Thomas Theis

NMR, MRI, Magnetic Resonance, Hyperpolarization, Quantum Mechanics, Molecular Imaging, Biomedical Engineering

Dr. Thomas Theis is Associate Professor of Chemistry and Physics, and Goodnight Distinguished Scholar in Molecular Characterization at North Carolina State University. His research is focused on hyperpolarization technology and unconventional NMR and MRI detection schemes. Dr. Theis was born in Heidelberg, Germany, raised in Tenerife, Spain, and completed his undergraduate and masters at the Georg-August University of Goettingen (Germany). Theis received his PhD in 2012 from UC Berkeley (USA) working with Prof. Alexander Pines on "zero-field NMR" and “parahydrogen hyperpolarization schemes” for portable NMR. Dr. Theis conducted postdoctoral research at Duke University (USA) with Prof. Warren Warren focused on "singlet states for hyperpolarization storage", and worked on "low-field NMR" as visiting fellow at RWTH Aachen University with Prof. Stephan Appelt (Germany). In 2015, he was promoted to Research Assistant Professor at Duke University developing “cost-efficient hyperpolarization techniques for molecular imaging”. Since 2018, Dr. Theis leads the NC State Hyperpolarization Laboratory at NC State University where he was promoted to Associate Professor in 2023 and received the Goodnitght Distinguished Scholarship. He has received numerous awards in recognition of his research including the Friedrich-Wilhelm-Bessel Award from the Humboldt Foundation and the Ampere Prize for Rising Stars in Magnetic Resonance.

Works (109)

Updated: April 15th, 2024 05:04

2024 journal article

<SUP>13</SUP>C MRI of hyperpolarized pyruvate at 120 μT

SCIENTIFIC REPORTS, 14(1).

By: N. Kempf*, R. Koerber, M. Plaumann*, A. Pravdivtsev*, J. Engelmann*, J. Boldt*, K. Scheffler*, T. Theis n, K. Buckenmaier*

TL;DR: These 13C images demonstrate the feasibility of low-field 13C metabolic magnetic resonance imaging (MRI) of 50 mM [1-13C]pyruvate hyperpolarized by parahydrogen in reversible exchange imaged at about twice Earth’s magnetic field. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: March 1, 2024

2024 article

Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-<SUP>13</SUP>C]Pyruvate

Nantogma, S., Maissin, H., Adelabu, I., Abdurraheem, A., Nelson, C., Chukanov, N. V., … Chekmenev, E. Y. (2024, January 10). ACS SENSORS, Vol. 1.

By: S. Nantogma*, H. Maissin*, I. Adelabu*, A. Abdurraheem*, C. Nelson n, N. Chukanov, O. Salnikov*, I. Koptyug* ...

author keywords: NMR; hyperpolarization; pyruvate; C-13; parahydrogen; laser; RASER
TL;DR: Sensing of hyperpolarized allyl [1-13C]pyruvate via the stimulated emission of radiation that mitigates the requirements currently blocking broader adoption is demonstrated, potentially unlocking hyperpolarized 13C MRI on virtually any MRI system. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 26, 2024

2023 journal article

C-13 Radiofrequency Amplification by Stimulated Emission of Radiation Threshold Sensing of Chemical Reactions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(20), 11121–11129.

UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 10, 2023

2023 journal article

Delivering Robust Proton-Only Sensing of Hyperpolarized [1,2-<SUP>13</SUP>C<sub>2</sub>]-Pyruvate Using Broad-Spectral-Range Nuclear Magnetic Resonance Pulse Sequences

ACS SENSORS, 8(11), 4101–4110.

author keywords: parahydrogen; hyperpolarization; pyruvate; SABRE; protonsensing; molecular imaging
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science
Added: November 11, 2023

2023 journal article

Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-C-13]ketoisocaproate

METABOLITES, 13(2).

author keywords: NMR; hyperpolarization; carbon-13; ketoisocaproate; signal amplification by reversible exchange; SABRE-SHEATH; branched chain amino acid; BCAT
Sources: ORCID, Web Of Science
Added: January 31, 2023

2023 journal article

Exploring synchrony and chaos of parahydrogen-pumped two-compartment radio-frequency amplification by stimulated emission of radiation

PHYSICAL REVIEW A, 108(2).

Sources: ORCID, Web Of Science
Added: August 16, 2023

2023 article

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo

Browning, A., MacCulloch, K., Bedoya, D. G., Dedesma, C., Goodson, B. M., Rosen, M. S., … Theis, T. (2023, March 20). ChemRxiv.

By: A. Browning n, K. MacCulloch n, D. Bedoya*, C. Dedesma, B. Goodson*, M. Rosen*, E. Chekmenev*, Y. Yen*, P. TomHon, T. Theis n

Contributors: A. Browning n, K. McCulloch, D. Bedoya*, C. Dedesma, B. Goodson*, M. Rosen*, E. Chekmenev*, Y. Yen*, P. TomHon, T. Theis n

Source: ORCID
Added: March 21, 2023

2023 journal article

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo

JOURNAL OF MAGNETIC RESONANCE OPEN, 16-17.

By: K. Macculloch n, A. Browning n, D. Bedoya*, S. Mcbride n, M. Abdulmojeed n, C. Dedesma, B. Goodson*, M. Rosen* ...

Contributors: K. MacCulloch n, A. Browning n, D. Guarin Bedoya*, S. McBride n, M. Abdulmojeed n, C. Dedesma, B. Goodson*, M. Rosen* ...

author keywords: Hyperpolarized MRI; Parahydrogen; SABRE; Metabolic imaging
TL;DR: A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science
Added: November 15, 2023

2023 article

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo

SSRN.

By: K. MacCulloch, A. Browning, D. Guarin Bedoya, S. McBride, M. Abdulmojeed, C. Dedesma, B. Goodson, M. Rosen* ...

Contributors: K. MacCulloch, A. Browning, D. Guarin Bedoya, S. McBride, M. Abdulmojeed, C. Dedesma, B. Goodson, M. Rosen* ...

Source: ORCID
Added: November 15, 2023

2023 journal article

Innentitelbild: Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation (Angew. Chem. 5/2023)

Angewandte Chemie.

By: C. Nelson n, A. Schmidt*, I. Adelabu*, S. Nantogma*, V. Kiselev*, A. Abdurraheem*, H. Maissin*, S. Lehmkuhl* ...

Source: ORCID
Added: December 29, 2022

2023 journal article

Inside Cover: Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation (Angew. Chem. Int. Ed. 5/2023)

Angewandte Chemie International Edition.

By: C. Nelson n, A. Schmidt*, I. Adelabu*, S. Nantogma*, V. Kiselev*, A. Abdurraheem*, H. Maissin*, S. Lehmkuhl* ...

Source: ORCID
Added: December 29, 2022

2023 article

LIGHT-SABRE Hyperpolarizes 1-13C-Pyruvate Continuously without Magnetic Field Cycling

Pravdivtsev, A. N., Buckenmaier, K., Kempf, N., Stevanato, G., Scheffler, K., Engelmann, J., … Theis, T. (2023, April 4). JOURNAL OF PHYSICAL CHEMISTRY C, Vol. 4.

By: A. Pravdivtsev*, K. Buckenmaier*, N. Kempf*, G. Stevanato*, K. Scheffler*, J. Engelmann*, M. Plaumann*, R. Koerber*, J. Hoevener, T. Theis n

Contributors: A. Pravdivtsev*, K. Buckenmaier*, N. Kempf*, G. Stevanato*, K. Scheffler*, J. Engelmann*, M. Plaumann*, R. Koerber*, J. Hövener*, T. Theis n

TL;DR: It is described that continuous, weak irradiation in the audio-frequency range of the 13C spin at the 121 μT magnetic field enables spin order transfer from parahydrogen to 13C magnetization of 1-13C-pyruvate. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: April 5, 2023

2023 article

LIGHT-SABRE hyperpolarizes 1-<sup>13</sup>C-pyruvate continuously, without magnetic field cycling

ArXiv.

