C-13(2)]Pyruvate
Mandzhieva, I., Adelabu, I., Chekmenev, E. Y., & Theis, T. (2022, November 22). ACS SENSORS, Vol. 11.
author keywords: Parahydrogen; hyperpolarization; pyruvate; SABRE; proton sensing; molecular imaging
MeSH headings : Protons; Magnetic Resonance Spectroscopy / methods; Pyruvic Acid / metabolism; Magnetic Resonance Imaging / methods; Contrast Media
Sources: ORCID, Web Of Science
Added: November 23, 2022
2022 journal article
RASER MRI: Magnetic resonance images formed spontaneously exploiting cooperative nonlinear interaction
SCIENCE ADVANCES, 8(28).
Sources: ORCID, Web Of Science
Added: July 14, 2022
2022 article
Rapid C-13 Hyperpolarization of the TCA Cycle Intermediate alpha-Ketoglutarate via SABRE-SHEATH
Adelabu, I., Ettedgui, J., Joshi, S. M., Nantogma, S., Chowdhury, M. R. H., McBride, S., … Chekmenev, E. Y. (2022, September 22). ANALYTICAL CHEMISTRY, Vol. 9.
MeSH headings : Catalysis; Contrast Media; Ketoglutaric Acids; Pyruvic Acid; Theophylline
Sources: ORCID, Web Of Science
Added: September 23, 2022
2022 article
Triplet Photosensitized para-Hydrogen Induced Polarization
Brown, E. E., Mandzhieva, I., TomHon, P. M., Theis, T., & Castellano, F. N. (2022, November 14). ACS CENTRAL SCIENCE, Vol. 11.
Sources: ORCID, Web Of Science
Added: November 15, 2022
2021 article
A Versatile Compact Parahydrogen Membrane Reactor
TomHon, P. M., Han, S., Lehmkuhl, S., Appelt, S., Chekmenev, E. Y., Abolhasani, M., & Theis, T. (2021, October 26). CHEMPHYSCHEM, Vol. 10.
author keywords: hyperpolarization; parahydrogen; NMR; fluidics; RASER
MeSH headings : Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy
Sources: Web Of Science, ORCID
Added: November 8, 2021
2021 article
Background-Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation
Joalland, B., Theis, T., Appelt, S., & Chekmenev, E. Y. (2021, October 1). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 10.
author keywords: hyperpolarization; NMR spectroscopy; parahydrogen; RASER
MeSH headings : Body Fluids / chemistry; Contrast Media / analysis; Humans; Magnetic Fields; Proton Magnetic Resonance Spectroscopy
Sources: ORCID, Web Of Science
Added: October 2, 2021
2021 journal article
Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation
Angewandte Chemie, 9.
Source: ORCID
Added: October 2, 2021
2021 article
Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange
Lin, K., TomHon, P., Lehmkuhl, S., Laasner, R., Theis, T., & Blum, V. (2021, September 22). CHEMPHYSCHEM, Vol. 9.
author keywords: computational chemistry; density functional calculations; hyperpolarization; NMR spectroscopy; reaction mechanisms; parahydrogen
MeSH headings : Density Functional Theory; Hydrogen / chemistry; Methanol / chemistry; Pyridines / chemistry; Surface Properties
Sources: ORCID, Web Of Science
Added: September 23, 2021
2021 article
Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange
Lin, K., TomHon, P., Lehmkuhl, S., Laasner, R., Theis, T., & Blum, V. (2021, October 5). CHEMPHYSCHEM, Vol. 22, pp. 1937–1938.
author keywords: computational chemistry; density functional calculations; hyperpolarization; NMR spectroscopy; reaction mechanisms; parahydrogen
Sources: ORCID, Web Of Science
Added: October 10, 2021
2021 journal article
Front Cover: Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange (ChemPhysChem 19/2021)
ChemPhysChem.
Source: ORCID
Added: October 10, 2021
2021 article
Hyperpolarization of common antifungal agents with SABRE
MacCulloch, K., Tomhon, P., Browning, A., Akeroyd, E., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2021, June 20). MAGNETIC RESONANCE IN CHEMISTRY, Vol. 6.
author keywords: N-15; H-1; antifungals; clotrimazole and fluconazole; contrast agents; hyperpolarization; NMR; parahydrogen; SABRE; voriconazole
MeSH headings : Antifungal Agents; Catalysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes
Sources: ORCID, Web Of Science
Added: June 21, 2021
2021 journal article
Innentitelbild: Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation (Angew. Chem. 50/2021)
Angewandte Chemie, 11.
