Tatiana Viktorovna Morozova

Works (18)

Updated: January 23rd, 2026 07:18

2025 article

Effects of aging on gene expression networks in the Drosophila genetic reference panel

Tan, S., Carbone, M. A., Zhou, S., Morozova, T., Arya, G., Zhang, F., … Mackay, T. F. C. (2025, July 1). Cell Reports, Vol. 44.

By: S. Tan *, M. Carbone n , S. Zhou n, T. Morozova n, G. Arya n, F. Zhang *, R. Anholt*, W. Huang, T. Mackay*

MeSH headings : Animals; Aging / genetics; Gene Regulatory Networks; Male; Female; Quantitative Trait Loci / genetics; Longevity / genetics; Transcriptome / genetics; Drosophila melanogaster / genetics; Phenotype; Gene Expression Profiling
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Genetic Mapping and Diversity in Plants and Animals; Genetic and phenotypic traits in livestock
Sources: Web Of Science, NC State University Libraries
Added: August 4, 2025

2025 article

Systems genetics of lifespan and senescence in Drosophila melanogaster

Aghdam, M. N., Unselt, D., Adonay, M. E., Morozova, T. V., Carbone, M. A., Arya, G. H., … Mackay, T. F. C. (2025, December 7). BMC Biology.

By: M. Aghdam *, D. Unselt  n, M. Adonay*, T. Morozova n, M. Carbone n , G. Arya n, L. Turlapati n, V. Shankar *, R. Anholt n, T. Mackay*

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Longevity / genetics; Female; Male; Aging / genetics; Quantitative Trait Loci
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Developmental Biology and Gene Regulation; Physiological and biochemical adaptations
Sources: NC State University Libraries, NC State University Libraries
Added: December 9, 2025

2022 article

Genome-Wide Analysis in Drosophila Reveals the Genetic Basis of Variation in Age-Specific Physical Performance and Response to ACE Inhibition

Gabrawy, M. M., Khosravian, N., Morcos, G. S., Morozova, T. V., Jezek, M., Walston, J. D., … Leips, J. (2022, January 14). Genes.

By: M. Gabrawy*, N. Khosravian*, G. Morcos *, T. Morozova n, M. Jezek *, J. Walston *, W. Huang *, P. Abadir *, J. Leips *

author keywords: aging; personalized medicine; frailty
MeSH headings : Age Factors; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Female; Gene Expression Regulation, Developmental / drug effects; Genome-Wide Association Study; Lisinopril / pharmacology; Male; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Physical Functional Performance
topics (OpenAlex): Genetics and Physical Performance; Neurobiology and Insect Physiology Research; Sports Performance and Training
TL;DR: The data show that functional response and sensitivity to Lisinopril treatment ranges from significant protection against physical decline to increased weakness depending on genotype and age, and genome-wide analyses led to identification of evolutionarily conserved genes in the WNT signaling pathway as being significantly associated with variations in physical performance traits and sensitivity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 31, 2022

2019 article

Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster

Gabrawy, M. M., Campbell, S., Carbone, M. A., Morozova, T. V., Arya, G. H., Turlapati, L. B., … Abadir, P. M. (2019, June 14). The Journals of Gerontology Series A, Vol. 74, pp. 1844–1852.

By: M. Gabrawy*, S. Campbell *, M. Carbone n , T. Morozova n, G. Arya n, L. Turlapati n, J. Walston *, M. Starz-Gaiano * ...

author keywords: Angiotensin; Aging; Locomotion; Muscle; Genetic variation
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Genotype; Lisinopril / pharmacology; Longevity / drug effects; Male; Peptidyl-Dipeptidase A / metabolism; Phenotype; Transcriptome
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Genetics and Physical Performance; Physiological and biochemical adaptations
TL;DR: It is demonstrated that skeletal muscle-specific Ance, the Drosophila ortholog of ACE, is involved in physical decline and genetic variation in phenotypic responses to an ACE inhibitor is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2016 article

Genetic Targets of Acute Toluene Inhalation inDrosophila melanogaster

Bushnell, P. J., Ward, W. O., Morozova, T. V., Oshiro, W. M., Lin, M. T., Judson, R. S., … Higuchi, M. (2016, November 22). Toxicological Sciences.

By: P. Bushnell*, W. Ward*, T. Morozova n, W. Oshiro*, M. Lin*, R. Judson *, S. Hester *, J. McKee *, M. Higuchi *

author keywords: fruit fly; volatile organic compound; motor activity; narcosis; genome-wide association; DGRP
MeSH headings : Air Pollutants / toxicity; Animals; Behavior, Animal / drug effects; Databases, Genetic; Drosophila Proteins / agonists; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drug Resistance; Gene Expression Regulation, Developmental / drug effects; Gene Ontology; Genome-Wide Association Study; Humans; Male; Molecular Sequence Annotation; Motor Activity / drug effects; Polymorphism, Genetic; Solvents / toxicity; Species Specificity; Toluene / toxicity
topics (OpenAlex): Neurobiology and Insect Physiology Research; Physiological and biochemical adaptations; Insect Resistance and Genetics
TL;DR: This analysis did not reveal a genetic signature consistent with processes previously shown to be involved in toluene-induced narcosis in mammals, but the list of the human orthologs included Gene Ontology terms associated with signaling, nervous system development and embryonic morphogenesis may provide insight into potential new pathways that could mediate the narcotic effects of toLUene. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

Modulation of Feeding Behavior by Odorant-Binding Proteins in Drosophila melanogaster

Swarup, S., Morozova, T. V., Sridhar, S., Nokes, M., & Anholt, R. R. H. (2013, December 3). Chemical Senses.