By: A. Pravdivtsev, K. Buckenmaier, N. Kempf, G. Stevanato, K. Scheffler, J. Engelmann, M. Plaumann, R. Koerber, J. Hövener, T. Theis*

Contributors: A. Pravdivtsev, K. Buckenmaier, N. Kempf, G. Stevanato, K. Scheffler, J. Engelmann, M. Plaumann, R. Koerber, J. Hövener, T. Theis*

Source: ORCID
Added: November 15, 2023

2023 article

Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole

MacCulloch, K., Browning, A., TomHon, P., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2023, May 10). ANALYTICAL CHEMISTRY, Vol. 5.

By: K. MacCulloch n, A. Browning n, P. TomHon n, S. Lehmkuhl n, E. Chekmenev* & T. Theis n

Contributors: K. MacCulloch n, A. Browning n, P. Tomhon n, S. Lehmkuhl n, E. Chekmenev* & T. Theis n

MeSH headings : Letrozole; Anastrozole; Magnetic Resonance Spectroscopy; Magnetic Resonance Imaging; Antineoplastic Agents / pharmacology
TL;DR: The nitrile 15N sites enable long-lasting polarization storage with [15N]T1 over 9 min, enabling signal detection from a single hyperpolarization cycle for over 30 min, and this sensitivity gain enables polarization studies at naturally abundant 15N enrichment level (0.4%). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: May 11, 2023

2023 journal article

Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation

Angewandte Chemie.

By: C. Nelson n, A. Schmidt*, I. Adelabu*, S. Nantogma*, V. Kiselev*, A. Abdurraheem*, H. Maissin*, S. Lehmkuhl* ...

Source: ORCID
Added: December 20, 2022

2023 journal article

SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(3).

By: A. Duchowny*, J. Denninger*, L. Lohmann*, T. Theis n, S. Lehmkuhl* & A. Adams*

Contributors: A. Duchowny*, J. Denninger*, L. Lohmann*, T. Theis n, S. Lehmkuhl* & A. Adams*

author keywords: high-pressure; benchtop NMR; SABRE; hyperpolarization; removable solvent
MeSH headings : Solvents / chemistry; Magnetic Resonance Spectroscopy / methods; Magnetic Resonance Imaging; Methanol
Sources: ORCID, Web Of Science
Added: January 31, 2023

2023 journal article

Spin dynamics of [1,2-C-13(2)]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25(24), 16446–16458.

UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: June 13, 2023

2022 article

Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange

Schmidt, A. B., Maissin, H., Adelabu, I., Nantogma, S., Ettedgui, J., TomHon, P., … Chekmenev, E. Y. (2022, November 15). ACS SENSORS, Vol. 11.

author keywords: Biosensors; magnetic resonance imaging; hyperpolarization; imaging agents; NMR spectroscopy; Parahydrogen; Pyruvate; SABRE
MeSH headings : Humans; Pyruvic Acid; Magnetic Resonance Spectroscopy / methods; Solubility; Magnetic Resonance Imaging / methods; Water
TL;DR: The development of Re-Dissolution Signal Amplification By Reversible Exchange (Re-D SABRE), which relies on fast and low-cost hyperpolarization of [1-13C]pyruvate by chemical exchange with parahydrogen at microtesla magnetic fields, is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: November 16, 2022

2022 article

Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques

Schmidt, A. B., Bowers, C. R., Buckenmaier, K., Chekmenev, E. Y., Maissin, H., Eills, J., … Hoevener, J.-B. (2022, January 1). ANALYTICAL CHEMISTRY, Vol. 1.

By: A. Schmidt*, C. Bowers*, K. Buckenmaier*, E. Chekmenev*, H. Maissin*, J. Eills*, F. Ellermann*, S. Gloeggler ...

MeSH headings : Hydrogen; Magnetic Resonance Spectroscopy
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: January 18, 2022

2022 article

Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-C-13]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH

Nantogma, S., Eriksson, S. L., Adelabu, I., Mandzhieva, I., Browning, A., TomHon, P., … Chekmenev, E. Y. (2022, November 28). JOURNAL OF PHYSICAL CHEMISTRY A, Vol. 11.

MeSH headings : Pyruvic Acid
TL;DR: The application of microtesla pulses is studied to investigate their effect on C-13 polarization efficiency, compared to that of conventional SABRE-SHEATH employing a static field, to provide the matching conditions of polarization transfer from parahydrogen-derived hydrides to the 13C-1 nucleus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: November 29, 2022

2022 article

Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation

Nelson, C., Schmidt, A. B., Adelabu, I., Nantogma, S., Kiselev, V. G., Abdurraheem, A., … Chekmenev, E. Y. (2022, December 19). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 62.

By: C. Nelson n, A. Schmidt*, I. Adelabu*, S. Nantogma*, V. Kiselev*, A. Abdurraheem*, H. Maissin*, S. Lehmkuhl* ...

Contributors: C. Nelson n, A. Schmidt*, I. Adelabu*, S. Nantogma*, V. Kiselev*, A. Abdurraheem*, H. Maissin*, S. Lehmkuhl* ...

author keywords: Carbon-13; Hyperpolarization; NMR Spectroscopy; Parahydrogen; RASER
MeSH headings : Hydrogen / chemistry; Protons; Magnetic Resonance Spectroscopy; Acetates / chemistry
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: December 20, 2022

2022 article

Proton-Only Sensing of Hyperpolarized [1,2-C-13(2)]Pyruvate

Mandzhieva, I., Adelabu, I., Chekmenev, E. Y., & Theis, T. (2022, November 22). ACS SENSORS, Vol. 11.

Contributors: I. Mandzhieva n, I. Adelabu*, E. Chekmenev* & T. Theis n

author keywords: Parahydrogen; hyperpolarization; pyruvate; SABRE; proton sensing; molecular imaging
MeSH headings : Protons; Magnetic Resonance Spectroscopy / methods; Pyruvic Acid / metabolism; Magnetic Resonance Imaging / methods; Contrast Media
TL;DR: The objective of this work is the development of an approach that works on conventional (i.e., proton-only) MRI systems while taking advantage of long-lived 13C hyperpolarization, which obviates 13C excitation and detection for proton sensing of 13C-hyperpolarized pyruvate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: November 23, 2022

2022 article

RASER MRI: Magnetic Resonance Images formed Spontaneously exploiting Cooperative Nonlinear Interaction

ArXiv.

By: S. Lehmkuhl, S. Fleischer, L. Lohmann, M. Rosen, E. Chekmenev, A. Adams, T. Theis*, S. Appelt

Contributors: S. Lehmkuhl, S. Fleischer, L. Lohmann, M. Rosen, E. Chekmenev, A. Adams, T. Theis*, S. Appelt

Source: ORCID
Added: November 15, 2023

2022 journal article

RASER MRI: Magnetic resonance images formed spontaneously exploiting cooperative nonlinear interaction

SCIENCE ADVANCES, 8(28).

Sources: ORCID, Web Of Science
Added: July 14, 2022

2022 article

Rapid C-13 Hyperpolarization of the TCA Cycle Intermediate alpha-Ketoglutarate via SABRE-SHEATH

Adelabu, I., Ettedgui, J., Joshi, S. M., Nantogma, S., Chowdhury, M. R. H., McBride, S., … Chekmenev, E. Y. (2022, September 22). ANALYTICAL CHEMISTRY, Vol. 9.

MeSH headings : Catalysis; Contrast Media; Ketoglutaric Acids; Pyruvic Acid; Theophylline
TL;DR: The fundamental studies reported here enable a wide range of research communities with a new hyperpolarized contrast agent potentially useful for metabolic imaging of brain function, cancer, and other metabolically challenging diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: September 23, 2022

2022 article

Triplet Photosensitized para-Hydrogen Induced Polarization

Brown, E. E., Mandzhieva, I., TomHon, P. M., Theis, T., & Castellano, F. N. (2022, November 14). ACS CENTRAL SCIENCE, Vol. 11.

