Works (16)
Updated: July 5th, 2023 15:49
2022 journal article
Genome-Wide Analysis in Drosophila Reveals the Genetic Basis of Variation in Age-Specific Physical Performance and Response to ACE Inhibition
GENES, 13(1).
author keywords: aging; personalized medicine; frailty
MeSH headings : Age Factors; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Female; Gene Expression Regulation, Developmental / drug effects; Genome-Wide Association Study; Lisinopril / pharmacology; Male; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Physical Functional Performance
TL;DR:
The data show that functional response and sensitivity to Lisinopril treatment ranges from significant protection against physical decline to increased weakness depending on genotype and age, and genome-wide analyses led to identification of evolutionarily conserved genes in the WNT signaling pathway as being significantly associated with variations in physical performance traits and sensitivity.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 31, 2022
2019 journal article
Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 74(12), 1844–1852.
author keywords: Angiotensin; Aging; Locomotion; Muscle; Genetic variation
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Genotype; Lisinopril / pharmacology; Longevity / drug effects; Male; Peptidyl-Dipeptidase A / metabolism; Phenotype; Transcriptome
TL;DR:
It is demonstrated that skeletal muscle-specific Ance, the Drosophila ortholog of ACE, is involved in physical decline and genetic variation in phenotypic responses to an ACE inhibitor is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 30, 2019
2016 journal article
Genetic Targets of Acute Toluene Inhalation in Drosophila melanogaster
TOXICOLOGICAL SCIENCES, 156(1), 230–239.
author keywords: fruit fly; volatile organic compound; motor activity; narcosis; genome-wide association; DGRP
MeSH headings : Air Pollutants / toxicity; Animals; Behavior, Animal / drug effects; Databases, Genetic; Drosophila Proteins / agonists; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drug Resistance; Gene Expression Regulation, Developmental / drug effects; Gene Ontology; Genome-Wide Association Study; Humans; Male; Molecular Sequence Annotation; Motor Activity / drug effects; Polymorphism, Genetic; Solvents / toxicity; Species Specificity; Toluene / toxicity
TL;DR:
This analysis did not reveal a genetic signature consistent with processes previously shown to be involved in toluene-induced narcosis in mammals, but the list of the human orthologs included Gene Ontology terms associated with signaling, nervous system development and embryonic morphogenesis may provide insight into potential new pathways that could mediate the narcotic effects of toLUene.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Modulation of Feeding Behavior by Odorant-Binding Proteins in Drosophila melanogaster
CHEMICAL SENSES, 39(2), 125–132.
author keywords: bitter taste; chemosensation; gustation; insects; proboscis extension reflex; RNAi
MeSH headings : Animals; Animals, Genetically Modified; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Feeding Behavior / physiology; Female; Gene Expression; Genes, Insect; Male; Odorants; RNA Interference; Receptors, Odorant / antagonists & inhibitors; Receptors, Odorant / genetics; Receptors, Odorant / physiology; Sex Characteristics; Sucrose / administration & dosage; Taste / physiology; Taste Buds / physiology
TL;DR:
RNAi lines that inhibit expression of individual target Obp genes are used and show that OBPs modulate sucrose intake in response to a panel of nine bitter compounds, consistent with roles for OBPs in transporting tastants to bitter taste receptors, sequestering them to limit their access to these receptors, or interacting directly with gustatory neurons that respond to sucrose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Alcohol Sensitivity in Drosophila: Translational Potential of Systems Genetics
GENETICS, 183(2), 733–745.
MeSH headings : Alcohol Drinking / genetics; Animals; Cluster Analysis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Ethanol / pharmacology; Female; Gene Expression Regulation / drug effects; Gene Regulatory Networks; Genes, Insect / genetics; Genetic Variation; Genome, Insect / genetics; Genome-Wide Association Study / methods; Genotype; Humans; Inbreeding; Malate Dehydrogenase / genetics; Malate Dehydrogenase / metabolism; Male; Phenotype; Polymorphism, Single Nucleotide; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Seven intronic single nucleotide polymorphisms of the Malic Enzyme 1 (ME1) gene that are associated with cocktail drinking in 1687 individuals of the Framingham Offspring cohort are identified, implicating that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
journal article
Genetic and genomic response to selection for food consumption in Drosophila melanogaster
Garlapow, M. E., Everett, L. J., Zhou, S. S., Gearhart, A. W., Fay, K. A., Huang, W., … Mackay, T. F. C. Behavior Genetics, 47(2), 227–243.
Source: NC State University Libraries
Added: August 6, 2018
review
Genetics and genomics of alcohol sensitivity
Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Molecular Genetics and Genomics, 289(3), 253–269.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetics of alcohol consumption in Drosophila melanogaster
Fochler, S., Morozova, T. V., Davis, M. R., Gearhart, A. W., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Genes Brain and Behavior, 16(7), 675–685.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Obp56h modulates mating behavior in Drosophila melanogaster
Shorter, J. R., Dembeck, L. M., Everett, L. J., Morozova, T. V., Arya, G. H., Turlapati, L., … Anholt, R. R. H. G3-Genes Genomes Genetics, 6(10), 3335–3342.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: Implications for glaucoma
Carbone, M. A., Ayroles, J. F., Yamamoto, A., Morozova, T. V., West, S. A., Magwire, M. M., … Anholt, R. R. H. PLoS One, 4(1).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster
Morozova, T. V., Anholt, R. R., & MacKay, T. F. Genome Biology, 8(10).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila
Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H., & Mackay, T. F. C. BMC Genomics, 16.
Source: NC State University Libraries
Added: August 6, 2018
journal article
The genetic basis for variation in sensitivity to lead toxicity in Drosophila melanogaster
Zhou, S. S., Morozova, T. V., Hussain, Y. N., Luoma, S. E., McCoy, L., Yamamoto, A., … Anholt, R. R. H. Environmental Health Perspectives, 124(7), 1062–1070.
Source: NC State University Libraries
Added: August 6, 2018
review
The genetic basis of alcoholism: Multiple phenotypes, many genes, complex networks
Morozova, T. V., Goldman, D., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Genome Biology, 13(2).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Transcriptional networks for alcohol sensitivity in drosophila melanogaster
Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 187(4), 1193–1345.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Transcriptional response to alcohol exposure in Drosophila melanogaster
Morozova, T. V., Anholt, R. R. H., & MacKay, T. F. C. Genome Biology, 7(10).
Source: NC State University Libraries
Added: August 6, 2018
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