By: S. Swarup n, T. Morozova n, S. Sridhar n, M. Nokes n & R. Anholt  n

author keywords: bitter taste; chemosensation; gustation; insects; proboscis extension reflex; RNAi
MeSH headings : Animals; Animals, Genetically Modified; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Feeding Behavior / physiology; Female; Gene Expression; Genes, Insect; Male; Odorants; RNA Interference; Receptors, Odorant / antagonists & inhibitors; Receptors, Odorant / genetics; Receptors, Odorant / physiology; Sex Characteristics; Sucrose / administration & dosage; Taste / physiology; Taste Buds / physiology
topics (OpenAlex): Neurobiology and Insect Physiology Research; Insect Utilization and Effects; Biochemical Analysis and Sensing Techniques
TL;DR: RNAi lines that inhibit expression of individual target Obp genes are used and show that OBPs modulate sucrose intake in response to a panel of nine bitter compounds, consistent with roles for OBPs in transporting tastants to bitter taste receptors, sequestering them to limit their access to these receptors, or interacting directly with gustatory neurons that respond to sucrose. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

Alcohol Sensitivity in Drosophila: Translational Potential of Systems Genetics

Morozova, T. V., Ayroles, J. F., Jordan, K. W., Duncan, L. H., Carbone, M. A., Lyman, R. F., … Anholt, R. R. H. (2009, August 4). Genetics, Vol. 183, pp. 733–745.

By: T. Morozova*, J. Ayroles*, K. Jordan*, L. Duncan*, M. Carbone* , R. Lyman*, E. Stone n, D. Govindaraju ...

MeSH headings : Alcohol Drinking / genetics; Animals; Cluster Analysis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Ethanol / pharmacology; Female; Gene Expression Regulation / drug effects; Gene Regulatory Networks; Genes, Insect / genetics; Genetic Variation; Genome, Insect / genetics; Genome-Wide Association Study / methods; Genotype; Humans; Inbreeding; Malate Dehydrogenase / genetics; Malate Dehydrogenase / metabolism; Male; Phenotype; Polymorphism, Single Nucleotide; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Genetic Associations and Epidemiology; Bioinformatics and Genomic Networks
TL;DR: Seven intronic single nucleotide polymorphisms of the Malic Enzyme 1 (ME1) gene that are associated with cocktail drinking in 1687 individuals of the Framingham Offspring cohort are identified, implicating that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

journal article

Genetic and genomic response to selection for food consumption in Drosophila melanogaster

Garlapow, M. E., Everett, L. J., Zhou, S. S., Gearhart, A. W., Fay, K. A., Huang, W., … Mackay, T. F. C. Behavior Genetics, 47(2), 227–243.

By: M. Garlapow, L. Everett, S. Zhou, A. Gearhart, K. Fay, W. Huang, T. Morozova, G. Arya ...

Source: NC State University Libraries
Added: August 6, 2018

review

Genetics and genomics of alcohol sensitivity

Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Molecular Genetics and Genomics, 289(3), 253–269.

By: T. Morozova, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetics of alcohol consumption in Drosophila melanogaster

Fochler, S., Morozova, T. V., Davis, M. R., Gearhart, A. W., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Genes Brain and Behavior, 16(7), 675–685.

By: S. Fochler, T. Morozova, M. Davis, A. Gearhart, W. Huang, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Obp56h modulates mating behavior in Drosophila melanogaster

Shorter, J. R., Dembeck, L. M., Everett, L. J., Morozova, T. V., Arya, G. H., Turlapati, L., … Anholt, R. R. H. G3-Genes Genomes Genetics, 6(10), 3335–3342.

By: J. Shorter, L. Dembeck, L. Everett, T. Morozova, G. Arya, L. Turlapati, G. St Armour, C. Schal , T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: Implications for glaucoma

Carbone, M. A., Ayroles, J. F., Yamamoto, A., Morozova, T. V., West, S. A., Magwire, M. M., … Anholt, R. R. H. PLoS One, 4(1).

By: M. Carbone , J. Ayroles, A. Yamamoto, T. Morozova, S. West, M. Magwire, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

Morozova, T. V., Anholt, R. R., & MacKay, T. F. Genome Biology, 8(10).

By: T. Morozova, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila

Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H., & Mackay, T. F. C. BMC Genomics, 16.

By: T. Morozova, W. Huang, V. Pray, T. Whitham, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic basis for variation in sensitivity to lead toxicity in Drosophila melanogaster

Zhou, S. S., Morozova, T. V., Hussain, Y. N., Luoma, S. E., McCoy, L., Yamamoto, A., … Anholt, R. R. H. Environmental Health Perspectives, 124(7), 1062–1070.

By: S. Zhou, T. Morozova, Y. Hussain, S. Luoma, L. McCoy, A. Yamamoto, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

review

The genetic basis of alcoholism: Multiple phenotypes, many genes, complex networks

Morozova, T. V., Goldman, D., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Genome Biology, 13(2).

By: T. Morozova, D. Goldman, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Transcriptional networks for alcohol sensitivity in drosophila melanogaster

Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 187(4), 1193–1345.

By: T. Morozova, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Transcriptional response to alcohol exposure in Drosophila melanogaster

Morozova, T. V., Anholt, R. R. H., & MacKay, T. F. C. Genome Biology, 7(10).

By: T. Morozova, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

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