By: E. Brown n, I. Mandzhieva n, P. TomHon n, T. Theis n & F. Castellano n

Contributors: E. Brown n, I. Mandzhieva n, P. Tomhon n, T. Theis n & F. Castellano n

UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: November 15, 2022

2021 article

A Versatile Compact Parahydrogen Membrane Reactor

TomHon, P. M., Han, S., Lehmkuhl, S., Appelt, S., Chekmenev, E. Y., Abolhasani, M., & Theis, T. (2021, October 26). CHEMPHYSCHEM, Vol. 10.

Contributors: P. TomHon n, S. Han n, S. Lehmkuhl n, S. Appelt*, E. Chekmenev*, M. Abolhasani n, T. Theis n

author keywords: hyperpolarization; parahydrogen; NMR; fluidics; RASER
MeSH headings : Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy
TL;DR: A Spin Transfer Automated Reactor that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days is introduced, and the PHIP variant called signal amplification by reversible exchange (SABRE) is used, which is particularly well suited to produce continuous hyperpolarization. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 8, 2021

2021 article

Background-Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation

Joalland, B., Theis, T., Appelt, S., & Chekmenev, E. Y. (2021, October 1). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 10.

Contributors: B. Joalland*, T. Theis n, S. Appelt* & E. Chekmenev*

author keywords: hyperpolarization; NMR spectroscopy; parahydrogen; RASER
MeSH headings : Body Fluids / chemistry; Contrast Media / analysis; Humans; Magnetic Fields; Proton Magnetic Resonance Spectroscopy
TL;DR: Completely background-free proton detection of hyperpolarized contrast agents in biological media paves the way to new applications in the areas of high-resolution NMR spectroscopy and in vivo spectroscopic and imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science
Added: October 2, 2021

2021 journal article

Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation

Angewandte Chemie, 9.

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: October 2, 2021

2021 article

Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange

Lin, K., TomHon, P., Lehmkuhl, S., Laasner, R., Theis, T., & Blum, V. (2021, September 22). CHEMPHYSCHEM, Vol. 9.

Contributors: K. Lin*, P. TomHon n, S. Lehmkuhl n, R. Laasner*, T. Theis n & V. Blum*

author keywords: computational chemistry; density functional calculations; hyperpolarization; NMR spectroscopy; reaction mechanisms; parahydrogen
MeSH headings : Density Functional Theory; Hydrogen / chemistry; Methanol / chemistry; Pyridines / chemistry; Surface Properties
TL;DR: An in-depth theoretical analysis of key chemical equilibria in Signal Amplification by Reversible Exchange (SABRE), employing density functional theory calculations to characterize the likely reaction network, shows that a methanol-containing intermediate is plausible as a transient species in the process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science
Added: September 23, 2021

2021 article

Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange

Lin, K., TomHon, P., Lehmkuhl, S., Laasner, R., Theis, T., & Blum, V. (2021, October 5). CHEMPHYSCHEM, Vol. 22, pp. 1937–1938.

Contributors: K. Lin*, P. TomHon n, S. Lehmkuhl n, R. Laasner*, T. Theis n & V. Blum*

author keywords: computational chemistry; density functional calculations; hyperpolarization; NMR spectroscopy; reaction mechanisms; parahydrogen
TL;DR: The front cover artwork is provided by the groups of Prof. Thomas Theis and Volker Blum and shows the reaction network of Signal Amplification by Reversible Exchange, elucidated by density functional theory (DFT). (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: October 10, 2021

2021 journal article

Front Cover: Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange (ChemPhysChem 19/2021)

ChemPhysChem.

Source: ORCID
Added: October 10, 2021

2021 article

Hyperpolarization of common antifungal agents with SABRE

MacCulloch, K., Tomhon, P., Browning, A., Akeroyd, E., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2021, June 20). MAGNETIC RESONANCE IN CHEMISTRY, Vol. 6.

By: K. MacCulloch n, P. Tomhon n, A. Browning n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev*, T. Theis n

Contributors: K. MacCulloch n, P. Tomhon n, A. Browning n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev*, T. Theis n

author keywords: N-15; H-1; antifungals; clotrimazole and fluconazole; contrast agents; hyperpolarization; NMR; parahydrogen; SABRE; voriconazole
MeSH headings : Antifungal Agents; Catalysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes
TL;DR: This work broadens the SABRE substrate scope and provides mechanistic and kinetic insights into the HP process, optimizing the polarization with respect to temperature and the polarization transfer field (PTF) for 1 H nuclei in the millitesla regime and for 15 N nucleiIn the microtesla regime, which provides detailed insights into exchange kinetics and spin evolution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: June 21, 2021

2021 journal article

Innentitelbild: Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation (Angew. Chem. 50/2021)

Angewandte Chemie, 11.

Source: ORCID
Added: November 3, 2021

2021 journal article

Inside Cover: Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation (Angew. Chem. Int. Ed. 50/2021)

Angewandte Chemie International Edition, 11.

Source: ORCID
Added: November 3, 2021

2021 journal article

Intensified continuous extraction of switchable hydrophilicity solvents triggered by carbon dioxide

GREEN CHEMISTRY, 23(8), 2900–2906.

By: S. Han n, M. Ramezani n, P. TomHon n, K. Abdel-Latif n, R. Epps n, T. Theis n, M. Abolhasani n

Contributors: S. Han n, M. Ramezani n, P. TomHon n, K. Abdel-Latif n, R. Epps n, T. Theis n, M. Abolhasani n

Sources: ORCID, Web Of Science
Added: April 1, 2021

2021 journal article

Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

PRX Quantum, 2(1), 010305.

By: N. Arunkumar*, D. Bucher*, M. Turner*, P. TomHon n, D. Glenn*, S. Lehmkuhl n, M. Lukin*, H. Park* ...

Contributors: N. Arunkumar*, D. Bucher*, M. Turner*, P. Tomhon n, D. Glenn*, S. Lehmkuhl n, M. Lukin*, H. Park* ...

Sources: ORCID, Crossref, Web Of Science
Added: January 13, 2021

2021 article

Order-Unity C-13 Nuclear Polarization of [1-C-13]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement

Adelabu, I., TomHon, P., Kabir, M. S. H., Nantogma, S., Abdulmojeed, M., Mandzhieva, I., … Chekmenev, E. Y. (2021, December 9). CHEMPHYSCHEM, Vol. 23.

By: I. Adelabu*, P. TomHon n, M. Kabir*, S. Nantogma*, M. Abdulmojeed n, I. Mandzhieva n, J. Ettedgui*, R. Swenson* ...

Contributors: I. Adelabu*, P. TomHon n, M. Kabir*, S. Nantogma*, M. Abdulmojeed n, I. Mandzhieva n, J. Ettedgui*, R. Swenson* ...

author keywords: hyperpolarization; NMR spectroscopy; parahydrogen; C-13; pyruvate
MeSH headings : Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Pyruvic Acid; Water / chemistry
TL;DR: Signal Amplification By Reversible Exchange in SHield Enabled Alignment Transfer (SABRE-SHEATH) is investigated to achieve rapid hyperpolarization of 13C1 spins of [1-13C]pyruvate, using parahydrogen as the source of nuclear spin order. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science
Added: December 10, 2021

2021 journal article

SABRE and PHIP pumped RASER and the route to chaos

Journal of Magnetic Resonance, 322, 106815.

author keywords: RASER; Hyperpolarization; NMR spectroscopy; MRI; Parahydrogen; PHIP; PASADENA; ALTADENA; SABRE; Synergetics; Slaving principle; Non-linear coupled oscillators; Mode collapse; Period doubling; Chaos; Intermittence
TL;DR: Light is shed on the links between NMR spectroscopy, RASER physics, synergetics and chaos theory and several new applications are envisioned in the fields of quantum sensor technology, structure investigation or magnetic resonance imaging (MRI). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Crossref, Web Of Science
Added: January 12, 2021

2021 article

Temperature Cycling Enables Efficient <sup>13</sup>C SABRE-SHEATH Hyperpolarization and Imaging of [1-<sup>13</sup>C]Pyruvate

ChemRxiv.