Source: ORCID
Added: November 3, 2021
2021 journal article
Inside Cover: Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation (Angew. Chem. Int. Ed. 50/2021)
Angewandte Chemie International Edition, 11.
Source: ORCID
Added: November 3, 2021
2021 journal article
Intensified continuous extraction of switchable hydrophilicity solvents triggered by carbon dioxide
GREEN CHEMISTRY, 23(8), 2900–2906.
Sources: ORCID, Web Of Science
Added: April 1, 2021
2021 journal article
Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange
PRX Quantum, 2(1), 010305.
Sources: ORCID, Crossref, Web Of Science
Added: January 13, 2021
2021 article
Order-Unity C-13 Nuclear Polarization of [1-C-13]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement
Adelabu, I., TomHon, P., Kabir, M. S. H., Nantogma, S., Abdulmojeed, M., Mandzhieva, I., … Chekmenev, E. Y. (2021, December 9). CHEMPHYSCHEM, Vol. 11.
author keywords: hyperpolarization; NMR spectroscopy; parahydrogen; C-13; pyruvate
MeSH headings : Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Pyruvic Acid; Water / chemistry
Sources: ORCID, Web Of Science
Added: December 10, 2021
2021 journal article
SABRE and PHIP pumped RASER and the route to chaos
Journal of Magnetic Resonance, 322, 106815.
author keywords: RASER; Hyperpolarization; NMR spectroscopy; MRI; Parahydrogen; PHIP; PASADENA; ALTADENA; SABRE; Synergetics; Slaving principle; Non-linear coupled oscillators; Mode collapse; Period doubling; Chaos; Intermittence
Sources: ORCID, Crossref, Web Of Science
Added: January 12, 2021
2021 article
Temperature Cycling Enables Efficient C-13 SABRE-SHEATH Hyperpolarization and Imaging of [1-C-13]-Pyruvate
TomHon, P., Abdulmojeed, M., Adelabu, I., Nantogma, S., Kabir, M. S. H., Lehmkuhl, S., … Theis, T. (2021, December 23). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12.
MeSH headings : Pyruvic Acid
Sources: ORCID, Web Of Science
Added: December 24, 2021
2020 journal article
Application of 15N2-Diazirines as a Versatile Platform for Hyperpolarization of Biological Molecules by d-DNP
Bioconjugate Chemistry, 31(3), 537–541.
MeSH headings : Diazomethane / chemistry; Magnetic Resonance Imaging / methods; Nitrogen Isotopes / chemistry
Sources: ORCID, Crossref
Added: January 12, 2021
2020 journal article
Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR
Journal of Magnetic Resonance, 312, 106700.
author keywords: Parahydrogen; SABRE; Magnetic field cycling; Pneumatic shuttling; Singlet states; Hyperpolarization
MeSH headings : Catalysis; Equipment Design; Hydrogen / chemistry; Magnetic Fields; Magnetic Resonance Spectroscopy / instrumentation; Models, Molecular; Nitrogen Isotopes / chemistry; Protons
Sources: Web Of Science, ORCID, Crossref
Added: March 23, 2020
2020 article
Micron-scale SABRE-enhanced NV-NMR Spectroscopy
(2020, June 6).
Source: ORCID
Added: January 12, 2021
2020 journal article
Parahydrogen‐Induced Hyperpolarization of Gases
Angewandte Chemie International Edition, 59(41), 17788–17797.
author keywords: hyperpolarization; MRI; NMR; parahydrogen; spectroscopy
MeSH headings : Catalysis; Gases / chemistry; Hydrogen / chemistry; Magnetic Resonance Imaging / methods; Magnetic Resonance Spectroscopy / methods
Sources: Web Of Science, ORCID, Crossref
Added: August 31, 2020
2020 journal article
Parahydrogen‐Induced Radio Amplification by Stimulated Emission of Radiation
Angewandte Chemie International Edition, 59(22), 8654–8660.
author keywords: hyperpolarization; NMR spectroscopy; parahydrogen; PHIP; RASER
Sources: Web Of Science, ORCID, Crossref
Added: June 1, 2020
2020 journal article
Parahydrogen‐Induced Radio Amplification by Stimulated Emission of Radiation
Angewandte Chemie, 132(22), 8732–8738.