Contributors: P. TomHon n, M. Abdulmojeed n, I. Adelabu*, S. Nantogma*, M. Kabir*, S. Lehmkuhl n, E. Chekmenev*, T. Theis n

Source: ORCID
Added: February 2, 2022

2021 article

Temperature Cycling Enables Efficient C-13 SABRE-SHEATH Hyperpolarization and Imaging of [1-C-13]-Pyruvate

TomHon, P., Abdulmojeed, M., Adelabu, I., Nantogma, S., Kabir, M. S. H., Lehmkuhl, S., … Theis, T. (2021, December 23). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12.

MeSH headings : Pyruvic Acid
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: ORCID, Web Of Science
Added: December 24, 2021

2020 journal article

Application of 15N2-Diazirines as a Versatile Platform for Hyperpolarization of Biological Molecules by d-DNP

Bioconjugate Chemistry, 31(3), 537–541.

Contributors: H. Park*, G. Zhang*, J. Bae*, T. Theis*, W. Warren* & Q. Wang*

MeSH headings : Diazomethane / chemistry; Magnetic Resonance Imaging / methods; Nitrogen Isotopes / chemistry
TL;DR: It is shown that efficient polarization of diverse 15N2-diazirine-labeled molecules in water can be readily achieved by dissolution dynamic nuclear polarization (d-DNP), a hyperpo-larization technique used in clinical practice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Crossref
Added: January 12, 2021

2020 journal article

Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR

Journal of Magnetic Resonance, 312, 106700.

By: P. TomHon n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev* & T. Theis n

Contributors: P. TomHon n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev* & T. Theis n

author keywords: Parahydrogen; SABRE; Magnetic field cycling; Pneumatic shuttling; Singlet states; Hyperpolarization
MeSH headings : Catalysis; Equipment Design; Hydrogen / chemistry; Magnetic Fields; Magnetic Resonance Spectroscopy / instrumentation; Models, Molecular; Nitrogen Isotopes / chemistry; Protons
TL;DR: A simple-to-implement pneumatic sample shuttle system that enables automated 2D hyperpolarized NMR, including the first inverse 15N/1H HSQC, and uncovers binding mechanisms of the catalytic species through cross peaks that are not accessible in standard one-dimensional hyperPolarized experiments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: March 23, 2020

2020 article

Micron-scale SABRE-enhanced NV-NMR Spectroscopy

ArXiv.

By: N. Arunkumar, D. Bucher, M. Turner, P. TomHon, D. Glenn, S. Lehmkuhl, M. Lukin, H. Park ...

Contributors: N. Arunkumar, D. Bucher, M. Turner, P. TomHon, D. Glenn, S. Lehmkuhl, M. Lukin, H. Park ...

Source: ORCID
Added: November 15, 2023

2020 article

Micron-scale SABRE-enhanced NV-NMR Spectroscopy

(2020, June 6).

Thomas Theis

Source: ORCID
Added: January 12, 2021

2020 journal article

Parahydrogen‐Induced Hyperpolarization of Gases

Angewandte Chemie International Edition, 59(41), 17788–17797.

Contributors: K. Kovtunov*, I. Koptyug*, M. Fekete*, S. Duckett*, T. Theis n, B. Joalland*, E. Chekmenev*

author keywords: hyperpolarization; MRI; NMR; parahydrogen; spectroscopy
MeSH headings : Catalysis; Gases / chemistry; Hydrogen / chemistry; Magnetic Resonance Imaging / methods; Magnetic Resonance Spectroscopy / methods
TL;DR: The focus of this Minireview is to highlight selected advances in the field of parahydrogen-induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 31, 2020

2020 journal article

Parahydrogen‐Induced Radio Amplification by Stimulated Emission of Radiation

Angewandte Chemie International Edition, 59(22), 8654–8660.

author keywords: hyperpolarization; NMR spectroscopy; parahydrogen; PHIP; RASER
TL;DR: This work uses a commercial bench-top NMR spectrometer in conjunction with pairwise parahydrogen addition producing proton-hyperpolarized molecules in the Earth's magnetic field or in a high magnetic field to induce RASER without any radio-frequency excitation pulses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: June 1, 2020

2020 journal article

Parahydrogen‐Induced Radio Amplification by Stimulated Emission of Radiation

Angewandte Chemie, 132(22), 8732–8738.

Source: ORCID
Added: January 12, 2021

2020 journal article

Parawasserstoff‐induzierte Hyperpolarisation von Gasen

Angewandte Chemie, 132(41), 17940–17949.

Sources: ORCID, Crossref
Added: January 12, 2021

2020 journal article

Rational ligand choice extends the SABRE substrate scope

Chemical Communications, 56(65), 9336–9339.

By: J. Colell*, A. Logan*, Z. Zhou*, J. Lindale*, R. Laasner*, R. Shchepin*, E. Chekmenev*, V. Blum* ...

Contributors: J. Colell*, A. Logan*, Z. Zhou*, J. Lindale*, R. Laasner*, R. Shchepin*, E. Chekmenev*, V. Blum* ...

TL;DR: Chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates are reported on. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 31, 2020

2020 journal article

SABRE polarized low field rare-spin spectroscopy

The Journal of Chemical Physics, 152(18), 184202.

By: S. Lehmkuhl n, M. Suefke*, A. Kentner*, Y. Yen*, B. Blümich*, M. Rosen*, S. Appelt*, T. Theis n

Contributors: S. Lehmkuhl n, M. Suefke*, A. Kentner*, Y. Yen*, B. Blümich*, M. Rosen*, S. Appelt*, T. Theis n

TL;DR: The combination of low field NMR instruments with SABRE polarization results in sensitive measurements, even for rare spins with low gyromagnetic ratios at low magnetic fields. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: June 15, 2020

2019 journal article

Hyperpolarizing Concentrated Metronidazole 15 NO 2 Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime

Chemistry – A European Journal, 25(37), 8829–8836.

author keywords: hyperpolarization; isotopic labeling; nitrogen heterocycles; NMR spectroscopy; SABRE; spin relays
TL;DR: A novel synthesis of uniformly 15 N-enriched metronidazole is reported with a yield of 15 %. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 12, 2019

2019 journal article

Iodonitrene in Action: Direct Transformation of Amino Acids into Terminal Diazirines and15N2-Diazirines and Their Application as Hyperpolarized Markers

Journal of the American Chemical Society, 141(34), 13689–13696.

Contributors: T. Glachet*, H. Marzag*, N. Saraiva Rosa*, J. Colell*, G. Zhang*, W. Warren*, X. Franck*, T. Theis n, V. Reboul*

MeSH headings : Amino Acids / chemistry; Ammonia / chemistry; Diazomethane / chemistry; Halogenation; Imines / chemistry; Iodine / chemistry; Nitrogen / chemistry; Onium Compounds / chemistry; Tyrosine / chemistry
TL;DR: The 15N2-diazirine from L-tyrosine was hyperpolarized by a parahydrogen-based method (SABRE-SHEATH), demonstrating the products utility as hyperPolarized molecular tag and the first experimental observation of 14/15N isotopomers directly creating an asymmetric carbon. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: September 23, 2019

2019 chapter

Nuclear Magnetic Resonance Spectroscopy Techniques: Hyperpolarization for Sensitivity Enhancement

In P. Worsfold, A. Townshend, C. Poole, & M. Miró (Eds.), Encyclopedia of Analytical Science (3rd ed., pp. 168–181).

Ed(s): P. Worsfold, A. Townshend, C. Poole & M. Miró

Sources: Crossref, ORCID
Added: January 21, 2021

2019 journal article

Quasi-Resonance Fluorine-19 Signal Amplification by Reversible Exchange

The Journal of Physical Chemistry Letters, 10(15), 4229–4236.

By: N. Ariyasingha*, J. Lindale*, S. Eriksson*, G. Clark*, T. Theis n, R. Shchepin*, N. Chukanov, K. Kovtunov* ...

Contributors: N. Ariyasingha*, J. Lindale*, S. Eriksson*, G. Clark*, T. Theis n, R. Shchepin*, N. Chukanov, K. Kovtunov* ...

TL;DR: It is shown that high-field SABRE can be efficient and broadly applicable for direct hyperpolarization of 19F spins and the presence or absence of the spin-1/2 15N nucleus has no impact on the efficiency of QUASR-SABRE polarization transfer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: October 7, 2019

2019 journal article

Selective hyperpolarization of heteronuclear singlet states via pulsed microtesla SABRE

The Journal of Chemical Physics, 151(4), 044201.

Contributors: C. Tanner n, J. Lindale n, S. Eriksson n, Z. Zhou n, J. Colell n, T. Theis n, W. Warren n

TL;DR: It is shown that pulsed methods (including pulsed field nulling) coherently and selectively pump such singlets, affording a significant enhancement on the resulting hyperpolarization. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 19, 2019

2019 journal article

Terminal Diazirines Enable Reverse Polarization Transfer from 15 N 2 Singlets

Angewandte Chemie International Edition, 58(32), 11118–11124.

MeSH headings : Azirines / chemistry; Molecular Structure; Nitrogen Isotopes
TL;DR: Diazirine groups investigated here are analogues to methyl groups, which provides the opportunity to transfer polarization stored on a relaxation protected (-CH15N2) moiety to 1H, thus combining the advantages of long lifetimes of 15N polarization with superior sensitivity of 1H detection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: September 3, 2019

2019 journal article

Terminal Diazirines Enable Reverse Polarization Transfer from 15N2 Singlets

Angewandte Chemie.

Source: ORCID
Added: January 12, 2021

2019 journal article

Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange

Nature Communications, 10(1).

MeSH headings : Catalysis; Hydrogen / chemistry; Kinetics; Magnetic Fields; Magnetic Resonance Spectroscopy; Models, Molecular; Models, Theoretical; Nitrogen Isotopes / chemistry; Pyridines / chemistry
TL;DR: It is demonstrated that pulsing the excitation field induces complex coherent polarization transfer dynamics, but in fact pulsing with a roughly 1% duty cycle on resonance produces more magnetization than constantly being on resonance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Crossref
Added: January 12, 2021

2018 journal article

15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para-N2

Science Advances, 4(3), eaar2978.

Contributors: J. Bae*, Z. Zhou*, T. Theis*, W. Warren* & Q. Wang*

TL;DR: This work suggests great potential of 15N4-1,2,4,5-tetrazines as molecular tags in HP-MR imaging (HP-MRI) and supports the production of hyperpolarized para-15N2 gas, a biologically and medically innocuous gas with great potential for HP-MRI. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2018 journal article

Parahydrogen-Based Hyperpolarization for Biomedicine

Angewandte Chemie International Edition, 57(35), 11140–11162.

Contributors: J. Hövener*, A. Pravdivtsev*, B. Kidd*, C. Bowers*, S. Glöggler*, K. Kovtunov*, M. Plaumann*, R. Katz-Brull* ...

author keywords: hyperpolarization; magnetic resonance imaging; NMR spectroscopy; parahydrogen
TL;DR: Considerable progress has been made in the past decade in the area of pH2 -based hyperpolarization techniques for biomedical applications, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2018 journal article

Parawasserstoff-basierte Hyperpolarisierung für die Biomedizin

Angewandte Chemie, 130(35), 11310–11333.

By: J. Hövener*, A. Pravdivtsev*, B. Kidd*, C. Bowers*, S. Glöggler*, K. Kovtunov*, M. Plaumann*, R. Katz-Brull* ...

Sources: Crossref, ORCID
Added: February 6, 2021

2018 journal article

Quasi-Resonance Signal Amplification by Reversible Exchange

The Journal of Physical Chemistry Letters, 9(20), 6136–6142.

TL;DR: The 15N hyperpolarization levels attained with QUASR-SABRE on metronidazole-15N2-13C2 were more than 2-fold greater than those with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei), demonstrating that QUASr-SA BRE can deliver significantly more efficient means of SABre hyperpolarsization. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: November 19, 2018

2017 journal article

Cover Picture: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. Int. Ed. 40/2017)

Angewandte Chemie International Edition.

Source: ORCID
Added: January 12, 2021

2017 journal article

Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization

Angewandte Chemie International Edition, 56(40), 12112–12116.

author keywords: diazirine; hyperpolarization; imaging agents; iridium; structure-activity relationships
TL;DR: The generality of this approach is shown by illustrating that the diazirine tag alone is sufficient for achieving excellent signal enhancements with long-lasting polarization, and reveals the critical role of Lewis basic additives, including water, on achieving SABRE-promoted hyperpolarization. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Crossref
Added: January 12, 2021

2017 journal article

Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization

Angewandte Chemie, 129(40), 12280–12284.

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: January 12, 2021

2017 journal article

Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange

Journal of the American Chemical Society, 139(23), 7761–7767.

By: J. Colell*, M. Emondts*, A. Logan*, K. Shen*, J. Bae*, R. Shchepin*, G. Ortiz*, P. Spannring* ...

Contributors: J. Colell*, M. Emondts*, A. Logan*, K. Shen*, J. Bae*, R. Shchepin*, G. Ortiz*, P. Spannring* ...

MeSH headings : Hydrogen / chemistry; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrogen Isotopes / chemistry; Water / chemistry
TL;DR: A water-soluble polarization transfer catalyst is used to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei) and this strategy works in pure H2O or D2O solutions, on substrates that could not behyperpolarized in traditional 1H-SABRE experiments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Crossref
Added: January 12, 2021

2017 journal article

Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange

The Journal of Physical Chemistry C, 121(12), 6626–6634.

By: J. Colell*, A. Logan*, Z. Zhou*, R. Shchepin*, D. Barskiy*, G. Ortiz*, Q. Wang*, S. Malcolmson* ...

Contributors: J. Colell*, A. Logan*, Z. Zhou*, R. Shchepin*, D. Barskiy*, G. Ortiz*, Q. Wang*, S. Malcolmson* ...

Sources: ORCID, Crossref
Added: January 12, 2021

2017 article

Instrumentation for nuclear magnetic resonance in zero and ultralow magnetic field

ArXiv.

By: M. Tayler, T. Theis, T. Sjolander, J. Blanchard, A. Kentner, S. Pustelny, A. Pines, D. Budker

Contributors: M. Tayler, T. Theis, T. Sjolander, J. Blanchard, A. Kentner, S. Pustelny, A. Pines, D. Budker

Source: ORCID
Added: November 15, 2023

2017 journal article

Invited Review Article: Instrumentation for nuclear magnetic resonance in zero and ultralow magnetic field

Review of Scientific Instruments, 88(9), 091101.

TL;DR: Experimental techniques in the laboratory for nuclear magnetic resonance (NMR) in zero and ultralow magnetic field (below 0.1 μT) where detection is based on a low-cost, non-cryogenic, spin-exchange relaxation free 87Rb atomic magnetometer are reviewed. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2017 journal article

Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields

The Journal of Physical Chemistry Letters, 8(13), 3008–3014.

By: Z. Zhou*, J. Yu*, J. Colell*, R. Laasner*, A. Logan*, D. Barskiy*, R. Shchepin*, E. Chekmenev* ...

Contributors: Z. Zhou*, J. Yu*, J. Colell*, R. Laasner*, A. Logan*, D. Barskiy*, R. Shchepin*, E. Chekmenev* ...

TL;DR: This work uses parahydrogen-based polarization transfer catalysis at microtesla fields to hyperpolarize 13C2 spin pairs and finds decay time constants of 12 s for magnetization at 0.3 mT, which are extended to 2 min at that same field, when long-lived singlet states arehyperpolarized instead. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2017 journal article

Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification by Reversible Exchange

The Journal of Physical Chemistry C, 121(51), 28425–28434.