Source: ORCID
Added: January 12, 2021
2020 journal article
Parawasserstoff‐induzierte Hyperpolarisation von Gasen
Angewandte Chemie, 132(41), 17940–17949.
Sources: ORCID, Crossref
Added: January 12, 2021
2020 journal article
Rational ligand choice extends the SABRE substrate scope
Chemical Communications, 56(65), 9336–9339.
Sources: Web Of Science, ORCID, Crossref
Added: August 31, 2020
2020 journal article
SABRE polarized low field rare-spin spectroscopy
The Journal of Chemical Physics, 152(18), 184202.
Sources: Web Of Science, ORCID, Crossref
Added: June 15, 2020
2019 journal article
Hyperpolarizing Concentrated Metronidazole 15 NO 2 Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime
Chemistry – A European Journal, 25(37), 8829–8836.
author keywords: hyperpolarization; isotopic labeling; nitrogen heterocycles; NMR spectroscopy; SABRE; spin relays
Sources: Web Of Science, ORCID, Crossref
Added: August 12, 2019
2019 journal article
Iodonitrene in Action: Direct Transformation of Amino Acids into Terminal Diazirines and15N2-Diazirines and Their Application as Hyperpolarized Markers
Journal of the American Chemical Society, 141(34), 13689–13696.
MeSH headings : Amino Acids / chemistry; Ammonia / chemistry; Diazomethane / chemistry; Halogenation; Imines / chemistry; Iodine / chemistry; Nitrogen / chemistry; Onium Compounds / chemistry; Tyrosine / chemistry
Sources: Web Of Science, ORCID, Crossref
Added: September 23, 2019
2019 chapter
Nuclear Magnetic Resonance Spectroscopy Techniques: Hyperpolarization for Sensitivity Enhancement
In P. Worsfold, A. Townshend, C. Poole, & M. Miró (Eds.), Encyclopedia of Analytical Science (3rd ed., pp. 168–181).
Ed(s): P. Worsfold, A. Townshend, C. Poole & M. Miró
Sources: Crossref, ORCID
Added: January 21, 2021
2019 journal article
Quasi-Resonance Fluorine-19 Signal Amplification by Reversible Exchange
The Journal of Physical Chemistry Letters, 10(15), 4229–4236.
Sources: Web Of Science, ORCID, Crossref
Added: October 7, 2019
2019 journal article
Selective hyperpolarization of heteronuclear singlet states via pulsed microtesla SABRE
The Journal of Chemical Physics, 151(4), 044201.
Sources: Web Of Science, ORCID, Crossref
Added: August 19, 2019
2019 journal article
Terminal Diazirines Enable Reverse Polarization Transfer from 15 N 2 Singlets
Angewandte Chemie International Edition, 58(32), 11118–11124.
MeSH headings : Azirines / chemistry; Molecular Structure; Nitrogen Isotopes
Sources: Web Of Science, ORCID, Crossref
Added: September 3, 2019
2019 journal article
Terminal Diazirines Enable Reverse Polarization Transfer from 15N2 Singlets
Angewandte Chemie.
Source: ORCID
Added: January 12, 2021
2019 journal article
Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange
Nature Communications, 10(1).
MeSH headings : Catalysis; Hydrogen / chemistry; Kinetics; Magnetic Fields; Magnetic Resonance Spectroscopy; Models, Molecular; Models, Theoretical; Nitrogen Isotopes / chemistry; Pyridines / chemistry
Sources: ORCID, Crossref
Added: January 12, 2021
2018 journal article
15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para-N2
Science Advances, 4(3), eaar2978.
Sources: ORCID, Crossref
Added: January 12, 2021
2018 journal article
Parahydrogen-Based Hyperpolarization for Biomedicine
Angewandte Chemie International Edition, 57(35), 11140–11162.
author keywords: hyperpolarization; magnetic resonance imaging; NMR spectroscopy; parahydrogen
Sources: ORCID, Crossref
Added: January 12, 2021
2018 journal article
Parawasserstoff-basierte Hyperpolarisierung für die Biomedizin
Angewandte Chemie, 130(35), 11310–11333.