By: R. Shchepin*, L. Jaigirdar*, T. Theis*, W. Warren*, B. Goodson* & E. Chekmenev*

Contributors: R. Shchepin*, L. Jaigirdar*, T. Theis*, W. Warren*, B. Goodson* & E. Chekmenev*

TL;DR: It is concluded that long-range sites can be efficiently hyperpolarized when a network of spin-½ nuclei enables relayed polarization transfer (i.e. via short-range interactions between sites); in case of proton SABRE in the milli-Tesla regime, a relay network consisting of protons only is sufficient. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2017 journal article

The Absence of Quadrupolar Nuclei Facilitates Efficient13C Hyperpolarization via Reversible Exchange with Parahydrogen

ChemPhysChem, 18(12), 1493–1498.

author keywords: carbon-13; hyperpolarization; NMR; parahydrogen; spectroscopy
MeSH headings : Carbon Isotopes; Magnetic Resonance Imaging; Nitrogen Isotopes; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry; Pyridines / chemistry
TL;DR: Different 13 C nuclei in the test molecular frameworks-pyridine and acetonitrile-can be hyperpolarized, including 13 C sites up to five chemical bonds away from the exchangeable hydrides, and the presented approach is highly scalable and can be applied to a rapidly growing number of biomolecules amendable to micro-Tesla SABRE. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2017 journal article

Titelbild: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. 40/2017)

Angewandte Chemie.

Source: ORCID
Added: January 12, 2021

2017 journal article

Toward Hyperpolarized 19F Molecular Imaging via Reversible Exchange with Parahydrogen

ChemPhysChem, 18(15), 1961–1965.

author keywords: fluorine-19; hyperpolarization; molecular imaging; MRI; parahydrogen
TL;DR: NMR hyperpolarization of 19 F nuclei using reversible exchange reactions with parahydrogen gas as the source of nuclear spin order is reported on. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2016 journal article

15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH

ACS Sensors, 1(6), 640–644.

By: R. Shchepin, D. Barskiy, A. Coffey, T. Theis*, F. Shi, W. Warren*, B. Goodson, E. Chekmenev*

Contributors: R. Shchepin, D. Barskiy, A. Coffey, T. Theis*, F. Shi, W. Warren*, B. Goodson, E. Chekmenev*

author keywords: NMR; hyperpolarization; parahydrogen; imidazole; pH sensing; N-15; chemical shift
TL;DR: 15N-Imidazole SABRE-SHEATH hyperpolarization potentially enables pH sensing on scales ranging from peptide and protein molecules to living organisms. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2016 journal article

Accessing long lived 1H states via 2H couplings

Journal of Magnetic Resonance, 263, 108–115.

Contributors: Z. Zhou*, K. Claytor*, W. Warren* & T. Theis*

author keywords: Solution NMR; Long lived states; Ethylene; Deuterium
TL;DR: It is shown that the remaining J-coupling between the two quadrupolar deuterium spins, JQQ, splits the conditions for optimally generating proton singlet states and sheds light on the coherent evolution during singlet-triplet conversion as well as on the incoherent evolution that causes relaxation. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2016 journal article

Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal 15N2-diazirine molecular tags

Science Advances, 2(3), e1501438–e1501438.

By: T. Theis*, G. Ortiz*, A. Logan*, K. Claytor*, Y. Feng*, W. Huhn*, V. Blum*, S. Malcolmson* ...

Contributors: T. Theis*, G. Ortiz*, A. Logan*, K. Claytor*, Y. Feng*, W. Huhn*, V. Blum*, S. Malcolmson* ...

MeSH headings : Diazomethane / chemistry; Electron Spin Resonance Spectroscopy; Magnetic Fields; Magnetic Resonance Spectroscopy; Models, Chemical; Nitrogen Isotopes / chemistry
TL;DR: This work uses a recently developed method, SABRE-SHEATH, to directly hyperpolarize 15N 2 magnetization and long-lived 15N2 singlet spin order, with signal decay time constants of 5.8 and 23 minutes, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: January 12, 2021

2016 journal article

Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen

Chemistry - A European Journal, 22(31), 10777–10781.

Contributors: A. Logan*, T. Theis*, J. Colell*, W. Warren* & S. Malcolmson*

author keywords: amino acids; homogeneous catalysis; imaging agents; iridium; NMR spectroscopy
TL;DR: The substrate scope of SABRE, a recently introduced hyperpolarization method, is expanded to allow access to (15) N-enriched Schiff bases, which show fractional N polarization levels of up to 2 % while having only minimal (1) H enhancements. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2016 journal article

Over 20%15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe

Journal of the American Chemical Society, 138(26), 8080–8083.

Contributors: D. Barskiy*, R. Shchepin*, A. Coffey*, T. Theis*, W. Warren*, B. Goodson*, E. Chekmenev*

TL;DR: The results significantly expand the range of molecular structures and sites amenable to hyperpolarization via low-cost parahydrogen-based methods and have powerful potential applications such as direct in vivo imaging of mechanisms of action or hypoxia sensing. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2015 journal article

15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH

The Journal of Physical Chemistry C, 119(16), 8786–8797.

By: M. Truong, T. Theis*, A. Coffey, R. Shchepin, K. Waddell, F. Shi, B. Goodson, W. Warren*, E. Chekmenev

Contributors: M. Truong, T. Theis*, A. Coffey, R. Shchepin, K. Waddell, F. Shi, B. Goodson, W. Warren*, E. Chekmenev

TL;DR: This method enables hyperpolarization of molecular sites with NMR T1 relaxation times suitable for biomedical imaging and spectroscopy and provides large enough signal gains to enable one of the first 15N images (2 × 2 mm2 resolution). (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2015 journal article

Hyperpolarization of “Neat” Liquids by NMR Signal Amplification by Reversible Exchange

The Journal of Physical Chemistry Letters, 6(10), 1961–1967.

By: R. Shchepin, M. Truong, T. Theis*, A. Coffey, F. Shi*, K. Waddell, W. Warren*, B. Goodson*, E. Chekmenev

Contributors: R. Shchepin, M. Truong, T. Theis*, A. Coffey, F. Shi*, K. Waddell, W. Warren*, B. Goodson*, E. Chekmenev

MeSH headings : Catalysis; Hydrogen / chemistry; Iridium / chemistry; Magnetic Resonance Spectroscopy; Nitrogen Isotopes / chemistry; Pyridines / chemistry
TL;DR: The capability of screening at n.a. level of 15N is demonstrated on examples of mono- and dimethyl-substituted Py (picolines and lutidines previously identified as promising pH sensors), showing that the presence of a methyl group in the ortho position significantly decreases SABRE hyperpolarization. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2015 journal article

Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization

Journal of the American Chemical Society, 137(4), 1404–1407.

By: T. Theis*, M. Truong*, A. Coffey*, R. Shchepin*, K. Waddell*, F. Shi*, B. Goodson*, W. Warren*, E. Chekmenev*

Contributors: T. Theis*, M. Truong*, A. Coffey*, R. Shchepin*, K. Waddell*, F. Shi*, B. Goodson*, W. Warren*, E. Chekmenev*

MeSH headings : Hydrogen / chemistry; Magnetic Resonance Spectroscopy; Models, Molecular; Niacinamide / chemistry; Nitrogen Isotopes / analysis; Pyridines / chemistry
TL;DR: Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide by conducting “signal amplification by reversible exchange” (SABRE) at microtesla fields within a magnetic shield, promising to be a simple, cost-effective way tohyperpolarize heteronuclei. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: ORCID
Added: January 12, 2021

2014 journal article

Accessing Long-Lived Disconnected Spin-1/2 Eigenstates through Spins > 1/2

Accessing Long-Lived Disconnected Spin-1/2 Eigenstates through Spins > 1/2. Journal of the American Chemical Society, 136(43), 15118–15121.

By: K. Claytor*, T. Theis*, Y. Feng*, J. Yu*, D. Gooden* & W. Warren*

Contributors: K. Claytor*, T. Theis*, Y. Feng*, J. Yu*, D. Gooden* & W. Warren*

MeSH headings : Acetylene / chemistry; Deuterium / chemistry; Magnetic Phenomena; Magnetic Resonance Spectroscopy
TL;DR: Here the classes of molecules known to have accessible long-lived states are extended to include those with chemically equivalent spin-1/2 nuclei accessed by coupling to nuclei with spin > 1/2, in this case deuterium, and experiments show that simple deuteration of molecules with (13)C pairs at their natural abundance is sufficient for successful lifetime measurements. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2014 journal article

Analysis of parahydrogen polarized spin system in low magnetic fields

Physical Chemistry Chemical Physics, 16(29), 15411–15421.

By: P. Türschmann*, J. Colell*, T. Theis*, B. Blümich* & S. Appelt*

Contributors: P. Türschmann*, J. Colell*, T. Theis*, B. Blümich* & S. Appelt*

TL;DR: Examination of the experimental data facilitates the extraction of all relevant NMR parameters using single-scan, high-resolution (1)H and (13)C NMR spectroscopy at low fields at a fraction of the cost associated with cryogenically cooled high-field N MR spectrometers. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2014 journal article

Composite and shaped pulses for efficient and robust pumping of disconnected eigenstates in magnetic resonance

The Journal of Chemical Physics, 140(1), 014201.

By: T. Theis*, Y. Feng*, T. Wu* & W. Warren*

Contributors: T. Theis*, Y. Feng*, T. Wu* & W. Warren*

TL;DR: Traditional composite and adiabatic pulses fail completely in this problem because the interactions driving the transitions are fundamentally different, but the new shapes introduced can move population between accessible and disconnected eigenstates over a wide range of radio-frequency amplitudes and offsets while depositing insignificant amounts of power. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Crossref
Added: January 12, 2021

2014 journal article

LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization

Journal of Magnetic Resonance, 248, 23–26.

By: T. Theis*, M. Truong*, A. Coffey*, E. Chekmenev* & W. Warren*

Contributors: T. Theis*, M. Truong*, A. Coffey*, E. Chekmenev* & W. Warren*

author keywords: NMR and MRI; Parahydrogen; Hyperpolarization; NMR spectroscopy; Magnetic properties
MeSH headings : Catalysis; Hydrogen / chemistry; Hydrogen / radiation effects; Iridium / chemistry; Iridium / radiation effects; Magnetic Fields; Pyridines / chemistry; Pyridines / radiation effects; Radiation Dosage; Singlet Oxygen / chemistry; Singlet Oxygen / radiation effects; Spin Labels
TL;DR: Low-Irradiation Generation of High Tesla-SABRE (LIGHT-SA BRE) which works with simple pulse sequences and low power deposition and should be usable at any magnetic field and for hyperpolarization of many different nuclei. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2014 journal article

LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization

Journal of Magnetic Resonance. http://www.sciencedirect.com/science/article/pii/S1090780714002420

Thomas Theis

Source: ORCID
Added: January 12, 2021

2014 journal article

Long-Lived Heteronuclear Spin-Singlet States in Liquids at a Zero Magnetic field

Phys. Rev. Lett., 112(7).

TL;DR: It is demonstrated that heteronuclear singlet states formed between a 1H and a 13C nucleus can exhibit longer lifetimes than the respective triplet states even in the presence of additional spins that couple to the spin pair of interest. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2014 journal article

Long-lived polarization protected by symmetry

The Journal of Chemical Physics, 141(13), 134307.

By: Y. Feng*, T. Theis*, T. Wu*, K. Claytor* & W. Warren*

Contributors: Y. Feng*, T. Theis*, T. Wu*, K. Claytor* & W. Warren*

MeSH headings : Alkynes / chemistry; Computer Simulation; Magnetic Resonance Spectroscopy / methods; Maleic Anhydrides / chemistry; Models, Molecular; Pyridazines / chemistry
TL;DR: This paper elucidates molecular motifs which permit Long-Lived Polarization Protected by Symmetry (LOLIPOPS), and describes the symmetry of the accessed states, the pulse sequences used to access these states, and quantifies the fraction of polarization that can be stored as LOLIPOPS. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: January 12, 2021

2014 journal article

Measuring long-lived 13C2 state lifetimes at natural abundance

Journal of Magnetic Resonance, 239, 81–86.

By: K. Claytor*, T. Theis*, Y. Feng* & W. Warren*

Contributors: K. Claytor*, T. Theis*, Y. Feng* & W. Warren*

author keywords: Hyperpolarization; Singlet state; Long lived state
MeSH headings : Algorithms; Alkynes; Carbon Isotopes; Electromagnetic Fields; Half-Life; Isotope Labeling; Nuclear Magnetic Resonance, Biomolecular / instrumentation; Nuclear Magnetic Resonance, Biomolecular / methods; Reproducibility of Results; Solvents
TL;DR: It is shown that it is possible to determine (13)C singlet state lifetimes by detecting the naturally abundant doubly-labeled species, which allows for rapid and low cost screening of potential molecular biomarkers bearing long-lived states. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2013 journal article

Chemical analysis using J-coupling multiplets in zero-field NMR

Chemical Physics Letters, 580, 160–165.

By: T. Theis*, J. Blanchard*, M. Butler*, M. Ledbetter*, D. Budker* & A. Pines*

Contributors: T. Theis*, J. Blanchard*, M. Butler*, M. Ledbetter*, D. Budker* & A. Pines*

Source: ORCID
Added: January 12, 2021

2013 journal article

Fundamental Aspects of Parahydrogen Enhanced Low-Field Nuclear Magnetic Resonance

Phys. Rev. Lett., 110(13).

Contributors: J. Colell*, P. Türschmann*, S. Glöggler*, P. Schleker*, T. Theis*, M. Ledbetter*, D. Budker*, A. Pines*, B. Blümich*, S. Appelt*

TL;DR: It is shown here that low-field PHIP experiments in the inverse weak coupling regime enable the precise determination of δν and J, and it is experimentally proved that observed splittings are related to δγ in a nonlinear way. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2013 journal article

High-Resolution Zero-Field NMR J -Spectroscopy of Aromatic Compounds

J. Am. Chem. Soc., 135(9), 3607–3612.

By: J. Blanchard*, M. Ledbetter*, T. Theis*, M. Butler*, D. Budker* & A. Pines*

Contributors: J. Blanchard*, M. Ledbetter*, T. Theis*, M. Butler*, D. Budker* & A. Pines*

MeSH headings : Benzene Derivatives / chemistry; Magnetic Fields; Magnetic Resonance Spectroscopy; Reference Standards
TL;DR: The acquisition and interpretation of nuclear magnetic resonance J-spectra at zero magnetic field for a series of benzene derivatives is reported, demonstrating the analytical capabilities of zero-field NMR. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2013 journal article

Multiplets at zero magnetic field: The geometry of zero-field NMR

J. Chem. Phys., 138(18), 184202.

By: M. Butler*, M. Ledbetter*, T. Theis*, J. Blanchard*, D. Budker* & A. Pines*

Contributors: M. Butler*, M. Ledbetter*, T. Theis*, J. Blanchard*, D. Budker* & A. Pines*

TL;DR: This work provides a formal description of zero-field spin systems with truncated scalar couplings while also emphasizing visualization based on a geometric model, and the theoretical results are in good agreement with experimental spectra that exhibit second-order shifts and splittings. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2013 journal article

Parahydrogen-induced polarization at zero magnetic field

J. Chem. Phys., 138(23), 234201.

By: M. Butler*, G. Kervern*, T. Theis*, M. Ledbetter*, P. Ganssle*, J. Blanchard*, D. Budker*, A. Pines*

Contributors: M. Butler*, G. Kervern*, T. Theis*, M. Ledbetter*, P. Ganssle*, J. Blanchard*, D. Budker*, A. Pines*

TL;DR: The conversion of the singlet state of parahydrogen into an oscillating sample magnetization at zero magnetic field is described and the vector order present at the end of the pulse evolves into detectable magnetization. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2013 journal article

Storage of Hydrogen Spin Polarization in Long-Lived 13 C 2 Singlet Order and Implications for Hyperpolarized Magnetic Resonance Imaging

J. Am. Chem. Soc., 135(26), 9632–9635.

By: Y. Feng*, T. Theis*, X. Liang*, Q. Wang*, P. Zhou* & W. Warren*

Contributors: Y. Feng*, T. Theis*, X. Liang*, Q. Wang*, P. Zhou* & W. Warren*

MeSH headings : Acetylene / analogs & derivatives; Acetylene / chemistry; Carbon Isotopes; Hydrogen / chemistry; Magnetic Resonance Imaging
TL;DR: It is shown that A(n)A'( n)XX' spin systems such as (13)C2-1,2-diphenylacetylene ((13) C2-DPA) sustain long-lived polarization for both ( 13)C and (1)H spins with decay constants of almost 4.5 min at high magnetic fields of up to 16.44 T without spin-locking. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2012 journal article

Vibrationally resolved transition state spectroscopy of the F + H2 and F + CH4 reactions

Faraday Discuss., 157, 399.