Sources: Crossref, ORCID
Added: February 6, 2021
2018 journal article
Quasi-Resonance Signal Amplification by Reversible Exchange
The Journal of Physical Chemistry Letters, 9(20), 6136–6142.
Sources: Web Of Science, ORCID, Crossref
Added: November 19, 2018
2017 journal article
Cover Picture: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. Int. Ed. 40/2017)
Angewandte Chemie International Edition.
Source: ORCID
Added: January 12, 2021
2017 journal article
Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization
Angewandte Chemie International Edition, 56(40), 12112–12116.
author keywords: diazirine; hyperpolarization; imaging agents; iridium; structure-activity relationships
Sources: ORCID, Crossref
Added: January 12, 2021
2017 journal article
Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization
Angewandte Chemie, 129(40), 12280–12284.
Source: ORCID
Added: January 12, 2021
2017 journal article
Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange
Journal of the American Chemical Society, 139(23), 7761–7767.
MeSH headings : Hydrogen / chemistry; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrogen Isotopes / chemistry; Water / chemistry
Sources: ORCID, Crossref
Added: January 12, 2021
2017 journal article
Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
The Journal of Physical Chemistry C, 121(12), 6626–6634.
Sources: ORCID, Crossref
Added: January 12, 2021
2017 journal article
Invited Review Article: Instrumentation for nuclear magnetic resonance in zero and ultralow magnetic field
Review of Scientific Instruments, 88(9), 091101.
Sources: ORCID, Crossref
Added: January 12, 2021
2017 journal article
Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields
The Journal of Physical Chemistry Letters, 8(13), 3008–3014.
Sources: ORCID, Crossref
Added: January 12, 2021
2017 journal article
Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification by Reversible Exchange
The Journal of Physical Chemistry C, 121(51), 28425–28434.
Source: ORCID
Added: January 12, 2021
2017 journal article
The Absence of Quadrupolar Nuclei Facilitates Efficient13C Hyperpolarization via Reversible Exchange with Parahydrogen
ChemPhysChem, 18(12), 1493–1498.
author keywords: carbon-13; hyperpolarization; NMR; parahydrogen; spectroscopy
MeSH headings : Carbon Isotopes; Magnetic Resonance Imaging; Nitrogen Isotopes; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry; Pyridines / chemistry
Sources: ORCID, Crossref
Added: January 12, 2021
2017 journal article
Titelbild: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. 40/2017)
Angewandte Chemie.
Source: ORCID
Added: January 12, 2021
2017 journal article
Toward Hyperpolarized 19F Molecular Imaging via Reversible Exchange with Parahydrogen
ChemPhysChem, 18(15), 1961–1965.
author keywords: fluorine-19; hyperpolarization; molecular imaging; MRI; parahydrogen
Sources: ORCID, Crossref
Added: January 12, 2021
2016 journal article
15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH
ACS Sensors, 1(6), 640–644.
author keywords: NMR; hyperpolarization; parahydrogen; imidazole; pH sensing; N-15; chemical shift
Source: ORCID
Added: January 12, 2021
2016 journal article
Accessing long lived 1H states via 2H couplings
Journal of Magnetic Resonance, 263, 108–115.
author keywords: Solution NMR; Long lived states; Ethylene; Deuterium
Source: ORCID
Added: January 12, 2021
2016 journal article
Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal 15N2-diazirine molecular tags
Science Advances, 2(3), e1501438–e1501438.
MeSH headings : Diazomethane / chemistry; Electron Spin Resonance Spectroscopy; Magnetic Fields; Magnetic Resonance Spectroscopy; Models, Chemical; Nitrogen Isotopes / chemistry
Source: ORCID
Added: January 12, 2021
2016 journal article
Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen
Chemistry - A European Journal, 22(31), 10777–10781.
author keywords: amino acids; homogeneous catalysis; imaging agents; iridium; NMR spectroscopy
Source: ORCID
Added: January 12, 2021
2016 journal article
Over 20%15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe
Journal of the American Chemical Society, 138(26), 8080–8083.
Source: ORCID
Added: January 12, 2021
2015 journal article
15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH
The Journal of Physical Chemistry C, 119(16), 8786–8797.
Source: ORCID
Added: January 12, 2021
2015 journal article
Hyperpolarization of “Neat” Liquids by NMR Signal Amplification by Reversible Exchange
The Journal of Physical Chemistry Letters, 6(10), 1961–1967.