By: T. Yacovitch*, E. Garand*, J. Kim*, C. Hock*, T. Theis* & D. Neumark*

Contributors: T. Yacovitch*, E. Garand*, J. Kim*, C. Hock*, T. Theis* & D. Neumark*

TL;DR: SEVI spectra of the 2P3/2 bands of FCH4- and FCD4- show extended structure from transitions to the entrance valley van der Waals region and the reactant side of the F + CH4 transition state region, attributed to bending or hindered rotation of the methane moiety and may be a spectroscopic signature of reactive resonances. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2012 journal article

Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange

J. Am. Chem. Soc., 134(9), 3987–3990.

By: T. Theis*, M. Ledbetter*, G. Kervern*, J. Blanchard*, P. Ganssle*, M. Butler*, H. Shin*, D. Budker*, A. Pines*

Contributors: T. Theis*, M. Ledbetter*, G. Kervern*, J. Blanchard*, P. Ganssle*, M. Butler*, H. Shin*, D. Budker*, A. Pines*

MeSH headings : Hydrogen / chemistry; Magnetic Resonance Spectroscopy; Pyridines / analysis
TL;DR: Because the NH-PHIP mechanism is nonreactive, operates in situ, and eliminates the need for a prepolarizing magnet, its combination with optical atomic magnetometry will greatly broaden the analytical capabilities of zero-field and low-field NMR. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2011 journal article

Near-Zero-Field Nuclear Magnetic Resonance

Phys. Rev. Lett., 107(10).

By: M. Ledbetter*, T. Theis*, J. Blanchard*, H. Ring*, P. Ganssle*, S. Appelt, B. Blümich*, A. Pines*, D. Budker*

Contributors: M. Ledbetter*, T. Theis*, J. Blanchard*, H. Ring*, P. Ganssle*, S. Appelt, B. Blümich*, A. Pines*, D. Budker*

TL;DR: It is shown that the presence of very small magnetic fields results in splitting of the zero-field NMR lines, imparting considerable additional information to the pure zero- field spectra. (via Semantic Scholar)
Source: ORCID
Added: January 12, 2021

2011 journal article

Near-zero field magnetic resonance

Physical Review Letters.

Thomas Theis

Source: ORCID
Added: January 12, 2021

2011 journal article

Parahydrogen-enhanced zero-field nuclear magnetic resonance

Nat Phys, 7(7), 571–575.

By: T. Theis*, P. Ganssle*, G. Kervern*, S. Knappe*, J. Kitching*, M. Ledbetter*, D. Budker*, A. Pines*

Contributors: T. Theis*, P. Ganssle*, G. Kervern*, S. Knappe*, J. Kitching*, M. Ledbetter*, D. Budker*, A. Pines*

Source: ORCID
Added: January 12, 2021

2008 journal article

PLP Labeling in ESR Spectroscopic Analysis of Secondary and Tertiary Acrylate Propagating Radicals

Macromolecules, 41(2), 288–291.

By: M. Buback*, P. Hesse*, T. Junkers*, T. Sergeeva* & T. Theis*

Contributors: M. Buback*, P. Hesse*, T. Junkers*, T. Sergeeva* & T. Theis*

Source: ORCID
Added: January 12, 2021

2007 journal article

Chain-Length-Dependent Termination in Acrylate Radical Polymerization Studied via Pulsed-Laser-Initiated RAFT Polymerization

Aust. J. Chem., 60(10), 779.

By: M. Buback*, P. Hesse*, T. Junkers*, T. Theis* & P. Vana*

Contributors: M. Buback*, P. Hesse*, T. Junkers*, T. Theis* & P. Vana*

Source: ORCID
Added: January 12, 2021

article

15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH

Thomas Theis

Source: ORCID
Added: January 12, 2021

article

Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange

Thomas Theis

Source: ORCID
Added: January 12, 2021

article

Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange

Thomas Theis

Source: ORCID
Added: January 12, 2021

article

Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange

Thomas Theis

Source: ORCID
Added: January 12, 2021

article

Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields

Thomas Theis

Source: ORCID
Added: January 12, 2021

Employment

Updated: February 28th, 2024 18:51

2023 - present

North Carolina State University Raleigh, US
Goodnight Distinguished Professor Chemistry

2023 - present

North Carolina State University Raleigh, North Carolina, US
Associate Professor Chemistry

2020 - present

NC State University Raleigh, NC, US
Associate Professor Physics

2019 - present

University of North Carolina NC, NC, US
Adjunct Assistant Professor Biomedical Engineering

2018 - 2023

NC State University Raleigh, NC, US
Assistant Professor Chemistry

2016 - 2018

Duke University Durham, NC, US
Assistant Professor Chemistry

2012 - 2015

Duke University Durham, NC, US
post-doc Chemistry

2013 - 2013

RWTH Aachen Fakultät für Mathematik Informatik und Naturwissenschaften Aachen, Nordrhein-Westfalen, DE
visiting professor Chemistry

Education

Updated: August 19th, 2019 16:06

2007 - 2012

University of California Berkeley Berkeley, CA, US
PhD Chemistry

2004 - 2006

Georg-August-Universitat Gottingen Gottingen, Niedersachsen, DE
Diplom Chemistry

Funding History

Funding history based on the linked ORCID record. Updated: February 28th, 2024 19:04

grant February 1, 2023 - July 31, 2024
Non-invasive molecular imaging tool for rapid, longitudinal assessment of localized metabolic disruptions in animal research and care
Office of the Director
grant September 1, 2022 - August 31, 2025
Non-Invasive Imaging of Nitrogen Assimilation in the Rhizosphere via Quantum-Entangled Hyperpolarized Spin States
Office of Biological and Environmental Research
grant September 15, 2020 - June 14, 2023
Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin States
National Institute of Biomedical Imaging and Bioengineering
grant October 1, 2019 - September 1, 2022
Affordable Molecular Imaging with Long-Lived Hyperpolarized Spin States to Understand, Diagnose and Treat Metabolic Disease
Edward Mallinckrodt, Jr. Foundation
grant September 1, 2019 - July 1, 2021
Democratization and Disruption of Biomedical Molecular Imaging with Simple Hyperpolarized Biotracers
North Carolina Biotechnology Center
grant June 4, 2019
Democratization and Disruption of Biomedical Molecular Imaging with Simple Hyperpolarized Biotracers
North Carolina Biotechnology Center
grant January 1, 2018 - December 31, 2020
Molecular imaging with a hyperpolarized Vitamin Shot
National Institute of Biomedical Imaging and Bioengineering
grant August 15, 2017 - July 31, 2020
Improving Understanding, Utility and Generality of Hyperpolarized, Long-lived Spin States in Magnetic Resonance
Directorate for Mathematical & Physical Sciences
award
Mapping In Vivo Metabolism with Long-lived Hyperpolarized Quantum States
Duke University
award
Biomolecular Imaging for Everyone
Trinity College of Arts and Sciences, Duke University
award
Ralph E. Powe Junior Faculty Enhancement Award
Oak Ridge Associated Universities
grant
Internationalization Seed Grant
North Carolina State University
grant
Seed Grant for start-up Vizma Life Sciences
NC IDEA
award
Goodnight Distinguished Professorship
Goodnight Foundation
award
Goodnight Early Innovator Award
Goodnight Foundation
grant
Towards Broadly Available Molecular Imaging with Parahydrogen Hyperpolarized MRI: The proof-of-concept study mapping reprogramed tumor metabolism in glioblastoma
North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill
award
Daugherty Endowment Award
Daugherty Endowment
award
Friedrich Wilhelm Bessel Award
Alexander von Humboldt-Stiftung

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