MeSH headings : Catalysis; Hydrogen / chemistry; Iridium / chemistry; Magnetic Resonance Spectroscopy; Nitrogen Isotopes / chemistry; Pyridines / chemistry
Source: ORCID
Added: January 12, 2021
2015 journal article
Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization
Journal of the American Chemical Society, 137(4), 1404–1407.
MeSH headings : Hydrogen / chemistry; Magnetic Resonance Spectroscopy; Models, Molecular; Niacinamide / chemistry; Nitrogen Isotopes / analysis; Pyridines / chemistry
Source: ORCID
Added: January 12, 2021
2014 journal article
Accessing Long-Lived Disconnected Spin-1/2 Eigenstates through Spins > 1/2
Accessing Long-Lived Disconnected Spin-1/2 Eigenstates through Spins > 1/2. Journal of the American Chemical Society, 136(43), 15118–15121.
MeSH headings : Acetylene / chemistry; Deuterium / chemistry; Magnetic Phenomena; Magnetic Resonance Spectroscopy
Sources: ORCID, Crossref
Added: January 12, 2021
2014 journal article
Analysis of parahydrogen polarized spin system in low magnetic fields
Physical Chemistry Chemical Physics, 16(29), 15411–15421.
Sources: ORCID, Crossref
Added: January 12, 2021
2014 journal article
Composite and shaped pulses for efficient and robust pumping of disconnected eigenstates in magnetic resonance
The Journal of Chemical Physics, 140(1), 014201.
Sources: ORCID, Crossref
Added: January 12, 2021
2014 journal article
LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization
Journal of Magnetic Resonance, 248, 23–26.
author keywords: NMR and MRI; Parahydrogen; Hyperpolarization; NMR spectroscopy; Magnetic properties
MeSH headings : Catalysis; Hydrogen / chemistry; Hydrogen / radiation effects; Iridium / chemistry; Iridium / radiation effects; Magnetic Fields; Pyridines / chemistry; Pyridines / radiation effects; Radiation Dosage; Singlet Oxygen / chemistry; Singlet Oxygen / radiation effects; Spin Labels
Source: ORCID
Added: January 12, 2021
2014 journal article
LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization
Journal of Magnetic Resonance. http://www.sciencedirect.com/science/article/pii/S1090780714002420
Source: ORCID
Added: January 12, 2021
2014 journal article
Long-Lived Heteronuclear Spin-Singlet States in Liquids at a Zero Magnetic field
Phys. Rev. Lett.
Source: ORCID
Added: January 12, 2021
2014 journal article
Long-lived polarization protected by symmetry
The Journal of Chemical Physics, 141(13), 134307.
MeSH headings : Alkynes / chemistry; Computer Simulation; Magnetic Resonance Spectroscopy / methods; Maleic Anhydrides / chemistry; Models, Molecular; Pyridazines / chemistry
Sources: ORCID, Crossref
Added: January 12, 2021
2014 journal article
Measuring long-lived 13C2 state lifetimes at natural abundance
Journal of Magnetic Resonance, 239, 81–86.
author keywords: Hyperpolarization; Singlet state; Long lived state
MeSH headings : Algorithms; Alkynes; Carbon Isotopes; Electromagnetic Fields; Half-Life; Isotope Labeling; Nuclear Magnetic Resonance, Biomolecular / instrumentation; Nuclear Magnetic Resonance, Biomolecular / methods; Reproducibility of Results; Solvents
Source: ORCID
Added: January 12, 2021
2013 journal article
Chemical analysis using J-coupling multiplets in zero-field NMR
Chemical Physics Letters, 580, 160–165.
Source: ORCID
Added: January 12, 2021
2013 journal article
Fundamental Aspects of Parahydrogen Enhanced Low-Field Nuclear Magnetic Resonance
Phys. Rev. Lett.
Source: ORCID
Added: January 12, 2021
2013 journal article
High-Resolution Zero-Field NMR J -Spectroscopy of Aromatic Compounds
J. Am. Chem. Soc., 135(9), 3607–3612.
MeSH headings : Benzene Derivatives / chemistry; Magnetic Fields; Magnetic Resonance Spectroscopy; Reference Standards
Source: ORCID
Added: January 12, 2021
2013 journal article
Multiplets at zero magnetic field: The geometry of zero-field NMR
J. Chem. Phys., 138(18), 184202.
Source: ORCID
Added: January 12, 2021
2013 journal article
Parahydrogen-induced polarization at zero magnetic field
J. Chem. Phys., 138(23), 234201.
Source: ORCID
Added: January 12, 2021
2013 journal article
Storage of Hydrogen Spin Polarization in Long-Lived 13 C 2 Singlet Order and Implications for Hyperpolarized Magnetic Resonance Imaging
J. Am. Chem. Soc., 135(26), 9632–9635.
MeSH headings : Acetylene / analogs & derivatives; Acetylene / chemistry; Carbon Isotopes; Hydrogen / chemistry; Magnetic Resonance Imaging
Source: ORCID
Added: January 12, 2021
2012 journal article
Vibrationally resolved transition state spectroscopy of the F + H2 and F + CH4 reactions
Faraday Discuss., 157, 399.
Source: ORCID
Added: January 12, 2021
2012 journal article
Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange
J. Am. Chem. Soc., 134(9), 3987–3990.
MeSH headings : Hydrogen / chemistry; Magnetic Resonance Spectroscopy; Pyridines / analysis
Source: ORCID
Added: January 12, 2021
2011 journal article
Near-Zero-Field Nuclear Magnetic Resonance
Phys. Rev. Lett.
Source: ORCID
Added: January 12, 2021
2011 journal article
Near-zero field magnetic resonance
Physical Review Letters.
Source: ORCID
Added: January 12, 2021
2011 journal article
Parahydrogen-enhanced zero-field nuclear magnetic resonance
Nat Phys, 7(7), 571–575.
Source: ORCID
Added: January 12, 2021
2008 journal article
PLP Labeling in ESR Spectroscopic Analysis of Secondary and Tertiary Acrylate Propagating Radicals
Macromolecules, 41(2), 288–291.
Source: ORCID
Added: January 12, 2021
2007 journal article
Chain-Length-Dependent Termination in Acrylate Radical Polymerization Studied via Pulsed-Laser-Initiated RAFT Polymerization
Aust. J. Chem., 60(10), 779.
Source: ORCID
Added: January 12, 2021
article
15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH
Source: ORCID
Added: January 12, 2021
article
Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange
Source: ORCID
Added: January 12, 2021
article
Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
Source: ORCID
Added: January 12, 2021
article
Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
Source: ORCID
Added: January 12, 2021
article
Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields
Source: ORCID
Added: January 12, 2021
Employment
Updated: July 18th, 2020 12:19
2020 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
Physics
2019 - present
University of North Carolina NC, NC, US
Adjunct Assistant Professor
Biomedical Engineering
2018 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
Chemistry
2016 - 2018
Duke University Durham, NC, US
Assistant Professor
Chemistry
2012 - 2015
Duke University Durham, NC, US
post-doc
Chemistry
2013 - 2013
RWTH Aachen Fakultät für Mathematik Informatik und Naturwissenschaften Aachen, Nordrhein-Westfalen, DE
visiting professor
Chemistry
Education
Updated: August 19th, 2019 16:06
2007 - 2012
University of California Berkeley Berkeley, CA, US
PhD
Chemistry
2004 - 2006
Georg-August-Universitat Gottingen Gottingen, Niedersachsen, DE
Diplom
Chemistry
Funding History
Funding history based on the linked ORCID record. Updated: July 19th, 2020 11:56
grant
October 1, 2019 - September 1, 2022
Affordable Molecular Imaging with Long-Lived Hyperpolarized Spin States to Understand, Diagnose and Treat Metabolic Disease
Edward Mallinckrodt, Jr. Foundation
grant
September 1, 2019 - July 1, 2021
Democratization and Disruption of Biomedical Molecular Imaging with Simple Hyperpolarized Biotracers
North Carolina Biotechnology Center
grant
January 1, 2018 - December 31, 2020
Molecular imaging with a hyperpolarized Vitamin Shot
National Institute of Biomedical Imaging and Bioengineering
grant
August 15, 2017 - July 31, 2020
Improving Understanding, Utility and Generality of Hyperpolarized, Long-lived Spin States in Magnetic Resonance
Directorate for Mathematical & Physical Sciences
